KEGG   PATHWAY: mcc04613
Entry
mcc04613                    Pathway                                
Name
Neutrophil extracellular trap formation - Macaca mulatta (rhesus monkey)
Description
Neutrophils play a central role in innate immune defense. One of the mechanisms of neutrophil action is the formation of neutrophil extracellular traps (NETs), the extracellular structures composed of chromatin coated with histones, proteases and granular and cytosolic proteins that help catch and kill microorganisms. NETs are formed by a process known as "NETosis" that can be triggered by microorganisms and endogenous stimuli, such as damage-associated molecular patterns and immune complexes, and involves activation in most cases of nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase, which produces reactive oxygen species (ROS). Recent study has reported that there are two different mechanisms of NETosis, including a lytic NETosis and a vital NETosis. Lytic NETosis begins with nuclear delobulation and the disassembly of the nuclear envelope and continues with loss of cellular polarization, chromatin decondensation and plasma membrane rupture. Vital NETosis can occur independently of cell death and involves the secreted expulsion of nuclear chromatin that is accompanied by the release of granule proteins through degranulation.
Class
Organismal Systems; Immune system
Pathway map
mcc04613  Neutrophil extracellular trap formation
mcc04613

Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
720006  FCGR3; low affinity immunoglobulin gamma Fc region receptor III isoform C precursor [KO:K06463]
704102  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
703101  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
694725  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
710415  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
721821  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
708938  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
698569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
719831  sialic acid-binding Ig-like lectin 9 isoform X1 [KO:K06740]
696542  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
694207  NCF1; neutrophil cytosol factor 1 [KO:K08011]
696748  cytochrome b-245 light chain isoform X2 [KO:K08009]
715052  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
695612  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
717755  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
696709  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
574291  TLR7; toll-like receptor 7 [KO:K05404]
574292  TLR8; toll-like receptor 8 precursor [KO:K10170]
106992354  ELANE; neutrophil elastase [KO:K01327] [EC:3.4.21.37]
714246  MPO; myeloperoxidase isoform X1 [KO:K10789] [EC:1.11.2.2]
713687  ACTG1; actin, cytoplasmic 2 [KO:K05692]
574285  ACTB; actin, cytoplasmic 1 [KO:K05692]
705671  actin, cytoplasmic 2-like [KO:K05692]
710045  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
704257  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
705116  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
695102  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
710042  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
719811  ADP/ATP translocase 3 [KO:K05863]
693502  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
574137  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
700806  PADI4; protein-arginine deiminase type-4 isoform X1 [KO:K24669] [EC:3.5.3.15]
721002  LOW QUALITY PROTEIN: immunoglobulin heavy variable 4-39 [KO:K06856]
106999628  immunoglobulin heavy variable 4-4 [KO:K06856]
114675805  uncharacterized protein LOC114675805 [KO:K06856]
720935  immunoglobulin heavy variable 4-61 [KO:K06856]
720985  immunoglobulin heavy variable 4-59 [KO:K06856]
714419  uncharacterized protein LOC714419 [KO:K06856]
721083  LOW QUALITY PROTEIN: immunoglobulin heavy variable 4-28 [KO:K06856]
722278  immunoglobulin heavy variable 4-59 [KO:K06856]
106996003  immunoglobulin heavy variable 4-38-2 [KO:K06856]
720452  Ig heavy chain V region MOPC 315 isoform X1 [KO:K06856]
720904  immunoglobulin heavy variable 4-59 isoform X1 [KO:K06856]
114679736  uncharacterized protein LOC114679736 [KO:K06856]
714664  FCGR1A; high affinity immunoglobulin gamma Fc receptor I precursor [KO:K06498]
719996  FCGR2A; low affinity immunoglobulin gamma Fc region receptor II-a precursor [KO:K06472]
714832  ITGAM; integrin alpha-M isoform X3 [KO:K06461]
710577  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
711945  ITGAL; integrin alpha-L isoform X2 [KO:K05718]
574356  CLEC7A; C-type lectin domain family 7 member A [KO:K10074]
701057  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
701951  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
718418  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
718387  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
717764  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
697069  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
714173  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
718412  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
701195  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
720263  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
696238  ATG7; ubiquitin-like modifier-activating enzyme ATG7 [KO:K08337]
719782  FPR1; fMet-Leu-Phe receptor [KO:K04172]
719802  FPR3; N-formyl peptide receptor 3 [KO:K04173]
100426968  FPR2; N-formyl peptide receptor 2 [KO:K04173]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106992736  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
710324  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
715919  RELA; transcription factor p65 isoform X1 [KO:K04735]
703613  C3; complement C3 [KO:K03990]
718120  CR1; complement receptor type 1 [KO:K04011]
700467  C5; complement C5 isoform X1 [KO:K03994]
718056  C5AR1; C5a anaphylatoxin chemotactic receptor 1 [KO:K04010]
712849  HMGB1; high mobility group protein B1 [KO:K10802]
574290  TLR2; toll-like receptor 2 precursor [KO:K10159]
574360  TLR4; toll-like receptor 4 precursor [KO:K10160]
715745  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
715794  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
718976  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
719085  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
714955  ITGA2B; integrin alpha-IIb isoform X2 [KO:K06476]
717379  ITGB3; integrin beta-3 [KO:K06493]
698244  FGA; fibrinogen alpha chain isoform X1 [KO:K03903]
698487  FGB; fibrinogen beta chain [KO:K03904]
698363  FGG; fibrinogen gamma chain isoform X1 [KO:K03905]
721584  GP1BA; platelet glycoprotein Ib alpha chain [KO:K06261]
722019  VWF; von Willebrand factor precursor [KO:K03900]
701277  SELP; P-selectin [KO:K06496]
706046  SELPLG; P-selectin glycoprotein ligand 1 [KO:K06544]
717296  AGER; advanced glycosylation end product-specific receptor precursor [KO:K19722]
704864  CASP4; caspase-4 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
706568  caspase-1 [KO:K01370] [EC:3.4.22.36]
100426388  LOW QUALITY PROTEIN: caspase-1-like [KO:K01370] [EC:3.4.22.36]
697137  GSDMD; gasdermin-D isoform X1 [KO:K20917]
695933  HAT1; histone acetyltransferase type B catalytic subunit isoform X2 [KO:K11303] [EC:2.3.1.48]
701863  H2AFJ; histone H2A.J [KO:K11251]
704994  histone H2A type 1-H [KO:K11251]
705054  HIST2H2AC; histone H2A type 2-C [KO:K11251]
698239  HIST1H2AA; histone H2A type 1-A [KO:K11251]
693768  HIST3H2A; histone cluster 3, H2a [KO:K11251]
697235  HIST1H2AD; histone H2A type 1-D [KO:K11251]
697977  histone H2A type 1-B/E [KO:K11251]
701826  histone H2A type 1-H [KO:K11251]
704006  HIST1H2AK; histone H2A type 1 [KO:K11251]
704664  histone H2A type 1 [KO:K11251]
705469  histone H2A type 1 [KO:K11251]
695551  HIST1H2AE; histone H2A type 1-B/E [KO:K11251]
711836  H2AFY; H2A histone family, member Y [KO:K11251]
701962  histone H2A.Z [KO:K11251]
696463  histone H2A type 2-A [KO:K11251]
705170  HIST2H2AB; histone H2A type 2-B [KO:K11251]
705636  uncharacterized protein LOC705636 [KO:K11251]
709326  H2AFZ; H2A histone family, member Z [KO:K11251]
696629  HIST1H2AC; histone H2A type 1-C [KO:K11251]
703073  H2AFX; histone H2A.x [KO:K11251]
704127  HIST1H2AJ; histone cluster 1, H2aj [KO:K11251]
703044  H2AFB3; histone H2A-Bbd type 2/3 [KO:K11251]
711117  H2AFY2; core histone macro-H2A.2 [KO:K11251]
701574  histone H2A type 1 [KO:K11251]
106995531  histone H2A-Bbd type 2/3-like [KO:K11251]
114670854  histone H2A type 2-A [KO:K11251]
114675038  histone H2A-Bbd type 2/3-like [KO:K11251]
114677660  uncharacterized protein LOC114677660 [KO:K11251]
704780  histone H2B type 1-N [KO:K11252]
702227  HIST1H2BO; histone H2B type 1-O [KO:K11252]
699275  H2BFWT; histone H2B type W-T [KO:K11252]
698109  HIST1H2BA; histone H2B type 1-A [KO:K11252]
695657  histone H2B type 1-B [KO:K11252]
696506  histone H2B type 1 [KO:K11252]
704241  histone H2B type 1-F/J/L [KO:K11252]
701337  HIST1H2BJ; histone H2B type 1-J [KO:K11252]
714818  histone H2B type 2-E [KO:K11252]
701464  HIST1H2BK; histone H2B type 1-K [KO:K11252]
693635  HIST3H2BB; histone H2B type 3-B [KO:K11252]
693507  HIST1H2BD; histone H2B type 3-A [KO:K11252]
696996  histone H2B type 1 [KO:K11252]
697469  histone H2B type 1 [KO:K11252]
697857  histone H2B type 1 [KO:K11252]
698482  HIST1H2BH; histone H2B type 1-H [KO:K11252]
704452  HIST1H2BM; histone H2B type 1-M [KO:K11252]
714001  histone H2B type 1-K [KO:K11252]
698767  histone H2B type W-T [KO:K11252]
696808  histone H2B type 1 [KO:K11252]
106997853  histone H2B type 1-M [KO:K11252]
107000817  histone H2B type 2-F isoform X2 [KO:K11252]
698679  histone H2B type F-M [KO:K11252]
106995678  histone H2B type F-M-like [KO:K11252]
698430  histone H2B type F-M [KO:K11252]
106997735  late histone H2B.L4-like [KO:K11252]
106997851  histone H2B type 1-A-like [KO:K11252]
114673509  histone H2B type 2-E-like [KO:K11252]
114674721  histone H2B type F-M-like [KO:K11252]
114674719  histone H2B type W-T-like [KO:K11252]
114675561  histone H2B type 2-E-like [KO:K11252]
695323  histone H4 [KO:K11254]
697115  histone H4 [KO:K11254]
697721  histone H4 [KO:K11254]
698354  histone H4 [KO:K11254]
699110  histone H4 [KO:K11254]
699317  histone H4 [KO:K11254]
704341  histone H4 [KO:K11254]
106996511  histone H4 [KO:K11254]
106997862  histone H4 [KO:K11254]
114677669  histone H4 [KO:K11254]
107000818  histone H4 [KO:K11254]
708899  histone H3.3 [KO:K11253]
710748  histone H3.3-like [KO:K11253]
695663  histone H3.3-like [KO:K11253]
699443  histone H3.3 [KO:K11253]
704104  histone H3.3 [KO:K11253]
695092  HIST1H3D; histone H3.1 [KO:K11253]
694024  HIST3H3; histone H3.1 [KO:K11253]
693887  histone H3.3 [KO:K11253]
695427  histone H3.1 [KO:K11253]
698105  histone H3.1 [KO:K11253]
703889  histone H3.1 [KO:K11253]
704845  HIST2H3A; uncharacterized protein HIST2H3A [KO:K11253]
705220  uncharacterized protein LOC705220 [KO:K11253]
718280  histone cluster 2, H3c pseudogene [KO:K11253]
693939  histone H3.3-like [KO:K11253]
694152  histone H3.3C-like [KO:K11253]
699015  histone H3.3C-like [KO:K11253]
708847  histone H3.3-like [KO:K11253]
709296  histone H3.3-like [KO:K11253]
100430668  histone H3.1 [KO:K11253]
114669830  histone H3 [KO:K11253]
107000233  histone H3.3-like [KO:K11253]
114677623  histone H3.3C-like [KO:K11253]
114677671  histone H3.1-like [KO:K11253]
708441  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
694662  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
704467  HDAC3; histone deacetylase 3 [KO:K11404] [EC:3.5.1.98]
710797  HDAC4; histone deacetylase 4 isoform X6 [KO:K11406] [EC:3.5.1.98]
711456  HDAC5; histone deacetylase 5 [KO:K11406] [EC:3.5.1.98]
711363  HDAC6; histone deacetylase 6 [KO:K11407] [EC:3.5.1.98]
718225  HDAC7; histone deacetylase 7 isoform X2 [KO:K11408] [EC:3.5.1.98]
699642  HDAC8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
708314  HDAC9; histone deacetylase 9 isoform X18 [KO:K11409] [EC:3.5.1.98]
715698  HDAC10; polyamine deacetylase HDAC10 isoform X1 [KO:K18671] [EC:3.5.1.98]
693537  HDAC11; histone deacetylase 11 [KO:K11418] [EC:3.5.1.98]
100425740  AZU1; azurocidin [KO:K24665]
716440  CTSG; cathepsin G [KO:K01319] [EC:3.4.21.20]
619186  CAMP; cathelicidin antimicrobial peptide precursor [KO:K13916]
694472  CLCN3; H(+)/Cl(-) exchange transporter 3 isoform X1 [KO:K05012]
694497  CLCN5; H(+)/Cl(-) exchange transporter 5 isoform X1 [KO:K05012]
709512  CLCN4; H(+)/Cl(-) exchange transporter 4 [KO:K05012]
700743  AQP9; aquaporin-9 isoform X1 [KO:K09877]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00464  Mannan
C00518  Hyaluronate
C00551  beta-D-Glucan
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05151  12-O-Tetradecanoylphorbol 13-acetate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11221  Formylmethionyl-leucyl-phenylalanine methyl ester
Reference
PMID:29543328
  Authors
Van Avondt K, Hartl D
  Title
Mechanisms and disease relevance of neutrophil extracellular trap formation.
  Journal
Eur J Clin Invest 48 Suppl 2:e12919 (2018)
DOI:10.1111/eci.12919
Reference
PMID:31518165
  Authors
Sorvillo N, Cherpokova D, Martinod K, Wagner DD
  Title
Extracellular DNA NET-Works With Dire Consequences for Health.
  Journal
Circ Res 125:470-488 (2019)
DOI:10.1161/CIRCRESAHA.119.314581
Reference
PMID:28990587
  Authors
Papayannopoulos V
  Title
Neutrophil extracellular traps in immunity and disease.
  Journal
Nat Rev Immunol 18:134-147 (2018)
DOI:10.1038/nri.2017.105
Reference
PMID:24837201
  Authors
Liu FC, Chuang YH, Tsai YF, Yu HP
  Title
Role of neutrophil extracellular traps following injury.
  Journal
Shock 41:491-8 (2014)
DOI:10.1097/SHK.0000000000000146
Reference
PMID:27570525
  Authors
Yang H, Biermann MH, Brauner JM, Liu Y, Zhao Y, Herrmann M
  Title
New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation.
  Journal
Front Immunol 7:302 (2016)
DOI:10.3389/fimmu.2016.00302
Reference
PMID:28983472
  Authors
Zawrotniak M, Bochenska O, Karkowska-Kuleta J, Seweryn-Ozog K, Aoki W, Ueda M, Kozik A, Rapala-Kozik M
  Title
Aspartic Proteases and Major Cell Wall Components in Candida albicans Trigger the Release of Neutrophil Extracellular Traps.
  Journal
Front Cell Infect Microbiol 7:414 (2017)
DOI:10.3389/fcimb.2017.00414
Reference
PMID:29382950
  Authors
Honda M, Kubes P
  Title
Neutrophils and neutrophil extracellular traps in the liver and gastrointestinal system.
  Journal
Nat Rev Gastroenterol Hepatol 15:206-221 (2018)
DOI:10.1038/nrgastro.2017.183
Reference
PMID:31416265
  Authors
Hamam HJ, Palaniyar N
  Title
Post-Translational Modifications in NETosis and NETs-Mediated Diseases.
  Journal
Biomolecules 9:E369 (2019)
DOI:10.3390/biom9080369
Reference
PMID:31767647
  Authors
Burgener SS, Schroder K
  Title
Neutrophil Extracellular Traps in Host Defense.
  Journal
Cold Spring Harb Perspect Biol 12:a037028 (2020)
DOI:10.1101/cshperspect.a037028
Reference
PMID:33202203
  Authors
Vorobjeva NV, Chernyak BV
  Title
NETosis: Molecular Mechanisms, Role in Physiology and Pathology.
  Journal
Biochemistry (Mosc) 85:1178-1190 (2020)
DOI:10.1134/S0006297920100065
Reference
PMID:31416173
  Authors
Ravindran M, Khan MA, Palaniyar N
  Title
Neutrophil Extracellular Trap Formation: Physiology, Pathology, and Pharmacology.
  Journal
Biomolecules 9:E365 (2019)
DOI:10.3390/biom9080365
Reference
PMID:28267716
  Authors
Jorch SK, Kubes P
  Title
An emerging role for neutrophil extracellular traps in noninfectious disease.
  Journal
Nat Med 23:279-287 (2017)
DOI:10.1038/nm.4294
Reference
PMID:31342866
  Authors
Goggs R, Jeffery U, LeVine DN, Li RHL
  Title
Neutrophil-Extracellular Traps, Cell-Free DNA, and Immunothrombosis in Companion Animals: A Review.
  Journal
Vet Pathol 57:6-23 (2020)
DOI:10.1177/0300985819861721
Reference
PMID:27876233
  Authors
Kim SJ, Jenne CN
  Title
Role of platelets in neutrophil extracellular trap (NET) production and tissue injury.
  Journal
Semin Immunol 28:546-554 (2016)
DOI:10.1016/j.smim.2016.10.013
Reference
PMID:29572545
  Authors
de Bont CM, Boelens WC, Pruijn GJM
  Title
NETosis, complement, and coagulation: a triangular relationship.
  Journal
Cell Mol Immunol 16:19-27 (2019)
DOI:10.1038/s41423-018-0024-0
Reference
PMID:31129510
  Authors
Zawrotniak M, Bartnicka D, Rapala-Kozik M
  Title
UVA and UVB radiation induce the formation of neutrophil extracellular traps by human polymorphonuclear cells.
  Journal
J Photochem Photobiol B 196:111511 (2019)
DOI:10.1016/j.jphotobiol.2019.111511
Reference
PMID:21293492
  Authors
Remijsen Q, Kuijpers TW, Wirawan E, Lippens S, Vandenabeele P, Vanden Berghe T
  Title
Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality.
  Journal
Cell Death Differ 18:581-8 (2011)
DOI:10.1038/cdd.2011.1
Reference
PMID:23819131
  Authors
Zawrotniak M, Rapala-Kozik M
  Title
Neutrophil extracellular traps (NETs) - formation and implications.
  Journal
Acta Biochim Pol 60:277-84 (2013)
Reference
PMID:28373871
  Authors
Rosales C
  Title
Fcgamma Receptor Heterogeneity in Leukocyte Functional Responses.
  Journal
Front Immunol 8:280 (2017)
DOI:10.3389/fimmu.2017.00280
Reference
PMID:25716722
  Authors
Vorobjeva NV, Pinegin BV
  Title
Neutrophil extracellular traps: mechanisms of formation and role in health and disease.
  Journal
Biochemistry (Mosc) 79:1286-96 (2014)
DOI:10.1134/S0006297914120025
Reference
PMID:28220120
  Authors
Delgado-Rizo V, Martinez-Guzman MA, Iniguez-Gutierrez L, Garcia-Orozco A, Alvarado-Navarro A, Fafutis-Morris M
  Title
Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview.
  Journal
Front Immunol 8:81 (2017)
DOI:10.3389/fimmu.2017.00081
Reference
PMID:30023352
  Authors
Fonseca Z, Diaz-Godinez C, Mora N, Aleman OR, Uribe-Querol E, Carrero JC, Rosales C
  Title
Entamoeba histolytica Induce Signaling via Raf/MEK/ERK for Neutrophil Extracellular Trap (NET) Formation.
  Journal
Front Cell Infect Microbiol 8:226 (2018)
DOI:10.3389/fcimb.2018.00226
Reference
PMID:27923601
  Authors
Agraz-Cibrian JM, Giraldo DM, Mary FM, Urcuqui-Inchima S
  Title
Understanding the molecular mechanisms of NETs and their role in antiviral innate immunity.
  Journal
Virus Res 228:124-133 (2017)
DOI:10.1016/j.virusres.2016.11.033
Reference
PMID:27698656
  Authors
Schonrich G, Raftery MJ
  Title
Neutrophil Extracellular Traps Go Viral.
  Journal
Front Immunol 7:366 (2016)
DOI:10.3389/fimmu.2016.00366
Reference
PMID:22817992
  Authors
Saitoh T, Komano J, Saitoh Y, Misawa T, Takahama M, Kozaki T, Uehata T, Iwasaki H, Omori H, Yamaoka S, Yamamoto N, Akira S
  Title
Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.
  Journal
Cell Host Microbe 12:109-16 (2012)
DOI:10.1016/j.chom.2012.05.015
Reference
PMID:29908538
  Authors
Kumar S, Gupta E, Kaushik S, Jyoti A
  Title
Neutrophil Extracellular Traps: Formation and Involvement in Disease Progression.
  Journal
Iran J Allergy Asthma Immunol 17:208-220 (2018)
Related
pathway
mcc04010  MAPK signaling pathway
mcc04020  Calcium signaling pathway
mcc04140  Autophagy - animal
mcc04151  PI3K-Akt signaling pathway
mcc04610  Complement and coagulation cascades
mcc04611  Platelet activation
mcc04620  Toll-like receptor signaling pathway
mcc04621  NOD-like receptor signaling pathway
mcc04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04613   
LinkDB

DBGET integrated database retrieval system