KEGG   PATHWAY: ecb04621
Entry
ecb04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Equus caballus (horse)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
ecb04621  NOD-like receptor signaling pathway
ecb04621

Organism
Equus caballus (horse) [GN:ecb]
Gene
100069844  NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
100051086  RIPK2; receptor-interacting serine/threonine-protein kinase 2 isoform X2 [KO:K08846] [EC:2.7.11.1]
100058432  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100070393  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100050167  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100064368  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
100058000  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100067894  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X4 [KO:K02580]
100057483  RELA; transcription factor p65 [KO:K04735]
100034237  IL1B; interleukin-1 beta [KO:K04519]
100052414  IL1B; interleukin-1 beta [KO:K04519]
111768185  interleukin-1 beta-like [KO:K04519]
100034216  IL18; interleukin-18 precursor [KO:K05482]
100034196  IL6; interleukin-6 precursor [KO:K05405]
100033834  TNF; tumor necrosis factor [KO:K03156]
100037400  CXCL8; interleukin-8 precursor [KO:K10030]
100034121  CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) precursor [KO:K05505]
100233237  CXCL2; C-X-C motif chemokine 2 precursor [KO:K05505]
100056258  MIP-2BETA; uncharacterized protein LOC100056258 precursor [KO:K05505]
100034136  CCL2; C-C motif chemokine 2 precursor [KO:K14624]
100033925  CCL5; C-C motif chemokine 5 precursor [KO:K12499]
100033946  ECATH-2; myeloid cathelicidin 2 precursor [KO:K13916]
100034135  ECATH-3; myeloid cathelicidin 3 precursor [KO:K13916]
100064172  cathelin [KO:K13916]
111768487  cathelin-like [KO:K13916]
100307027  DEFA5L; Paneth cell-specific alpha-defensin 5L precursor [KO:K05230]
100306992  DEFA20; Paneth cell-specific alpha-defensin 20 precursor [KO:K05230]
100306994  DEFA22; Paneth cell-specific alpha-defensin 22 precursor [KO:K05230]
100307002  DEFA1; alpha-defensin 1 precursor [KO:K05230]
100307023  DEFA36L; Paneth cell-specific alpha-defensin 36L precursor [KO:K05230]
100307018  DEFA31L; Paneth cell-specific alpha-defensin 31L precursor [KO:K05230]
100306984  DEFA12; Paneth cell-specific alpha-defensin 12 precursor [KO:K05230]
100306998  DEFA26; Paneth cell-specific alpha-defensin 26 [KO:K05230]
100306988  DEFA16; Paneth cell-specific alpha-defensin 16 precursor [KO:K05230]
100307022  DEFA35L; Paneth cell-specific alpha-defensin 35L precursor [KO:K05230]
100306983  DEFA11; Paneth cell-specific alpha-defensin 11 precursor [KO:K05230]
100307028  DEFA5; defensin-5 precursor [KO:K05230]
100033989  DEFB4B; beta-defensin 4B precursor [KO:K21100]
100629456  beta-defensin 103A [KO:K23126]
100059123  NOD2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
100065841  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
100070300  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
100060433  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100051087  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
100057701  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100066173  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100052608  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100057961  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100051798  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100056278  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100056239  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100063532  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
106782258  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100067469  JUN; transcription factor AP-1 [KO:K04448]
100064920  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
100066344  ATG5; autophagy protein 5 isoform X2 [KO:K08339]
100073160  ATG12; ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
100053911  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 isoform X2 [KO:K08341]
100055295  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
111775730  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
100060547  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
100146217  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
100060830  MAP1LC3C; LOW QUALITY PROTEIN: microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
102147898  microtubule-associated proteins 1A/1B light chain 3 beta 2-like [KO:K10435]
102150519  microtubule-associated proteins 1A/1B light chain 3 beta 2-like [KO:K10435]
100630367  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
100051549  SUGT1; protein SGT1 homolog [KO:K12795]
100071666  sharpin [KO:K20894]
100065232  SHARPIN; sharpin isoform X1 [KO:K20894]
100067987  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
100060870  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
100053107  CARD6; LOW QUALITY PROTEIN: caspase recruitment domain-containing protein 6 [KO:K12797]
100069114  TRIP6; thyroid receptor-interacting protein 6 [KO:K12792]
100057128  ERBIN; protein LAP2 [KO:K12796]
100061273  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
100068894  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
100068006  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
100055119  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
100052296  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100068666  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
100073197  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
100066212  MAVS; mitochondrial antiviral-signaling protein isoform X2 [KO:K12648]
100055110  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
100051650  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100055384  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X4 [KO:K07211] [EC:2.7.11.10]
100051339  TANK; TRAF family member-associated NF-kappa-B activator isoform X4 [KO:K12650]
100055868  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
100055087  IRF7; interferon regulatory factor 7 isoform X6 [KO:K09447]
100064468  interferon alpha-2-like [KO:K05414]
100064551  interferon alpha-2-like [KO:K05414]
100052921  interferon alpha-4 precursor [KO:K05414]
100052818  IFN-ALPHA2; interferon alpha-2 precursor [KO:K05414]
100629951  interferon alpha-1 [KO:K05414]
100053110  interferon alpha-4 [KO:K05414]
100053022  IFNA1; interferon alpha-1 precursor [KO:K05414]
100053210  interferon alpha-2-like [KO:K05414]
100064612  interferon alpha-2-like [KO:K05414]
100064731  IFND1; interferon delta 1 precursor [KO:K05414]
100064975  IFND2; interferon-delta 2 precursor [KO:K05414]
100629885  interferon alpha-2-like [KO:K05414]
100052545  IFNB1; interferon beta precursor [KO:K05415]
100052658  interferon beta-like [KO:K05415]
100147174  interferon beta [KO:K05415]
100071383  NLRX1; NLR family member X1 isoform X1 [KO:K12653]
100051770  ANTXR2; anthrax toxin receptor 2 isoform X1 [KO:K20909]
100061334  ANTXR1; anthrax toxin receptor 1 isoform X1 [KO:K20909]
100072788  NLRP1; NACHT, LRR and PYD domains-containing protein 1 isoform X1 [KO:K12798]
100063252  apoptosis-associated speck-like protein containing a CARD isoform X2 [KO:K12799]
100033888  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
100050934  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
100053597  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
100060963  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
100073322  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
100058241  PANX1; pannexin-1 isoform X1 [KO:K03443]
100058464  P2RX7; P2X purinoceptor 7 [KO:K05220]
100056810  TRPM2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
102149157  TRPM7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
100063195  TRPV2; transient receptor potential cation channel subfamily V member 2 isoform X1 [KO:K04971]
100034084  CASR; extracellular calcium-sensing receptor precursor [KO:K04612]
100067090  GPRC6A; G-protein coupled receptor family C group 6 member A [KO:K04622]
100057315  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100051558  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100055407  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100051485  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100052808  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100064557  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
100053019  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
100062974  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100064276  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100050036  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100072824  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
100034147  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
791250  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
791225  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
100048950  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
100072797  DHX33; putative ATP-dependent RNA helicase DHX33 isoform X1 [KO:K17820] [EC:5.6.2.6]
100058230  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
100055966  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
100058015  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
100054255  RIPK3; receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
100070034  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
100059684  NAMPT; nicotinamide phosphoribosyltransferase isoform X1 [KO:K03462] [EC:2.4.2.12]
100050132  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
100049843  CYBA; cytochrome b-245 light chain isoform X1 [KO:K08009]
111773538  TXNIP; thioredoxin-interacting protein [KO:K20910]
100069490  TXN2; thioredoxin, mitochondrial [KO:K03671]
100033827  TXN; thioredoxin [KO:K03671]
100061722  NEK7; serine/threonine-protein kinase Nek7 isoform X1 [KO:K20876] [EC:2.7.11.34]
100062237  BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X1 [KO:K11864] [EC:3.4.19.-]
100034150  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100033837  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
100051820  GPSM3; G-protein-signaling modulator 3 [KO:K15838]
100069286  MEFV; pyrin isoform X1 [KO:K12803]
100050881  PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 isoform X4 [KO:K12804]
100066502  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100061802  FADD; FAS-associated death domain protein [KO:K02373]
100069290  caspase-12 isoform X1 [KO:K04741] [EC:3.4.22.-]
100146460  NLRP6; NACHT, LRR and PYD domains-containing protein 6 isoform X1 [KO:K20863]
100054965  NACHT, LRR and PYD domains-containing protein 2 [KO:K20864]
100063024  NLRP12; NACHT, LRR and PYD domains-containing protein 12 isoform X2 [KO:K20865]
100073304  NAIP; baculoviral IAP repeat-containing protein 1 isoform X1 [KO:K12807]
100070605  NLRC4; NLR family CARD domain-containing protein 4 isoform X2 [KO:K12805]
100051333  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
105761007  uncharacterized protein LOC105761007 [KO:K20897]
100052023  GBP5; guanylate-binding protein 5 [KO:K20898]
100057148  AIM2; interferon-inducible protein AIM2 isoform X2 [KO:K12966]
100056988  interferon-activable protein 203 isoform X1 [KO:K20914]
106783181  MNDA; myeloid cell nuclear differentiation antigen [KO:K20914]
100056322  TP53BP1; TP53-binding protein 1 isoform X1 [KO:K20915]
100053343  RHOA; transforming protein RhoA [KO:K04513]
102148973  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
100052266  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
100059962  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
100052081  guanylate-binding protein 1 [KO:K20899]
100061885  guanylate-binding protein 7 isoform X1 [KO:K20899]
100146267  guanylate-binding protein 7 [KO:K20899]
100069322  caspase-13-like [KO:K04394] [EC:3.4.22.57 3.4.22.64]
100069303  CASP4; caspase 4, apoptosis-related cysteine peptidase [KO:K04394] [EC:3.4.22.57 3.4.22.64]
100063519  GSDMD; gasdermin-D [KO:K20917]
100063402  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100052489  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
100054008  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100146182  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100069633  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100052513  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
100051589  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
100066890  TLR4; toll-like receptor 4 precursor [KO:K10160]
111771935  toll-like receptor 4 [KO:K10160]
100062414  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
100053940  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100054848  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
100062046  TMEM173; stimulator of interferon genes protein isoform X2 [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
ecb04010  MAPK signaling pathway
ecb04064  NF-kappa B signaling pathway
ecb04140  Autophagy - animal
ecb04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
LinkDB

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