KEGG   PATHWAY: ecb05207
Entry
ecb05207                    Pathway                                
Name
Chemical carcinogenesis - receptor activation - Equus caballus (horse)
Description
Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stages. Chemicals or environmental factors may act at any of these stages to induce and/or enhance the carcinogenic process. Based on their mode-of-action, carcinogens can be classified as genotoxic or non-genotoxic. Genotoxic agent begins their action at the deoxyribonucleic acid (DNA) level, causing DNA damage through several mechanisms. Non-genotoxic carcinogens are chemicals that cause the development of tumors through multiple non-genotoxic events and epigenetic alterations without direct interaction with DNA. One non-genotoxic mechanism involves receptor activation. Biological mechanisms involving receptor activation fall into two broad categories: (i) those that involve cell surface receptors and some intracellular receptors that activate signal transduction pathways, resulting in biological responses, including gene transcription, and (ii) those that involve intracellular receptors that translocate into the nucleus and act as transcription factors regulating gene expression. Both classes of receptors can be involved in mechanisms of carcinogenesis.
Class
Human Diseases; Cancer: overview
Pathway map
ecb05207  Chemical carcinogenesis - receptor activation
ecb05207

Organism
Equus caballus (horse) [GN:ecb]
Gene
100060521  neuronal acetylcholine receptor subunit alpha-7 isoform X2 [KO:K04809]
100064657  ARRB1; beta-arrestin-1 isoform X4 [KO:K04439]
100072892  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
100069870  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100051110  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100057080  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
100069192  E2F1; transcription factor E2F1 [KO:K17454]
100050808  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
100060870  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
100067788  CDC6; cell division control protein 6 homolog isoform X1 [KO:K02213]
100064223  CDC25A; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
100051487  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100034011  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
100055384  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X4 [KO:K07211] [EC:2.7.11.10]
102149114  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100146784  CHRNA4; neuronal acetylcholine receptor subunit alpha-4 [KO:K04806]
102150777  CHRNB2; neuronal acetylcholine receptor subunit beta-2 isoform X1 [KO:K04813]
100060452  CHRNA3; neuronal acetylcholine receptor subunit alpha-3 isoform X1 [KO:K04805]
100060486  CHRNB4; neuronal acetylcholine receptor subunit beta-4 isoform X1 [KO:K04815]
100049924  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
100051186  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100062861  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
100034092  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100058760  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
100063873  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
100051623  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100058141  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100051753  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100052122  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100050227  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100146348  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100064671  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100054961  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100061130  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100051341  MTOR; serine/threonine-protein kinase mTOR isoform X3 [KO:K07203] [EC:2.7.11.1]
100067894  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X4 [KO:K02580]
100057483  RELA; transcription factor p65 [KO:K04735]
100055481  HRAS; GTPase HRas isoform X1 [KO:K02833]
100064473  KRAS; GTPase KRas isoform X1 [KO:K07827]
100051785  LOW QUALITY PROTEIN: GTPase KRas-like [KO:K07827]
100059469  NRAS; GTPase NRas [KO:K07828]
100065996  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100063190  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100057701  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100066173  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100051632  FOS; proto-oncogene c-Fos [KO:K04379]
100067469  JUN; transcription factor AP-1 [KO:K04448]
100068097  MYC; myc proto-oncogene protein [KO:K04377]
100050934  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
100063318  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100069215  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100062549  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100033839  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
100033955  FGF2; fibroblast growth factor 2 [KO:K18497]
100146832  ADRB1; beta-1 adrenergic receptor [KO:K04141]
100060659  ADRB2; beta-2 adrenergic receptor [KO:K04142]
100147322  ADRB3; beta-3 adrenergic receptor [KO:K04143]
100056464  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
100050675  neuroendocrine secretory protein 55 [KO:K04632]
100065563  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100071337  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100055961  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100054305  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100070498  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100051295  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
100058891  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100057796  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100066046  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
100052828  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100064302  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
100066388  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
100053304  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100070334  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100062307  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100064828  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100057002  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100067794  CREB3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100063153  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
100054803  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100059348  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
100055673  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100062085  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100058238  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
100055447  BAD; bcl2-associated agonist of cell death [KO:K02158]
100054940  CHRNA9; neuronal acetylcholine receptor subunit alpha-9 [KO:K04810]
100058911  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
100057166  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
100050176  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
100072397  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
791249  ESR1; estrogen receptor [KO:K08550]
100033964  ESR2; estrogen receptor beta [KO:K08551]
100034072  VDR; vitamin D3 receptor [KO:K08539]
100066590  CCND3; G1/S-specific cyclin-D3 isoform X3 [KO:K10152]
100067755  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100051866  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100053889  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100066282  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100057875  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100053005  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
100057481  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100071257  PAQR7; membrane progestin receptor alpha [KO:K25039]
100056251  PAQR8; membrane progestin receptor beta [KO:K25040]
100064749  PAQR5; membrane progestin receptor gamma isoform X1 [KO:K25041]
100033883  PGR; progesterone receptor [KO:K08556]
100060254  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
100052904  STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
100052954  signal transducer and activator of transcription 5B isoform X3 [KO:K11224]
100059642  BCL6; B-cell lymphoma 6 protein isoform X1 [KO:K15618]
100052058  KLF5; Krueppel-like factor 5 isoform X2 [KO:K09206]
100054047  KLF4; Krueppel-like factor 4 isoform X2 [KO:K17846]
100058859  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100067078  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
100064289  JAG1; protein jagged-1 isoform X1 [KO:K06052]
100315033  MIR141; eca-miR-141 [KO:K17018]
100314800  MIR29A; eca-miR-29a [KO:K16995]
100315043  MIR29B; eca-miR-29b [KO:K16996]
100315047  MIR29B-2; eca-miR-29b [KO:K16996]
100314812  MIR29C; eca-miR-29c [KO:K16997]
100315101  MIR29C-2; eca-miR-29c [KO:K16997]
100033980  AR; androgen receptor [KO:K08557]
100315027  MIRLET7A-2; eca-let-7a [KO:K16980]
100314820  MIRLET7A; eca-let-7a [KO:K16980]
100314889  MIRLET7D; eca-let-7d [KO:K16980]
100314974  MIRLET7E; eca-let-7e [KO:K16980]
100315074  MIRLET7F; eca-let-7f [KO:K16980]
100314867  MIRLET7G; eca-let-7g [KO:K16980]
106782874  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100033961  FGF7; fibroblast growth factor 7 [KO:K04358]
100056444  FGF17; fibroblast growth factor 17 isoform X3 [KO:K04358]
100071790  FGF16; fibroblast growth factor 16 [KO:K04358]
100050353  FGF9; fibroblast growth factor 9 [KO:K04358]
100060219  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100052655  FGF10; fibroblast growth factor 10 [KO:K04358]
100050037  FGF20; fibroblast growth factor 20 [KO:K04358]
100060309  FGF8; fibroblast growth factor 8 [KO:K04358]
100051221  FGF6; fibroblast growth factor 6 [KO:K04358]
100629648  FGF18; fibroblast growth factor 18 [KO:K04358]
100072461  FGF22; fibroblast growth factor 22 [KO:K04358]
100146649  FGF3; fibroblast growth factor 3 [KO:K04358]
100060525  FGF4; fibroblast growth factor 4 [KO:K04358]
100067648  DLL3; delta-like protein 3 [KO:K06051]
100052876  DLL1; delta-like protein 1 [KO:K06051]
100057073  DLL4; delta-like protein 4 [KO:K06051]
100059858  PTGES3; prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
100034148  AIP; AH receptor-interacting protein [KO:K17767]
100072761  AIPL1; aryl-hydrocarbon-interacting protein-like 1 [KO:K17767]
100066186  AHR; aryl hydrocarbon receptor [KO:K09093]
100054611  LOW QUALITY PROTEIN: aryl hydrocarbon receptor-like [KO:K09093]
100034150  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100033837  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
100033933  HSP90B1; endoplasmin precursor [KO:K09487]
100070623  KPNA1; importin subunit alpha-5 [KO:K23940]
100053778  KPNA2; importin subunit alpha-1 [KO:K15043]
100146627  KPNA7; importin subunit alpha-8 [KO:K15043]
100052650  KPNA4; importin subunit alpha-3 [KO:K23583]
100055705  KPNA3; importin subunit alpha-4 isoform X1 [KO:K23583]
100067045  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
100070377  KPNA6; importin subunit alpha-7 isoform X2 [KO:K15042]
100069121  KPNB1; importin subunit beta-1 [KO:K14293]
100059178  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
100062285  CYP1A1; cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
100070088  CYP1B1; cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
100054269  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
100060414  EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
100063124  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
100051576  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
100058329  glutathione S-transferase Mu 1 isoform X3 [KO:K00799] [EC:2.5.1.18]
100058290  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
100056506  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
100056597  GSTA4; glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
100056462  glutathione S-transferase A1 isoform X2 [KO:K00799] [EC:2.5.1.18]
100056332  GSTA1; glutathione S-transferase alpha 1 [KO:K00799] [EC:2.5.1.18]
100050322  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
100069318  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
100061826  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
100058514  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
100069640  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
100064102  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
100061761  LOW QUALITY PROTEIN: glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
100069628  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
100271875  glutathione S-transferase A1 isoform X1 [KO:K00799] [EC:2.5.1.18]
100630562  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
100056418  GSTA3; glutathione S-transferase A3 [KO:K00799] [EC:2.5.1.18]
100064796  glutathione S-transferase A1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
100069298  LOW QUALITY PROTEIN: glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
100146315  glutathione S-transferase A1 isoform X1 [KO:K00799] [EC:2.5.1.18]
100146804  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
100629609  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
100050390  glutathione S-transferase theta-4 isoform X1 [KO:K00799] [EC:2.5.1.18]
100053468  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
100068176  UGT2A2; UDP-glucuronosyltransferase 2A2 isoform X2 [KO:K00699] [EC:2.4.1.17]
100066444  UDP-glucuronosyltransferase 2B31 [KO:K00699] [EC:2.4.1.17]
100065342  UDP-glucuronosyltransferase 1-1 isoform X1 [KO:K00699] [EC:2.4.1.17]
100066472  UDP-glucuronosyltransferase 2B31 isoform X1 [KO:K00699] [EC:2.4.1.17]
100146977  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
100066329  UDP-glucuronosyltransferase 2B31 [KO:K00699] [EC:2.4.1.17]
100066359  UDP-glucuronosyltransferase 2B31 [KO:K00699] [EC:2.4.1.17]
100066501  UDP-glucuronosyltransferase 2B31 [KO:K00699] [EC:2.4.1.17]
100067994  UDP-glucuronosyltransferase 2C1 isoform X1 [KO:K00699] [EC:2.4.1.17]
100068026  UDP-glucuronosyltransferase 2C1 isoform X1 [KO:K00699] [EC:2.4.1.17]
100068041  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
111773863  UDP-glucuronosyltransferase 1-10-like [KO:K00699] [EC:2.4.1.17]
111773864  UDP-glucuronosyltransferase 1-10-like [KO:K00699] [EC:2.4.1.17]
111772894  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
100068569  cytochrome P450 2B4 [KO:K07412] [EC:1.14.14.1]
100068603  cytochrome P450 2B11-like precursor [KO:K07412] [EC:1.14.14.1]
100066015  NR1I3; nuclear receptor subfamily 1 group I member 3 isoform X1 [KO:K08541]
100069096  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
100061303  RXRB; retinoic acid receptor RXR-beta isoform X3 [KO:K08525]
100060371  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
100067064  CYP3A89; cytochrome P450 3A89 [KO:K07424] [EC:1.14.14.1]
100067084  CYP3A94; cytochrome p450 3A94 [KO:K07424] [EC:1.14.14.1]
100067041  CYP3A93; cytochrome p450 3A93 [KO:K07424] [EC:1.14.14.1]
100067109  CYP3A95; cytochrome p450 3A95 [KO:K07424] [EC:1.14.14.1]
100067131  CYP3A96; cytochrome P450 3A96 [KO:K07424] [EC:1.14.14.1]
100067154  CYP3A97; cytochrome P450 3A97 [KO:K07424] [EC:1.14.14.1]
102149219  cytochrome P450 3A12-like isoform X1 [KO:K07424] [EC:1.14.14.1]
100062244  CYP1A2; cytochrome P450 1A2 isoform X2 [KO:K07409] [EC:1.14.14.1]
100049840  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
Compound
C00076  Calcium cation
C00410  Progesterone
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00780  Serotonin
C00788  L-Adrenaline
C00951  Estradiol-17beta
C03690  Bis(2-ethylhexyl)phthalate
C04623  DDT
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06697  Arsenite
C06790  Trichloroethene
C06916  Clofibrate
C07020  Gemfibrozil
C07434  Phenobarbital
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C08150  Medroxyprogesterone acetate
C11042  Hexachlorobenzene
C11150  Trichloroacetate
C11371  Nafenopin
C11906  Sodium arsenite
C13624  Bisphenol A
C14240  Di(2-ethylhexyl) adipate
C14573  3,3',4,4',5-Pentachlorobiphenyl
C15995  Bombesin
C16452  N'-Nitrosonornicotine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
Reference
PMID:15660110
  Authors
Luch A.
  Title
Nature and nurture - lessons from chemical carcinogenesis.
  Journal
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546
Reference
PMID:19631282
  Authors
Hernandez LG, van Steeg H, Luijten M, van Benthem J
  Title
Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach.
  Journal
Mutat Res 682:94-109 (2009)
DOI:10.1016/j.mrrev.2009.07.002
Reference
PMID:21444681
  Authors
Wu CH, Lee CH, Ho YS
  Title
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
  Journal
Clin Cancer Res 17:3533-41 (2011)
DOI:10.1158/1078-0432.CCR-10-2434
Reference
PMID:19194381
  Authors
Schuller HM
  Title
Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
  Journal
Nat Rev Cancer 9:195-205 (2009)
DOI:10.1038/nrc2590
Reference
PMID:21541211
  Authors
Singh S, Pillai S, Chellappan S
  Title
Nicotinic acetylcholine receptor signaling in tumor growth and metastasis.
  Journal
J Oncol 2011:456743 (2011)
DOI:10.1155/2011/456743
Reference
PMID:31956359
  Authors
Cheng WL, Chen KY, Lee KY, Feng PH, Wu SM
  Title
Nicotinic-nAChR signaling mediates drug resistance in lung cancer.
  Journal
J Cancer 11:1125-1140 (2020)
DOI:10.7150/jca.36359
Reference
PMID:24827506
  Authors
Grando SA
  Title
Connections of nicotine to cancer.
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Nat Rev Cancer 14:419-29 (2014)
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Related
pathway
ecb00980  Metabolism of xenobiotics by cytochrome P450
ecb03320  PPAR signaling pathway
ecb04010  MAPK signaling pathway
ecb04024  cAMP signaling pathway
ecb04150  mTOR signaling pathway
ecb04151  PI3K-Akt signaling pathway
ecb04370  VEGF signaling pathway
ecb04915  Estrogen signaling pathway
ecb05204  Chemical carcinogenesis - DNA adducts
ecb05206  MicroRNAs in cancer
ecb05208  Chemical carcinogenesis - reactive oxygen species
KO pathway
ko05207   
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