KEGG   PATHWAY: csem04810
Entry
csem04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Cynoglossus semilaevis (tongue sole)
Class
Cellular Processes; Cell motility
Pathway map
csem04810  Regulation of actin cytoskeleton
csem04810

Other DBs
GO: 0030036
Organism
Cynoglossus semilaevis (tongue sole) [GN:csem]
Gene
103376625  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103376672  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103376707  pdgfra; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
103376757  [KO:K00889] [EC:2.7.1.68]
103376844  mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
103376848  [KO:K05769]
103376889  pip4k2a; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X7 [KO:K00920] [EC:2.7.1.149]
103376893  c8g; complement component C8 gamma chain [KO:K03999]
103377032  itgb1; integrin beta-1 isoform X1 [KO:K05719]
103377087  vav3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
103377138  [KO:K05769]
103377298  [KO:K04361] [EC:2.7.10.1]
103377397  [KO:K27976]
103377455  [KO:K12757]
103377652  [KO:K04456] [EC:2.7.11.1]
103377723  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
103377730  ssh2; protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103377807  [KO:K04438]
103377907  pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
103377927  actn4; alpha-actinin-4 isoform X3 [KO:K05699]
103377945  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
103378091  arhgap35; rho GTPase-activating protein 35 [KO:K05732]
103378129  [KO:K05743] [EC:2.7.11.1]
103378218  [KO:K05731]
103378227  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103378423  arhgef12; rho guanine nucleotide exchange factor 12 [KO:K07532]
103378536  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
103378652  diaph3; protein diaphanous homolog 3 [KO:K05745]
103378678  itgb6; integrin beta-6 isoform X1 [KO:K06589]
103378692  [KO:K05717]
103378868  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103378962  fgf19; fibroblast growth factor 19 [KO:K22603]
103378963  fgf4; fibroblast growth factor 4 [KO:K04358]
103378969  fgf3; fibroblast growth factor 3 [KO:K04358]
103379099  fgf7; fibroblast growth factor 7 [KO:K04358]
103379106  [KO:K04410] [EC:2.7.11.1]
103379283  rras2; ras-related protein R-Ras2 [KO:K07830]
103379560  [KO:K04358]
103379665  [KO:K03916]
103379673  [KO:K03916]
103379693  chrm4; LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M4 [KO:K04132]
103379713  [KO:K06587]
103379847  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
103379878  wasl; neural Wiskott-Aldrich syndrome protein [KO:K23612]
103380146  kras; GTPase KRas isoform X1 [KO:K07827]
103380168  [KO:K04130]
103380238  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103380280  [KO:K06270]
103380387  hras; GTPase HRas [KO:K02833]
103380735  [KO:K27976]
103380861  wasf1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
103380873  [KO:K08007]
103380939  [KO:K17388] [EC:2.7.11.39]
103380955  sos2; son of sevenless homolog 2 isoform X3 [KO:K03099]
103381003  pak7; serine/threonine-protein kinase PAK 7 isoform X4 [KO:K05736] [EC:2.7.11.1]
103381068  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
103381105  [KO:K23612]
103381170  chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
103381242  [KO:K06269] [EC:3.1.3.16]
103381463  itgb3; integrin beta-3 [KO:K06493]
103381489  [KO:K08007]
103381494  [KO:K00907] [EC:2.7.11.18]
103381500  [KO:K05700]
103381595  [KO:K06269] [EC:3.1.3.16]
103381607  [KO:K12758]
103381644  dock1; dedicator of cytokinesis protein 1 isoform X2 [KO:K13708]
103381664  [KO:K07861]
103381794  [KO:K04639]
103381966  cfl2; cofilin-2 [KO:K05765]
103381978  [KO:K06461]
103381999  fgf21; fibroblast growth factor 21 [KO:K22429]
103382104  itga3; integrin alpha-3 isoform X2 [KO:K06482]
103382112  itgb4; integrin beta-4 isoform X1 [KO:K06525]
103382288  [KO:K05627]
103382358  [KO:K04392]
103382390  [KO:K04131]
103382552  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
103382732  [KO:K04130]
103382741  [KO:K04358]
103382742  fgf23; fibroblast growth factor 23 [KO:K22428]
103382833  [KO:K23612]
103383021  braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
103383204  fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
103383219  [KO:K04359]
103383231  [KO:K04291]
103383236  [KO:K17386]
103383240  gna12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
103383302  sos1; son of sevenless homolog 1 [KO:K03099]
103383441  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
103383482  [KO:K05757]
103383483  [KO:K05757]
103383494  [KO:K05692]
103383497  vav1; proto-oncogene vav isoform X1 [KO:K05730]
103383562  [KO:K10352]
103383692  [KO:K17388] [EC:2.7.11.39]
103383769  [KO:K10352]
103383890  [KO:K04456] [EC:2.7.11.1]
103384060  myh11; myosin-11 [KO:K10352]
103384081  [KO:K10031]
103384120  fgf20; fibroblast growth factor 20 [KO:K04358]
103384355  pip4k2b; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
103384365  [KO:K05718]
103384367  [KO:K17457]
103384395  fgd1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
103384870  [KO:K04513]
103385009  [KO:K04513]
103385041  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103385138  [KO:K04513]
103385206  [KO:K00920] [EC:2.7.1.149]
103385228  [KO:K05704] [EC:2.7.10.2]
103385260  [KO:K06484]
103385321  [KO:K12329]
103385334  [KO:K04393]
103385474  [KO:K05722]
103385533  raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
103385722  brk1; protein BRICK1 [KO:K05752]
103385808  [KO:K06269] [EC:3.1.3.16]
103385834  [KO:K04513]
103385929  [KO:K05755]
103386054  [KO:K00920] [EC:2.7.1.149]
103386121  [KO:K12755]
103386159  [KO:K05755]
103386218  pxn; paxillin isoform X2 [KO:K05760]
103386220  [KO:K10351]
103386290  [KO:K06484]
103386293  [KO:K04393]
103386373  itga7; integrin alpha-7 isoform X1 [KO:K06583]
103386377  nckap1l; nck-associated protein 1-like [KO:K05750]
103386498  [KO:K17260]
103386563  [KO:K04513]
103386740  [KO:K05704] [EC:2.7.10.2]
103387066  [KO:K04456] [EC:2.7.11.1]
103387093  actr2; actin-related protein 2 [KO:K17260]
103387250  chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
103387352  cxcl12; stromal cell-derived factor 1 [KO:K10031]
103387439  [KO:K05700]
103387563  itga9; integrin alpha-9 [KO:K06585]
103387756  fgf8; fibroblast growth factor 8 isoform X2 [KO:K04358]
103387760  nckap1; LOW QUALITY PROTEIN: nck-associated protein 1 [KO:K05750]
103387948  [KO:K04393]
103388013  [KO:K05742]
103388046  iqgap3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
103388143  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103388166  [KO:K00889] [EC:2.7.1.68]
103388244  itga10; integrin alpha-10 [KO:K06586]
103388266  [KO:K05627]
103388400  itga8; integrin alpha-8 [KO:K06584]
103388446  ptk2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
103388802  arhgef1; rho guanine nucleotide exchange factor 1 isoform X6 [KO:K12330]
103389047  [KO:K00889] [EC:2.7.1.68]
103389109  [KO:K04358]
103389279  c6; complement component C6 [KO:K03995]
103389280  [KO:K03996]
103389293  gsn; gelsolin isoform X1 [KO:K05768]
103389364  [KO:K04362] [EC:2.7.10.1]
103389369  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
103389381  [KO:K18584]
103389411  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
103389418  crkl; crk-like protein [KO:K04438]
103389423  [KO:K04132]
103389492  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
103389531  [KO:K05764]
103389606  abi2; abl interactor 2 isoform X1 [KO:K05751]
103389837  f2; prothrombin [KO:K01313] [EC:3.4.21.5]
103389897  [KO:K03914]
103389936  pfn1; profilin-1 [KO:K05759]
103390036  [KO:K04000]
103390039  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103390120  [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103390307  lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
103390350  apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
103390377  [KO:K12753]
103390416  itga1; integrin alpha-1 [KO:K06480]
103390522  diaph2; protein diaphanous homolog 2 isoform X3 [KO:K05741]
103390617  [KO:K06485]
103390644  egf; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
103390671  pdgfc; platelet-derived growth factor C [KO:K05450]
103390695  fgf2; fibroblast growth factor 2 [KO:K18497]
103390704  [KO:K04358]
103390735  cfl1; cofilin-1 [KO:K05765]
103390776  arhgef6; rho guanine nucleotide exchange factor 6 isoform X2 [KO:K05729]
103390897  [KO:K04358]
103390936  diaph1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
103390972  [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103391002  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103391155  [KO:K26108]
103391182  fgf16; fibroblast growth factor 16 [KO:K04358]
103391194  [KO:K18496]
103391227  [KO:K05763]
103391274  [KO:K04358]
103391316  lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
103391367  [KO:K05093] [EC:2.7.10.1]
103391412  cyfip2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
103391576  rgcc; regulator of cell cycle RGCC isoform X1 [KO:K26108]
103391620  itgb5; integrin beta-5 [KO:K06588]
103391640  pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
103391717  arhgef7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
103391801  itga4; integrin alpha-4 [KO:K06483]
103391821  [KO:K05735] [EC:2.7.11.1]
103391840  [KO:K06485]
103391967  [KO:K05762]
103392104  [KO:K05089] [EC:2.7.10.1]
103392313  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
103392345  [KO:K18584]
103392358  itgb2; integrin beta-2 [KO:K06464]
103392366  mylk; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
103392367  itgav; integrin alpha-V [KO:K06487]
103392459  mras; ras-related protein M-Ras [KO:K07831]
103392484  [KO:K05717]
103392586  cyfip1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
103392671  mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
103392690  [KO:K06269] [EC:3.1.3.16]
103392793  baiap2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
103392869  [KO:K04291]
103392924  [KO:K04133]
103392942  [KO:K04347]
103392975  [KO:K07827]
103393020  [KO:K04392]
103393040  [KO:K04359]
103393124  [KO:K06493]
103393163  [KO:K00907] [EC:2.7.11.18]
103393219  [KO:K04371] [EC:2.7.11.24]
103393304  actb; actin, beta [KO:K05692]
103393402  [KO:K10352]
103393404  [KO:K06482]
103393488  [KO:K04639]
103393502  rras; ras-related protein R-Ras [KO:K07830]
103393532  [KO:K05757]
103393680  [KO:K10352]
103393775  [KO:K04393]
103393918  [KO:K05742]
103394159  [KO:K05725] [EC:2.7.10.2]
103394187  pfn2; profilin-2 isoform X1 [KO:K05759]
103394337  wasf2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
103394543  [KO:K00889] [EC:2.7.1.68]
103394627  itgb8; integrin beta-8 isoform X1 [KO:K06591]
103394667  [KO:K27976]
103394768  [KO:K02649]
103394934  [KO:K05095] [EC:2.7.10.1]
103394996  [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103395024  limk1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
103395035  [KO:K04456] [EC:2.7.11.1]
103395214  [KO:K18496]
103395259  arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
103395301  [KO:K05763]
103395343  [KO:K07532]
103395373  [KO:K04438]
103395510  [KO:K05731]
103395548  [KO:K05732]
103395561  pak3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
103395680  ins; insulin [KO:K04526]
103395817  [KO:K02649]
103395841  [KO:K05759]
103395882  [KO:K02649]
103395903  itga6; integrin alpha-6 isoform X1 [KO:K06485]
103395913  [KO:K00889] [EC:2.7.1.68]
103396088  gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
103396090  [KO:K05768]
103396148  [KO:K00922] [EC:2.7.1.153]
103396190  [KO:K03998]
103396191  [KO:K03997]
103396234  [KO:K04189]
103396270  mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
103396351  egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
103396393  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
103396417  [KO:K12757]
103396496  [KO:K05730]
103396566  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103396573  [KO:K03898]
103396629  [KO:K05754]
103396775  [KO:K05719]
103396849  fam49b; protein FAM49B [KO:K27976]
103397002  [KO:K04358]
103397038  [KO:K06269] [EC:3.1.3.16]
103397120  [KO:K04392]
103397124  [KO:K08845] [EC:2.7.11.1]
103397254  [KO:K05744] [EC:2.7.11.1]
103397335  ssh1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103397433  myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
103397434  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
103397535  fgf5; fibroblast growth factor 5 [KO:K04358]
103397571  [KO:K08845] [EC:2.7.11.1]
103397685  c7; complement component C7 [KO:K03996]
103397740  itga2; integrin alpha-2 [KO:K06481]
103397742  [KO:K04358]
103397746  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
103397828  [KO:K04371] [EC:2.7.11.24]
103397960  [KO:K05768]
103397976  [KO:K03994]
103398008  [KO:K02649]
103398096  [KO:K05760]
103398127  f2r; proteinase-activated receptor 1 [KO:K03914]
103398128  iqgap2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
103398138  [KO:K00889] [EC:2.7.1.68]
103398463  apc2; adenomatous polyposis coli protein 2 [KO:K02085]
103398470  iqgap1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
103398479  itga11; integrin alpha-11 [KO:K06587]
103398611  [KO:K05744] [EC:2.7.11.1]
103398805  [KO:K04362] [EC:2.7.10.1]
103399010  pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
103399363  [KO:K04289]
103399916  fgf22; fibroblast growth factor 22 [KO:K04358]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
csem04010  MAPK signaling pathway
csem04510  Focal adhesion
csem04520  Adherens junction
KO pathway
ko04810   

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