KEGG   PATHWAY: pale04810
Entry
pale04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Pteropus alecto (black flying fox)
Class
Cellular Processes; Cell motility
Pathway map
pale04810  Regulation of actin cytoskeleton
pale04810

Other DBs
GO: 0030036
Organism
Pteropus alecto (black flying fox) [GN:pale]
Gene
102891503  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
102891807  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102881134  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
102892521  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102881363  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
102888277  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102877724  F2; prothrombin isoform X2 [KO:K01313] [EC:3.4.21.5]
102886001  F2R; proteinase-activated receptor 1 [KO:K03914]
102881117  insulin [KO:K04526]
102891552  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102894192  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
107196088  FGF2; fibroblast growth factor 2 [KO:K18497]
102895922  FGF10; fibroblast growth factor 10 [KO:K04358]
102887777  FGF7; fibroblast growth factor 7 [KO:K04358]
102892141  FGF6; fibroblast growth factor 6 [KO:K04358]
102895642  FGF5; fibroblast growth factor 5 [KO:K04358]
102890153  FGF16; fibroblast growth factor 16 [KO:K04358]
102893226  FGF8; fibroblast growth factor 8 isoform X4 [KO:K04358]
102894115  FGF18; fibroblast growth factor 18 [KO:K04358]
102888098  FGF20; fibroblast growth factor 20 [KO:K04358]
102893244  FGF4; fibroblast growth factor 4 [KO:K04358]
102894279  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102887882  FGF9; fibroblast growth factor 9 [KO:K04358]
102896895  FGF22; fibroblast growth factor 22 [KO:K04358]
102885081  FGF19; fibroblast growth factor 19 [KO:K22603]
102886540  FGF21; fibroblast growth factor 21 [KO:K22429]
102883346  FGF23; fibroblast growth factor 23 [KO:K22428]
102893670  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102897699  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102894123  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102890668  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102893617  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
102893495  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102898943  FGFR1; fibroblast growth factor receptor 1 isoform X9 [KO:K04362] [EC:2.7.10.1]
102882899  FGFR2; fibroblast growth factor receptor 2 isoform X8 [KO:K05093] [EC:2.7.10.1]
102878342  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
102879288  FGFR4; fibroblast growth factor receptor 4 isoform X3 [KO:K05095] [EC:2.7.10.1]
102895362  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
102887643  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102891509  FN1; fibronectin isoform X1 [KO:K05717]
102884999  ITGA1; integrin alpha-1 [KO:K06480]
102897185  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
102883900  ITGA2B; integrin alpha-IIb [KO:K06476]
102884713  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
102896887  ITGA4; integrin alpha-4 [KO:K06483]
102889111  ITGA5; integrin alpha-5 [KO:K06484]
102883425  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
102890305  ITGA7; integrin alpha-7 isoform X3 [KO:K06583]
102878211  ITGA8; LOW QUALITY PROTEIN: integrin alpha-8 [KO:K06584]
102878201  ITGA9; integrin alpha-9 [KO:K06585]
102896303  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
102890264  ITGA11; integrin alpha-11 [KO:K06587]
102895440  ITGAV; integrin alpha-V [KO:K06487]
102879417  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
102889241  ITGAM; integrin alpha-M [KO:K06461]
102884089  LOW QUALITY PROTEIN: integrin alpha-D [KO:K06594]
102880291  ITGAE; integrin alpha-E [KO:K06524]
102886785  ITGB1; integrin beta-1 [KO:K05719]
102896231  ITGB2; integrin beta-2 [KO:K06464]
102881894  ITGB3; integrin beta-3 [KO:K06493]
102898254  ITGB4; integrin beta-4 [KO:K06525]
102892062  ITGB5; integrin beta-5 [KO:K06588]
102885280  ITGB6; integrin beta-6 isoform X2 [KO:K06589]
102896485  ITGB7; integrin beta-7 [KO:K06590]
102893900  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
102885643  KNG1; kininogen-1 isoform X1 [KO:K03898]
102895893  B2 bradykinin receptor isoform X1 [KO:K03916]
102885993  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
102883382  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
102890762  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
102896255  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
102882247  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
102894162  C5; complement C5 [KO:K03994]
102887523  C6; LOW QUALITY PROTEIN: complement component C6 [KO:K03995]
102887274  C7; complement component C7 [KO:K03996]
102894085  C8A; complement component C8 alpha chain [KO:K03997]
102894338  C8B; complement component C8 beta chain [KO:K03998]
102892200  C8G; complement component C8 gamma chain isoform X3 [KO:K03999]
102890182  C9; complement component C9 [KO:K04000]
102891706  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
102891607  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
102886682  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102877921  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
102894529  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
102880805  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
102898998  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
102897097  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
102898080  CRKL; crk-like protein [KO:K04438]
102885553  CRK; adapter molecule crk isoform X1 [KO:K04438]
102889149  DOCK1; LOW QUALITY PROTEIN: dedicator of cytokinesis protein 1 [KO:K13708]
102891249  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
102882462  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102889597  SOS2; son of sevenless homolog 2 [KO:K03099]
102896270  HRAS; GTPase HRas isoform X3 [KO:K02833]
102895590  KRAS; GTPase KRas isoform X1 [KO:K07827]
102885950  NRAS; GTPase NRas isoform X2 [KO:K07828]
102881941  RRAS; ras-related protein R-Ras [KO:K07829]
102881508  RRAS2; ras-related protein R-Ras2 [KO:K07830]
102879891  MRAS; ras-related protein M-Ras [KO:K07831]
102885217  ARHGEF6; rho guanine nucleotide exchange factor 6 [KO:K05729]
102889227  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102880320  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102889576  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102879163  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102891637  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X3 [KO:K02649]
102879453  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102883521  VAV1; proto-oncogene vav [KO:K05730]
102886772  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
102884766  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
102883973  TIAM1; LOW QUALITY PROTEIN: T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
102877877  ARAF; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
102878393  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
102893439  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102883781  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
102897122  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102879034  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102895390  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102885749  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102885144  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102879337  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102898305  AKT2; LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102882318  RGCC; regulator of cell cycle RGCC [KO:K26108]
102894194  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
102879072  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
102898992  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
102891515  RHOA; transforming protein RhoA [KO:K04513]
102897644  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102885507  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102887421  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
102889114  CDC42; cell division control protein 42 homolog [KO:K04393]
102880323  PAK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102886796  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102886090  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
102880509  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
102884535  PAK5; serine/threonine-protein kinase PAK 5 isoform X2 [KO:K05736] [EC:2.7.11.1]
102896564  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
102885573  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
102881511  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
102879861  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
102897424  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
102894361  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
102890778  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
102891799  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
102878549  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
102892254  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
102881448  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
102887827  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102898474  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X3 [KO:K06270]
102879733  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X2 [KO:K12329]
102878573  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
102888244  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
102880875  MYL5; myosin light chain 5 [KO:K12753]
102888738  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
102886777  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
102880440  MYL10; myosin regulatory light chain 10 [KO:K12756]
102885115  myosin regulatory light chain 12B [KO:K12757]
102884859  myosin regulatory light polypeptide 9 [KO:K12757]
102898508  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
102898791  MYH10; myosin-10 isoform X1 [KO:K10352]
102877832  MYH9; myosin-9 isoform X1 [KO:K10352]
102879626  MYH14; LOW QUALITY PROTEIN: myosin-14 [KO:K10352]
102884069  MYH11; myosin-11 [KO:K10352]
102886612  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
102879994  DIAPH2; protein diaphanous homolog 2 isoform X2 [KO:K05741]
102888463  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
102889348  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
102887359  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
102890845  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
102883619  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
102884135  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
102891645  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
102890594  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
102896062  LIMK2; LIM domain kinase 2 isoform X3 [KO:K05744] [EC:2.7.11.1]
102893093  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
102892095  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
102884415  ENAH; protein enabled homolog isoform X6 [KO:K05746]
102878816  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
102886126  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
102881253  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
102884981  CYFIP1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
102885385  NCKAP1L; nck-associated protein 1-like isoform X1 [KO:K05750]
102878434  NCKAP1; nck-associated protein 1 [KO:K05750]
102883763  ABI2; abl interactor 2 isoform X4 [KO:K05751]
102888350  BRK1; protein BRICK1 [KO:K05752]
102893633  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X2 [KO:K05753]
102896516  ACTR2; actin-related protein 2 [KO:K17260]
102883423  ACTR3; actin-related protein 3 [KO:K18584]
102897124  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
102896697  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
102897107  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
102888140  ARPC2; LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 2 [KO:K05758]
102885988  ARPC3; actin-related protein 2/3 complex subunit 3 isoform X1 [KO:K05756]
102885023  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
102893761  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
102890301  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
102884158  ACTG1; actin, cytoplasmic 2 [KO:K05692]
102884469  ACTB; actin, cytoplasmic 1 [KO:K05692]
102881675  PFN3; profilin-3 [KO:K05759]
102885079  PFN4; profilin-4 [KO:K05759]
102894047  PFN2; profilin-2 isoform X2 [KO:K05759]
102891169  PFN1; profilin-1 [KO:K05759]
102896555  profilin-1-like [KO:K05759]
102891920  PXN; paxillin isoform X2 [KO:K05760]
102897360  EZR; ezrin [KO:K08007]
102898450  RDX; radixin isoform X1 [KO:K05762]
102879953  MSN; moesin [KO:K05763]
102888843  TMSB4X; thymosin beta-4 [KO:K05764]
102893652  thymosin beta-4 [KO:K05764]
102886318  CFL1; cofilin-1 [KO:K05765]
102893502  CFL2; cofilin-2 [KO:K05765]
102893243  SSH3; protein phosphatase Slingshot homolog 3 isoform X2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102879806  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102893197  SSH1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102879421  VCL; vinculin isoform X1 [KO:K05700]
102888464  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
102882352  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
102892349  IQGAP2; LOW QUALITY PROTEIN: ras GTPase-activating-like protein IQGAP2 [KO:K05767]
102892531  GSN; gelsolin [KO:K05768]
102887420  SCIN; adseverin [KO:K05768]
102884236  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
102887929  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
102880260  APC; adenomatous polyposis coli protein isoform X3 [KO:K02085]
102891886  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
102896883  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X3 [KO:K05769]
102893669  SPATA13; spermatogenesis-associated protein 13 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
pale04010  MAPK signaling pathway
pale04510  Focal adhesion
pale04520  Adherens junction
KO pathway
ko04810   
LinkDB

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