KEGG   PATHWAY: uar05208
Entry
uar05208                    Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Ursus americanus (American black bear)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
uar05208  Chemical carcinogenesis - reactive oxygen species
uar05208

Organism
Ursus americanus (American black bear) [GN:uar]
Gene
123795917  AS3MT; arsenite methyltransferase isoform X1 [KO:K07755] [EC:2.1.1.137]
123800140  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
123793269  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
123794950  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
123795096  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
123795097  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
123795098  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
123795099  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
123795542  glutathione S-transferase A3-like [KO:K00799] [EC:2.5.1.18]
123795557  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
123795558  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
123795565  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
123795620  glutathione S-transferase theta-3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
123795622  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
123795623  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
123795624  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
123795625  glutathione S-transferase theta-2B-like isoform X1 [KO:K00799] [EC:2.5.1.18]
123781726  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
123795936  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
123795938  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
804833  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
804834  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
804845  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
804839  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
804842  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
804837  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
804843  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
123778416  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
123789911  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
123777477  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
123799762  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
123785620  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
123794646  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
123787661  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
123795955  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
123798818  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
123790272  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
123793221  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
123786983  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
123786465  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
123787225  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
123780485  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
123789236  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
123789009  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
123780547  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
123777567  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
123788004  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
123781567  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1 [KO:K03953]
123790007  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
123778825  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
123779018  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
123780731  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
123803761  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12-like [KO:K11352]
123779949  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
123798882  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
123778638  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
123788874  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
123798195  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
123784016  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
123786415  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
123781024  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
123801757  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
123795870  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
123797719  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
123783789  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
123787627  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
123798236  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
123783503  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
123785035  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
123803707  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
123776125  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
123799093  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform X1 [KO:K03939]
123794024  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
123778395  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
123793273  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
123804239  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
123799114  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
123796770  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
123783229  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
123776651  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
804840  CYTB; cytochrome b [KO:K00412]
123779343  LOW QUALITY PROTEIN: cytochrome c1, heme protein, mitochondrial [KO:K00413]
123779962  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
123778813  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
123793744  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
123797864  cytochrome b-c1 complex subunit 7 [KO:K00417]
123790360  cytochrome b-c1 complex subunit 8 [KO:K00418]
123788258  cytochrome b-c1 complex subunit 9 [KO:K00419]
123794011  cytochrome b-c1 complex subunit 10 [KO:K00420]
804841  COX3; cytochrome c oxidase subunit III [KO:K02262]
804835  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
804844  COX2; cytochrome c oxidase subunit II [KO:K02261]
123798702  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
123776617  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
123790674  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
123784571  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
123776038  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
123802677  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
123788280  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
123784685  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
123793890  cytochrome c oxidase subunit 6B1 [KO:K02267]
123787036  cytochrome c oxidase subunit 6B2 [KO:K02267]
123798599  cytochrome c oxidase subunit 6B1-like [KO:K02267]
123799794  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
123796368  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
123797362  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
123794870  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
123803988  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
123799314  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
123789241  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123791502  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
123803966  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
123778503  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
123787354  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
123787239  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
123802301  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
123794039  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
123803295  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
804838  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
123795077  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
123794098  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
123794686  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
123802874  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
123802976  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
123797560  ATP synthase subunit d, mitochondrial-like [KO:K02138]
123784215  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
123784171  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
804836  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
123797500  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
123790351  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
123788811  voltage-dependent anion-selective channel protein 2 [KO:K15040]
123782868  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
123780315  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
123793297  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
123787795  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
123802759  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
123784508  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
123783021  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
123784194  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
123799428  CAT; catalase [KO:K03781] [EC:1.11.1.6]
123777819  SLC26A1; sulfate anion transporter 1 isoform X1 [KO:K14700]
123803659  SLC26A2; sulfate transporter [KO:K14701]
123779892  SLC26A6; solute carrier family 26 member 6 isoform X1 [KO:K14704]
123785850  SLC26A9; solute carrier family 26 member 9 [KO:K14706]
123790681  cytochrome P450 1A2 isoform X1 [KO:K07409] [EC:1.14.14.1]
123800068  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
123782952  cytochrome P450 2F5 [KO:K07416] [EC:1.14.14.1]
123790682  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
123799824  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
123791844  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
123777357  EPHX2; bifunctional epoxide hydrolase 2 isoform X1 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
123780013  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
123794959  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
123793759  AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
123802294  AKR1C8; putative aldo-keto reductase family 1 member C8 isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
123791110  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
123786548  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
123786550  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
123786552  LOW QUALITY PROTEIN: carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
123786553  LOW QUALITY PROTEIN: carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
123786554  LOW QUALITY PROTEIN: carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
123802675  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
123802676  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
123804157  LOW QUALITY PROTEIN: carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
123784231  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
123784232  LOW QUALITY PROTEIN: carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
123784385  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
123775789  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
123789203  AHR; aryl hydrocarbon receptor [KO:K09093]
123777067  LPO; lactoperoxidase isoform X1 [KO:K12550] [EC:1.11.1.7]
123803818  NADPH oxidase 4-like isoform X1 [KO:K21423] [EC:1.6.3.-]
123776589  LOW QUALITY PROTEIN: cytochrome b-245 light chain [KO:K08009]
123796195  NOX1; NADPH oxidase 1 [KO:K08008]
123784723  NCF1; neutrophil cytosol factor 1 [KO:K08011]
123801424  NCF2; neutrophil cytosol factor 2 [KO:K08010]
123793362  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
123786270  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
123789349  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
123789034  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
123802938  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
123799809  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
123793291  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
123775506  HRAS; GTPase HRas isoform X1 [KO:K02833]
123801699  KRAS; GTPase KRas isoform X1 [KO:K07827]
123795037  NRAS; GTPase NRas [KO:K07828]
123786515  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
123788872  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
123802053  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123800861  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
123796818  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123795639  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123784602  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123803353  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
123792071  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
123777544  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
123800287  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123788054  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123790496  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123803776  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
123803793  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
123776209  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
123776212  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
123795376  JUN; transcription factor AP-1 [KO:K04448]
123798968  FOS; proto-oncogene c-Fos [KO:K04379]
123800228  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123793748  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
123779926  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123786407  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123788422  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123779078  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123802589  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123783746  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
123793473  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123784096  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123791373  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123798497  FOXO3; forkhead box protein O3 [KO:K09408]
123778440  BAD; bcl2-associated agonist of cell death [KO:K02158]
123775918  PTPN1; tyrosine-protein phosphatase non-receptor type 1 isoform X1 [KO:K05696] [EC:3.1.3.48]
123795550  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
123795860  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
123780295  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
123791737  NF-kappa-B essential modulator-like [KO:K07210]
123793902  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
123778302  RELA; transcription factor p65 [KO:K04735]
123788912  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123798757  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
123785044  PTPRJ; receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
123793453  low molecular weight phosphotyrosine protein phosphatase [KO:K14394] [EC:3.1.3.2 3.1.3.48]
123786590  ACP1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
123778834  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
123792708  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
123796968  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
123775749  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
123801443  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
123799829  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
123795721  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
123778726  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
123779697  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
123792197  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
123786391  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
123802960  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
123800588  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
123787736  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
123796996  VEGFA; vascular endothelial growth factor A [KO:K05448]
123777573  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
123798077  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
123780691  HMOX1; heme oxygenase 1 isoform X1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
uar00190  Oxidative phosphorylation
uar00980  Metabolism of xenobiotics by cytochrome P450
uar04010  MAPK signaling pathway
uar04064  NF-kappa B signaling pathway
uar04066  HIF-1 signaling pathway
uar04151  PI3K-Akt signaling pathway
uar04370  VEGF signaling pathway
uar05207  Chemical carcinogenesis - receptor activation
uar05211  Renal cell carcinoma
uar05215  Prostate cancer
uar05219  Bladder cancer
uar05221  Acute myeloid leukemia
uar05222  Small cell lung cancer
uar05223  Non-small cell lung cancer
uar05224  Breast cancer
uar05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

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