KEGG   PATHWAY: ajm04810
Entry
ajm04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Artibeus jamaicensis (Jamaican fruit-eating bat)
Class
Cellular Processes; Cell motility
Pathway map
ajm04810  Regulation of actin cytoskeleton
ajm04810

Other DBs
GO: 0030036
Organism
Artibeus jamaicensis (Jamaican fruit-eating bat) [GN:ajm]
Gene
119034635  PDGFC; platelet-derived growth factor C [KO:K05450]
119034995  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3 [KO:K00889] [EC:2.7.1.68]
119034996  EZR; ezrin [KO:K08007]
119035060  ACTR2; actin-related protein 2 [KO:K17260]
119035149  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
119035155  PFN3; profilin-3 [KO:K05759]
119035521  MYL5; myosin light chain 5 [KO:K12753]
119035526  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
119035668  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X2 [KO:K00920] [EC:2.7.1.149]
119035937  C5; complement C5 isoform X1 [KO:K03994]
119036058  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
119036066  C8G; complement component C8 gamma chain [KO:K03999]
119036213  FGF18; fibroblast growth factor 18 [KO:K04358]
119036264  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
119036564  [KO:K05764]
119036699  RHOA; transforming protein RhoA [KO:K04513]
119036780  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
119036918  FGF20; fibroblast growth factor 20 [KO:K04358]
119037064  MYH11; myosin-11 isoform X1 [KO:K10352]
119037695  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
119037762  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
119037951  BDKRB1; B1 bradykinin receptor [KO:K03915]
119037962  BDKRB2; B2 bradykinin receptor [KO:K03916]
119038027  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
119038034  ITGAX; LOW QUALITY PROTEIN: integrin alpha-X [KO:K06462]
119038143  VCL; vinculin isoform X1 [KO:K05700]
119038262  [KO:K05764]
119038267  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
119038645  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
119038902  CRKL; crk-like protein [KO:K04438]
119039251  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
119039397  ITGB5; integrin beta-5 [KO:K06588]
119039457  FGF16; fibroblast growth factor 16 [KO:K04358]
119039478  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
119039481  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
119039504  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
119039740  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
119039783  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
119039848  CYFIP1; LOW QUALITY PROTEIN: cytoplasmic FMR1-interacting protein 1 [KO:K05749]
119040173  ITGAE; integrin alpha-E [KO:K06524]
119040181  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
119040261  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
119040297  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
119040451  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
119040469  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
119040479  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119040664  CRK; adapter molecule crk isoform X1 [KO:K04438]
119040930  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119041144  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
119041402  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
119041444  BRK1; protein BRICK1 [KO:K05752]
119041500  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
119041512  ACTB; actin, cytoplasmic 1 [KO:K05692]
119041711  NRAS; GTPase NRas [KO:K07828]
119041770  MSN; moesin [KO:K05763]
119041821  FGF19; fibroblast growth factor 19 [KO:K22603]
119041822  FGF3; fibroblast growth factor 3 [KO:K04358]
119041829  FGF4; fibroblast growth factor 4 [KO:K04358]
119041867  CFL1; cofilin-1 [KO:K05765]
119041883  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
119041906  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
119042192  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
119042357  CFL2; cofilin-2 isoform X1 [KO:K05765]
119042370  [KO:K12757]
119042371  [KO:K12757]
119042688  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
119042993  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
119043036  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119043116  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
119043505  ITGB7; integrin beta-7 [KO:K06590]
119043632  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
119043665  [KO:K05752]
119043762  PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
119043796  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
119043982  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
119043987  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
119043997  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
119044080  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
119044236  C7; complement component C7 [KO:K03996]
119044248  C6; complement component C6 [KO:K03995]
119044257  C9; complement component C9 isoform X1 [KO:K04000]
119044299  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
119044385  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
119044440  ENAH; protein enabled homolog isoform X1 [KO:K05746]
119044502  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
119044655  MYL10; myosin regulatory light chain 10 [KO:K12756]
119044815  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
119044861  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119044865  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
119045439  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
119045650  ITGB6; integrin beta-6 isoform X3 [KO:K06589]
119045786  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
119045876  [KO:K05764]
119046000  RRAS; ras-related protein R-Ras [KO:K07829]
119046313  ITGA8; integrin alpha-8 [KO:K06584]
119046553  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
119046588  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
119046722  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
119046830  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119046896  GSN; gelsolin isoform X1 [KO:K05768]
119047624  [KO:K03898]
119047724  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
119048157  F2R; proteinase-activated receptor 1 [KO:K03914]
119048177  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
119048446  ACTR3; actin-related protein 3 [KO:K18584]
119048528  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
119048602  PFN1; profilin-1 [KO:K05759]
119048883  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
119048924  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X3 [KO:K05726]
119048987  KRAS; GTPase KRas isoform X1 [KO:K07827]
119049053  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
119049154  FGF10; fibroblast growth factor 10 [KO:K04358]
119049161  ITGA1; integrin alpha-1 [KO:K06480]
119049164  ITGA2; integrin alpha-2 [KO:K06481]
119049326  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
119049402  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
119049622  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
119049646  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
119049942  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
119050357  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
119050865  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
119051020  [KO:K05740]
119051433  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
119051441  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
119051649  C8B; complement component C8 beta chain [KO:K03998]
119051656  C8A; complement component C8 alpha chain isoform X1 [KO:K03997]
119051685  SPATA13; spermatogenesis-associated protein 13 isoform X6 [KO:K05769]
119052006  MYH14; myosin-14 isoform X1 [KO:K10352]
119052051  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
119052120  IQGAP1; ras GTPase-activating-like protein IQGAP1 isoform X1 [KO:K16848]
119052227  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
119052315  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
119052458  WASF2; actin-binding protein WASF2 [KO:K05748]
119052574  WASL; actin nucleation-promoting factor WASL isoform X1 [KO:K23612]
119052612  ITGA3; integrin alpha-3 [KO:K06482]
119052766  [KO:K05764]
119052883  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
119052925  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
119053003  PFN2; profilin-2 isoform X1 [KO:K05759]
119053055  RRAS2; ras-related protein R-Ras2 [KO:K07830]
119053288  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119053408  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119053637  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
119053927  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
119053939  CYRIA; CYFIP-related Rac1 interactor A [KO:K27976]
119054288  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
119054357  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
119054523  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
119054717  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
119054785  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
119054793  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
119054853  FGF23; fibroblast growth factor 23 [KO:K22428]
119054857  FGF6; fibroblast growth factor 6 [KO:K04358]
119055086  [KO:K05764]
119055427  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X6 [KO:K07532]
119055519  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
119056018  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
119056082  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
119056355  LIMK1; LIM domain kinase 1 isoform X2 [KO:K05743] [EC:2.7.11.1]
119056409  FGF9; fibroblast growth factor 9 [KO:K04358]
119056620  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
119056920  FGF5; fibroblast growth factor 5 [KO:K04358]
119056966  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
119057101  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119057120  ITGA11; integrin alpha-11 [KO:K06587]
119057339  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
119057411  PXN; paxillin isoform X5 [KO:K05760]
119057431  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
119057488  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
119057541  INS; insulin [KO:K04526]
119057632  FGF7; fibroblast growth factor 7 [KO:K04358]
119058108  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
119058123  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
119058291  FGF21; fibroblast growth factor 21 [KO:K22429]
119058331  TMSB4X; thymosin beta-4 [KO:K05764]
119058505  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
119058560  ACTG1; actin, cytoplasmic 2 [KO:K05692]
119058595  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
119058605  ITGB4; integrin beta-4 isoform X2 [KO:K06525]
119058752  ITGB2; integrin beta-2 [KO:K06464]
119058893  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
119058905  MYL11; myosin regulatory light chain 11 isoform X1 [KO:K12758]
119058981  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
119058989  [KO:K05764]
119059062  [KO:K05764]
119059083  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
119059157  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119059436  WASF1; actin-binding protein WASF1 isoform X1 [KO:K05753]
119059478  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
119059701  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
119059816  [KO:K04513]
119059833  NCKAP1L; nck-associated protein 1-like [KO:K05750]
119059834  ITGA5; integrin alpha-5 [KO:K06484]
119059962  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
119060125  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
119060144  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
119060271  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
119060356  MYH9; myosin-9 [KO:K10352]
119060441  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
119060446  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
119060830  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X13 [KO:K12329]
119061032  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
119061312  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
119061365  PDGFRB; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
119061593  ITGA2B; integrin alpha-IIb [KO:K06476]
119061623  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
119062005  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
119062012  GIT1; ARF GTPase-activating protein GIT1 [KO:K05737]
119062206  HRAS; GTPase HRas isoform X1 [KO:K02833]
119062561  FN1; fibronectin isoform X1 [KO:K05717]
119062621  ITGB3; integrin beta-3 [KO:K06493]
119062810  RDX; radixin isoform X1 [KO:K05762]
119062840  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
119063115  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119063248  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
119063288  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
119063507  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
119063564  MYH10; myosin-10 isoform X1 [KO:K10352]
119063701  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
119063754  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
119063841  PFN4; profilin-4 [KO:K05759]
119063915  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
119063985  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
119064089  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119064204  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
119064312  ABI2; abl interactor 2 isoform X1 [KO:K05751]
119064378  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X4 [KO:K00921] [EC:2.7.1.150]
119064411  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
119064490  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
119064507  RGCC; regulator of cell cycle RGCC [KO:K26108]
119064798  PTK2; focal adhesion kinase 1 isoform X3 [KO:K05725] [EC:2.7.10.2]
119064856  CYRIB; CYFIP-related Rac1 interactor B isoform X1 [KO:K27976]
119064893  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
119065040  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
119065104  APC; adenomatous polyposis coli protein isoform X4 [KO:K02085]
119065357  SCIN; scinderin [KO:K05768]
128626265  [KO:K03898]
128627225  [KO:K05765]
128627765  [KO:K05764]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
ajm04010  MAPK signaling pathway
ajm04510  Focal adhesion
ajm04520  Adherens junction
KO pathway
ko04810   

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