KEGG   PATHWAY: mpah05208
Entry
mpah05208                   Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Mus pahari (shrew mouse)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
mpah05208  Chemical carcinogenesis - reactive oxygen species
mpah05208

Organism
Mus pahari (shrew mouse) [GN:mpah]
Gene
110330191  As3mt; arsenite methyltransferase [KO:K07755] [EC:2.1.1.137]
110317390  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
110317397  Gsto1; glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
110320222  glutathione S-transferase Mu 2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
110319755  glutathione S-transferase Mu 7 isoform X1 [KO:K00799] [EC:2.5.1.18]
110322363  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
110320468  glutathione S-transferase Mu 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
110320060  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
110320061  glutathione S-transferase Mu 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
110320062  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
110320064  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
110316996  Mgst1; LOW QUALITY PROTEIN: microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
110320770  Mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
110322134  glutathione S-transferase A3 [KO:K00799] [EC:2.5.1.18]
110322139  glutathione S-transferase alpha-3 [KO:K00799] [EC:2.5.1.18]
110319963  Gstm3; glutathione S-transferase Mu 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
110326404  glutathione S-transferase theta-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
110326405  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
110326406  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
110327672  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
110328389  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
110326652  glutathione S-transferase theta-3 isoform X1 [KO:K00799] [EC:2.5.1.18]
36165356  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
36165352  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
36165337  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
36165334  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
36165335  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
36165330  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
36165329  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
110316888  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
110335628  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
110338235  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
110313685  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
110333203  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
110337062  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
110326234  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
110317006  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
110316386  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
110335084  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
110335777  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
110318772  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
110316704  Ndufa9; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
110321748  Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
110328243  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
110335867  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
110326784  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
110336643  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
110324555  Ndufb1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
110317149  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
110322308  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
110326037  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
110329959  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
110320492  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
110338914  Ndufb6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
110333533  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6-like [KO:K03962]
110337650  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
110331668  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
110334970  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
110338345  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
110314570  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
110321204  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
110321406  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
110318572  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
110329019  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
110323693  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
110329167  Ndufs6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
110326881  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
110327359  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
110320722  Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
110332408  NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform X1 [KO:K03968]
110328746  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
110323139  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
110322178  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
110324197  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like isoform X1 [KO:K00237]
110328112  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
110333870  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
36165327  CYTB; cytochrome b [KO:K00412]
110334724  cytochrome c1, heme protein, mitochondrial [KO:K00413]
110327331  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
110318232  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
110323660  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
110334014  cytochrome b-c1 complex subunit 7 [KO:K00417]
110332489  cytochrome b-c1 complex subunit 8 [KO:K00418]
110330872  cytochrome b-c1 complex subunit 9 [KO:K00419]
110326979  cytochrome b-c1 complex subunit 10 [KO:K00420]
36165339  COX3; cytochrome c oxidase subunit III [KO:K02262]
36165346  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
36165343  COX2; cytochrome c oxidase subunit II [KO:K02261]
110319299  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
110337554  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263]
110328046  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
110322258  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
110313018  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
110325548  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
110332943  cytochrome c oxidase subunit 6B1 [KO:K02267]
110336798  cytochrome c oxidase subunit 6B2 isoform X1 [KO:K02267]
110335202  cytochrome c oxidase subunit 6C [KO:K02268]
110328169  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
110338814  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
110335711  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
110313979  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
110330226  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
110329085  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
110332346  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
110324960  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
110339130  cytochrome c oxidase subunit 8B, mitochondrial [KO:K02273]
110333376  Atp5a1; ATP synthase subunit alpha, mitochondrial isoform X1 [KO:K02132]
110324657  ATP synthase subunit beta, mitochondrial-like [KO:K02133] [EC:7.1.2.2]
110326266  Atp5b; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
110333647  Atp5c1; ATP synthase subunit gamma, mitochondrial [KO:K02136]
110326670  Atp5d; ATP synthase subunit delta, mitochondrial isoform X1 [KO:K02134]
110319359  Atp5e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
36165340  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
110320209  Atp5f1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
110318554  Atp5g3; ATP synthase F(0) complex subunit C3, mitochondrial isoform X1 [KO:K02128]
110331847  Atp5g1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
110334965  Atp5g2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
110320480  ATP synthase subunit d, mitochondrial-like isoform X1 [KO:K02138]
110332361  Atp5h; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
110329905  Atp5o; ATP synthase subunit O, mitochondrial [KO:K02137]
110329594  Atp5j; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
36165341  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
110338019  Sod2; superoxide dismutase [Mn], mitochondrial isoform X1 [KO:K04564] [EC:1.15.1.1]
110331342  Vdac1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
110325370  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
110336305  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
110313362  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
110336417  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
110320569  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
110325751  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
110329810  Sod1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
110319293  Cat; catalase [KO:K03781] [EC:1.11.1.6]
110330559  Slc26a1; sulfate anion transporter 1 isoform X1 [KO:K14700]
110333193  Slc26a2; sulfate transporter [KO:K14701]
110327525  Slc26a6; solute carrier family 26 member 6 isoform X1 [KO:K14704]
110321749  Slc26a9; solute carrier family 26 member 9 [KO:K14706]
110328034  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
110329381  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
110331873  cytochrome P450 2F2 [KO:K07416] [EC:1.14.14.1]
110328033  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
110335735  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
110321688  Ephx1; epoxide hydrolase 1 isoform X1 [KO:K01253] [EC:3.3.2.9]
110325104  Ephx2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
110335924  Ephx3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
110330911  Ephx4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
110322723  Akr1a1; alcohol dehydrogenase [NADP(+)] [KO:K00002] [EC:1.1.1.2]
110315750  estradiol 17 beta-dehydrogenase 5 isoform X1 [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
110333790  aldo-keto reductase family 1 member C21 isoform X1 [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
110333848  3-alpha-hydroxysteroid dehydrogenase [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
110333839  estradiol 17 beta-dehydrogenase 5-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
110337573  Nqo1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
110329855  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
110329915  carbonyl reductase [NADPH] 1-like isoform X1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
110324220  Ahr; aryl hydrocarbon receptor isoform X1 [KO:K09093]
110332497  Lpo; lactoperoxidase isoform X1 [KO:K12550] [EC:1.11.1.7]
110317743  Nox4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
110337603  cytochrome b-245 light chain isoform X1 [KO:K08009]
110313286  Nox1; NADPH oxidase 1 [KO:K08008]
110312979  Ncf1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
110321813  Ncf2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
110320006  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
110330480  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
110316234  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
110316104  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
110331195  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
110335780  Sos1; son of sevenless homolog 1 [KO:K03099]
110324314  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110318967  GTPase HRas-like isoform X1 [KO:K02833]
110319567  Hras; GTPase HRas [KO:K02833]
110338480  GTPase HRas-like [KO:K02833]
110333346  GTPase HRas-like [KO:K02833]
110316221  Kras; GTPase KRas isoform X1 [KO:K07827]
110320340  Nras; GTPase NRas [KO:K07828]
110314283  Araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
110316269  Braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
110314893  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110327244  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110326321  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110329343  Mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
110320020  Mapk3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
110337870  Map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
110331563  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
110336400  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
110330449  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110332652  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110325466  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110334495  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
110337896  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
110337946  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
110334829  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
110323252  Jun; transcription factor AP-1 [KO:K04448]
110324365  Fos; proto-oncogene c-Fos isoform X1 [KO:K04379]
110328811  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110336420  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110322865  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110323448  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110319750  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110327251  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110339030  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110337888  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
110317258  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110324386  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110322284  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110326428  Foxo3; forkhead box protein O3 [KO:K09408]
110326250  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
110317689  Ptpn1; tyrosine-protein phosphatase non-receptor type 1 isoform X1 [KO:K05696] [EC:3.1.3.48]
110312812  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
110334538  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
110336182  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
110313464  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
110324484  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
110317041  Rela; transcription factor p65 [KO:K04735]
110319789  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
110326026  Prkcd; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
110318155  Ptprj; receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
110324784  Acp1; low molecular weight phosphotyrosine protein phosphatase [KO:K14394] [EC:3.1.3.2 3.1.3.48]
110336841  low molecular weight phosphotyrosine protein phosphatase [KO:K14394] [EC:3.1.3.2 3.1.3.48]
110339175  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
110317793  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
110318646  Abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
110322217  Abl2; Abelson tyrosine-protein kinase 2 isoform X1 [KO:K08887] [EC:2.7.10.2]
110324219  Prkd1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
110336302  Prkd2; serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
110335448  Prkd3; serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
110334478  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
110331978  Pld2; LOW QUALITY PROTEIN: phospholipase D2 [KO:K01115] [EC:3.1.4.4]
110320262  Pld1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
110332218  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
110323979  Hif1a; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
110319819  Arnt; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
110335444  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
110327787  Keap1; kelch-like ECH-associated protein 1 [KO:K10456]
110318263  Nfe2l2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
110336229  Hmox1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
mpah00190  Oxidative phosphorylation
mpah00980  Metabolism of xenobiotics by cytochrome P450
mpah04010  MAPK signaling pathway
mpah04064  NF-kappa B signaling pathway
mpah04066  HIF-1 signaling pathway
mpah04151  PI3K-Akt signaling pathway
mpah04370  VEGF signaling pathway
mpah05207  Chemical carcinogenesis - receptor activation
mpah05211  Renal cell carcinoma
mpah05215  Prostate cancer
mpah05219  Bladder cancer
mpah05221  Acute myeloid leukemia
mpah05222  Small cell lung cancer
mpah05223  Non-small cell lung cancer
mpah05224  Breast cancer
mpah05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

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