KEGG   PATHWAY: ipu04510
Entry
ipu04510                    Pathway                                
Name
Focal adhesion - Ictalurus punctatus (channel catfish)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
ipu04510  Focal adhesion
ipu04510

Other DBs
GO: 0005925
Organism
Ictalurus punctatus (channel catfish) [GN:ipu]
Gene
108279263  col1a1a; collagen, type I, alpha 1a isoform X1 [KO:K06236]
108273947  col1a1b; collagen, type I, alpha 1b [KO:K06236]
108257075  collagen alpha-2(I) chain [KO:K06236]
108265655  col2a1a; collagen, type II, alpha 1a isoform X1 [KO:K19719]
108267417  collagen alpha-5(IV) chain [KO:K06237]
108267418  col4a6; collagen alpha-6(IV) chain [KO:K06237]
108266297  collagen alpha-2(IV) chain isoform X1 [KO:K06237]
108266298  collagen alpha-1(IV) chain [KO:K06237]
108277694  col4a3; collagen alpha-5(IV) chain [KO:K06237]
108277693  col4a4; collagen alpha-4(IV) chain [KO:K06237]
108280703  collagen alpha-5(IV) chain isoform X1 [KO:K06237]
108280291  collagen alpha-4(IV) chain [KO:K06237]
108261130  uncharacterized protein LOC108261130 isoform X1 [KO:K06238]
108263687  collagen alpha-6(VI) chain [KO:K06238]
108270894  collagen alpha-6(VI) chain isoform X2 [KO:K06238]
108270904  collagen alpha-6(VI) chain isoform X2 [KO:K06238]
108270926  collagen alpha-6(VI) chain isoform X1 [KO:K06238]
108271051  collagen alpha-2(VI) chain isoform X1 [KO:K06238]
108271102  collagen alpha-1(VI) chain [KO:K06238]
108260768  collagen alpha-1(IX) chain [KO:K08131]
108276009  collagen alpha-3(IX) chain [KO:K08131]
108270765  col9a1a; collagen, type IX, alpha 1a [KO:K08131]
108272917  collagen alpha-2(IX) chain [KO:K08131]
108274548  collagen alpha-3(IX) chain [KO:K08131]
108275333  laminin subunit alpha-2 [KO:K05637]
108272667  laminin subunit alpha-1 [KO:K05637]
108270685  lama3; laminin subunit alpha-3 [KO:K06240]
108275926  laminin subunit alpha-5 isoform X1 [KO:K06240]
108267308  si:ch211-241e1.3; laminin subunit alpha-3 isoform X1 [KO:K06240]
108275439  laminin subunit alpha-4 [KO:K06241]
108275309  lamb1a; laminin subunit beta-1a [KO:K05636]
108279853  lamb1b; laminin subunit beta-1b [KO:K05636]
108275997  lamb2; laminin subunit beta-2 isoform X1 [KO:K06243]
108276201  lamb2l; laminin subunit beta-1 [KO:K06243]
108281073  lamb3; laminin subunit beta-3 [KO:K06244]
108275290  laminin subunit beta-4 [KO:K06245]
108267334  laminin subunit gamma-1 [KO:K05635]
108267337  lamc2; laminin subunit gamma-2 [KO:K06246]
108260275  laminin subunit gamma-3 isoform X1 [KO:K06247]
108273870  chondroadherin [KO:K06248]
108264645  reelin [KO:K06249] [EC:3.4.21.-]
108257932  thbs1b; thrombospondin-1 isoform X1 [KO:K16857]
108270370  thrombospondin-1 [KO:K16857]
108260953  thbs2a; thrombospondin-2 isoform X1 [KO:K04659]
108274281  thbs2b; thrombospondin-2 [KO:K04659]
108269310  thbs3a; thrombospondin-3a [KO:K04659]
108270565  cartilage oligomeric matrix protein [KO:K04659]
108272910  thbs3b; thrombospondin-3b [KO:K04659]
108255332  thbs4a; thrombospondin-4a [KO:K04659]
108279270  thbs4b; thrombospondin-4-B [KO:K04659]
108266812  fn1a; fibronectin 1a [KO:K05717]
108279116  vtnb; vitronectin b [KO:K06251]
108277704  vtna; vitronectin a [KO:K06251]
108267268  tenascin-R [KO:K06252]
108274787  tenascin isoform X1 [KO:K06252]
108274578  tnxba; uncharacterized protein tnxba isoform X1 [KO:K06252]
108268097  tenascin-N isoform X1 [KO:K06252]
108255935  tncb; tenascin isoform X2 [KO:K06252]
108264049  von Willebrand factor [KO:K03900]
108276985  integrin alpha-1 isoform X1 [KO:K06480]
108276854  itga2.2; integrin alpha-2 isoform X3 [KO:K06481]
108258137  integrin alpha-IIb isoform X1 [KO:K06476]
108256143  itga3a; integrin alpha-3 [KO:K06482]
108274083  itga3b; integrin alpha-3b isoform X1 [KO:K06482]
108266204  integrin alpha-4 [KO:K06483]
108275658  integrin alpha-5 [KO:K06484]
108258655  itga6b; integrin alpha-6b isoform X1 [KO:K06485]
108266131  itga6a; integrin alpha-6 isoform X1 [KO:K06485]
108268716  itga6l; integrin alpha-6 [KO:K06485]
108254787  itga7; integrin alpha-7 isoform X1 [KO:K06583]
108256655  integrin alpha-8 [KO:K06584]
108263163  integrin alpha-9 isoform X1 [KO:K06585]
108267060  integrin alpha-10 [KO:K06586]
108275317  itga11b; integrin alpha-11 isoform X1 [KO:K06587]
108259098  itga11a; integrin alpha-11a [KO:K06587]
108266447  integrin alpha-V [KO:K06487]
100304492  itgb1; integrin, beta 1 precursor [KO:K05719]
108271845  itgb1a; integrin beta-1a isoform X1 [KO:K05719]
108279461  itgb3a; integrin beta-3a isoform X1 [KO:K06493]
108274212  itgb3b; integrin beta-3b [KO:K06493]
108265318  integrin beta-4 isoform X1 [KO:K06525]
108266628  integrin beta-5 [KO:K06588]
108270759  integrin beta-6 isoform X1 [KO:K06589]
108271744  itgb7; integrin beta-7 isoform X1 [KO:K06590]
108257400  integrin beta-8 isoform X1 [KO:K06591]
108276881  epithelial membrane protein 2 [KO:K26256]
108259440  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
108260470  pdgfbb; uncharacterized protein pdgfbb isoform X1 [KO:K04359]
108259423  si:ch211-79m20.1; myb-like protein Q isoform X3 [KO:K17386]
108277755  platelet-derived growth factor D [KO:K05450]
108269254  platelet-derived growth factor C isoform X1 [KO:K05450]
108268549  pro-epidermal growth factor isoform X1 [KO:K04357]
100305062  igf1; insulin-like growth factor I precursor [KO:K05459]
108280002  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
108280865  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
108279200  vascular endothelial growth factor A [KO:K05448]
108270479  pgfb; vascular endothelial growth factor A [KO:K16859]
108258015  pgfa; vascular endothelial growth factor A [KO:K16859]
108259562  vascular endothelial growth factor D isoform X1 [KO:K05449]
108263825  vascular endothelial growth factor C [KO:K05449]
108264660  hepatocyte growth factor [KO:K05460]
108258040  platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
108274697  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
108271091  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
100304999  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
108258084  vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
108280575  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
108269076  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
108256487  vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
108268674  vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
108268944  hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
108273851  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
108258510  emp1; epithelial membrane protein 1 [KO:K26255]
100528179  epithelial membrane protein 2 [KO:K26255]
108255075  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
108276199  src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
108277872  arhgap35a; rho GTPase-activating protein 35 [KO:K05732]
108260288  arhgap35b; rho GTPase-activating protein 35 [KO:K05732]
108270154  rho GTPase-activating protein 5 [KO:K13709]
108271788  rhoca; ras homolog family member Ca [KO:K04513]
108275781  rhoac; rho-related GTP-binding protein RhoA-C isoform X1 [KO:K04513]
108265463  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
108254710  transforming protein RhoA [KO:K04513]
108265880  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
100528424  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
108274925  protein diaphanous homolog 1 isoform X1 [KO:K05740]
108267074  rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
108263171  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
108256302  rho-associated protein kinase 2 isoform X5 [KO:K17388] [EC:2.7.11.1]
100528893  myl5; myosin light chain 5 [KO:K12753]
108265071  myosin regulatory light chain 2, atrial isoform [KO:K12754]
100528638  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
108276062  myl9a; myosin regulatory light polypeptide 9 [KO:K12755]
108276823  myl10; myosin regulatory light chain 2B, cardiac muscle isoform [KO:K12756]
100528744  mlrb; myosin regulatory light chain 2b cardiac muscle isoform [KO:K12756]
108267514  myosin regulatory light chain 12B [KO:K12757]
108267401  myosin regulatory light polypeptide 9 [KO:K12757]
100528939  mylpfa; myosin regulatory light chain 11 [KO:K12758]
108274226  mylpfb; myosin regulatory light chain 2, skeletal muscle [KO:K12758]
108269700  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
108280818  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
100528446  pp1b; serine/threonine-protein phosphatase pp1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
108259981  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
108274218  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
108279475  protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
108273132  ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
108273224  mylkb; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
108264077  myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
108276275  myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
108266375  mylka; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
108259589  myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
108257896  mylk4b; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
108256285  mylk5; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
108268043  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
108272671  pip5k1aa; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a isoform X1 [KO:K00889] [EC:2.7.1.68]
108280566  pip5k1cb; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b isoform X2 [KO:K00889] [EC:2.7.1.68]
108276882  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
108268485  pip5k1ab; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2 [KO:K00889] [EC:2.7.1.68]
108265367  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
108271405  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
108258691  actb1; actin, cytoplasmic 1 [KO:K05692]
100526698  actb2; actin, cytoplasmic 2 [KO:K05692]
108264256  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
108259406  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
108259404  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
108259420  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
108261236  alpha-actinin-1 isoform X1 [KO:K05699]
108280413  alpha-actinin-4 isoform X1 [KO:K05699]
108275246  tln2b; talin-2 [KO:K06271]
108276934  talin-1 isoform X1 [KO:K06271]
101154674  flna; filamin-A isoform X1 [KO:K04437]
108254750  filamin-B isoform X1 [KO:K27392]
108265409  protein piccolo isoform X1 [KO:K05760]
108277251  integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
108268373  zyxin [KO:K06273]
108276935  vaspa; vasodilator stimulated phosphoprotein a [KO:K06274]
108264341  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
108263186  vcla; vinculin a isoform X1 [KO:K05700]
108273866  vinculin-like [KO:K05700]
108271331  parvab; parvin, alpha b isoform X2 [KO:K06275]
108269306  parvaa; parvin, alpha a [KO:K06275]
108274638  beta-parvin isoform X1 [KO:K06275]
108274639  gamma-parvin isoform X1 [KO:K06275]
108257355  pdpk1a; 3-phosphoinositide-dependent protein kinase 1a isoform X1 [KO:K06276] [EC:2.7.11.1]
108264442  pdpk1b; 3-phosphoinositide dependent protein kinase 1b [KO:K06276] [EC:2.7.11.1]
108263416  akt3a; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
108264340  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108269621  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108259077  akt3b; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
108258646  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate b isoform X1 [KO:K03083] [EC:2.7.11.26]
108266408  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
108268846  catenin beta-1 isoform X1 [KO:K02105]
108256545  catenin beta-1 [KO:K02105]
108259727  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
108273127  prkcaa; protein kinase C, alpha, a isoform X2 [KO:K02677] [EC:2.7.11.13]
108258960  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
108260780  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
108266582  prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
108256909  ptk2aa; protein tyrosine kinase 2aa isoform X3 [KO:K05725] [EC:2.7.10.2]
108267913  ptk2ab; focal adhesion kinase 1 isoform X6 [KO:K05725] [EC:2.7.10.2]
108275608  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108276156  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
108280664  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108271155  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108272037  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
108260231  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108269686  ptena; phosphatase and tensin homolog A [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
108273661  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
108278776  guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
108273150  guanine nucleotide exchange factor VAV3 [KO:K05730]
108258736  proto-oncogene vav [KO:K05730]
108273830  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
108257150  rac1b; ras-related C3 botulinum toxin substrate 1b isoform X1 [KO:K04392]
108276437  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
108259609  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
108264802  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
108271286  pak2b; serine/threonine-protein kinase PAK 2b isoform X1 [KO:K04410] [EC:2.7.11.1]
108267562  pak2a; serine/threonine-protein kinase PAK 2a isoform X1 [KO:K04410] [EC:2.7.11.1]
108260344  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
108278171  serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
108257526  pak5; serine/threonine-protein kinase PAK 5 isoform X2 [KO:K05736] [EC:2.7.11.1]
108269614  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
108276251  cdc42l2; cell division cycle 42 like 2 [KO:K04393]
100528978  cdc42; cell division control protein 42 homolog [KO:K04393]
108272678  cell division control protein 42 homolog [KO:K04393]
108264615  breast cancer anti-estrogen resistance protein 1 isoform X3 [KO:K05726]
108260055  adapter molecule crk [KO:K04438]
108278795  crk-like protein [KO:K04438]
108278187  adapter molecule crk [KO:K04438]
108273880  dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
108279164  rapgef1b; rap guanine nucleotide exchange factor 1b isoform X1 [KO:K06277]
108265900  rapgef1a; rap guanine nucleotide exchange factor 1 isoform X3 [KO:K06277]
108265690  rap1aa; RAP1A, member of RAS oncogene family a [KO:K04353]
108255244  rap1ab; ras-related protein rap1ab [KO:K04353]
100528315  rap1b; ras-related protein Rap-1b [KO:K07836]
108278622  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
108274025  mapk8b; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
108263675  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
108278438  mapk10; mitogen-activated protein kinase 10 isoform X6 [KO:K04440] [EC:2.7.11.24]
108267848  transcription factor Jun isoform X1 [KO:K04448]
108258130  jun; transcription factor AP-1 [KO:K04448]
108260086  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
108279928  serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
108269231  cav1; caveolin-1 [KO:K06278]
108275955  cav4b; caveolin-2 [KO:K12958]
108281023  cav4a; caveolin-2 [KO:K12958]
108269359  caveolin-2 [KO:K12958]
100528411  cav3; caveolin-3 [KO:K12959]
108255503  fynb; tyrosine-protein kinase Fyn isoform X2 [KO:K05703] [EC:2.7.10.2]
108270342  tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
108265869  SHC-transforming protein 1 isoform X1 [KO:K06279]
108270761  SHC-transforming protein 2 [KO:K17447]
108279345  shc3; SHC-transforming protein 3 [KO:K17448]
108256494  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
100528114  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
108270875  son of sevenless homolog 1 isoform X1 [KO:K03099]
108263000  LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
128631210  LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
100528230  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
108259582  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
108276324  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X5 [KO:K04366] [EC:2.7.11.1]
108255012  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
124627985  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108255782  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108256206  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108265889  ETS domain-containing protein Elk-1 [KO:K04375]
108271119  G1/S-specific cyclin-D1 [KO:K04503]
100528326  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
108279704  ccnd2b; G1/S-specific cyclin-D2b [KO:K10151]
108281084  G1/S-specific cyclin-D3 [KO:K10152]
100304597  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
108269205  xiap; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
108269206  E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
108278747  bada; uncharacterized protein bada [KO:K02158]
108267538  badb; BCL2 associated agonist of cell death b [KO:K02158]
108267470  bcl2b; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
108256596  bcl2a; apoptosis regulator Bcl-2a [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
ipu04010  MAPK signaling pathway
ipu04060  Cytokine-cytokine receptor interaction
ipu04070  Phosphatidylinositol signaling system
ipu04110  Cell cycle
ipu04310  Wnt signaling pathway
ipu04512  ECM-receptor interaction
ipu04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

DBGET integrated database retrieval system