KEGG    Network variation - Mitophagy
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ENTRYnt06536
NameMitophagy
CategoryPathway view; Cellular process
Pathwayhsa04137 Mitophagy - animal
DiseaseH00057 Parkinson disease
H01600 Parkinsonian syndrome
Display drug-target relation   disease type
N01756    AMBRA1PINK1(PRKN,ARIH1,SIAH1,..Outer_membrane_pro..=(SQSTM1,OPTN,NDP52..=LC3-II
    MRXST     HUWE1*
N01757      PINK1PRKNOuter_membrane_pro..
    PARK6   PINK1*
    PARK2     PRKN*
N01140          TBK1(SQSTM1,OPTN,NDP52..=LC3-II
    FTDALS4       TBK1*
    FTDALS3/PDB3/DMRV         SQSTM1*
    ALS12         OPTN*
    GLC1E         OPTN*
 
N01759    VCPMFN1/2=OPA1
    CMT2Y/FTDALS6 VCP*
    CMT2A2/6   MFN2*
    OPA1/MTDPS14     OPA1*
 
N01760    RAB5(GDP)RABGEF1RAB5(GTP)(MON1+CCZ1)RAB7(GTP)(TBC1D15,TBC1D17)RAB7(GDB)
    CMT2B         RAB7A*

Disease nameDisease category
MRXSTH00658X-linked syndromic intellectual developmental disorderMental and behavioural disorder
PARK6H00057Parkinson diseaseNeurodegenerative disease
H01600Parkinsonian syndromeNeurodegenerative disease
PARK2H00057Parkinson diseaseNeurodegenerative disease
H01600Parkinsonian syndromeNeurodegenerative disease
FTDALS4H02342Frontotemporal dementia and amyotrophic lateral sclerosisNervous system disease
FTDALS3/PDB3/DMRVH02342Frontotemporal dementia and amyotrophic lateral sclerosisNervous system disease
H00437Paget disease of boneMusculoskeletal disease
H00594Distal myopathyNervous system disease
ALS12H00058Amyotrophic lateral sclerosis (ALS)Neurodegenerative disease
GLC1EH00612Primary open angle glaucomaNervous system disease
CMT2Y/FTDALS6H00264Charcot-Marie-Tooth diseaseNeurodegenerative disease
H02342Frontotemporal dementia and amyotrophic lateral sclerosisNervous system disease
CMT2A2/6H00264Charcot-Marie-Tooth diseaseNeurodegenerative disease
OPA1/MTDPS14H01020Optic atrophyNervous system disease
H00469Mitochondrial DNA depletion syndromeInherited metabolic disorder, Mitochondrial disease
CMT2BH00264Charcot-Marie-Tooth diseaseNeurodegenerative disease