KEGG   Homo sapiens (human): 5071
Entry
5071              CDS       T01001                                 
Symbol
PRKN, AR-JP, LPRS2, PARK2, PDJ
Name
(RefSeq) E3 ubiquitin-protein ligase parkin isoform 1
  KO
K04556  parkin [EC:2.3.2.31]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
hsa04137  Mitophagy - animal
hsa04141  Protein processing in endoplasmic reticulum
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06028  Dopamine and serotonin metabolism
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06536  Mitophagy
  Element
N01019  Parkin-mediated ubiquitination
N01020  Mutation-inactivated PRKN to Parkin-mediated ubiquitination
N01021  Parkin-mediated ubiquitination
N01022  Mutation-inactivated PRKN to Parkin-mediated ubiquitination
N01023  Parkin-mediated ubiquitination
N01024  Mutation-inactivated PRKN to Parkin-mediated ubiquitination
N01025  Parkin-mediated ubiquitination
N01026  Mutation-inactivated PRKN to Parkin-mediated ubiquitination
N01032  Mutation-inactivated PRKN to mGluR1 signaling pathway
N01039  Mutation-inactivated PRKN to DOPAL generation
N01049  Mutation-inactivated PRKN to intrinsic apoptotic pathway
N01050  Mutation-inactivated PINK1 to intrinsic apoptotic pathway
N01052  PINK1-Parkin-mediated MFN2 degradation
N01053  Mutation-inactivated PINK1 to PINK1-Parkin-mediated MFN2 degradation
N01054  Mutation-inactivated PRKN to PINK1-Parkin-mediated MFN2 degradation
N01137  PINK-Parkin-mediated autophagosome formation
N01138  Mutation-inactivated OPTN to PINK-Parkin-mediated autophagosome formation
N01139  Mutation-inactivated p62 to PINK-Parkin-mediated autophagosome formation
N01756  PINK-Parkin-independent ubiquitin-mediated mitophagy
N01757  PINK-Parkin-independent ubiquitin-mediated mitophagy, ubiquitin E3 ligase
Disease
H00027  Ovarian cancer
H00057  Parkinson disease
H01600  Parkinsonian syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    5071 (PRKN)
   04120 Ubiquitin mediated proteolysis
    5071 (PRKN)
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    5071 (PRKN)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    5071 (PRKN)
   05014 Amyotrophic lateral sclerosis
    5071 (PRKN)
   05022 Pathways of neurodegeneration - multiple diseases
    5071 (PRKN)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    5071 (PRKN)
   04121 Ubiquitin system [BR:hsa04121]
    5071 (PRKN)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    5071 (PRKN)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.31  RBR-type E3 ubiquitin transferase
     5071 (PRKN)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Mitophagy
   PINK1-Parkin associated proteins
    5071 (PRKN)
  Aggrephagy
   Other aggrephagy associated proteins
    5071 (PRKN)
  Xenophagy
   Other xenophagy associated proteins
    5071 (PRKN)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   RBR proteins
    5071 (PRKN)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-dependent mechanism factors
    5071 (PRKN)
SSDB
Motif
Pfam: zf-RING_14 zf-RING_12 ubiquitin IBR_2 IBR_1 IBR Rad60-SLD Rcat_RNF216 Rad60-SLD_2 Dsc3_N Crinkler
Other DBs
NCBI-GeneID: 5071
NCBI-ProteinID: NP_004553
OMIM: 602544
HGNC: 8607
Ensembl: ENSP00000355865.1
UniProt: O60260 X5DR79
Structure
LinkDB
Position
6:complement(161347417..162727766)
AA seq 465 aa
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCD
LDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLA
VILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGP
SCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCIT
CTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKE
LHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGC
GFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPR
CHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
NT seq 1398 nt   +upstreamnt  +downstreamnt
atgatagtgtttgtcaggttcaactccagccatggtttcccagtggaggtcgattctgac
accagcatcttccagctcaaggaggtggttgctaagcgacagggggttccggctgaccag
ttgcgtgtgattttcgcagggaaggagctgaggaatgactggactgtgcagaattgtgac
ctggatcagcagagcattgttcacattgtgcagagaccgtggagaaaaggtcaagaaatg
aatgcaactggaggcgacgaccccagaaacgcggcgggaggctgtgagcgggagccccag
agcttgactcgggtggacctcagcagctcagtcctcccaggagactctgtggggctggct
gtcattctgcacactgacagcaggaaggactcaccaccagctggaagtccagcaggtaga
tcaatctacaacagcttttatgtgtattgcaaaggcccctgtcaaagagtgcagccggga
aaactcagggtacagtgcagcacctgcaggcaggcaacgctcaccttgacccagggtcca
tcttgctgggatgatgttttaattccaaaccggatgagtggtgaatgccaatccccacac
tgccctgggactagtgcagaatttttctttaaatgtggagcacaccccacctctgacaag
gaaacatcagtagctttgcacctgatcgcaacaaatagtcggaacatcacttgcattacg
tgcacagacgtcaggagccccgtcctggttttccagtgcaactcccgccacgtgatttgc
ttagactgtttccacttatactgtgtgacaagactcaatgatcggcagtttgttcacgac
cctcaacttggctactccctgccttgtgtggctggctgtcccaactccttgattaaagag
ctccatcacttcaggattctgggagaagagcagtacaaccggtaccagcagtatggtgca
gaggagtgtgtcctgcagatggggggcgtgttatgcccccgccctggctgtggagcgggg
ctgctgccggagcctgaccagaggaaagtcacctgcgaagggggcaatggcctgggctgt
gggtttgccttctgccgggaatgtaaagaagcgtaccatgaaggggagtgcagtgccgta
tttgaagcctcaggaacaactactcaggcctacagagtcgatgaaagagccgccgagcag
gctcgttgggaagcagcctccaaagaaaccatcaagaaaaccaccaagccctgtccccgc
tgccatgtaccagtggaaaaaaatggaggctgcatgcacatgaagtgtccgcagccccag
tgcaggctcgagtggtgctggaactgtggctgcgagtggaaccgcgtctgcatgggggac
cactggttcgacgtgtag

KEGG   Homo sapiens (human): 25820
Entry
25820             CDS       T01001                                 
Symbol
ARIH1, ARI, HARI, HHARI, UBCH7BP
Name
(RefSeq) E3 ubiquitin-protein ligase ARIH1
  KO
K11968  ariadne-1 [EC:2.3.2.31]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
Network
nt06536  Mitophagy
  Element
N01756  PINK-Parkin-independent ubiquitin-mediated mitophagy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    25820 (ARIH1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    25820 (ARIH1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.31  RBR-type E3 ubiquitin transferase
     25820 (ARIH1)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   RBR proteins
    25820 (ARIH1)
SSDB
Motif
Pfam: IBR UBA_ARI1 IBR_1 IBR_2 Ariadne zf-C3HC4_2 zf-C3HC4 zf-RING_5 zf-RING_14 zf-RING_2 Rcat_RNF216 zf-C3HC4_4 zf-RING_UBOX RING_XB3-XBAT31 UBA_ARIH2_N
Other DBs
NCBI-GeneID: 25820
NCBI-ProteinID: NP_005735
OMIM: 605624
HGNC: 689
Ensembl: ENSP00000369217.4
UniProt: Q9Y4X5
Structure
LinkDB
Position
15:72474330..72602987
AA seq 557 aa
MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDTLDLGEVELVEPGLGVGGERDG
LLCGETGGGGGSALGPGGGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREV
NEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECHVINPSKKSRTRQMNTRSS
AQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDILV
DDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRCKCG
RQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHM
VCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYCNR
YMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIEVQFLKKAVDVLCQCRATLMYTYVFAF
YLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRRVLL
QHVHEGYEKDLWEYIED
NT seq 1674 nt   +upstreamnt  +downstreamnt
atggactcggacgagggctacaactacgagttcgacgaggacgaggagtgcagtgaggag
gacagcggcgccgaggaggaggaggacgaagacgacgacgagccggacgatgataccctg
gatctgggcgaggtggagctggtggagcccgggctgggcgtcggcggggagcgggacgga
ctgctgtgcggggagacgggcggtggcggcggcagcgctctggggcccggcggtggcggc
ggcggcggcggcggcggtggtggtggcgggccggggcatgagcaggaggaggattaccgc
tacgaggtgctcacggccgagcagattctacaacacatggtggaatgtatccgggaggtc
aacgaggtcatccagaatccagcaactatcacaagaatactccttagccacttcaattgg
gataaagagaagctaatggaaaggtactttgatggaaacctggagaagctctttgctgag
tgtcatgtaattaatccaagtaaaaagtctcgaacacgccagatgaatacaaggtcatca
gcacaggatatgccttgtcagatctgctacttgaactaccctaactcgtatttcactggc
cttgaatgtggacataagttttgtatgcagtgctggagtgaatatttaactaccaaaata
atggaagaaggcatgggtcagactatttcgtgtcctgctcatggttgtgatatcttagtg
gatgacaacacagttatgcgcctgatcacagattcaaaagttaaattaaagtatcagcat
ttaataacaaatagctttgtagagtgcaatcgactgttaaagtggtgtcctgccccagat
tgccaccatgttgttaaagtccaatatcctgatgctaaacctgttcgctgcaaatgtggg
cgccaattttgctttaactgtggagaaaattggcatgatcctgttaaatgtaagtggtta
aagaaatggattaaaaagtgtgatgatgacagtgaaacctccaattggattgcagccaac
acaaaggaatgtcccaaatgccatgtcacaattgagaaggatggtggttgtaatcacatg
gtctgtcgtaaccagaattgtaaagcagagttttgctgggtgtgtcttggcccatgggaa
ccacatggatctgcctggtacaactgtaaccgctataatgaggatgatgcaaaggcagca
agagatgcacaggagcgatctagggcagccctgcagaggtacctgttctactgtaatcgc
tatatgaaccacatgcagagcctgcgctttgagcacaaactatatgctcaggtgaaacag
aaaatggaggagatgcagcagcacaacatgtcctggattgaggtgcagttcctgaagaag
gcagttgatgtcctctgccagtgtcgtgccacactcatgtacacttatgtcttcgctttc
tacctcaaaaagaataaccagtccattatctttgagaataaccaagcagatctagagaat
gccacagaggtgctctcgggctaccttgaacgagatatttcccaagattctctgcaggat
ataaagcagaaagtacaagacaagtacagatactgtgagagtcgacgaagggttttgtta
cagcatgtgcatgaaggctatgaaaaagatctgtgggagtacattgaggactga

KEGG   Homo sapiens (human): 6477
Entry
6477              CDS       T01001                                 
Symbol
SIAH1, BURHAS, SIAH1A
Name
(RefSeq) E3 ubiquitin-protein ligase SIAH1 isoform a
  KO
K04506  E3 ubiquitin-protein ligase SIAH1 [EC:2.3.2.27]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04115  p53 signaling pathway
hsa04120  Ubiquitin mediated proteolysis
hsa04137  Mitophagy - animal
hsa04310  Wnt signaling pathway
Network
nt06536  Mitophagy
  Element
N01756  PINK-Parkin-independent ubiquitin-mediated mitophagy
Disease
H02715  Neurodevelopmental disorder with defects of ubiquitin-proteasome system
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    6477 (SIAH1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    6477 (SIAH1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    6477 (SIAH1)
  09143 Cell growth and death
   04115 p53 signaling pathway
    6477 (SIAH1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    6477 (SIAH1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     6477 (SIAH1)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   SINA (Seven in absentia) proteins
    6477 (SIAH1)
SSDB
Motif
Pfam: Sina_TRAF Sina_ZnF Sina_RING
Other DBs
NCBI-GeneID: 6477
NCBI-ProteinID: NP_003022
OMIM: 602212
HGNC: 10857
Ensembl: ENSP00000378214.2
UniProt: Q8IUQ4
Structure
LinkDB
Position
16:complement(48360531..48387246)
AA seq 282 aa
MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL
VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL
CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM
MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP
RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
NT seq 849 nt   +upstreamnt  +downstreamnt
atgagccgtcagactgctacagcattacctaccggtacctcgaagtgtccaccatcccag
agggtgcctgccctgactggcacaactgcatccaacaatgacttggcgagtctttttgag
tgtccagtctgctttgactatgtgttaccgcccattcttcaatgtcagagtggccatctt
gtttgtagcaactgtcgcccaaagctcacatgttgtccaacttgccggggccctttggga
tccattcgcaacttggctatggagaaagtggctaattcagtacttttcccctgtaaatat
gcgtcttctggatgtgaaataactctgccacacacagaaaaagcagaccatgaagagctc
tgtgagtttaggccttattcctgtccgtgccctggtgcttcctgtaaatggcaaggctct
ctggatgctgtaatgccccatctgatgcatcagcataagtccattacaaccctacaggga
gaggatatagtttttcttgctacagacattaatcttcctggtgctgttgactgggtgatg
atgcagtcctgttttggctttcacttcatgttagtcttagagaaacaggaaaaatacgat
ggtcaccagcagttcttcgcaatcgtacagctgataggaacacgcaagcaagctgaaaat
tttgcttaccgacttgagctaaatggtcataggcgacgattgacttgggaagcgactcct
cgatctattcatgaaggaattgcaacagccattatgaatagcgactgtctagtctttgac
accagcattgcacagctttttgcagaaaatggcaatttaggcatcaatgtaactatttcc
atgtgttga

KEGG   Homo sapiens (human): 10075
Entry
10075             CDS       T01001                                 
Symbol
HUWE1, ARF-BP1, HECTH9, HSPC272, Ib772, LASU1, MRXST, MULE, URE-B1, UREB1
Name
(RefSeq) E3 ubiquitin-protein ligase HUWE1 isoform 1
  KO
K10592  E3 ubiquitin-protein ligase HUWE1 [EC:2.3.2.26]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
hsa04137  Mitophagy - animal
Network
nt06536  Mitophagy
  Element
N01756  PINK-Parkin-independent ubiquitin-mediated mitophagy
Disease
H00658  X-linked syndromic intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    10075 (HUWE1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    10075 (HUWE1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    10075 (HUWE1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.26  HECT-type E3 ubiquitin transferase
     10075 (HUWE1)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  HECT type E3
   10075 (HUWE1)
SSDB
Motif
Pfam: HECT DUF913 UBM DUF908 WWE UBA_7 UBA WWE_5 UIM_2
Other DBs
NCBI-GeneID: 10075
NCBI-ProteinID: NP_001427986
OMIM: 300697
HGNC: 30892
UniProt: Q7Z6Z7
Structure
LinkDB
Position
X:complement(53532096..53686719)
AA seq 4374 aa
MKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDR
FDGILADAGQTVENMSWMLVCDRPEREQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLT
TLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLA
ECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIM
ESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANSI
LYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASYHGFLP
VLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLG
DEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQ
RPNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSL
KHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREV
LGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLG
SAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNH
AAEEASSEDEEEEEVQAMQSFNSTQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESI
LSNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKV
LQEGLLQLDSILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAH
AYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSL
PSGCEFGQADMQKLVPKDEKAGTTQGGKRSDGEQDGAAGSMDASTQGLLEGIGLDGDTLA
PMETDEPTASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVR
QRRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSP
MLFDERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLD
AWLMLVEKMVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKNLWNRK
PLKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQ
QLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIMGGVVRDLSMSEEDQMMRAIA
MSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPLEQDELHTFT
DTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEAADVLIKAAL
PLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESSGILNVLIKL
LEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYLQSNSNNWRWF
DDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEETGNRRPVML
TLLRVPRLNKNSKNSNGQELEKTLEESKEMDIKRKENKGNDTPLALESTNTEKETSLEET
KIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHATLRLCLRLTRDHKYAMMFAELKS
TRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTMEKVVRSAATSGAGSTTSGVVSG
SLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALPAPRGSGTASDDEFENLRIKGPN
AVQLVKTTPLKPSPLPVIPDTIKEVIYDMLNALAAYHAPEEADKSDPKPGVMTQEVGQLL
QDMGDDVYQQYRSLTRQSSDFDTQSGFSINSQVFAADGASTETSASGTSQGEASTPEESR
DGKKDKEGDRASEEGKQKGKGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQSE
LIKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEVKAAL
GRALAMAESTEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLKKG
LVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQDAQ
GASQDSSSNQQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQ
EMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANR
EDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDD
DGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPLMV
RHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQRL
LGPSAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQAGT
LSSIPTALTRWTEECKVLDAESMHDCVSVVKVSIVNHLEFLRDEELEERREKRRKQLAEE
ETKITDKGKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKE
TLGTLQSSQQQPTLPTPPALGEVPQELQSPAGEGGSSTQLLMPVEPEELGPTRPSGEAET
TQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTSAAGSS
EQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADS
RGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRTAPS
TNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNASSDTPMDPVT
FIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFGHSSTSA
LSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLRLRGRLL
LDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSSESELCI
ETPKLTTSEEKGKKSSKSCGSSSHENRPLDLLHKMESKSSNQLSWLSVSMDAALGCRTNI
FQIQRSGGRKHTEKHASGGSTVHIHPQAAPVVCRHVLDTLIQLAKVFPSHFTQQRTKETN
CESDRERGNKACSPCSSQSSSSGICTDFWDLLVKLDNMNVSRKGKNSVKSVPVSAGGEGE
TSPYSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPENKVSEAQANSGSGA
SSTTTATSTTSTTTTTAASTTPTPPTAPTPVTSAPALVAATAISTIVVAASTTVTTPTTA
TTTVSISPTTKGSKSPAKVSDGGSSSTDFKMVSSGLTENQLQLSVEVLTSHSCSEEGLED
AANVLLQLSRGDSGTRDTVLKLLLNGARHLGYTLCKQIGTLLAELREYNLEQQRRAQCET
LSPDGLPEEQPQTTKLKGKMQSRFDMAENVVIVASQKRPLGGRELQLPSMSMLTSKTSTQ
KFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVRQLEAEADAIIQMVR
EGQRARRQQQAATSESSQSEASVRREESPMDVDQPSPSAQDTQSIASDGTPQGEKEKEER
PPELPLLSEQLSLDELWDMLGECLKELEESHDQHAVLVLQPAVEAFFLVHATERESKPPV
RDTRESQLAHIKDEPPPLSPAPLTPATPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAE
THRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVH
VRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYAL
FRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKS
VRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTE
ENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDID
DLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGI
QKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA
NT seq 13125 nt   +upstreamnt  +downstreamnt
atgaaagtagacaggactaaactgaagaagacacctactgaggctcctgcagactgcaga
gccttaatagacaaactcaaagtttgtaatgatgagcaacttctcttggaactgcagcag
atcaaaacatggaacattggaaagtgcgagttatatcactgggtggacctgttggaccgc
ttcgatggaatactggcagatgctggacagacagtggagaatatgtcatggatgctcgta
tgtgataggccagaaagagagcaactgaaaatgcttctcttggctgtgttgaacttcaca
gccttgctcattgagtacagcttttcccggcatctgtacagttccatagagcatttgaca
actttattggcttcctctgatatgcaagtggtgctggcagtcctcaatctcctatatgta
tttagcaaaagatcaaactacatcactcgtctgggatctgacaagaggaccccgctgcta
actcggctacaacatttggcagagagctggggtggaaaggagaatggctttggacttgca
gaatgttgcagagacttgcatatgatgaaatatccacccagtgcaactacactacacttt
gaattctatgcagatcctggggccgaggtcaaaattgagaaaaggacaactagtaacaca
ctacattatattcacatagagcaacttgacaagatttcagaaagcccttctgaaatcatg
gaatctcttaccaaaatgtacagcattcctaaggataagcagatgctgttatttacacac
atacgactggcccatggcttttctaatcacaggaagcgattgcaggcagttcaggccaga
ctgcatgcaatatctatattagtgtattccaatgccttgcaggaatcagcaaacagtatc
ttgtataatggcttgatagaggagttggtagatgtccttcagataacggataagcagctt
atggagattaaagcagcttctttacgaacattaacatcaattgtccacttggagagaact
cccaaactcagcagtattattgactgtactggaactgcctcctaccatggatttttgcca
gtgcttgtaaggaactgtatccaggccatgattgatccttccatggatccataccctcac
cagtttgccactgctctcttctcttttttataccatctggccagctacgatgctggtggt
gaagccttggtctcctgtggaatgatggaagccttattgaaggtcataaagtttcttggc
gatgaacaggaccagataacatttgtcaccagagccgtcagagtggttgaccttatcacc
aacctggatatggcagcttttcaatcccatagtggactttctatcttcatttatagactt
gagcatgaagtagatttgtgccgaaaagaatgtccgtttgtgatcaagccaaagatccag
agacccaatactacacaagaaggagaggaaatggaaactgatatggatggagtccagtgt
attccacaacgagcagcacttctgaaatccatgttgaatttcctcaagaaggccatccaa
gaccctgctttctcagatggcatacgacatgtgatggatggttctctgcctacctccctg
aaacacatcatcagcaatgcagaatactatggcccatcactcttcctcctagctactgaa
gtggtgactgtgtttgtatttcaagaaccatcactgctctcctcactccaggacaatgga
ttgacagatgtcatgctgcatgcactgcttatcaaagatgttcctgctacccgtgaagtc
cttggctccctcccaaatgtattcagtgcactctgtttgaatgcccgaggtcttcagtct
tttgttcagtgtcagccttttgaacgcctcttcaaagttcttctgtctccagattacctc
ccagccatgcggaggaggagaagttctgatccccttggggatactgcatccaacctgggg
agtgctgtcgatgagctcatgagacatcagcccacccttaaaacagatgcaacgactgcc
atcatcaagttacttgaagaaatctgtaatcttggaagggaccccaaatacatctgtcag
aagccatcaatccagaaggcagatggcactgccactgctcctcccccaaggtctaatcat
gccgcagaagaagcctctagtgaggatgaggaggaagaggaagtacaggccatgcagagc
tttaattctacccagcaaaatgaaactgagcctaatcagcaggttgttggtacagaggaa
cgtattcctattcccctcatggattacatccttaatgtgatgaaatttgtggaatctatt
ctgagcaacaatacaacagatgaccactgccaggaatttgtgaatcagaaaggactgttg
cctttggttaccattttgggtcttcccaatctgcccattgactttcccacatctgctgcc
tgtcaggctgttgcaggtgtctgcaaatccatattgacactgtcacatgaacccaaagtc
cttcaagagggtctccttcagttggactccatcctctcctccctggagcccttacaccgc
cccattgaatcccctgggggctcagtgttgttgcgagaactggcttgcgcaggcaatgtt
gctgatgctaccctctcagcccaggccacacctctgctgcatgcactcactgctgcccat
gcctacatcatgatgtttgttcatacttgcagagttggacagagtgaaattcgttccatc
tccgtaaaccagtggggctctcaattgggtctgagtgttttgagcaagctgagccagtta
tactgttccctggtgtgggaaagcactgtcctcctctctctgtgtaccccaaacagccta
ccatctgggtgtgaatttggccaggcagatatgcagaaactggttccaaaggatgagaag
gcaggtacgacccagggcggaaaaagatcagatggggaacaggatggagcagctggaagt
atggatgcttctacccagggcttattagaaggcattgggctagatggtgacacattggct
cccatggagacagatgaacctactgcttcagactctaagggcaaatctaaaatcacacca
gcaatggctgccagaattaagcaaatcaagcctttgttatcagcttcctccagattaggc
cgagcacttgctgagctatttggacttcttgttaaactttgtgtgggatctcctgtccgc
cagagaaggagccatcatgctgccagcaccactacagcaccgacacctgccgcgcgatca
acagcctcagctctcactaagctcttgactaaggggttatcttggcagcccccaccatat
acacctactccccgattcaggctgacattcttcatctgttcagttggtttcacatcccca
atgctgtttgatgagaggaagtatccctaccacctcatgctgcaaaaatttctctgctcc
ggaggccacaatgctctttttgaaactttcaactgggctctgtccatgggaggtaaagtt
cctgtttctgagggattggaacactcagacttgcctgatggcacaggagaattcctagat
gcctggcttatgctggtggagaagatggtgaatcccaccacggtgcttgaatctccacat
tcgctgcctgccaaattgcctggaggtgtccagaactttccccagttcagtgcactgcgc
ttccttgtggtaactcagaaagcagcctttacttgcatcaaaaacttatggaaccggaaa
cccctgaaggtatatggtggacgaatggctgaatcgatgctggccattctatgccacatc
ctccgaggagaacctgtgattcgagagagactaagcaaggagaaggaggggtctcgagga
gaagaggatacagggcaagaggaaggtggctcccgccgggaacctcaagtcaaccagcaa
caactgcaacagctcatggacatgggcttcacaagggaacatgcaatggaggcactgttg
aacaccagcaccatggagcaggccacagagtaccttttaacccaccctcctccaatcatg
ggaggagttgttcgggatctcagcatgtctgaagaggaccagatgatgagagcaattgct
atgtctctgggacaggatattccaatggatcaaagggcagagtcacctgaggaagttgct
tgccggaaggaggaagaggaacggaaagctcgggaaaagcaggaggaggaagaggctaaa
tgtctagagaagttccaggatgctgacccgttggaacaagatgagctccacactttcaca
gatactatgttgccaggctgcttccaccttcttgatgagctgccagacacagtataccgt
gtgtgtgacctgatcatgacagcaatcaaacgtaatggagcagattatcgtgacatgatt
ctgaagcaagtagtcaatcaggtgtgggaagctgctgatgtattgatcaaagctgctctt
cccctgacaacaagtgacacaaaaaccgtgtcagagtggataagtcagatggccacactg
ccccaggcctccaatttggctactagaatcttgcttttaacgctactttttgaggagttg
aagctaccttgtgcttgggtggttgaatcaagtggcatccttaatgtcctaatcaaactc
ttggaagtggttcagccctgcctccaggcagccaaggagcagaaggaagtccagacccca
aagtggatcacaccagtgttgctcctgattgatttctatgaaaagacagccatctcctca
aaaaggagagcccagatgactaagtacctgcaatccaacagcaacaactggcgctggttt
gatgatcgctctgggcgttggtgtagttacagtgcaagcaacaatagcactattgattct
gcctggaaatctggagagacaagcgtgcgattcactgcaggccgaagaagatacacggtc
caattcactacaatggtgcaggttaatgaggaaacagggaaccgacgccctgtgatgctg
actctcctcagggtacctcggctgaataaaaattcaaaaaacagcaatggacaggaacta
gagaagacgctggaagaaagcaaagaaatggatatcaaacgtaaagaaaataaaggcaat
gatacccctttggccctagagagtacaaacactgaaaaggagacaagcctggaggaaaca
aaaatcggggagatcctgatccagggcttgacagaagatatggtgactgttttaatccgg
gcctgcgtgagcatgctgggagtccctgtggacccagatactttgcatgccacccttcgt
ctctgtctgaggctcacccgggaccacaaatatgccatgatgtttgcagaactgaagagt
acccgcatgatcttgaatttgacccagagctcaggcttcaatgggtttactcccctggtc
acccttctcttaagacacatcattgaggacccctgtacccttcgtcataccatggaaaag
gttgttcgctcagcagctacaagtggagctggtagcactacctctggtgttgtgtctggc
agcctcggctctcgggagatcaactacatccttcgtgtccttgggccagccgcatgccgc
aatccagacatattcacagaagtggccaactgctgtatccgcatcgcccttcctgcccct
cgaggctcaggaactgcttcagatgatgaatttgagaatcttagaattaaaggccctaat
gctgtacagctggtgaagaccacccctttgaagccctcacctctgcctgtcatccctgat
actatcaaggaagtgatctatgatatgctgaatgctctggctgcataccatgctccagag
gaagcagataaatctgatcctaaacctggggttatgacccaagaggttggccagctcctg
caagacatgggtgatgatgtataccagcagtaccggtcacttacgcgtcagagcagtgac
tttgatacgcagtcaggtttttccattaatagtcaggtctttgctgcagatggtgcctcc
actgagacttccgcatctgggacctcccaaggagaggcttcaactccagaggagtctcga
gatgggaagaaagataaagaaggggaccgggcctctgaggaaggcaaacagaaaggcaag
ggcagcaaacctttaatgcctacctccactatccttcgtcttctggcagagttggtgagg
tcctatgttggtattgctaccctgattgccaactacagctacactgtgggccagtctgaa
ctgatcaaagaggactgcagtgtgctagcttttgttctggaccacctgctcccacatacc
cagaatgcagaagacaaggacacccctgccttggcccgcctgttcctcgcaagcctggct
gctgcagggagtggcacagatgcccaggtggccctagtgaatgaagtaaaagcagccctt
ggacgggcactggctatggctgagagtacagagaaacatgccaggcttcaggcagtgatg
tgtatcatcagtactatcatggagtcctgcccctccacctccagcttctacagcagtgcc
acagcgaagacccagcacaatggcatgaacaacatcattcggcttttcctgaagaaggga
ctggttaatgacctggccagagtacctcacagcttagacctgtccagtcccaacatggcc
aacacagtcaatgctgctctgaagcctttggaaacactttcccggattgtgaaccagccc
agtagcctttttggcagcaagagtgcttctagcaagaacaagtctgagcaggatgcccaa
ggagcctctcaagattccagtagcaaccagcaggacccaggcgagcctggggaagcagaa
gtgcaggaggaggatcatgatgtcactcagacagaggtggcagatggggatatcatggat
ggggaggctgaaaccgactcagtggtgattgctgggcagcctgaggtgctcagttcacaa
gagatgcaggttgagaatgagctggaggacctgatagatgagttgcttgagagggatggc
ggatctgggaacagtacaattatagtgagcagaagtggagaggatgaatcacaagaggac
gtgctgatggatgaagctccttccaacctcagccaagcttccaccttgcaggccaaccga
gaagattccatgaatatcctggaccctgaggatgaggaggagcacactcaggaagaggac
agcagtggcagtaacgaggatgaggatgatagtcaggatgaagaggaggaggaggaggaa
gatgaggaagatgatcaggaggatgatgaaggtgaagagggagatgaagacgatgacgac
gatggctctgagatggaattggatgaggattatcctgatatgaacgcttctcccttggtc
cgatttgagcgctttgaccgggaggatgatctcatcattgagtttgacaacatgttctcc
agtgctacagacatccccccatccccaggaaatatccctaccacccatccactgatggtg
cgccatgcagaccacagttctctgacactgggcagtggctcttcaacaactcgtctcacc
cagggcatcgggcgcagtcagaggaccctaaggcagctgacggccaatactggccacacc
attcatgttcactaccctgggaatcgccagcccaaccctcctcttatactgcagaggttg
cttggtccctcagctgctgctgacatccttcagctgagcagcagccttcccctacaaagc
cggggtcgggcccgcctcctggtaggcaacgatgacgtccacatcatcgcccgttctgat
gatgagctgctggatgactttttccatgatcagagcacagctaccagccaagcaggaacc
ctgtccagcatccccacagccctgacccgctggacagaagaatgcaaagttctcgatgct
gagagcatgcatgactgtgtttcagtggttaaagtgtccattgtcaatcacctggaattc
ctgagggatgaggagctggaagaaaggcgagagaagcgcaggaaacaactggctgaggaa
gaaacaaagataactgataaaggcaaagaagataaggagaacagggatcagagtgcacag
tgtactgcatctaagtcaaatgactccactgaacagaatctctcagatgggacgcctatg
cctgacagctacccaacaaccccatcttcaactgatgcagctacatctgagtccaaggag
acccttggcactctgcaatcctcacaacagcaaccaacactcccaaccccaccagctttg
ggagaggttcctcaggagctgcagtctccagctggagaagggggcagctctacacagcta
ttgatgcctgtagagccagaggaattgggtcccacaaggccaagtggggaagcagaaaca
actcagatggagttatccccagctcccactataacctcactttccccagagagagctgag
gattctgatgcactgacggctgtcagcagtcagctagaaggctctcctatggatacaagc
agcctggcttcctgtaccttagaggaggctgtgggtgacacttcagcagctggcagttct
gagcagcccagagcaggcagctccactcctggggatgccccaccagctgtggcggaagtg
caaggcaggagtgatgggtcaggggaatctgcccagccacctgaggacagctccccacct
gcatcctctgagagctcttccaccagagattctgccgtggccatttctggagcagattcc
cgaggaatcctagaagagccgttgccttcaacaagcagtgaagaagaagatccccttgcg
ggtatcagtctccctgaaggtgtggacccctcttttctggctgccctgcctgatgacatc
cgtcgggaagttctacagaaccagctaggcattcgtccaccaacccggactgccccctcc
acaaatagctcagcgcctgcagtggtggggaatcctggtgtgactgaagtgagccctgag
tttctggctgccctgcctccagccattcaggaggaagtactggcacagcagagagctgag
cagcagcgacgagaactagcacagaatgccagctcagacacccctatggaccctgtgacc
ttcatccagactctgccctcagacctgcgccgtagtgtcctagaggatatggaggacagt
gtgttagctgtgatgccacctgacattgcagctgaggctcaagccctgagacgagagcaa
gaagcccggcagcgacagctcatgcatgagcgtctgtttgggcacagtagcacctccgca
ctctctgctattctccgaagcccggctttcaccagtcgcttaagtggcaaccgtggggtc
cagtatactcgccttgctgtgcagagaggtggcaccttccagatggggggtagcagcagc
cataacaggccttctggcagtaatgtagatactctcctccgcctccgaggacggctcctt
ctggaccacgaagccctttcttgtctcttggtcctactttttgtggatgagccaaagctc
aatactagccgtctacaccgagtactgagaaatctctgctaccatgcccagacccgccac
tgggtcatccgcagtctgctctccatcttgcagcgcagcagtgagagtgagctatgcatt
gaaacacccaaactcactacaagtgaggaaaagggcaaaaagtcgagcaagagctgtggg
tcaagtagccatgagaaccgtcccctggacctgctacacaagatggagtcaaagagctcc
aaccagctttcctggctctcagtatccatggatgcagccctaggctgcaggactaatata
tttcagatccagcgttcaggggggcgtaaacataccgagaagcatgcaagcggtggctcc
accgtccacatccatccccaagctgctcctgttgtctgcagacacgttttggatacactc
attcaattggccaaggtatttcccagccacttcacacagcagcggaccaaagaaacaaac
tgtgagagtgatcgggaaaggggcaataaggcctgtagcccatgctcctcacagtcctcc
agcagtggcatttgcacagacttctgggacttattggtaaaactggacaacatgaatgtc
agccggaaaggcaagaactccgtgaagtcagtgccagtgagcgctggcggtgagggggaa
acctctccatacagcctcgaggcctctccactggggcagctcatgaacatgttgtcacac
ccagtcatccgccggagctctctcttaactgagaaactcctcagactcctttctctcatc
tcaattgctctcccagaaaacaaggtgtcagaagcacaggctaattctggcagcggtgct
tcctccaccaccactgccacctcaaccacatctaccaccaccaccactgccgcctccacc
acgcccacaccccctactgcacccacccctgtcacttctgctccagccctggttgctgcc
acggctatttccaccattgtcgtagctgcttcgaccacagtgactacccccacgactgct
accactactgtttcaatttctcccactactaagggcagcaaatctccagcgaaggtgagt
gatgggggcagcagcagtacagactttaagatggtgtcctctggcctcactgaaaaccag
ctacagctctctgtagaggtgttgacatcccactcttgttctgaggaaggcttagaggat
gcagccaacgtactactgcagctctcccggggggactctgggacccgggacactgttctc
aagctgctactgaatggagcccgccatctgggttataccctttgtaaacaaataggtacc
ctgctggccgagctgcgggaatacaacctcgagcagcagcggcgagcccaatgtgaaacc
ctctctcctgatggcctgcctgaggagcagccacagaccaccaagctgaagggcaaaatg
cagagcaggtttgacatggctgagaatgtggtaattgtggcatctcagaagcgacctttg
ggtggccgggagctccagctgccttctatgtccatgttgacatccaagacatctacccag
aagttcttcttgagggtactacaggtcatcatccagctccgggacgacacgcgccgggct
aacaagaaagccaagcagacaggcaggctaggttcctccggtttaggctcagctagcagc
atccaggcagctgttcggcagctggaggctgaggctgatgccattatacaaatggtacgt
gagggtcaaagggcgcggagacagcaacaagcagcaacgtcggagtctagccagtcagag
gcgtctgtccggagggaggaatcacccatggatgtggaccagccatctcccagtgctcaa
gatactcaatccattgcctccgatggaaccccacagggggagaaggaaaaggaagaaaga
ccacctgagttacccctgctcagcgagcagctgagtttggacgagctgtgggacatgctt
ggggagtgtctaaaggaactagaggaatcccatgaccagcatgcggtgctagtgctacag
cctgctgtcgaggccttctttctggtccatgccacagagcgggagagcaagcctcctgtc
cgagacacccgtgagagccagctggcacacatcaaggacgagcctcctccactctcccct
gcccccttaaccccagccacgccttcctcccttgacccattcttctcccgggagccctca
tctatgcacatctcctcaagcctgccccctgacacacagaagttccttcgctttgcagag
actcaccgcactgtgttaaaccagatcctacggcagtccacgacccaccttgctgatggg
ccttttgctgtcctggtagactacattcgtgtcctcgactttgatgtcaagcgcaaatat
ttccgccaagagctggagcgtttagatgaggggctccggaaagaagacatggctgtgcat
gtccgtcgtgaccatgtgtttgaagactcctatcgtgagctgcatcgcaaatcccccgaa
gaaatgaagaatcgattgtatatagtatttgaaggagaagaagggcaggatgctggtggg
ctcctgcgggagtggtatatgatcatctctcgagagatgtttaaccctatgtatgccttg
ttccgtacctcacctggtgatcgagtcacctacaccatcaatccatcttcccactgcaac
cccaaccacctcagctacttcaagtttgtcggacgcattgtggccaaagctgtatatgac
aaccgtcttctggagtgctactttactcgatccttttacaaacacatcttgggcaagtca
gtcagatatacagatatggagagtgaagattaccacttctaccaaggtctggtttatctg
ctggaaaatgatgtctccacactaggctatgacctcaccttcagcactgaggtccaagag
tttggagtttgtgaagttcgtgacctcaaacccaatggggccaacatcttggtaacagag
gagaataagaaggagtatgtacacctggtatgccagatgagaatgacaggagccatccgc
aagcagttggcggctttcttagaaggcttctatgagatcattccaaagcgcctcatttcc
atcttcactgagcaggagttagagctgcttatatcaggactgcccaccattgacatcgat
gatctgaaatccaacactgaataccacaagtaccagtccaactctattcagatccagtgg
ttctggagagcattgcgttctttcgatcaagctgaccgtgccaagttcctccagtttgtc
acaggtacttccaaggtacccctgcaaggctttgctgccctcgaaggcatgaatggcatt
cagaagtttcagatccatcgagatgacaggtccacagatcgcctgccttcagctcacaca
tgttttaatcagctggatctgcctgcctatgagagctttgagaagctccgccacatgcta
ctgttggctatccaggagtgctctgaaggctttgggctggcctaa

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