KEGG   PATHWAY: uar04810
Entry
uar04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Ursus americanus (American black bear)
Class
Cellular Processes; Cell motility
Pathway map
uar04810  Regulation of actin cytoskeleton
uar04810

Other DBs
GO: 0030036
Organism
Ursus americanus (American black bear) [GN:uar]
Gene
123803378  LPAR1; LOW QUALITY PROTEIN: lysophosphatidic acid receptor 1 [KO:K04289]
123779913  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
123796629  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
123781679  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
123800307  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
123782571  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
123785006  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
123791553  F2R; proteinase-activated receptor 1 [KO:K03914]
123775502  INS; insulin [KO:K04526]
123793362  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
123790206  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
123793143  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
123785536  FGF10; fibroblast growth factor 10 [KO:K04358]
123794063  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
123801808  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
123780440  FGF20; fibroblast growth factor 20 [KO:K04358]
123794868  FGF16; fibroblast growth factor 16 [KO:K04358]
123781579  FGF6; fibroblast growth factor 6 isoform X1 [KO:K04358]
123788636  FGF18; fibroblast growth factor 18 [KO:K04358]
123795836  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
123789204  FGF5; fibroblast growth factor 5 [KO:K04358]
123791977  FGF9; fibroblast growth factor 9 [KO:K04358]
123778359  FGF4; LOW QUALITY PROTEIN: fibroblast growth factor 4 [KO:K04358]
123778371  FGF3; fibroblast growth factor 3 [KO:K04358]
123777458  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
123778372  FGF19; fibroblast growth factor 19 [KO:K22603]
123776278  FGF21; fibroblast growth factor 21 [KO:K22429]
123781630  FGF23; fibroblast growth factor 23 [KO:K22428]
123802515  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123780665  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
123792511  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
123793193  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
123783389  INSRR; insulin receptor-related protein isoform X1 [KO:K05086] [EC:2.7.10.1]
123786270  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
123780346  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
123796025  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
123777846  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
123793342  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
123804080  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
123803639  PDGFRB; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
123798278  FN1; fibronectin isoform X1 [KO:K05717]
123803661  ITGA1; integrin alpha-1 [KO:K06480]
123803701  ITGA2; integrin alpha-2 [KO:K06481]
123803148  ITGA2B; integrin alpha-IIb [KO:K06476]
123776779  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
123798102  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
123794668  ITGA5; integrin alpha-5 [KO:K06484]
123780702  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
123787285  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
123785864  ITGA8; integrin alpha-8 [KO:K06584]
123792843  ITGA9; integrin alpha-9 [KO:K06585]
123778699  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
123800835  ITGA11; integrin alpha-11 [KO:K06587]
123798116  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
123784641  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
123784682  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
123784683  ITGAX; integrin alpha-X [KO:K06462]
123784684  ITGAD; integrin alpha-D [KO:K06594]
123776890  ITGAE; LOW QUALITY PROTEIN: integrin alpha-E [KO:K06524]
123784876  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
123779127  ITGB2; integrin beta-2 [KO:K06464]
123803040  ITGB3; integrin beta-3 [KO:K06493]
123803018  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
123802198  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
123781472  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
123794706  ITGB7; integrin beta-7 [KO:K06590]
123789193  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
123801268  KNG1; kininogen-1 isoform X1 [KO:K03898]
123803924  BDKRB1; B1 bradykinin receptor [KO:K03915]
123803922  BDKRB2; B2 bradykinin receptor [KO:K03916]
123789797  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
123788910  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
123795530  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
123799574  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
123776435  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
123788019  C5; complement C5 [KO:K03994]
123785513  C6; complement component C6 [KO:K03995]
123785511  C7; complement component C7 [KO:K03996]
123795382  C8A; complement component C8 alpha chain [KO:K03997]
123795381  C8B; complement component C8 beta chain [KO:K03998]
123785502  C9; complement component C9 [KO:K04000]
123802492  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
123802930  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
123795327  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
123777697  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
123791453  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
123776529  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
123779697  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
123791314  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
123795650  CRKL; crk-like protein [KO:K04438]
123776898  CRK; adapter molecule crk isoform X1 [KO:K04438]
123800053  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
123796968  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
123799809  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
123793291  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
123775506  HRAS; GTPase HRas isoform X1 [KO:K02833]
123801699  KRAS; GTPase KRas isoform X1 [KO:K07827]
123795037  NRAS; GTPase NRas [KO:K07828]
123776255  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
123791661  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
123788418  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
123787608  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
123786407  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123788422  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123779078  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123800228  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123793748  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
123779926  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123795136  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
123779019  VAV1; proto-oncogene vav [KO:K05730]
123775750  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
123784191  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
123786515  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
123788872  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
123802053  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123786756  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
123800861  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
123796818  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123795639  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123784602  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123793473  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123784096  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123791373  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123801053  RGCC; regulator of cell cycle RGCC [KO:K26108]
123778847  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
123792667  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
123776341  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
123780073  RHOA; transforming protein RhoA [KO:K04513]
123802589  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123780787  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
123777961  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
123803163  cell division control protein 42 homolog [KO:K04393]
123782153  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
123804163  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
123802208  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
123794865  PAK3; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
123784330  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
123799754  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
123804233  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
123776716  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
123776852  GIT1; ARF GTPase-activating protein GIT1 [KO:K05737]
123782085  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
123778572  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
123801590  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
123802103  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
123798683  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
123776613  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
123799882  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
123795174  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
123778467  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
123779126  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
123780848  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
123785739  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
123786950  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
123779111  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
123777844  MYL5; myosin light chain 5 [KO:K12753]
123789626  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
123796948  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
123777317  MYL10; myosin regulatory light chain 10 [KO:K12756]
123782001  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
123782002  myosin regulatory light chain 12B [KO:K12757]
123784777  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
123792097  MYH10; myosin-10 isoform X1 [KO:K10352]
123780894  MYH9; myosin-9 [KO:K10352]
123777967  MYH14; LOW QUALITY PROTEIN: myosin-14 [KO:K10352]
123778591  MYH11; myosin-11 isoform X1 [KO:K10352]
123790225  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
123787638  LOW QUALITY PROTEIN: protein diaphanous homolog 2-like [KO:K05741]
123782222  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
123787715  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
123796830  PIP5K1C; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
123776489  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
123785435  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
123786542  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
123787208  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
123798257  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
123784733  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
123788184  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
123801086  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
123777915  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
123791857  ENAH; LOW QUALITY PROTEIN: protein enabled homolog [KO:K05746]
123789005  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
123782123  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
123788539  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
123790740  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
123794667  NCKAP1L; nck-associated protein 1-like [KO:K05750]
123798109  NCKAP1; nck-associated protein 1 [KO:K05750]
123798226  ABI2; abl interactor 2 isoform X1 [KO:K05751]
123799203  BRK1; protein BRICK1 [KO:K05752]
123792946  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
123786000  ACTR2; actin-related protein 2 [KO:K17260]
123788750  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
123796581  ACTR3; actin-related protein 3 [KO:K18584]
123777257  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
123777322  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
123779417  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
123779195  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
123799193  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
123801405  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
123787979  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
123802532  ACTB; actin, cytoplasmic 1 [KO:K05692]
123777926  ACTG1; actin, cytoplasmic 2 [KO:K05692]
123799959  PFN4; profilin-4 [KO:K05759]
123802230  PFN2; profilin-2 isoform X1 [KO:K05759]
123797155  PFN1; profilin-1 [KO:K05759]
123790874  profilin-1-like [KO:K05759]
123791855  PFN3; profilin-3 [KO:K05759]
123788286  PXN; paxillin isoform X1 [KO:K05760]
123797494  EZR; ezrin isoform X1 [KO:K08007]
123792543  RDX; radixin isoform X1 [KO:K05762]
123791277  MSN; moesin [KO:K05763]
123788269  thymosin beta-4-like [KO:K05764]
123788659  thymosin beta-4 [KO:K05764]
123796367  TMSB4X; thymosin beta-4 [KO:K05764]
123803836  LOW QUALITY PROTEIN: thymosin beta-4-like [KO:K05764]
123791354  thymosin beta-4-like [KO:K05764]
123798856  thymosin beta-4-like [KO:K05764]
123794010  CFL2; cofilin-2 [KO:K05765]
123803854  LOW QUALITY PROTEIN: cofilin-2-like [KO:K05765]
123778453  CFL1; cofilin-1 [KO:K05765]
123788226  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
123778421  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
123776880  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
123782824  VCL; vinculin isoform X1 [KO:K05700]
123802462  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
123783386  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
123791556  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
123788015  GSN; gelsolin isoform X1 [KO:K05768]
123789222  SCIN; adseverin [KO:K05768]
123784522  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
123799050  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
123794019  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
123779308  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
123791969  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
123791756  uncharacterized protein LOC123791756 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
uar04010  MAPK signaling pathway
uar04510  Focal adhesion
uar04520  Adherens junction
KO pathway
ko04810   
LinkDB

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