KEGG   PATHWAY: fca05010
Entry
fca05010                    Pathway                                
Name
Alzheimer disease - Felis catus (domestic cat)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
fca05010  Alzheimer disease
fca05010

Organism
Felis catus (domestic cat) [GN:fca]
Gene
101087998  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
101089004  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
101085564  APP; amyloid-beta A4 protein isoform X1 [KO:K04520]
101086523  NAE1; NEDD8-activating enzyme E1 regulatory subunit isoform X1 [KO:K04532]
101090045  APBB1; amyloid-beta A4 precursor protein-binding family B member 1 isoform X1 [KO:K04529]
493876  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
101084319  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
101101594  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
101086840  BACE1; beta-secretase 1 [KO:K04521] [EC:3.4.23.46]
101096756  BACE2; beta-secretase 2 isoform X1 [KO:K07747] [EC:3.4.23.45]
101094953  RTN3; reticulon-3 isoform X3 [KO:K20723]
101091611  RTN4; reticulon-4 isoform X1 [KO:K20720]
101084076  PSENEN; gamma-secretase subunit PEN-2 isoform X1 [KO:K06170]
101087239  PSEN1; presenilin-1 isoform X2 [KO:K04505] [EC:3.4.23.-]
101081693  PSEN2; presenilin-2 isoform X2 [KO:K04522] [EC:3.4.23.-]
101090586  NCSTN; nicastrin [KO:K06171]
101083193  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
102902223  APH1B; gamma-secretase subunit APH-1B isoform X1 [KO:K06172]
101093646  IDE; insulin-degrading enzyme isoform X4 [KO:K01408] [EC:3.4.24.56]
101087516  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
101089557  MAPT; microtubule-associated protein tau isoform X15 [KO:K04380]
807939  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
807935  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
807938  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
807928  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
807937  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
807929  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
807930  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
101093395  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
101080579  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
101084817  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
101085609  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
101085348  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
101096376  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
101081685  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X2 [KO:K03947]
101099952  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101091711  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
101093612  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
101092508  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
101084209  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
101091174  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X3 [KO:K03951]
101091412  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
101092862  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
101093631  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X4 [KO:K03954]
101099010  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
101093917  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
101081479  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
101100189  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
101086911  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X1 [KO:K03957]
123380058  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
101082389  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
101093382  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X3 [KO:K03959]
101089135  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
101090177  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
101096614  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
101091850  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
101091655  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
101085859  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
101083475  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
101097623  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101100747  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
101088298  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
101096914  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
101089240  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X2 [KO:K03937]
101094940  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
101101113  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
101096448  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
101094451  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X2 [KO:K03941] [EC:7.1.1.2]
101091693  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
101080736  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
751619  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
751617  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
101087808  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X2 [KO:K00236]
101095280  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
101094311  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
807931  CYTB; cytochrome b [KO:K00412]
101094239  CYC1; cytochrome c1, heme protein, mitochondrial [KO:K00413]
101089499  UQCRC1; cytochrome b-c1 complex subunit 1, mitochondrial isoform X2 [KO:K00414]
101101684  UQCRC2; cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
101095032  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
101090590  cytochrome b-c1 complex subunit 7 [KO:K00417]
101096871  UQCRQ; cytochrome b-c1 complex subunit 8 [KO:K00418]
105261050  UQCR10; uncharacterized protein UQCR10 isoform X1 [KO:K00419]
101086703  cytochrome b-c1 complex subunit 10 [KO:K00420]
102900799  cytochrome b-c1 complex subunit 10-like [KO:K00420]
807933  COX3; cytochrome c oxidase subunit III [KO:K02262]
807934  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
807936  COX2; cytochrome c oxidase subunit II [KO:K02261]
101096643  COX4I2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X2 [KO:K02263]
101089914  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263]
101081808  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
123386183  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
101090761  COX5B; cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
102899476  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
101095773  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
105261306  COX6A2; cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
101100266  cytochrome c oxidase subunit 6B1 [KO:K02267]
109496610  cytochrome c oxidase subunit 6B1-like [KO:K02267]
105261211  cytochrome c oxidase subunit 6B2 [KO:K02267]
111559153  cytochrome c oxidase subunit 6B1-like [KO:K02267]
101096876  cytochrome c oxidase subunit 6C [KO:K02268]
101092350  COX7A2L; cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
101083819  COX7A1; cytochrome c oxidase subunit 7A1, mitochondrial isoform X2 [KO:K02270]
101093608  COX7A2; cytochrome c oxidase subunit 7A2, mitochondrial isoform X1 [KO:K02270]
101098629  COX7B2; cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
101085531  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
102899183  cytochrome c oxidase subunit 7C, mitochondrial isoform X2 [KO:K02272]
101096603  COX8A; cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
101101674  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
101087245  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
101080547  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
101085528  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
105260413  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
101093741  LOW QUALITY PROTEIN: ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
807932  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
101097006  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
101097110  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
101097080  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
101100487  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X2 [KO:K02128]
109502991  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
123384428  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
102901624  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
123381617  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
101097436  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
101087259  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
101099742  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
807940  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
101090672  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
101085200  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
101098515  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
102899304  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
101092793  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
101099117  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
102902352  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 3-like [KO:K15041]
101086294  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
101082635  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
101096309  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101100868  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
101095941  ADP/ATP translocase 2-like [KO:K05863]
101099589  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X4 [KO:K09565] [EC:5.2.1.8]
727696  LPL; lipoprotein lipase precursor [KO:K01059] [EC:3.1.1.34]
101086769  APOE; apolipoprotein E [KO:K04524]
101090780  LRP1; prolow-density lipoprotein receptor-related protein 1 isoform X2 [KO:K04550]
493881  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
493957  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
101087871  FADD; FAS-associated death domain protein [KO:K02373]
100142684  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100502578  BID; BH3-interacting domain death agonist [KO:K04726]
101081534  CALM2; calmodulin-2 [KO:K02183]
101099307  calmodulin-like protein 3 [KO:K02183]
102902667  calmodulin-like [KO:K02183]
101091063  CALM3; calmodulin-3 [KO:K02183]
101097703  calmodulin-alpha-like [KO:K02183]
101094679  CALM1; calmodulin-1 [KO:K02183]
101086824  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
101100214  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
101097144  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101086926  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101093097  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
101097765  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101090344  PPP3R1; calcineurin subunit B type 1 isoform X4 [KO:K06268]
768269  BAD; bcl2-associated agonist of cell death [KO:K02158]
101098213  cytochrome c [KO:K08738]
101088122  cytochrome c-like [KO:K08738]
101100947  cytochrome c [KO:K08738]
101088339  cytochrome c-like [KO:K08738]
109503558  cytochrome c-like [KO:K08738]
768257  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
768260  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
493932  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
101093801  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101100919  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
101097246  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
101091895  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
101094708  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [KO:K04634]
101090942  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101092961  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101092262  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101090005  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101082021  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
101086110  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101094356  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101091740  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
101095061  GRIN2D; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
101082923  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101088394  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X8 [KO:K04851]
101080870  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
654399  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
751113  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
101083455  MCU; calcium uniporter protein, mitochondrial isoform X2 [KO:K20858]
101087614  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101087958  MAPK3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
101090190  RYR3; ryanodine receptor 3 [KO:K04963]
101100546  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
101101230  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
101087993  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
101091492  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X2 [KO:K05853] [EC:7.2.2.10]
101101678  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
493691  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
101086780  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
101092150  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
101081819  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101084148  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101095973  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
101096363  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
101082912  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
101095157  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101091310  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101101463  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101084765  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101091455  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101084297  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101090365  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
101088226  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
101084967  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
101101091  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
101084949  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
101098808  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
101093640  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
101097403  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
101091823  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
101081009  PSMB7; proteasome subunit beta type-7 isoform X2 [KO:K02739] [EC:3.4.25.1]
101087282  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
101086664  PSMB2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
101092368  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
101101060  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
101099992  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
101086215  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
101094025  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
101090224  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
101098797  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
101095435  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
101097360  PSMC5; 26S proteasome regulatory subunit 8 isoform X2 [KO:K03066]
101095190  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
101082082  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
101094305  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 isoform X3 [KO:K03033]
101093051  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
101100851  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
101091665  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
101085106  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
101098912  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
101101591  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X2 [KO:K03039]
101098564  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X2 [KO:K03029]
101095118  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
101095457  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
101097227  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
101086493  LOW QUALITY PROTEIN: 26S proteasome complex subunit SEM1 [KO:K10881]
111560594  26S proteasome complex subunit SEM1-like [KO:K10881]
100135767  CASP12; inactive caspase-12 [KO:K04741] [EC:3.4.22.-]
101100342  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
101096916  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
101083231  CAPN2; calpain-2 catalytic subunit isoform X2 [KO:K03853] [EC:3.4.22.53]
101094890  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
101088725  SLC39A3; zinc transporter ZIP3 isoform X2 [KO:K14709]
101082917  SLC39A2; zinc transporter ZIP2 isoform X1 [KO:K14709]
101100859  SLC39A1; zinc transporter ZIP1 [KO:K14709]
101080686  SLC39A4; zinc transporter ZIP4 isoform X1 [KO:K14710]
101097567  SLC39A5; zinc transporter ZIP5 [KO:K14711]
101095202  SLC39A6; zinc transporter ZIP6 [KO:K14712]
101086060  SLC39A7; zinc transporter SLC39A7 isoform X1 [KO:K14713]
101096887  SLC39A8; metal cation symporter ZIP8 [KO:K14714]
101100479  SLC39A9; zinc transporter ZIP9 [KO:K14715]
101086494  SLC39A10; zinc transporter ZIP10 [KO:K14716]
101090564  SLC39A11; zinc transporter ZIP11 isoform X3 [KO:K14717]
101092444  SLC39A12; zinc transporter ZIP12 isoform X1 [KO:K14718]
101095193  SLC39A13; zinc transporter ZIP13 isoform X1 [KO:K14719]
101087988  SLC39A14; metal cation symporter ZIP14 isoform X1 [KO:K14720]
101089199  SLC11A2; natural resistance-associated macrophage protein 2 isoform X2 [KO:K21398]
101097226  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
101081660  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
768262  CASP7; caspase-7 isoform X2 [KO:K04397] [EC:3.4.22.60]
101097173  DKK1; dickkopf-related protein 1 [KO:K02165]
101090100  DKK2; dickkopf-related protein 2 [KO:K02165]
101099547  DKK4; dickkopf-related protein 4 [KO:K02165]
101094190  WNT1; proto-oncogene Wnt-1 [KO:K03209]
493672  WNT2; protein Wnt-2 precursor [KO:K00182]
101080904  WNT2B; protein Wnt-2b [KO:K00182]
101088533  WNT3; proto-oncogene Wnt-3 [KO:K00312]
101080607  WNT3A; protein Wnt-3a [KO:K00312]
101095185  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
101085809  WNT5B; protein Wnt-5b [KO:K00444]
101080694  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
101099392  WNT6; protein Wnt-6 [KO:K00445]
101083664  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
101095592  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
101089489  WNT8A; LOW QUALITY PROTEIN: protein Wnt-8a [KO:K00714]
101096357  WNT8B; protein Wnt-8b [KO:K00714]
101080844  WNT9B; protein Wnt-9b [KO:K01064]
111560436  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
101092455  WNT10A; protein Wnt-10a [KO:K01357]
101093948  WNT10B; protein Wnt-10b [KO:K01357]
101100080  WNT11; protein Wnt-11 [KO:K01384]
101090252  WNT16; protein Wnt-16 [KO:K01558]
101082735  FZD1; frizzled-1 [KO:K02432]
101087255  FZD7; frizzled-7 [KO:K02432]
101085253  FZD2; frizzled-2 [KO:K02235]
101095250  FZD3; frizzled-3 isoform X1 [KO:K02329]
101093710  FZD4; frizzled-4 isoform X1 [KO:K02354]
101101229  FZD8; frizzled-8 [KO:K02375]
101097508  FZD5; frizzled-5 [KO:K02375]
101101443  FZD6; frizzled-6 [KO:K02376]
101087697  FZD9; frizzled-9 [KO:K02842]
101081169  FZD10; frizzled-10 [KO:K02842]
101084481  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
101082246  LRP6; low-density lipoprotein receptor-related protein 6 isoform X2 [KO:K03068]
101101321  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
101094385  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
101084782  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
101095675  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X2 [KO:K02353]
101087686  FRAT1; proto-oncogene FRAT1 [KO:K03069]
105261037  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
101084186  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
101093065  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
101087664  CSNK2B; casein kinase II subunit beta [KO:K03115]
101088804  AXIN1; LOW QUALITY PROTEIN: axin-1 [KO:K02157]
101093061  AXIN2; axin-2 isoform X1 [KO:K04385]
101096138  APC; adenomatous polyposis coli protein isoform X4 [KO:K02085]
101097211  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
101097342  CTNNB1; catenin beta-1 [KO:K02105]
101085602  CSNK1A1; casein kinase I isoform X2 [KO:K08957] [EC:2.7.11.1]
101094768  KIF5A; kinesin heavy chain isoform X2 [KO:K10396]
101098883  KIF5C; kinesin heavy chain [KO:K10396]
101092693  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
101082343  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
101099130  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
101084245  KLC3; kinesin light chain 3 [KO:K10407]
101084963  KLC4; kinesin light chain 4 [KO:K10407]
101098780  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
101095277  TUBA4A; tubulin alpha-4A chain isoform X2 [KO:K07374]
101096402  tubulin alpha-1B chain [KO:K07374]
101099268  tubulin alpha-8 chain isoform X1 [KO:K07374]
101081992  tubulin alpha-1C chain [KO:K07374]
101090556  tubulin alpha-3 chain [KO:K07374]
101096902  TUBA1A; tubulin alpha-1A chain [KO:K07374]
101080975  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
100188929  TUBB1; tubulin beta-1 chain [KO:K07375]
101084876  TUBB2B; tubulin beta-2B chain [KO:K07375]
101095657  TUBB; tubulin beta chain [KO:K07375]
101096420  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
101084324  TUBB4B; tubulin beta-4B chain [KO:K07375]
101086953  TUBB4A; tubulin beta-4A chain [KO:K07375]
109499596  TUBB2A; tubulin beta-2A chain [KO:K07375]
101096892  AGER; advanced glycosylation end product-specific receptor isoform X6 [KO:K19722]
751103  HRAS; GTPase HRas isoform X1 [KO:K02833]
751104  KRAS; GTPase KRas isoform X2 [KO:K07827]
751105  NRAS; GTPase NRas [KO:K07828]
101089839  ARAF; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
101092346  BRAF; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
101096047  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101081387  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X3 [KO:K04368] [EC:2.7.12.2]
101100281  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101086376  NOX1; LOW QUALITY PROTEIN: NADPH oxidase 1 [KO:K08008]
101086207  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101089891  NOX4; NADPH oxidase 4 isoform X3 [KO:K21423] [EC:1.6.3.-]
101096604  RELA; transcription factor p65 [KO:K04735]
100142683  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101087020  NOS2; nitric oxide synthase, inducible isoform X2 [KO:K13241] [EC:1.14.13.39]
100126581  PTGS2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
493755  TNF; tumor necrosis factor precursor [KO:K03156]
493687  IL6; interleukin-6 precursor [KO:K05405]
493944  IL1A; interleukin-1 alpha precursor [KO:K04383]
768274  IL1B; interleukin-1 beta [KO:K04519]
101091467  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
101091694  SNCA; alpha-synuclein [KO:K04528]
101082744  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X3 [KO:K16195] [EC:2.7.11.1]
101095617  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100142682  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
101086544  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
493804  INS; insulin precursor [KO:K04526]
100127108  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
101087257  IRS1; insulin receptor substrate 1 [KO:K16172]
101095791  IRS2; insulin receptor substrate 2 [KO:K07187]
101100432  insulin receptor substrate 1-like isoform X2 [KO:K17445]
101093251  IRS4; insulin receptor substrate 4 [KO:K17446]
100271864  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
101093286  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
101093586  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101094274  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101091892  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101097413  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101087931  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101092818  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
100499544  AKT2; RAC-beta serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
101098152  MTOR; serine/threonine-protein kinase mTOR isoform X3 [KO:K07203] [EC:2.7.11.1]
101098658  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
101083981  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
101098308  ATG101; autophagy-related protein 101 [KO:K19730]
101089141  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
101091994  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
101088613  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
101101015  BECN1; beclin-1 isoform X2 [KO:K08334]
101094563  BECN2; beclin-2 [KO:K08334]
101091893  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
101092860  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
101082779  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
101099249  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
101080739  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
101090948  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
101088378  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
101095300  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Neurobiol Aging 32:763-77 (2011)
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J Neurosci 23:4499-508 (2003)
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Acta Neuropathol 109:5-13 (2005)
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Front Cell Neurosci 9:191 (2015)
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Alzheimers Dement 10:S26-32 (2014)
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Front Neurosci 9:204 (2015)
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Related
pathway
fca00190  Oxidative phosphorylation
fca03050  Proteasome
fca04020  Calcium signaling pathway
fca04140  Autophagy - animal
fca04141  Protein processing in endoplasmic reticulum
fca04210  Apoptosis
fca04310  Wnt signaling pathway
fca04910  Insulin signaling pathway
fca04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
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