KEGG   PATHWAY: mcc05205
Entry
mcc05205                    Pathway                                
Name
Proteoglycans in cancer - Macaca mulatta (rhesus monkey)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
mcc05205  Proteoglycans in cancer
mcc05205

Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100315127  MIR21; mml-miR-21-5p [KO:K16863]
100315178  MIR10B; mml-miR-10b-5p [KO:K16864]
100315444  MIR10A; mml-miR-10a-5p [KO:K16864]
100424037  [KO:K01365] [EC:3.4.22.15]
100424246  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
100424616  [KO:K10164]
100431039  HSPB2; heat shock protein beta-2 [KO:K09543]
106992315  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
106992736  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
107000728  [KO:K10164]
114672301  [KO:K04375]
114674157  PPP1R12C; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12C [KO:K17457]
574128  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
574136  FGF2; fibroblast growth factor 2 [KO:K18497]
574159  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
574201  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
574209  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
574265  CTNNB1; catenin beta-1 [KO:K02105]
574278  TWIST1; twist-related protein 1 [KO:K09069]
574285  ACTB; actin, cytoplasmic 1 [KO:K05692]
574290  TLR2; toll-like receptor 2 precursor [KO:K10159]
574312  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
574315  ITGA5; integrin alpha-5 [KO:K06484]
574320  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
574332  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
574360  TLR4; toll-like receptor 4 precursor [KO:K10160]
574381  TIMP3; metalloproteinase inhibitor 3 precursor [KO:K16866]
613025  ESR1; estrogen receptor isoform X1 [KO:K08550]
613027  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
613269  FN1; fibronectin isoform X1 [KO:K05717]
677694  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
692081  DROSHA; ribonuclease 3 [KO:K03685] [EC:3.1.26.3]
693341  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
693419  WNT7A; protein Wnt-7a [KO:K00572]
693554  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
694069  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
694473  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
694569  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
694625  FZD6; frizzled-6 precursor [KO:K02376]
694626  MYC; myc proto-oncogene protein [KO:K04377]
694685  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
694725  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
694747  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
695345  PDCD4; programmed cell death protein 4 [KO:K16865]
695559  HBEGF; proheparin-binding EGF-like growth factor precursor [KO:K08523]
695735  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
696200  WNT3A; protein Wnt-3a [KO:K00312]
696326  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
696336  PXN; paxillin isoform X1 [KO:K05760]
696845  WNT11; protein Wnt-11 isoform X2 [KO:K01384]
697069  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
697078  TWIST2; twist-related protein 2 [KO:K09069]
697523  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X2 [KO:K06276] [EC:2.7.11.1]
697573  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
697581  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
698223  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
698293  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
698326  GPC1; glypican-1 precursor [KO:K08107]
698444  IGF1; insulin-like growth factor I precursor [KO:K05459]
698478  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
698538  [KO:K17457]
698569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
698585  PAK1; serine/threonine-protein kinase PAK 1 isoform X5 [KO:K04409] [EC:2.7.11.1]
698830  HRAS; GTPase HRas [KO:K02833]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
699518  ANK3; ankyrin-3 isoform X10 [KO:K09259]
699524  FLNA; filamin-A isoform X1 [KO:K04437]
699700  RRAS2; ras-related protein R-Ras2 [KO:K07830]
700126  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
700318  HOXD10; homeobox protein Hox-D10 [KO:K09295]
700359  COL1A2; collagen alpha-2(I) chain precursor [KO:K06236]
700367  GAB1; GRB2-associated-binding protein 1 [KO:K09593]
700573  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
700634  PTK2; focal adhesion kinase 1 isoform X8 [KO:K05725] [EC:2.7.10.2]
700652  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
700688  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
700692  WNT10A; protein Wnt-10a [KO:K01357]
701057  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
701195  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
701334  SMO; smoothened homolog isoform X2 [KO:K06226]
701544  SDC1; syndecan-1 isoform X1 [KO:K06257]
701758  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
702041  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
702163  CAV3; caveolin-3 [KO:K12959]
702180  ANK2; ankyrin-2 isoform X1 [KO:K09255]
702288  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
702504  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
703064  FZD7; frizzled-7 [KO:K02432]
703302  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
703572  ITGA2; integrin alpha-2 precursor [KO:K06481]
703669  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
703841  SDC2; syndecan-2 precursor [KO:K16336]
703942  FZD1; frizzled-1 [KO:K02432]
704046  IHH; indian hedgehog protein [KO:K11989]
704311  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
704449  CAV1; caveolin-1 [KO:K06278]
704562  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
704678  HIF1A; hypoxia-inducible factor 1-alpha isoform X4 [KO:K08268]
704716  EZR; ezrin isoform X1 [KO:K08007]
704754  FZD4; frizzled-4 precursor [KO:K02354]
704991  WNT2; protein Wnt-2 precursor [KO:K00182]
705413  THBS1; thrombospondin-1 [KO:K16857]
705601  SOS2; son of sevenless homolog 2 [KO:K03099]
705671  [KO:K05692]
705692  WNT5A; protein Wnt-5a isoform X2 [KO:K00444]
705773  WNT2B; protein Wnt-2b [KO:K00182]
705775  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X6 [KO:K12329]
705853  PLAU; urokinase-type plasminogen activator isoform X1 [KO:K01348] [EC:3.4.21.73]
705980  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
706072  NUDT16L1; tudor-interacting repair regulator protein isoform X2 [KO:K16867]
706455  RHOA; transforming protein RhoA [KO:K04513]
706773  GPC3; glypican-3 [KO:K08109]
706977  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X11 [KO:K04515] [EC:2.7.11.17]
706980  CAV2; caveolin-2 [KO:K12958]
707167  [KO:K01365] [EC:3.4.22.15]
707169  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
707213  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X7 [KO:K06255]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
707513  TFAP4; transcription factor AP-4 isoform X1 [KO:K09108]
707540  TGFB2; transforming growth factor beta-2 precursor [KO:K13376]
707583  HPSE; heparanase isoform X1 [KO:K07964] [EC:3.2.1.166]
707637  CDC42; cell division control protein 42 homolog [KO:K04393]
707756  ITGAV; integrin alpha-V precursor [KO:K06487]
707864  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
707977  KRAS; GTPase KRas [KO:K07827]
708084  MMP9; matrix metalloproteinase-9 precursor [KO:K01403] [EC:3.4.24.35]
708227  IGF1R; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
708291  CTTN; src substrate cortactin [KO:K06106]
708316  HGF; hepatocyte growth factor isoform X3 [KO:K05460]
708368  FZD8; frizzled-8 [KO:K02375]
708444  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
708499  VTN; vitronectin [KO:K06251]
708714  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
708795  HPSE2; inactive heparanase-2 [KO:K07965] [EC:3.2.1.-]
708906  WNT10B; protein Wnt-10b precursor [KO:K01357]
708938  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
709009  WNT1; proto-oncogene Wnt-1 [KO:K03209]
709018  RDX; radixin isoform X2 [KO:K05762]
709089  NRAS; GTPase NRas [KO:K07828]
709283  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
709728  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
709828  CD63; CD63 antigen [KO:K06497]
709830  LUM; lumican precursor [KO:K08122]
709933  DCN; decorin [KO:K04660]
709935  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710242  WNT8B; protein Wnt-8b [KO:K00714]
710415  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
710540  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
710662  PLAUR; urokinase plasminogen activator surface receptor isoform X2 [KO:K03985]
710796  FZD5; frizzled-5 [KO:K02375]
710802  IGF2; insulin-like growth factor II isoform X2 [KO:K13769]
710904  ANK1; ankyrin-1 isoform X1 [KO:K10380]
710914  SDC4; syndecan-4 precursor [KO:K16338]
711407  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
711712  MSN; moesin [KO:K05763]
711979  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
712044  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
712096  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X2 [KO:K07532]
712274  [KO:K02991]
712381  FZD2; frizzled-2 [KO:K02235]
712610  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
713227  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
713687  ACTG1; actin, cytoplasmic 2 [KO:K05692]
713764  WNT8A; protein Wnt-8a [KO:K00714]
713777  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
713839  FZD3; frizzled-3 precursor [KO:K02329]
713864  WNT7B; protein Wnt-7b isoform X2 [KO:K00572]
714044  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
714173  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
714374  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
715467  TNF; tumor necrosis factor [KO:K03156]
715710  ITGB5; integrin beta-5 precursor [KO:K06588]
715745  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
715746  NANOG; homeobox protein NANOG isoform X1 [KO:K10164]
715794  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
716170  TP53; cellular tumor antigen p53 [KO:K04451]
716352  MRAS; ras-related protein M-Ras [KO:K07831]
716392  FZD9; frizzled-9 [KO:K02842]
716553  SHH; sonic hedgehog protein [KO:K11988]
716877  WNT9B; protein Wnt-9b [KO:K01064]
716909  WNT3; proto-oncogene Wnt-3 [KO:K00312]
717117  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
717204  CD44; CD44 antigen isoform X1 [KO:K06256]
717379  ITGB3; integrin beta-3 [KO:K06493]
717755  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
717812  FZD10; frizzled-10 [KO:K02842]
718040  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
718284  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
718412  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
718632  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
718751  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
718939  RRAS; ras-related protein R-Ras [KO:K07829]
718976  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
719085  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
719199  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
720079  SLC9A1; sodium/hydrogen exchanger 1 isoform X3 [KO:K05742]
720263  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
721685  WNT5B; protein Wnt-5b [KO:K00444]
721731  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
721735  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
721821  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
722198  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X2 [KO:K12330]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
PMID:10687947
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
PMID:10633082
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
PMID:12509413
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
PMID:14711376
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
PMID:17971838
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
PMID:18505598
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
PMID:23305321
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
PMID:22563565
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
PMID:24412155
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
PMID:18413366
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
PMID:21155971
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
PMID:18949819
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
mcc04010  MAPK signaling pathway
mcc04020  Calcium signaling pathway
mcc04066  HIF-1 signaling pathway
mcc04150  mTOR signaling pathway
mcc04151  PI3K-Akt signaling pathway
mcc04210  Apoptosis
mcc04310  Wnt signaling pathway
mcc04340  Hedgehog signaling pathway
mcc04350  TGF-beta signaling pathway
mcc04370  VEGF signaling pathway
mcc04510  Focal adhesion
mcc04520  Adherens junction
mcc04810  Regulation of actin cytoskeleton
KO pathway
ko05205   

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