KEGG   PATHWAY: myb05010
Entry
myb05010                    Pathway                                
Name
Alzheimer disease - Myotis brandtii (Brandt's bat)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
myb05010  Alzheimer disease
myb05010

Organism
Myotis brandtii (Brandt's bat) [GN:myb]
Gene
102260183  ADAM10; ADAM metallopeptidase domain 10 [KO:K06704] [EC:3.4.24.81]
102256292  ADAM17; ADAM metallopeptidase domain 17 [KO:K06059] [EC:3.4.24.86]
102238735  APP; amyloid beta precursor protein [KO:K04520]
102242903  NAE1; NEDD8 activating enzyme E1 subunit 1 [KO:K04532]
102245013  APBB1; amyloid beta precursor protein binding family B member 1 [KO:K04529]
102239814  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102251121  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102245543  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
102256451  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102262029  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102250966  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102248429  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102243306  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102250073  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102247187  BACE1; beta-secretase 1 [KO:K04521] [EC:3.4.23.46]
102254769  BACE2; beta-site APP-cleaving enzyme 2 [KO:K07747] [EC:3.4.23.45]
102255373  RTN3; reticulon 3 [KO:K20723]
102257905  RTN4; reticulon 4 [KO:K20720]
102251634  reticulon-4-like [KO:K20720]
102244405  PSENEN; presenilin enhancer gamma-secretase subunit [KO:K06170]
102251307  PSEN1; presenilin 1 [KO:K04505] [EC:3.4.23.-]
102242706  PSEN2; presenilin 2 [KO:K04522] [EC:3.4.23.-]
102247882  NCSTN; nicastrin [KO:K06171]
102248896  APH1B; aph-1 homolog B, gamma-secretase subunit [KO:K06172]
102243839  APH1A; aph-1 homolog A, gamma-secretase subunit [KO:K06172]
102263187  IDE; insulin degrading enzyme [KO:K01408] [EC:3.4.24.56]
102259140  MME; membrane metalloendopeptidase [KO:K01389] [EC:3.4.24.11]
102260052  MAPT; microtubule associated protein tau [KO:K04380]
20964692  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
20964693  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
20964699  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
20964701  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
20964700  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
20964702  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
20964703  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
102246622  NDUFV1; NADH:ubiquinone oxidoreductase core subunit V1 [KO:K03942] [EC:7.1.1.2]
102260201  NDUFV2; NADH:ubiquinone oxidoreductase core subunit V2 [KO:K03943] [EC:7.1.1.2]
102256583  NDUFV3; NADH:ubiquinone oxidoreductase subunit V3 [KO:K03944]
102251359  NDUFA1; NADH:ubiquinone oxidoreductase subunit A1 [KO:K03945]
102260520  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
102247135  NDUFA2; NADH:ubiquinone oxidoreductase subunit A2 [KO:K03946]
102245681  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
106723654  NDUFA3; NADH:ubiquinone oxidoreductase subunit A3 [KO:K03947]
102242476  NDUFA4; NDUFA4, mitochondrial complex associated [KO:K03948]
102252735  NDUFA4L2; NDUFA4, mitochondrial complex associated like 2 [KO:K03948]
102253695  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
102250395  NDUFA5; NADH:ubiquinone oxidoreductase subunit A5 [KO:K03949]
106725124  NDUFA6; NADH:ubiquinone oxidoreductase subunit A6 [KO:K03950]
102258543  NDUFA7; NADH:ubiquinone oxidoreductase subunit A7 [KO:K03951]
102261034  NDUFA8; NADH:ubiquinone oxidoreductase subunit A8 [KO:K03952]
102256722  NDUFA9; NADH:ubiquinone oxidoreductase subunit A9 [KO:K03953]
102245859  NDUFA10; NADH:ubiquinone oxidoreductase subunit A10 [KO:K03954]
102262457  NDUFAB1; NADH:ubiquinone oxidoreductase subunit AB1 [KO:K03955]
102248319  NDUFA11; NADH:ubiquinone oxidoreductase subunit A11 [KO:K03956]
102244003  NDUFA12; NADH:ubiquinone oxidoreductase subunit A12 [KO:K11352]
102248846  NDUFA13; NADH:ubiquinone oxidoreductase subunit A13 [KO:K11353]
102256003  NDUFB1; NADH:ubiquinone oxidoreductase subunit B1 [KO:K03957]
102260343  NDUFB2; NADH:ubiquinone oxidoreductase subunit B2 [KO:K03958]
102245439  NDUFB3; NADH:ubiquinone oxidoreductase subunit B3 [KO:K03959]
102243450  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
102250344  NDUFB4; NADH:ubiquinone oxidoreductase subunit B4 [KO:K03960]
102262870  NDUFB5; NADH:ubiquinone oxidoreductase subunit B5 [KO:K03961]
102242316  NDUFB6; NADH:ubiquinone oxidoreductase subunit B6 [KO:K03962]
102260101  NDUFB7; NADH:ubiquinone oxidoreductase subunit B7 [KO:K03963]
102258518  NDUFB8; NADH:ubiquinone oxidoreductase subunit B8 [KO:K03964]
102242906  NDUFB9; NADH:ubiquinone oxidoreductase subunit B9 [KO:K03965]
102262382  NDUFB10; NADH:ubiquinone oxidoreductase subunit B10 [KO:K03966]
102262600  NDUFB11; NADH:ubiquinone oxidoreductase subunit B11 [KO:K11351]
102251040  NDUFS1; NADH:ubiquinone oxidoreductase core subunit S1 [KO:K03934] [EC:7.1.1.2]
102262139  NDUFS2; NADH:ubiquinone oxidoreductase core subunit S2 [KO:K03935] [EC:7.1.1.2]
102262598  NDUFS3; NADH:ubiquinone oxidoreductase core subunit S3 [KO:K03936] [EC:7.1.1.2]
102243749  NDUFS4; NADH:ubiquinone oxidoreductase subunit S4 [KO:K03937]
102249038  NDUFS5; NADH:ubiquinone oxidoreductase subunit S5 [KO:K03938]
102263660  NDUFS6; NADH:ubiquinone oxidoreductase subunit S6 [KO:K03939]
102240432  NDUFS7; NADH:ubiquinone oxidoreductase core subunit S7 [KO:K03940] [EC:7.1.1.2]
102256678  NDUFS8; NADH:ubiquinone oxidoreductase core subunit S8 [KO:K03941] [EC:7.1.1.2]
102247113  NDUFC1; NADH:ubiquinone oxidoreductase subunit C1 [KO:K03967]
102252992  NDUFC2; NADH:ubiquinone oxidoreductase subunit C2 [KO:K03968]
102240483  SDHA; succinate dehydrogenase complex flavoprotein subunit A [KO:K00234] [EC:1.3.5.1]
102242794  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
102254448  SDHB; succinate dehydrogenase complex iron sulfur subunit B [KO:K00235] [EC:1.3.5.1]
102263682  SDHC; succinate dehydrogenase complex subunit C [KO:K00236]
102259933  SDHD; succinate dehydrogenase complex subunit D [KO:K00237]
102249581  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
20964704  CYTB; cytochrome b [KO:K00412]
102261758  cytochrome c1, heme protein, mitochondrial [KO:K00413]
102262645  cytochrome c1, heme protein, mitochondrial-like [KO:K00413]
102238662  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
102239933  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
102256902  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
102252155  cytochrome b-c1 complex subunit 7 [KO:K00417]
102256499  cytochrome b-c1 complex subunit 9 [KO:K00419]
102246747  cytochrome b-c1 complex subunit 10 [KO:K00420]
20964698  COX3; cytochrome c oxidase subunit III [KO:K02262]
20964694  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
20964695  COX2; cytochrome c oxidase subunit II [KO:K02261]
102261338  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
102249206  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
102256974  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
102252278  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
102261874  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
102258622  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
106728119  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
102243207  cytochrome c oxidase subunit 6B1 [KO:K02267]
102247436  cytochrome c oxidase subunit 6B1 [KO:K02267]
102258861  cytochrome c oxidase subunit 6C-2 [KO:K02268]
102241508  cytochrome c oxidase subunit 6C [KO:K02268]
102243868  cytochrome c oxidase subunit 6C [KO:K02268]
102256775  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
102242411  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
102261647  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
102248066  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
102249757  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
102256817  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
102257114  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
102247376  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
102261765  ATP5A1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle [KO:K02132]
102246768  ATP5B; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide [KO:K02133] [EC:7.1.2.2]
102244312  ATP5C1; ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 [KO:K02136]
102242355  ATP5D; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit [KO:K02134]
20964697  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
102245250  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
102260264  ATP5F1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1 [KO:K02127]
102250118  ATP5G2; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9) [KO:K02128]
102250429  ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) [KO:K02128]
102254181  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
102247128  ATP synthase lipid-binding protein, mitochondrial [KO:K02128]
102254725  ATP5G3; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) [KO:K02128]
102253099  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
102245806  ATP synthase subunit d, mitochondrial-like [KO:K02138]
102246732  ATP5H; ATP synthase, H+ transporting, mitochondrial Fo complex subunit D [KO:K02138]
102263769  ATP5O; ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit [KO:K02137]
102240075  ATP5J; ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6 [KO:K02131]
20964696  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
102241897  3-hydroxyacyl-CoA dehydrogenase type-2-like [KO:K08683] [EC:1.1.1.35 1.1.1.178]
102245583  PPID; peptidylprolyl isomerase D [KO:K05864] [EC:5.2.1.8]
102249622  VDAC1; voltage dependent anion channel 1 [KO:K05862]
102245606  VDAC2; voltage dependent anion channel 2 [KO:K15040]
102263138  VDAC3; voltage dependent anion channel 3 [KO:K15041]
102255058  SLC25A4; solute carrier family 25 member 4 [KO:K05863]
102239133  SLC25A31; solute carrier family 25 member 31 [KO:K05863]
102256951  SLC25A5; solute carrier family 25 member 5 [KO:K05863]
102256266  ADP/ATP translocase 3 [KO:K05863]
102246203  ADP/ATP translocase 3-like [KO:K05863]
102248275  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
102247387  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
102239171  APOE; apolipoprotein E [KO:K04524]
102242924  LRP1; LDL receptor related protein 1 [KO:K04550]
102259838  FAS; Fas cell surface death receptor [KO:K04390]
102251038  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
102246377  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
102238957  BID; BH3 interacting domain death agonist [KO:K04726]
102244216  CALM2; calmodulin 2 [KO:K02183]
102251233  CALM1; calmodulin 1 [KO:K02183]
102253504  CALML3; calmodulin-like protein 3 [KO:K02183]
102253811  CALML5; calmodulin like 5 [KO:K02183]
102240022  CALML6; calmodulin like 6 [KO:K02183]
102251350  CALM3; calmodulin 3 [KO:K02183]
102256865  calmodulin [KO:K02183]
102242522  CALML4; calmodulin like 4 [KO:K02183]
102264111  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
102251300  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
102245752  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
102250711  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
102247129  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
102239479  BAD; BCL2 associated agonist of cell death [KO:K02158]
102247230  cytochrome c-like [KO:K08738]
102248856  cytochrome c-like [KO:K08738]
102240781  cytochrome c [KO:K08738]
102248212  cytochrome c [KO:K08738]
102256457  cytochrome c-like [KO:K08738]
102242936  APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
102254877  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
102258599  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
102238610  CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
102258675  CHRM3; cholinergic receptor muscarinic 3 [KO:K04131]
102238762  CHRM5; cholinergic receptor muscarinic 5 [KO:K04133]
102247263  GNAQ; G protein subunit alpha q [KO:K04634]
102238655  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
102254054  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
102241255  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
102240650  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
102240692  GRIN1; glutamate ionotropic receptor NMDA type subunit 1 [KO:K05208]
102245838  GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209]
102249136  GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B [KO:K05210]
102264015  GRIN2C; glutamate ionotropic receptor NMDA type subunit 2C [KO:K05211]
102257658  GRIN2D; glutamate ionotropic receptor NMDA type subunit 2D [KO:K05212]
102240225  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
102259218  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
102260789  CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
102243265  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
102246452  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
102238865  MCU; mitochondrial calcium uniporter [KO:K20858]
102255250  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102245641  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102245812  RYR3; ryanodine receptor 3 [KO:K04963]
102262150  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
102256216  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
102241889  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102242162  ATP2A1; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 [KO:K05853] [EC:7.2.2.10]
102239308  ATP2A3; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [KO:K05853] [EC:7.2.2.10]
102263136  ATP2A2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [KO:K05853] [EC:7.2.2.10]
102239267  ATF6; activating transcription factor 6 [KO:K09054]
102252117  XBP1; X-box binding protein 1 [KO:K09027]
102255226  DDIT3; DNA damage inducible transcript 3 [KO:K04452]
102243225  ERN1; endoplasmic reticulum to nucleus signaling 1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
102256242  EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
102263277  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
102256847  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102247950  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
102259984  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102263026  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102246292  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102257034  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
102238786  ATF4; activating transcription factor 4 [KO:K04374]
102250105  PSMA6; proteasome subunit alpha 6 [KO:K02730] [EC:3.4.25.1]
102260017  PSMA2; proteasome subunit alpha 2 [KO:K02726] [EC:3.4.25.1]
102245793  proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
102242175  PSMA4; proteasome subunit alpha 4 [KO:K02728] [EC:3.4.25.1]
102238663  PSMA7; proteasome subunit alpha 7 [KO:K02731] [EC:3.4.25.1]
102239019  PSMA8; proteasome subunit alpha 8 [KO:K02731] [EC:3.4.25.1]
102246596  PSMA5; proteasome subunit alpha 5 [KO:K02729] [EC:3.4.25.1]
102257299  PSMA1; proteasome subunit alpha 1 [KO:K02725] [EC:3.4.25.1]
102243314  PSMA3; proteasome subunit alpha 3 [KO:K02727] [EC:3.4.25.1]
102263781  PSMB6; proteasome subunit beta 6 [KO:K02738] [EC:3.4.25.1]
102246361  proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
102258290  PSMB7; proteasome subunit beta 7 [KO:K02739] [EC:3.4.25.1]
102250389  PSMB3; proteasome subunit beta 3 [KO:K02735] [EC:3.4.25.1]
102259307  PSMB2; proteasome subunit beta 2 [KO:K02734] [EC:3.4.25.1]
102256664  PSMB5; proteasome subunit beta 5 [KO:K02737] [EC:3.4.25.1]
102256923  proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
102258263  PSMB1; proteasome subunit beta 1 [KO:K02732] [EC:3.4.25.1]
102259848  proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
102239269  PSMB4; proteasome subunit beta 4 [KO:K02736] [EC:3.4.25.1]
102250194  PSMC2; proteasome 26S subunit, ATPase 2 [KO:K03061]
102250739  PSMC1; proteasome 26S subunit, ATPase 1 [KO:K03062]
102241041  PSMC4; proteasome 26S subunit, ATPase 4 [KO:K03063]
102252899  PSMC6; proteasome 26S subunit, ATPase 6 [KO:K03064]
102261295  PSMC3; proteasome 26S subunit, ATPase 3 [KO:K03065]
102248075  PSMC5; proteasome 26S subunit, ATPase 5 [KO:K03066]
102241562  PSMD2; proteasome 26S subunit, non-ATPase 2 [KO:K03028]
102248019  PSMD1; proteasome 26S subunit, non-ATPase 1 [KO:K03032]
102241207  PSMD3; proteasome 26S subunit, non-ATPase 3 [KO:K03033]
102256113  PSMD9; proteasome 26S subunit, non-ATPase 9 [KO:K06693]
102258763  PSMD12; proteasome 26S subunit, non-ATPase 12 [KO:K03035]
102260044  PSMD11; proteasome 26S subunit, non-ATPase 11 [KO:K03036]
102241675  PSMD6; proteasome 26S subunit, non-ATPase 6 [KO:K03037]
102245781  PSMD7; proteasome 26S subunit, non-ATPase 7 [KO:K03038]
102253023  26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
102261927  PSMD4; proteasome 26S subunit, non-ATPase 4 [KO:K03029]
102251555  PSMD14; proteasome 26S subunit, non-ATPase 14 [KO:K03030]
102252261  PSMD8; proteasome 26S subunit, non-ATPase 8 [KO:K03031]
102253489  ADRM1; adhesion regulating molecule 1 [KO:K06691]
102247806  SEM1; SEM1, 26S proteasome complex subunit [KO:K10881]
102240773  caspase-12-like [KO:K04741] [EC:3.4.22.-]
102260489  NOS1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
102249013  CAPN1; calpain 1 [KO:K01367] [EC:3.4.22.52]
102240228  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
102241074  CDK5R1; cyclin dependent kinase 5 regulatory subunit 1 [KO:K11716]
102257714  SLC39A1; solute carrier family 39 member 1 [KO:K14709]
102240562  SLC39A2; solute carrier family 39 member 2 [KO:K14709]
102263666  SLC39A3; solute carrier family 39 member 3 [KO:K14709]
102247172  zinc transporter ZIP2 [KO:K14709]
102239486  SLC39A4; solute carrier family 39 member 4 [KO:K14710]
102263339  SLC39A5; solute carrier family 39 member 5 [KO:K14711]
102247650  SLC39A6; solute carrier family 39 member 6 [KO:K14712]
102247456  SLC39A7; solute carrier family 39 member 7 [KO:K14713]
102255760  SLC39A8; solute carrier family 39 member 8 [KO:K14714]
102263751  SLC39A9; solute carrier family 39 member 9 [KO:K14715]
102251644  SLC39A10; solute carrier family 39 member 10 [KO:K14716]
106725336  zinc transporter ZIP11-like [KO:K14717]
102244195  SLC39A11; solute carrier family 39 member 11 [KO:K14717]
102244526  SLC39A12; solute carrier family 39 member 12 [KO:K14718]
102260413  SLC39A13; solute carrier family 39 member 13 [KO:K14719]
102255981  SLC39A14; solute carrier family 39 member 14 [KO:K14720]
102252488  SLC11A2; solute carrier family 11 member 2 [KO:K21398]
102255036  CDK5; cyclin dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
102248758  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
102243767  CASP7; caspase 7 [KO:K04397] [EC:3.4.22.60]
102253524  DKK1; dickkopf WNT signaling pathway inhibitor 1 [KO:K02165]
102257728  DKK2; dickkopf WNT signaling pathway inhibitor 2 [KO:K02165]
102245856  WNT1; Wnt family member 1 [KO:K03209]
102261227  WNT2; Wnt family member 2 [KO:K00182]
102255951  WNT2B; Wnt family member 2B [KO:K00182]
102244362  WNT3A; Wnt family member 3A [KO:K00312]
102240785  WNT3; Wnt family member 3 [KO:K00312]
102240589  WNT4; Wnt family member 4 [KO:K00408]
102241642  WNT5B; Wnt family member 5B [KO:K00444]
102240132  WNT5A; Wnt family member 5A [KO:K00444]
102256374  WNT6; Wnt family member 6 [KO:K00445]
102249626  WNT7A; Wnt family member 7A [KO:K00572]
102257706  WNT7B; Wnt family member 7B [KO:K00572]
102260194  WNT8B; Wnt family member 8B [KO:K00714]
102255244  WNT8A; Wnt family member 8A [KO:K00714]
102244068  WNT9A; Wnt family member 9A [KO:K01064]
102240485  WNT9B; Wnt family member 9B [KO:K01064]
102256067  WNT10A; Wnt family member 10A [KO:K01357]
102245559  WNT10B; Wnt family member 10B [KO:K01357]
102243634  WNT11; Wnt family member 11 [KO:K01384]
102247057  WNT16; Wnt family member 16 [KO:K01558]
102255722  FZD1; frizzled class receptor 1 [KO:K02432]
102254143  FZD7; frizzled class receptor 7 [KO:K02432]
102240100  FZD2; frizzled class receptor 2 [KO:K02235]
102250456  FZD3; frizzled class receptor 3 [KO:K02329]
102238804  FZD4; frizzled class receptor 4 [KO:K02354]
102261392  FZD5; frizzled class receptor 5 [KO:K02375]
102254257  FZD8; frizzled class receptor 8 [KO:K02375]
102241703  FZD6; frizzled class receptor 6 [KO:K02376]
102255327  FZD9; frizzled class receptor 9 [KO:K02842]
102243449  FZD10; frizzled class receptor 10 [KO:K02842]
102258692  LRP5; LDL receptor related protein 5 [KO:K03068]
102238882  LRP6; LDL receptor related protein 6 [KO:K03068]
102257996  CSNK1E; casein kinase I isoform epsilon [KO:K08960] [EC:2.7.11.1]
102247666  DVL3; dishevelled segment polarity protein 3 [KO:K02353]
102263975  DVL2; dishevelled segment polarity protein 2 [KO:K02353]
102242768  DVL1; dishevelled segment polarity protein 1 [KO:K02353]
102252710  CSNK2A1; casein kinase 2 alpha 1 [KO:K03097] [EC:2.7.11.1]
102247763  CSNK2A2; casein kinase 2 alpha 2 [KO:K03097] [EC:2.7.11.1]
102243592  CSNK2B; casein kinase 2 beta [KO:K03115]
102248340  AXIN1; axin 1 [KO:K02157]
102260435  AXIN2; axin 2 [KO:K04385]
102246124  APC; APC, WNT signaling pathway regulator [KO:K02085]
102243742  APC2; APC2, WNT signaling pathway regulator [KO:K02085]
102252849  CTNNB1; catenin beta 1 [KO:K02105]
102253697  CSNK1A1; casein kinase 1 alpha 1 [KO:K08957] [EC:2.7.11.1]
102262221  casein kinase I isoform alpha [KO:K08957] [EC:2.7.11.1]
102261017  casein kinase I isoform alpha [KO:K08957] [EC:2.7.11.1]
102240976  casein kinase I isoform alpha [KO:K08957] [EC:2.7.11.1]
102241578  KIF5B; kinesin family member 5B [KO:K10396]
102257255  KIF5A; kinesin family member 5A [KO:K10396]
102257038  KIF5C; kinesin family member 5C [KO:K10396]
102247212  KLC4; kinesin light chain 4 [KO:K10407]
102249559  KLC1; kinesin light chain 1 [KO:K10407]
102262355  KLC3; kinesin light chain 3 [KO:K10407]
102262676  KLC2; kinesin light chain 2 [KO:K10407]
102257777  tubulin alpha-8 chain-like [KO:K07374]
102249754  tubulin alpha-3 chain-like [KO:K07374]
102254409  TUBAL3; tubulin alpha like 3 [KO:K07374]
102255814  tubulin alpha-1C chain [KO:K07374]
102243100  TUBA1A; tubulin alpha-1A chain [KO:K07374]
102242793  tubulin alpha-1A chain [KO:K07374]
102262928  tubulin alpha chain [KO:K07374]
102257275  TUBA8; tubulin alpha 8 [KO:K07374]
102262047  tubulin alpha-1D chain [KO:K07374]
102261453  TUBA4A; tubulin alpha 4a [KO:K07374]
102257200  tubulin alpha-1B chain [KO:K07374]
102250856  tubulin alpha-3 chain [KO:K07374]
102258108  TUBB1; tubulin beta 1 class VI [KO:K07375]
102252766  TUBB4A; tubulin beta 4A class IVa [KO:K07375]
102239388  TUBB6; tubulin beta 6 class V [KO:K07375]
102257052  TUBB3; tubulin beta 3 class III [KO:K07375]
102242843  TUBB; tubulin beta class I [KO:K07375]
102246023  tubulin beta-2B chain [KO:K07375]
102258384  AGER; advanced glycosylation end-product specific receptor [KO:K19722]
102263667  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102244940  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102247606  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102241454  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
102260644  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102254003  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102240696  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102245571  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102251611  NOX1; NADPH oxidase 1 [KO:K08008]
102244245  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
102259353  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
102263790  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102255251  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102253125  NOS2; nitric oxide synthase 2 [KO:K13241] [EC:1.14.13.39]
102259598  PTGS2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
102246703  TNF; tumor necrosis factor [KO:K03156]
102243367  IL6; interleukin 6 [KO:K05405]
102251877  IL1A; interleukin 1 alpha [KO:K04383]
102251576  IL1B; interleukin 1 beta [KO:K04519]
102263365  CSF1; colony stimulating factor 1 [KO:K05453]
102259672  SNCA; synuclein alpha [KO:K04528]
102242739  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
102261467  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102261405  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102252013  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
102254396  insulin [KO:K04526]
102252005  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102247525  IRS1; insulin receptor substrate 1 [KO:K16172]
102249810  IRS2; insulin receptor substrate 2 [KO:K07187]
102242347  IRS4; insulin receptor substrate 4 [KO:K17446]
102258430  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102253405  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102242302  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102260487  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102252921  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102239669  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102254864  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102254191  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102251050  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102241670  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102240341  ULK1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
102260328  ULK2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
102257528  autophagy-related protein 101 [KO:K19730]
102245231  ATG101; autophagy related 101 [KO:K19730]
102250643  ATG13; autophagy related 13 [KO:K08331]
102257294  RB1CC1; RB1 inducible coiled-coil 1 [KO:K17589]
102248838  AMBRA1; autophagy and beclin 1 regulator 1 [KO:K17985]
102256414  BECN1; beclin 1 [KO:K08334]
102244808  beclin-2 [KO:K08334]
102253655  beclin-2-like [KO:K08334]
102252872  PIK3R4; phosphoinositide-3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
102249790  ATG14; autophagy related 14 [KO:K17889]
102256778  NRBF2; nuclear receptor binding factor 2 [KO:K21246]
102257257  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
102243916  ATG2A; autophagy related 2A [KO:K17906]
102249037  ATG2B; autophagy related 2B [KO:K17906]
102255438  WIPI2; WD repeat domain, phosphoinositide interacting 2 [KO:K17908]
102260137  WIPI1; WD repeat domain, phosphoinositide interacting 1 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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De Felice FG, Lourenco MV, Ferreira ST
  Title
How does brain insulin resistance develop in Alzheimer's disease?
  Journal
Alzheimers Dement 10:S26-32 (2014)
DOI:10.1016/j.jalz.2013.12.004
Reference
PMID:26136647
  Authors
Bedse G, Di Domenico F, Serviddio G, Cassano T
  Title
Aberrant insulin signaling in Alzheimer's disease: current knowledge.
  Journal
Front Neurosci 9:204 (2015)
DOI:10.3389/fnins.2015.00204
Reference
PMID:20101724
  Authors
Funderburk SF, Marcellino BK, Yue Z
  Title
Cell "self-eating" (autophagy) mechanism in Alzheimer's disease.
  Journal
Mt Sinai J Med 77:59-68 (2010)
DOI:10.1002/msj.20161
Related
pathway
myb00190  Oxidative phosphorylation
myb03050  Proteasome
myb04020  Calcium signaling pathway
myb04140  Autophagy - animal
myb04141  Protein processing in endoplasmic reticulum
myb04210  Apoptosis
myb04310  Wnt signaling pathway
myb04910  Insulin signaling pathway
myb04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
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