KEGG ORTHOLOGY: K08018

ORTHOLOGY: K08018

Entry

K08018                      KO

Symbol

RAPGEF2, PDZGEF1

Name

Rap guanine nucleotide exchange factor 2

Pathway

map04010

MAPK signaling pathway

map04015

Rap1 signaling pathway

map04530

Tight junction

Disease

H02213

Familial adult myoclonic epilepsy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K08018  RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor 2
   04015 Rap1 signaling pathway
    K08018  RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor 2
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K08018  RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor 2

Genes

HSA:	9693(RAPGEF2)

PTR:	461577(RAPGEF2)

PPS:	100972977(RAPGEF2)

GGO:	101154294(RAPGEF2)

PON:	100444094(RAPGEF2)

NLE:	100594311(RAPGEF2)

HMH:	116465643(RAPGEF2)

MCC:	704717(RAPGEF2)

MCF:	102145680(RAPGEF2)

MTHB:

126954894

MNI:	105488645(RAPGEF2)

CSAB:

103236456(RAPGEF2)

CATY:

105597871(RAPGEF2)

PANU:

101004196(RAPGEF2)

TGE:	112624756(RAPGEF2)

MLEU:

105532347(RAPGEF2)

RRO:	104677918(RAPGEF2)

RBB:

108520366

PTEH:

111553506(RAPGEF2)

CANG:

105524433(RAPGEF2)

CJC:	100388886(RAPGEF2)

SBQ:	101033151(RAPGEF2)

CIMI:

108302401(RAPGEF2)

CSYR:

103250500(RAPGEF2)

MMUR:

105854966(RAPGEF2)

LCAT:

123638526(RAPGEF2) 123638794 123638804

PCOQ:

105816487(RAPGEF2)

OGA:	100941053(RAPGEF2)

MMU:	76089(Rapgef2)

MCAL:

110290848(Rapgef2)

RNO:	310533(Rapgef2)

MCOC:

116093009(Rapgef2)

ANU:	117707165(Rapgef2)

MUN:	110564013(Rapgef2)

CGE:	100754995(Rapgef2)

MAUA:

101826195(Rapgef2)

PROB:

127232827(Rapgef2)

PLEU:

114700477(Rapgef2)

MORG:

121452725(Rapgef2)

MFOT:

126511571

AAMP:

119826540(Rapgef2)

NGI:	103751016(Rapgef2)

HGL:	101718791(Rapgef2)

CPOC:

100725060(Rapgef2) 100725331 100725604 100726875

CCAN:

109689106

DORD:

105995908(Rapgef2)

DSP:	122097797(Rapgef2)

PLOP:

125364642(Rapgef2)

NCAR:

124959202 124994402

MMMA:

107141298(Rapgef2) 125619942

OCU:

100346752

OPI:	101532068(RAPGEF2)

TUP:	102476593(RAPGEF2)

GVR:	103595406(RAPGEF2)

CFA:	100856359(RAPGEF2)

CLUD:

112654608(RAPGEF2)

VVP:	112926924(RAPGEF2)

VLG:	121481097(RAPGEF2)

NPO:	129516844(RAPGEF2)

AML:	100484273(RAPGEF2)

UMR:	103658068(RAPGEF2)

UAH:	113255808(RAPGEF2)

UAR:	123793179(RAPGEF2)

ELK:

111155074

LLV:

125093089

MPUF:

101684904(RAPGEF2)

MNP:	132000687(RAPGEF2)

MLK:	131831843(RAPGEF2)

NVS:	122889517(RAPGEF2)

ORO:	101373494(RAPGEF2)

EJU:	114210141(RAPGEF2)

ZCA:	113924290(RAPGEF2)

MLX:	118022195(RAPGEF2)

NSU:	110588368(RAPGEF2)

LWW:	102742899(RAPGEF2)

FCA:	101084954(RAPGEF2)

PYU:	121027743(RAPGEF2)

PCOO:

112859075(RAPGEF2)

PBG:	122474939(RAPGEF2)

PVIV:

125163688(RAPGEF2)

LRUF:

124520008

PTG:	102950679(RAPGEF2)

PPAD:

109262464(RAPGEF2)

PUC:

125923161

AJU:

106967455

HHV:	120220354(RAPGEF2)

BTA:	100139484(RAPGEF2)

BOM:	102275520(RAPGEF2)

BIU:	109571167(RAPGEF2)

BBUB:

102405471(RAPGEF2)

BBIS:

104985761(RAPGEF2)

CHX:	102187973(RAPGEF2)

OAS:	101111578(RAPGEF2)

BTAX:

128062012(RAPGEF2)

ODA:	120870997(RAPGEF2)

CCAD:

122453356(RAPGEF2)

MBEZ:

129542549(RAPGEF2)

SSC:	100517409(RAPGEF2)

CFR:	102510135(RAPGEF2)

CBAI:

105069401(RAPGEF2)

CDK:	105094767(RAPGEF2)

VPC:	102546108(RAPGEF2)

BACU:

103005459

BMUS:

118895629(RAPGEF2)

LVE:	103076487(RAPGEF2)

OOR:	101274731(RAPGEF2)

DLE:	111179022(RAPGEF2)

PCAD:

102982227(RAPGEF2)

PSIU:

116753860(RAPGEF2)

NASI:

112393731(RAPGEF2)

ECB:	100069003(RAPGEF2)

EPZ:	103545519(RAPGEF2)

EAI:	106823789(RAPGEF2)

MYB:	102244394(RAPGEF2)

MYD:	102762387(RAPGEF2)

MMYO:

118658949(RAPGEF2)

MLF:	102436397(RAPGEF2)

PKL:	118711384(RAPGEF2)

EFUS:

103288686(RAPGEF2)

MNA:	107527478(RAPGEF2)

DRO:	112312369(RAPGEF2)

SHON:

118995360(RAPGEF2)

AJM:	119034621(RAPGEF2)

PDIC:

114503947(RAPGEF2)

PHAS:

123813684(RAPGEF2)

MMF:	118615237(RAPGEF2)

PPAM:

129072585(RAPGEF2)

HAI:	109395998(RAPGEF2)

RFQ:	117037655(RAPGEF2)

PALE:

102879764(RAPGEF2)

PGIG:

120613457(RAPGEF2)

PVP:	105294479(RAPGEF2)

RAY:	107511410(RAPGEF2)

MJV:	108392300(RAPGEF2)

TOD:	119234576(RAPGEF2)

SARA:

101538440(RAPGEF2)

SETR:

126003878(RAPGEF2)

LAV:	100670174(RAPGEF2)

TMU:

101340649

ETF:	101644473(RAPGEF2)

DNM:	101415624(RAPGEF2)

MDO:	100023159(RAPGEF2)

GAS:	123252097(RAPGEF2)

SHR:	100923893(RAPGEF2)

AFZ:

127540766

PCW:	110196451(RAPGEF2)

OAA:	100079239(RAPGEF2)

GGA:	422418(RAPGEF2)

PCOC:

116243180(RAPGEF2)

MGP:	100549357(RAPGEF2)

CJO:	107313022(RAPGEF2)

TPAI:

128084359(RAPGEF2)

LMUT:

125691715(RAPGEF2)

NMEL:

110398765(RAPGEF2)

APLA:

101802476(RAPGEF2)

ACYG:

106032300(RAPGEF2)

CATA:

118248181(RAPGEF2)

AFUL:

116488451(RAPGEF2)

TGU:	100224541(RAPGEF2)

LSR:	110473752(RAPGEF2)

SCAN:

103825944(RAPGEF2)

PMOA:

120497914(RAPGEF2)

OTC:	121348413(RAPGEF2)

PRUF:

121360217(RAPGEF2)

GFR:	102042003(RAPGEF2)

FAB:	101805788(RAPGEF2)

OMA:	130252596(RAPGEF2)

PHI:	102109398(RAPGEF2)

PMAJ:

107203090(RAPGEF2)

CCAE:

111927874(RAPGEF2)

CCW:	104697194(RAPGEF2)

CBRC:

103622905(RAPGEF2)

ETL:	114057051(RAPGEF2)

ZAB:	102072245(RAPGEF2)

ACHL:

103807681(RAPGEF2)

SVG:	106857523(RAPGEF2)

MMEA:

130579047(RAPGEF2)

HRT:	120752511(RAPGEF2)

FPG:	101920342(RAPGEF2)

FCH:	102060194(RAPGEF2)

CLV:	102086538(RAPGEF2)

EGZ:	104124157(RAPGEF2)

NNI:	104021249(RAPGEF2)

PCRI:

104027034(RAPGEF2)

PLET:

104623610(RAPGEF2)

EHS:	104511973(RAPGEF2)

PCAO:

104048392(RAPGEF2)

ACUN:

113479525(RAPGEF2)

TALA:

104360745(RAPGEF2)

PADL:

103917939(RAPGEF2)

AFOR:

103902303(RAPGEF2)

ACHC:

115340706(RAPGEF2)

HALD:

104313180(RAPGEF2)

HLE:	104843254(RAPGEF2)

AGEN:

126052573

GCL:

127015409

CCRI:

104168325(RAPGEF2)

CSTI:

104558243(RAPGEF2)

CMAC:

104480251(RAPGEF2)

MUI:	104534394(RAPGEF2)

BREG:

104639613(RAPGEF2)

FGA:	104080031(RAPGEF2)

LDI:	104352516(RAPGEF2)

MNB:	103771848(RAPGEF2)

OHA:	104331598(RAPGEF2)

NNT:	104412979(RAPGEF2)

SHAB:

115610417(RAPGEF2)

DPUB:

104303880(RAPGEF2)

PGUU:

104458504(RAPGEF2)

ACAR:

104525297(RAPGEF2)

CPEA:

104387210(RAPGEF2)

AVIT:

104271158(RAPGEF2)

CVF:	104294146(RAPGEF2)

RTD:	128910738(RAPGEF2)

CUCA:

104062037(RAPGEF2)

TEO:	104384003(RAPGEF2)

BRHI:

104493266(RAPGEF2)

AAM:

106491974

AROW:

112963819(RAPGEF2)

NPD:	112949231(RAPGEF2)

DNE:	112995323(RAPGEF2)

SCAM:

104145570

ASN:	102382228(RAPGEF2)

AMJ:	102563879(RAPGEF2)

CPOO:

109309712(RAPGEF2)

GGN:	109300859(RAPGEF2)

PSS:	102457114(RAPGEF2)

CMY:	102941224(RAPGEF2)

CCAY:

125635628(RAPGEF2)

DCC:	119854506(RAPGEF2)

CPIC:

101940840(RAPGEF2)

TST:	117878482(RAPGEF2)

CABI:

116838340(RAPGEF2)

MRV:	120405555(RAPGEF2)

ACS:	100561833(rapgef2)

ASAO:

132776766(RAPGEF2)

PVT:	110072791(RAPGEF2)

SUND:

121931376(RAPGEF2)

PBI:

103066867

PMUR:

107286040(RAPGEF2)

CTIG:

120306493(RAPGEF2)

TSR:	106550917(RAPGEF2)

PGUT:

117674702(RAPGEF2)

APRI:

131203444(RAPGEF2)

PTEX:

113435947(RAPGEF2)

NSS:	113417434(RAPGEF2)

VKO:	123023712(RAPGEF2)

PMUA:

114603804(RAPGEF2)

PRAF:

128420917(RAPGEF2)

ZVI:	118083321(RAPGEF2)

HCG:	128327061(RAPGEF2)

GJA:

107109403

STOW:

125439983(RAPGEF2)

EMC:	129336433(RAPGEF2)

XLA:	108706643 447229(rapgef2.L)

XTR:	100145659(rapgef2)

NPR:	108791705(RAPGEF2)

RTEM:

120920381(RAPGEF2)

BBUF:

120990082(RAPGEF2)

BGAR:

122942349(RAPGEF2)

MUO:	115461627(RAPGEF2)

GSH:	117359178(RAPGEF2)

DRE:	557693(rapgef2) 793952(si:dkey-253i9.4)

SRX:	107745058 107750423 107756462 107758567

SANH:

107655945 107665530 107680625 107702384

SGH:	107548350 107566698 107591577 107594895

CCAR:

109049617 109072264 109077190

CAUA:

113044232 113057582 113077504 113106949 113114031

CGIB:

127948857 127960013 127971467 128027564

PTET:

122342281(rapgef2a) 122357604(rapgef2b)

LROH:

127163628(rapgef2a) 127176523(rapgef2b)

OMC:	131538485(rapgef2a) 131552986(rapgef2b)

PPRM:

120460755(rapgef2) 120493821(si:dkey-253i9.4)

RKG:	130089535(rapgef2a) 130089734(rapgef2b)

MAMB:

125259354(rapgef2b) 125272614(rapgef2a)

CIDE:

127510384 127525669

MASI:

127413030 127418323 127443821 127444489

TROS:

130552642(rapgef2a) 130563592(rapgef2b)

TDW:	130436675(rapgef2a) 130437668(rapgef2b)

MANU:

129422594(rapgef2b) 129444706(rapgef2a)

IPU:	108260802(rapgef2a) 108263426 108269045(rapgef2b)

IFU:	128604470(rapgef2a) 128611917(rapgef2b)

PHYP:

113542715(rapgef2) 113544331

SMEO:

124381348(rapgef2a) 124385808(rapgef2b)

TFD:	113647706(rapgef2b) 113660687(rapgef2a)

TVC:	132841895(rapgef2a) 132855978(rapgef2b)

AMEX:

103034322(rapgef2) 103036243

CMAO:

118807008(rapgef2) 118816528(si:dkey-253i9.4)

EEE:	113570740(rapgef2) 113586113

CHAR:

105903569(rapgef2a) 105908693 122128541(rapgef2b)

TRU:	101068626(rapgef2)

TFS:	130531009(rapgef2b)

TNG:	GSTEN00024432G001

LCO:	104932582(rapgef2)

NCC:	104941952(rapgef2)

TBEN:

117491053(rapgef2)

CGOB:

115015125(rapgef2)

PGEO:

117454322(rapgef2)

GACU:

117553597(rapgef2)

EMAC:

134859649(rapgef2b)

ELY:	117260729(rapgef2)

EFO:	125894019(rapgef2b)

PLEP:

121948211(rapgef2b)

SLUC:

116062486(rapgef2)

ECRA:

117951280(rapgef2)

ESP:	116696435(rapgef2)

PFLV:

114562530(rapgef2)

GAT:	120817001(rapgef2b)

PPUG:

119210090(rapgef2)

AFB:	129090116(rapgef2b)

CLUM:

117737267(rapgef2)

PSWI:

130209824(rapgef2b)

MSAM:

119888255(rapgef2)

SCHU:

122880728(rapgef2b)

CUD:	121515938(rapgef2b)

ALAT:

119007195(rapgef2)

MZE:	101469290(rapgef2)

ONL:	100709689(rapgef2)

OAU:	116335306(rapgef2)

OLA:	101158677(rapgef2)

OML:	112139725(rapgef2)

CSAI:

133446750 133446751

XMA:	102216833(rapgef2)

XCO:	114139721(rapgef2)

XHE:	116714923(rapgef2)

PRET:

103471849(rapgef2)

PFOR:

103137325(rapgef2)

PLAI:

106937380

PMEI:

106932496

GAF:	122836816(rapgef2b)

PPRL:

129360415 129360475

CVG:

107095759

CTUL:

119793629(rapgef2)

GMU:	124860141(rapgef2b)

NFU:	107380014(rapgef2)

KMR:	108236655(rapgef2)

ALIM:

106513263(rapgef2)

NWH:	119408352(rapgef2b)

AOCE:

111574983(rapgef2)

MCEP:

125008677(rapgef2b)

CSEM:

103390684(rapgef2)

POV:	109640036(rapgef2)

SSEN:

122778263(rapgef2b)

HHIP:

117769843(rapgef2)

HSP:	118111870(rapgef2b)

SMAU:

118319812(rapgef2b)

LCF:	108885198(rapgef2b)

SDU:	111232429(rapgef2)

SLAL:

111655148(rapgef2)

XGL:	120785147(rapgef2b)

HCQ:	109526251(rapgef2)

SSCV:

125991261

SBIA:

133509194(rapgef2b)

PEE:	133407343(rapgef2b)

PTAO:

133484376(rapgef2b)

BPEC:

110153676(rapgef2)

MALB:

109973331(rapgef2)

BSPL:

114863902(rapgef2b)

SJO:	128363361(rapgef2b)

SASA:

106604533(rapgef2) 106611555

STRU:

115170583 115205100

OTW:	112247599 112256345

OMY:	110488939 110504162

OGO:	123993519 124011328

ONE:	115129556(rapgef2) 115130821

OKI:	109864853 109905286(rapgef2)

OKE:	118363598 118375339

SALP:

111965514 111967587

SNH:	120048027 120062243

CCLU:

121535521 121541384

ELS:	105027765(rapgef2)

SFM:	108924469(rapgef2) 108930833

PKI:	111833211 111837306(rapgef2)

AANG:

118228077 118231908(rapgef2)

LOC:	102687483(rapgef2)

PSPA:

121322860(rapgef2b) 121326444

ARUT:

117408609 117420947

PSEX:

120527176(rapgef2)

LCM:	102349377(RAPGEF2)

CMK:	103182258(rapgef2b)

RTP:

125480966

CPLA:

122539311(rapgef2b)

HOC:	132833447(rapgef2b)

LERI:

129703470(rapgef2b)

PMRN:

116940216 116951089

LRJ:	133350673 133354458

BFO:

118411352

BBEL:

109466768

CIN:	100179213 100184714

SCLV:

SPU:

LPIC:

APLC:

AJC:

DME:	Dmel_CG9491(PDZ-GEF)

DER:

6542976

DSE:

6613608

DSI:	Dsimw501_GD23402(Dsim_GD23402)

DYA:	Dyak_GE13791

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI11520

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:	105233376 125775313

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:	119614605 119615376

GFS:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ005470

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_202280

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:	126901822 126909022

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM596850

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_106274 DAPPUDRAFT_328339

DMK:

116932695

DPZ:

124349272

PVM:	113802398 113802404

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

HAZT:

EAF:	111701468 111717689

LSM:

121124234

TCF:	131888029 131892218

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:	129220771 129226365

SDM:	118194037 118197654

LPOL:

106458108 106463665 106474436 106474868

CEL:	CELE_T14G10.2(pxf-1)

CBR:	CBG_03403(Cbr-pxf-1)

CRQ:	GCK72_014367

NAI:	NECAME_13025

BMY:	BM_BM5795(Bma-pxf-1)

LOA:	LOAG_04977

TSP:	Tsp_05894 Tsp_12574 Tsp_12677

HRO:	HELRODRAFT_170597 HELRODRAFT_188331 HELRODRAFT_190559

LGI:	LOTGIDRAFT_107273

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:	115211100 118765226

LAK:	106165990 106171520

SMM:	Smp_053100

OVI:	T265_03393

EGL:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

HSY:

TAD:	TRIADDRAFT_59148

MBR:	MONBRDRAFT_26683 MONBRDRAFT_30451

SRE:	PTSG_09152

» show all

Reference

PMID:12581858

Authors

Kuiperij HB, de Rooij J, Rehmann H, van Triest M, Wittinghofer A, Bos JL, Zwartkruis FJ

Title

Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2.

Journal

Biochim Biophys Acta 1593:141-9 (2003)
DOI:10.1016/S0167-4889(02)00365-8

Reference

PMID:10608883

Authors

de Rooij J, Boenink NM, van Triest M, Cool RH, Wittinghofer A, Bos JL

Title

PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2.

Journal

J Biol Chem 274:38125-30 (1999)
DOI:10.1074/jbc.274.53.38125

Sequence

[hsa:9693]

LinkDB

DBGET integrated database retrieval system