KEGG   PATHWAY: zof00053
Entry
zof00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Zingiber officinale (ginger)
Class
Metabolism; Carbohydrate metabolism
Pathway map
zof00053  Ascorbate and aldarate metabolism
zof00053

Module
zof_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:zof00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Zingiber officinale (ginger) [GN:zof]
Gene
121975640  UDP-glucose 6-dehydrogenase 5-like [KO:K00012] [EC:1.1.1.22]
122019983  UDP-glucose 6-dehydrogenase 5-like [KO:K00012] [EC:1.1.1.22]
122027278  UDP-glucose 6-dehydrogenase 4-like [KO:K00012] [EC:1.1.1.22]
122007058  UDP-glucose 6-dehydrogenase 5-like [KO:K00012] [EC:1.1.1.22]
122029624  UDP-glucose 6-dehydrogenase 4-like [KO:K00012] [EC:1.1.1.22]
121977344  UDP-glucose 6-dehydrogenase 4-like [KO:K00012] [EC:1.1.1.22]
122031001  UDP-glucose 6-dehydrogenase 4-like [KO:K00012] [EC:1.1.1.22]
122034351  UDP-glucose 6-dehydrogenase 4-like [KO:K00012] [EC:1.1.1.22]
122034447  UDP-glucose 6-dehydrogenase 5-like [KO:K00012] [EC:1.1.1.22]
122023416  UDP-glucose 6-dehydrogenase 5-like [KO:K00012] [EC:1.1.1.22]
122023663  UDP-glucose 6-dehydrogenase 5 [KO:K00012] [EC:1.1.1.22]
121973104  UDP-glucose 6-dehydrogenase 4-like [KO:K00012] [EC:1.1.1.22]
122002786  UDP-glucose 6-dehydrogenase 5-like [KO:K00012] [EC:1.1.1.22]
121988662  UDP-sugar pyrophosphorylase-like [KO:K12447] [EC:2.7.7.64]
121975759  UDP-sugar pyrophosphorylase-like [KO:K12447] [EC:2.7.7.64]
121997589  UDP-sugar pyrophosphorylase-like [KO:K12447] [EC:2.7.7.64]
121970675  UDP-sugar pyrophosphorylase-like [KO:K12447] [EC:2.7.7.64]
122045225  glucuronokinase 1-like isoform X1 [KO:K16190] [EC:2.7.1.43]
122040684  glucuronokinase 1-like [KO:K16190] [EC:2.7.1.43]
122027952  probable inositol oxygenase [KO:K00469] [EC:1.13.99.1]
122028789  probable inositol oxygenase [KO:K00469] [EC:1.13.99.1]
122028133  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
122030213  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
121967096  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
122052291  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
122008737  L-gulonolactone oxidase 3-like [KO:K00103] [EC:1.1.3.8]
122031546  probable L-gulonolactone oxidase 4 [KO:K00103] [EC:1.1.3.8]
121981092  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
122011480  L-gulonolactone oxidase 3-like [KO:K00103] [EC:1.1.3.8]
122011795  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
122014446  L-gulonolactone oxidase 3-like [KO:K00103] [EC:1.1.3.8]
121984901  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
122001966  L-gulonolactone oxidase 3-like [KO:K00103] [EC:1.1.3.8]
121972732  probable L-gulonolactone oxidase 4 [KO:K00103] [EC:1.1.3.8]
121977197  GDP-mannose 3,5-epimerase 2-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
121982095  GDP-mannose 3,5-epimerase 2-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
122051284  GDP-mannose 3,5-epimerase 2-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
121985972  GDP-mannose 3,5-epimerase 2-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
122055803  GDP-mannose 3,5-epimerase 1 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
121972179  GDP-mannose 3,5-epimerase 1-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
122004264  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
122017276  GDP-L-galactose phosphorylase 2-like isoform X1 [KO:K14190] [EC:2.7.7.69]
121975323  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
122045310  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
121978328  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
122008237  GDP-L-galactose phosphorylase 2-like isoform X1 [KO:K14190] [EC:2.7.7.69]
121967496  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
121970238  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
121999329  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
122052724  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
122024339  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
122040801  GDP-L-galactose phosphorylase 2-like isoform X1 [KO:K14190] [EC:2.7.7.69]
121979752  inositol monophosphatase 3-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
121981732  inositol-phosphate phosphatase-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
121984073  inositol monophosphatase 3-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
121985600  inositol-phosphate phosphatase-like isoform X1 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
121976096  bifunctional phosphatase IMPL2, chloroplastic-like [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
121978554  bifunctional phosphatase IMPL2, chloroplastic-like [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
121978561  bifunctional phosphatase IMPL2, chloroplastic-like [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
121978567  bifunctional phosphatase IMPL2, chloroplastic-like [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
121971558  bifunctional phosphatase IMPL2, chloroplastic-like [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
121972880  bifunctional phosphatase IMPL2, chloroplastic-like [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
121975486  L-galactose dehydrogenase-like [KO:K17744] [EC:1.1.1.316]
121970413  L-galactose dehydrogenase-like [KO:K17744] [EC:1.1.1.316]
121992252  L-galactono-1,4-lactone dehydrogenase 1, mitochondrial-like [KO:K00225] [EC:1.3.2.3]
122010396  L-galactono-1,4-lactone dehydrogenase, mitochondrial-like [KO:K00225] [EC:1.3.2.3]
122016917  L-galactono-1,4-lactone dehydrogenase, mitochondrial-like [KO:K00225] [EC:1.3.2.3]
122017731  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
122042791  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
121989798  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
122019781  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
122019871  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
121976433  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
122047308  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
122009431  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
121980923  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
122010670  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
122010861  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
122033869  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
121981662  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
122051314  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
121982351  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
121998749  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
121984813  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
121971241  UDP-glucuronate 4-epimerase 4-like [KO:K08679] [EC:5.1.3.6]
121985525  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
122015599  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
122023347  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
122023627  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
121986236  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
122043080  monodehydroascorbate reductase 3, cytosolic-like [KO:K08232] [EC:1.6.5.4]
121992519  monodehydroascorbate reductase 3, cytosolic-like isoform X1 [KO:K08232] [EC:1.6.5.4]
121992939  monodehydroascorbate reductase 2, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
122047580  monodehydroascorbate reductase 3, cytosolic-like [KO:K08232] [EC:1.6.5.4]
121980300  monodehydroascorbate reductase 3, cytosolic-like [KO:K08232] [EC:1.6.5.4]
121980702  monodehydroascorbate reductase 2, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
122009392  monodehydroascorbate reductase 3, cytosolic-like [KO:K08232] [EC:1.6.5.4]
121996459  monodehydroascorbate reductase 3, cytosolic-like isoform X1 [KO:K08232] [EC:1.6.5.4]
121996934  monodehydroascorbate reductase 2, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
121984213  monodehydroascorbate reductase 3, cytosolic-like [KO:K08232] [EC:1.6.5.4]
121987511  monodehydroascorbate reductase 2, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
122016496  monodehydroascorbate reductase 3, cytosolic-like isoform X1 [KO:K08232] [EC:1.6.5.4]
121988513  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
121988808  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
121988809  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
122005309  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
122019986  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
121976899  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
122007419  L-ascorbate peroxidase 2, cytosolic-like [KO:K00434] [EC:1.11.1.11]
122008331  L-ascorbate peroxidase 2, cytosolic-like [KO:K00434] [EC:1.11.1.11]
121997389  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
122051428  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
121968459  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
121982423  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
122052343  probable L-ascorbate peroxidase 4, peroxisomal isoform X1 [KO:K00434] [EC:1.11.1.11]
122021044  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
122014382  L-ascorbate peroxidase 2, cytosolic-like [KO:K00434] [EC:1.11.1.11]
122001029  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
121971860  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
122024395  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
121986318  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
121989275  probable glutathione S-transferase DHAR2, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
122006961  probable glutathione S-transferase DHAR1, cytosolic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
122038808  probable glutathione S-transferase DHAR2, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
122002718  probable glutathione S-transferase DHAR1, cytosolic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
122002996  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
122003609  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
122004807  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
122005576  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
122008336  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
121994302  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
122049507  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
121997791  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
121999211  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
122036553  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
122036821  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
122037170  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
121999981  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
122014395  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
122022413  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
122001281  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
121972065  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
122040107  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
122017739  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
122005308  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
122027050  benzaldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
122045429  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
122029435  benzaldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
122049409  aldehyde dehydrogenase family 3 member H1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
121967559  aldehyde dehydrogenase family 3 member F1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
121982356  benzaldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
122052791  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
122001027  aldehyde dehydrogenase family 3 member H1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
121986242  benzaldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
122040918  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
122041536  aldehyde dehydrogenase family 7 member A1-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
121988679  aldehyde dehydrogenase family 7 member A1-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
122046049  aldehyde dehydrogenase family 7 member A1-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
121997609  aldehyde dehydrogenase family 7 member A1-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
zof00020  Citrate cycle (TCA cycle)
zof00040  Pentose and glucuronate interconversions
zof00051  Fructose and mannose metabolism
zof00520  Amino sugar and nucleotide sugar metabolism
zof00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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