KEGG   PATHWAY: lruf04810
Entry
lruf04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Lynx rufus (bobcat)
Class
Cellular Processes; Cell motility
Pathway map
lruf04810  Regulation of actin cytoskeleton
lruf04810

Other DBs
GO: 0030036
Organism
Lynx rufus (bobcat) [GN:lruf]
Gene
124502841  lysophosphatidic acid receptor 1 [KO:K04289]
124524552  lysophosphatidic acid receptor 2 [KO:K04291]
124509171  lysophosphatidic acid receptor 4 [KO:K04275]
124501374  lysophosphatidic acid receptor 5-like [KO:K08390]
124506687  stromal cell-derived factor 1 isoform X1 [KO:K10031]
124515642  C-X-C chemokine receptor type 4 [KO:K04189]
124505518  prothrombin [KO:K01313] [EC:3.4.21.5]
124518259  proteinase-activated receptor 1-like [KO:K03914]
124527868  insulin [KO:K04526]
124520329  LOW QUALITY PROTEIN: pro-epidermal growth factor-like [KO:K04357]
124517067  fibroblast growth factor 1 isoform X1 [KO:K18496]
124521134  LOW QUALITY PROTEIN: fibroblast growth factor 2-like [KO:K18497]
124510046  fibroblast growth factor 18 [KO:K04358]
124510963  fibroblast growth factor 9 [KO:K04358]
124504714  fibroblast growth factor 4 [KO:K04358]
124519959  fibroblast growth factor 5 isoform X1 [KO:K04358]
124506118  fibroblast growth factor 3-like [KO:K04358]
124527665  fibroblast growth factor 22-like [KO:K04358]
124506722  fibroblast growth factor 8 isoform X1 [KO:K04358]
124520853  fibroblast growth factor 20 [KO:K04358]
124520903  fibroblast growth factor 17 isoform X1 [KO:K04358]
124501069  fibroblast growth factor 6 [KO:K04358]
124507410  fibroblast growth factor 10 [KO:K04358]
124508605  fibroblast growth factor 7 [KO:K04358]
124509155  fibroblast growth factor 16 [KO:K04358]
124506117  fibroblast growth factor 19-like [KO:K22603]
124511571  fibroblast growth factor 21-like [KO:K22429]
124501214  fibroblast growth factor 23-like [KO:K22428]
124519341  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
124502365  platelet-derived growth factor subunit B [KO:K17386]
124504901  platelet-derived growth factor D isoform X1 [KO:K05450]
124520961  platelet-derived growth factor C [KO:K05450]
124521816  insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
124523868  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
124520453  LOW QUALITY PROTEIN: fibroblast growth factor receptor 1-like [KO:K04362] [EC:2.7.10.1]
124506756  LOW QUALITY PROTEIN: fibroblast growth factor receptor 2-like [KO:K05093] [EC:2.7.10.1]
124522669  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
124520052  fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
124520247  platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
124507266  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
124515423  fibronectin-like isoform X1 [KO:K05717]
124521712  integrin alpha-1 [KO:K06480]
124521689  integrin alpha-2 [KO:K06481]
124522131  integrin alpha-IIb-like [KO:K06476]
124513240  integrin alpha-3 [KO:K06482]
124515409  integrin alpha-4 isoform X1 [KO:K06483]
124501243  integrin alpha-5 isoform X1 [KO:K06484]
124516428  integrin alpha-6 isoform X1 [KO:K06485]
124502102  integrin alpha-7 isoform X1 [KO:K06583]
124502613  integrin alpha-8 [KO:K06584]
124526622  integrin alpha-9 [KO:K06585]
124515542  integrin alpha-10 isoform X1 [KO:K06586]
124508452  integrin alpha-11 [KO:K06587]
124515657  integrin alpha-V [KO:K06487]
124517784  integrin alpha-L-like isoform X1 [KO:K05718]
124517946  integrin alpha-M-like isoform X1 [KO:K06461]
124517723  integrin alpha-X-like isoform X1 [KO:K06462]
124518000  integrin alpha-D-like [KO:K06594]
124518008  integrin alpha-D-like [KO:K06594]
124512939  integrin alpha-E-like [KO:K06524]
124501220  integrin beta-1 [KO:K05719]
124526693  integrin beta-2-like [KO:K06464]
124513557  integrin beta-3 [KO:K06493]
124513411  integrin beta-4 isoform X1 [KO:K06525]
124526267  integrin beta-5 [KO:K06588]
124515488  integrin beta-6 isoform X1 [KO:K06589]
124501417  integrin beta-7 [KO:K06590]
124525149  integrin beta-8 [KO:K06591]
124526765  kininogen-2-like isoform X1 [KO:K03898]
124512427  B1 bradykinin receptor-like [KO:K03915]
124512289  B2 bradykinin receptor-like [KO:K03916]
124506424  muscarinic acetylcholine receptor M1 [KO:K04129]
124525022  muscarinic acetylcholine receptor M2 [KO:K04130]
124518672  muscarinic acetylcholine receptor M3 [KO:K04131]
124506450  muscarinic acetylcholine receptor M4 [KO:K04132]
124508738  muscarinic acetylcholine receptor M5 [KO:K04133]
124526637  complement C5-like [KO:K03994]
124507484  complement component C6-like [KO:K03995]
124510229  complement component C7 [KO:K03996]
124514432  complement component C8 alpha chain-like [KO:K03997]
124514133  complement component C8 beta chain [KO:K03998]
124522350  complement component C8 gamma chain-like [KO:K03999]
124507513  complement component C9-like [KO:K04000]
124519214  guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
124513497  guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
124516147  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
124523582  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
124522296  FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
124527430  FYVE, RhoGEF and PH domain-containing protein 3-like isoform X1 [KO:K05722]
124507840  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
124511865  LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1-like [KO:K05726]
124519825  crk-like protein [KO:K04438]
124512970  adapter molecule crk isoform X1 [KO:K04438]
124507224  dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
124504000  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
124504040  son of sevenless homolog 1 isoform X1 [KO:K03099]
124512209  son of sevenless homolog 2 isoform X1 [KO:K03099]
124527565  GTPase HRas isoform X1 [KO:K02833]
124502703  GTPase KRas isoform X1 [KO:K07827]
124516245  GTPase NRas [KO:K07828]
124510904  ras-related protein R-Ras isoform X1 [KO:K07829]
124504915  ras-related protein R-Ras2 isoform X1 [KO:K07830]
124526277  ras-related protein M-Ras isoform X1 [KO:K07831]
124513949  rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
124525968  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
124527077  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
124514827  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
124517840  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
124514527  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
124523730  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
124524673  proto-oncogene vav isoform X1 [KO:K05730]
124522388  guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
124516558  guanine nucleotide exchange factor VAV3 [KO:K05730]
124526864  rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
124509491  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
124524722  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
124523760  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
124507600  proto-oncogene serine/threonine-protein kinase mos-like [KO:K04367] [EC:2.7.11.1]
124508471  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124524782  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
124517731  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
124519861  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
124510270  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
124511119  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124512474  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124512632  regulator of cell cycle RGCC isoform X1 [KO:K26108]
124511074  rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
124504834  rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
124510988  rho GTPase-activating protein 35 isoform X1 [KO:K05732]
124523904  transforming protein RhoA [KO:K04513]
124519305  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
124501030  ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
124522479  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
124519312  cell division control protein 42 homolog [KO:K04393]
124514573  cell division control protein 42 homolog [KO:K04393]
124504646  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
124526056  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
124513933  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
124511141  LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4-like [KO:K05734] [EC:2.7.11.1]
124504252  serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
124508097  serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
124513778  rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
124513004  ARF GTPase-activating protein GIT1 [KO:K05737]
124517572  rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
124504219  rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
124504387  myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
124511824  myosin light chain kinase 3-like isoform X1 [KO:K00907] [EC:2.7.11.18]
124526284  myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
124518235  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
124504709  serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
124502925  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
124501034  protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
124510019  protein phosphatase 1 regulatory subunit 12B-like [KO:K12329]
124527723  protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
124518424  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
124522618  myosin light chain 5 [KO:K12753]
124523379  myosin regulatory light chain 2, atrial isoform [KO:K12754]
124503723  myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
124519365  myosin regulatory light chain 10 [KO:K12756]
124517541  myosin regulatory light chain 12B [KO:K12757]
124517599  myosin regulatory light polypeptide 9 [KO:K12757]
124518016  myosin regulatory light chain 2, skeletal muscle isoform type 2 [KO:K12758]
124510879  myosin-14 isoform X1 [KO:K10352]
124517773  myosin-11 [KO:K10352]
124519487  myosin-10 isoform X1 [KO:K10352]
124502610  myosin-9 [KO:K10352]
124516779  protein diaphanous homolog 1 isoform X1 [KO:K05740]
124509568  protein diaphanous homolog 2 isoform X1 [KO:K05741]
124514790  sodium/hydrogen exchanger 1 [KO:K05742]
124528234  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
124515943  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
124523072  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
124513306  phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
124501533  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
124502284  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
124514679  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
124519234  LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
124518218  LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
124512885  protein diaphanous homolog 3 [KO:K05745]
124522526  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
124510307  LOW QUALITY PROTEIN: protein enabled homolog [KO:K05746]
124523823  neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
124516408  wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
124517304  cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
124520829  cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
124515416  nck-associated protein 1 isoform X1 [KO:K05750]
124502650  nck-associated protein 1-like [KO:K05750]
124514931  abl interactor 2 isoform X1 [KO:K05751]
124525055  probable protein BRICK1 [KO:K05752]
124523838  probable protein BRICK1 isoform X1 [KO:K05752]
124529326  wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
124504393  actin-related protein 2 [KO:K17260]
124524281  actin-related protein 3B isoform X1 [KO:K18584]
124516187  actin-related protein 3 [KO:K18584]
124519178  actin-related protein 2/3 complex subunit 1A [KO:K05757]
124519244  actin-related protein 2/3 complex subunit 1B [KO:K05757]
124515851  actin-related protein 2/3 complex subunit 2 [KO:K05758]
124518265  actin-related protein 2/3 complex subunit 3 [KO:K05756]
124523182  actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
124510152  actin-related protein 2/3 complex subunit 5 [KO:K05754]
124504076  actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
124519153  actin, cytoplasmic 1 [KO:K05692]
124522513  actin, cytoplasmic 2 [KO:K05692]
124503245  profilin-4 [KO:K05759]
124519718  profilin-1 [KO:K05759]
124526963  profilin-2 isoform X1 [KO:K05759]
124506740  profilin-3 [KO:K05759]
124518460  paxillin isoform X1 [KO:K05760]
124529385  LOW QUALITY PROTEIN: ezrin-like [KO:K08007]
124504938  radixin isoform X1 [KO:K05762]
124521532  moesin [KO:K05763]
124519152  thymosin beta-4-like [KO:K05764]
124526206  thymosin beta-4, Y-chromosomal-like [KO:K05764]
124521307  thymosin beta-4-like [KO:K05764]
124507415  thymosin beta-4-like [KO:K05764]
124509350  thymosin beta-4 [KO:K05764]
124510444  LOW QUALITY PROTEIN: cofilin-1-like [KO:K05765]
124505490  cofilin-1 [KO:K05765]
124508900  cofilin-2 [KO:K05765]
124518280  protein phosphatase Slingshot homolog 1-like isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
124505355  protein phosphatase Slingshot homolog 3-like isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
124513000  protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
124506914  vinculin isoform X1 [KO:K05700]
124517266  ras GTPase-activating-like protein IQGAP1 [KO:K16848]
124518245  ras GTPase-activating-like protein IQGAP2 [KO:K05767]
124521838  ras GTPase-activating-like protein IQGAP3 [KO:K05767]
124503673  gelsolin isoform X1 [KO:K05768]
124523826  scinderin [KO:K05768]
124511156  alpha-actinin-4 [KO:K05699]
124512082  alpha-actinin-1 isoform X1 [KO:K05699]
124519809  adenomatous polyposis coli protein isoform X1 [KO:K02085]
124527684  adenomatous polyposis coli protein 2-like isoform X1 [KO:K02085]
124511005  spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
lruf04010  MAPK signaling pathway
lruf04510  Focal adhesion
lruf04520  Adherens junction
KO pathway
ko04810   
LinkDB

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