KEGG   PATHWAY: csyr04810
Entry
csyr04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Carlito syrichta (Philippine tarsier)
Class
Cellular Processes; Cell motility
Pathway map
csyr04810  Regulation of actin cytoskeleton
csyr04810

Other DBs
GO: 0030036
Organism
Carlito syrichta (Philippine tarsier) [GN:csyr]
Gene
103272585  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
103250826  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
103267801  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
103269764  stromal cell-derived factor 1-like [KO:K10031]
103277206  stromal cell-derived factor 1-like [KO:K10031]
103273984  CXCR4; C-X-C chemokine receptor type 4 isoform X2 [KO:K04189]
103267776  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
103267942  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
103251528  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
103250105  FGF6; fibroblast growth factor 6 [KO:K04358]
103250493  FGF16; fibroblast growth factor 16 [KO:K04358]
103271859  FGF5; LOW QUALITY PROTEIN: fibroblast growth factor 5 [KO:K04358]
103272378  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
103253572  fibroblast growth factor 20 [KO:K04358]
103263537  FGF20; fibroblast growth factor 20 [KO:K04358]
103262295  fibroblast growth factor 9-like [KO:K04358]
103254562  fibroblast growth factor 20 [KO:K04358]
103273553  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
103268138  FGF18; fibroblast growth factor 18 [KO:K04358]
103265845  FGF3; fibroblast growth factor 3 [KO:K04358]
103265847  FGF4; fibroblast growth factor 4 [KO:K04358]
103267964  FGF10; fibroblast growth factor 10 [KO:K04358]
103250473  FGF21; fibroblast growth factor 21 [KO:K22429]
103250111  FGF23; fibroblast growth factor 23 [KO:K22428]
103255351  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
103250983  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
103267441  PDGFD; platelet-derived growth factor D [KO:K05450]
103265612  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
103251203  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
103268107  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103274944  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
103250719  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
103272218  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
103249185  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103263367  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103256200  FN1; fibronectin isoform X1 [KO:K05717]
103272898  ITGA1; integrin alpha-1 [KO:K06480]
103272895  ITGA2; LOW QUALITY PROTEIN: integrin alpha-2 [KO:K06481]
103272352  ITGA2B; integrin alpha-IIb [KO:K06476]
103276493  integrin alpha-3-like [KO:K06482]
103273427  ITGA4; integrin alpha-4 [KO:K06483]
103256307  ITGA5; integrin alpha-5 [KO:K06484]
103273336  ITGA6; integrin alpha-6 isoform X2 [KO:K06485]
103255294  ITGA7; integrin alpha-7 [KO:K06583]
103264529  ITGA8; integrin alpha-8 [KO:K06584]
103256188  integrin alpha-9-like [KO:K06585]
103263605  ITGA9; integrin alpha-9 [KO:K06585]
103268448  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
103252907  ITGA11; integrin alpha-11 [KO:K06587]
103268155  ITGAV; integrin alpha-V [KO:K06487]
103260120  ITGAL; integrin alpha-L [KO:K05718]
103264400  ITGAM; integrin alpha-M [KO:K06461]
103249796  ITGAX; integrin alpha-X [KO:K06462]
103249794  ITGAD; integrin alpha-D isoform X2 [KO:K06594]
103263070  ITGAE; integrin alpha-E [KO:K06524]
103267282  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
103272700  integrin beta-2-like [KO:K06464]
103263899  ITGB2; integrin beta-2 [KO:K06464]
103252761  ITGB4; integrin beta-4 [KO:K06525]
103275476  ITGB5; integrin beta-5 [KO:K06588]
103261773  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
103274618  ITGB7; integrin beta-7 [KO:K06590]
103270895  ITGB8; integrin beta-8 [KO:K06591]
103258701  KNG1; kininogen-1 isoform X1 [KO:K03898]
103254082  BDKRB1; B1 bradykinin receptor [KO:K03915]
103254072  BDKRB2; B2 bradykinin receptor [KO:K03916]
103255622  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
103257129  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
103271325  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
103252719  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
103255547  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
103258021  C5; complement C5 isoform X1 [KO:K03994]
103272410  C6; complement component C6 [KO:K03995]
103254430  C7; complement component C7 [KO:K03996]
103255085  C8A; complement component C8 alpha chain [KO:K03997]
103255086  C8B; complement component C8 beta chain isoform X1 [KO:K03998]
103269067  C9; complement component C9 [KO:K04000]
103254023  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
103260636  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
110595573  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
103275278  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
103249504  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
103249709  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
103251606  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
103271341  CRKL; crk-like protein [KO:K04438]
103275951  CRK; adapter molecule crk isoform X1 [KO:K04438]
103254912  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
103273857  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103270607  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
103276422  SOS2; son of sevenless homolog 2 isoform X2 [KO:K03099]
103250130  HRAS; GTPase HRas isoform X1 [KO:K02833]
103263630  KRAS; GTPase KRas isoform X2 [KO:K07827]
103259236  NRAS; GTPase NRas [KO:K07828]
103249780  RRAS; ras-related protein R-Ras [KO:K07829]
103270410  RRAS2; ras-related protein R-Ras2 [KO:K07830]
103251734  MRAS; ras-related protein M-Ras [KO:K07831]
103272732  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
103251553  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103266233  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103276054  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
103262537  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
103272136  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
103265889  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
103267580  guanine nucleotide exchange factor VAV3-like [KO:K05730]
103267759  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
103270865  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
103271179  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
103263745  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X3 [KO:K04366] [EC:2.7.11.1]
103259048  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
103277453  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103251709  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103265435  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103274188  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103257728  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103254239  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103263958  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103273601  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
103261835  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
103266429  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
103250976  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
103253660  transforming protein RhoA-like [KO:K04513]
103264336  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103273938  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103258883  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
103251325  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103265024  CDC42; cell division control protein 42 homolog [KO:K04393]
103266815  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
103266599  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103271975  PAK3; serine/threonine-protein kinase PAK 3 isoform X3 [KO:K05733] [EC:2.7.11.1]
103276952  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
103261220  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
103272333  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
103253882  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
103261766  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
103272758  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
103267985  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
103256318  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
103257292  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
103258482  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
103250671  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
103252205  serine/threonine-protein phosphatase PP1-beta [KO:K06269] [EC:3.1.3.16]
103251817  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103262486  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
103258562  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X2 [KO:K06270]
103275384  protein phosphatase 1 regulatory subunit 12B [KO:K12329]
103267507  PPP1R12C; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12C [KO:K17457]
103258791  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
103266402  MYL5; myosin light chain 5 [KO:K12753]
103259590  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
103249472  myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
103274606  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
103256881  MYL10; myosin regulatory light chain 10 [KO:K12756]
103255576  myosin regulatory light chain 12B-like isoform X1 [KO:K12757]
103267542  LOW QUALITY PROTEIN: myosin regulatory light chain, striated muscle, 25 kDa isoform-like [KO:K12757]
103277366  myosin regulatory light polypeptide 9 isoform X2 [KO:K12757]
103277367  myosin regulatory light chain 12B [KO:K12757]
103275165  myosin regulatory light chain RLC-A-like [KO:K12757]
103270153  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
103252352  myosin-14 [KO:K10352]
103255041  myosin-11 [KO:K10352]
103263458  MYH10; myosin-10 isoform X2 [KO:K10352]
103258614  MYH9; myosin-9 isoform X1 [KO:K10352]
103269903  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
103276266  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
103262706  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
103252404  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
103274333  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
103257958  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
103263164  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
103265997  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
103268840  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
103251667  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
103276202  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
103258527  LIMK2; LIM domain kinase 2 isoform X2 [KO:K05744] [EC:2.7.11.1]
103261692  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
103251868  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
103261805  ENAH; protein enabled homolog [KO:K05746]
103259407  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
103262698  WASF2; wiskott-Aldrich syndrome protein family member 2 isoform X1 [KO:K05748]
103274640  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
103257756  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X4 [KO:K05749]
103267671  NCKAP1L; nck-associated protein 1-like [KO:K05750]
103268875  NCKAP1; nck-associated protein 1 [KO:K05750]
103276857  ABI2; abl interactor 2 isoform X1 [KO:K05751]
103262038  BRK1; protein BRICK1 isoform X4 [KO:K05752]
103270825  probable protein BRICK1 [KO:K05752]
103271561  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
103265168  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
103264563  ACTR3; actin-related protein 3 [KO:K18584]
103271101  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
103259481  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
103259475  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
103276281  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X2 [KO:K05758]
103273728  ARPC3; actin-related protein 2/3 complex subunit 3 isoform X1 [KO:K05756]
103270580  ARPC4; LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 4 [KO:K05755]
103257872  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
103276971  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
103250241  ACTG1; actin, cytoplasmic 2 [KO:K05692]
103258260  actin-like isoform X1 [KO:K05692]
103252825  actin, cytoplasmic 2 [KO:K05692]
103263822  actin, cytoplasmic 1-like isoform X1 [KO:K05692]
103262634  PFN4; profilin-4 [KO:K05759]
103259657  profilin-2 [KO:K05759]
103268048  profilin-2 [KO:K05759]
103268363  PFN1; profilin-1 isoform X1 [KO:K05759]
103271808  PXN; LOW QUALITY PROTEIN: paxillin [KO:K05760]
103250389  EZR; ezrin isoform X3 [KO:K08007]
103258876  RDX; radixin isoform X1 [KO:K05762]
103263607  MSN; moesin [KO:K05763]
103264132  thymosin beta-4 [KO:K05764]
103268519  thymosin beta-4 [KO:K05764]
103272116  thymosin beta-4 isoform X1 [KO:K05764]
103261809  thymosin beta-4 [KO:K05764]
103269809  thymosin beta-4 [KO:K05764]
103271183  CFL2; cofilin-2 [KO:K05765]
103267124  CFL1; cofilin-1 isoform X1 [KO:K05765]
103261762  SSH2; protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103271898  SSH1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103258731  SSH3; protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103271489  VCL; vinculin [KO:K05700]
103261946  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
103252398  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
103268749  ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
103251191  GSN; gelsolin isoform X1 [KO:K05768]
103272204  SCIN; adseverin [KO:K05768]
103252684  alpha-actinin-1 isoform X3 [KO:K05699]
103276630  ACTN4; alpha-actinin-4 isoform X2 [KO:K05699]
103263000  APC; adenomatous polyposis coli protein isoform X2 [KO:K02085]
103262399  SPATA13; LOW QUALITY PROTEIN: spermatogenesis-associated protein 13 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
csyr04010  MAPK signaling pathway
csyr04510  Focal adhesion
csyr04520  Adherens junction
KO pathway
ko04810   
LinkDB

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