KEGG    Network variation - KISS1-GnRH-LH/FSH-E2 signaling
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ENTRYnt06323
NameKISS1-GnRH-LH/FSH-E2 signaling
CategoryPathway view; Endocrine system
Pathwayhsa04929 GnRH secretion
hsa04912 GnRH signaling pathway
hsa04024 cAMP signaling pathway
hsa04915 Estrogen signaling pathway
DiseaseH00255 Hypogonadotropic hypogonadism (HH)
Display drug-target relation   disease type
N00869    KISS1→KISS1R→(GNAQ,GNA11)→PLCB→(Ca2+,DAG)→PKC
    HH13 KISS1*
    Precocious puberty   KISS1R*↗
    HH8   KISS1R*
 
N00882    TAC3→TACR3→GNAQ→PLCB→(Ca2+,DAG)→PKC
    HH10 TAC3*
    HH11   TACR3*
 
   D2,D3
 |		                  
N00873    GNRH1/2→GNRHR→(GNAQ,GNA11)→PLCB→(Ca2+,DAG)→PKC→RAF1→MEK→ERK→ELK1⇒(LHB,CGA,FSHB)
    HH12 GNRH1*
    HH7   GNRHR*
 
   D4,D1
 |		        
N00885    (LHB+CGA)→LHCGR→GNAS→ADCY→cAMP→PKA
    Precocious puberty   LHCGR*↗
 
   D1
 |		        
N00922    (CGA+FSHB)→FSHR→GNAS→ADCY→cAMP→PKA
    IFSHD FSHB*
 
N00286    E2→((ESR1/2)+(NCOA1/2..⇒(BCL2,EBAG9,KRT19,..
      ESR1*

Disease nameDisease category
HH13H00255Hypogonadotropic hypogonadismEndocrine and metabolic disease
Precocious pubertyH00937Precocious pubertyEndocrine and metabolic disease
HH8H00255Hypogonadotropic hypogonadismEndocrine and metabolic disease
HH10H00255Hypogonadotropic hypogonadismEndocrine and metabolic disease
HH11H00255Hypogonadotropic hypogonadismEndocrine and metabolic disease
HH12H00255Hypogonadotropic hypogonadismEndocrine and metabolic disease
HH7H00255Hypogonadotropic hypogonadismEndocrine and metabolic disease
IFSHDH01253Isolated follicle-stimulating hormone deficiencyEndocrine and metabolic disease
Estrogen resistance syndromeH02061Estrogen resistance syndromeEndocrine and metabolic disease


Drug name
D1D06457Gonadotropin, chorionic (USP)
D2D00990Nafarelin acetate (USAN)
D3D03267Gonadorelin diacetate (JP18)
D4D03478Choriogonadotropin alfa (USAN/INN)