KEGG   PATHWAY: vpd03070
Entry
vpd03070                    Pathway                                
Name
Bacterial secretion system - Variovorax paradoxus B4
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
vpd03070  Bacterial secretion system
vpd03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Variovorax paradoxus B4 [GN:vpd]
Gene
VAPA_2c04960  putative outer membrane efflux protein, TolC family [KO:K12340]
VAPA_1c38480  type I secretion system outer membrane protein, TolC family [KO:K12340]
VAPA_2c06250  type III secretion outer membrane pore, YscC/HrcC family [KO:K03219]
VAPA_2c06290  putative type III secretion apparatus lipoprotein, YscJ/HrcJ family [KO:K03222]
VAPA_2c06210  putative type III secretion apparatus protein, YscR/HrcR family [KO:K03226]
VAPA_2c06240  putative type III secretion protein, HrpO family [KO:K03227]
VAPA_2c06340  putative type III secretion apparatus protein SpaR/YscT/HrcT [KO:K03228]
VAPA_2c06350  putative type III secretion system substrate exporter, FlhB/HrpN/YscU/SpaS family [KO:K03229]
VAPA_2c06230  type III secretion protein, HrcV family [KO:K03230]
VAPA_2c06320  ATPase, FliI/YscN family [KO:K03224] [EC:7.4.2.8]
VAPA_2c06220  putative type III secretion apparatus protein, YscQ/HrcQ family [KO:K03225]
VAPA_2c06310  type III secretion apparatus protein, HrpE/YscL family [KO:K03223]
VAPA_1c11270  general secretion pathway protein D [KO:K02453]
VAPA_1c11360  putative membrane protein [KO:K02452]
VAPA_1c11250  general secretion pathway protein F [KO:K02455]
VAPA_1c11350  general secretion pathway protein G [KO:K02456]
VAPA_1c11340  putative general secretion pathway protein H [KO:K02457]
VAPA_1c11330  general secretion pathway protein I [KO:K02458]
VAPA_1c11320  putative general secretion pathway protein J [KO:K02459]
VAPA_1c11310  general secretion pathway protein K [KO:K02460]
VAPA_1c11300  general secretion pathway protein L [KO:K02461]
VAPA_1c11290  putative general secretion pathway protein M [KO:K02462]
VAPA_1c11260  general secretion pathway protein E [KO:K02454] [EC:7.4.2.8]
VAPA_1c13150  putative type II/IV secretion system protein [KO:K02454] [EC:7.4.2.8]
VAPA_1c53100  secD; protein translocase subunit SecD [KO:K03072]
VAPA_1c53090  secF; protein translocase subunit SecF [KO:K03074]
VAPA_1c07360  preprotein translocase, SecE subunit [KO:K03073]
VAPA_1c36200  secG; preprotein translocase, subunit SecG [KO:K03075]
VAPA_1c52420  secY; preprotein translocase subunit SecY [KO:K03076]
VAPA_1c53110  preprotein translocase subunit YajC [KO:K03210]
VAPA_1c55100  yidC; membrane protein insertase YidC [KO:K03217]
VAPA_1c43900  secA; protein translocase, subunit SecA [KO:K03070] [EC:7.4.2.8]
VAPA_1c45470  ftsY; cell division protein FtsY [KO:K03110]
VAPA_1c42550  secB; protein-export protein SecB [KO:K03071]
VAPA_1c10140  ffh; signal recognition particle protein Ffh [KO:K03106] [EC:3.6.5.4]
VAPA_1c12390  tatA; Sec-independent protein translocase protein TatA [KO:K03116]
VAPA_1c12400  tatB; Sec-independent protein translocase protein TatB [KO:K03117]
VAPA_1c12410  tatC; Sec-independent protein translocase protein TatC [KO:K03118]
VAPA_2c13310  type IV secretion system VirB2-like protein [KO:K03197]
VAPA_2c13300  type IV secretion system VirB3-like protein [KO:K03198]
VAPA_2c13280  type IV secretion system VirB5-like protein [KO:K03200]
VAPA_2c13250  type IV secretion system VirB9-like protein [KO:K03204]
VAPA_2c13270  type IV secretion system VirB6-like protein [KO:K03201]
VAPA_2c13260  type IV secretion system VirB8-like protein [KO:K03203]
VAPA_2c13240  type IV secretion system VirB10-like protein [KO:K03195]
VAPA_2c13290  type IV secretion system VirB4-like protein [KO:K03199] [EC:7.4.2.8]
VAPA_2c13230  type IV secretion system VirB11-like protein [KO:K03196] [EC:7.4.2.8]
VAPA_2c13220  type IV secretion system VirD4-like protein [KO:K03205] [EC:7.4.2.8]
VAPA_1c39780  type VI secretion system, Vgr family protein [KO:K11904]
VAPA_2c02160  type VI secretion system, Vgr family protein [KO:K11904]
VAPA_1c02360  type VI secretion system Vgr family protein [KO:K11904]
VAPA_1c26900  type VI secretion system Vgr family protein [KO:K11904]
VAPA_1c02650  type VI secretion system protein, Vgr family [KO:K11904]
VAPA_1c03040  type VI secretion system protein, Vgr family [KO:K11904]
VAPA_2c03170  putative type VI secretion system protein, Vgr family [KO:K11904]
VAPA_1c06130  putative type VI secretion system protein, Vgr family [KO:K11904]
VAPA_1c06080  type VI secretion system protein, Vgr family [KO:K11904]
VAPA_1c06240  putative type VI secretion system effector, Hcp1 family [KO:K11903]
VAPA_1c02300  hypothetical protein [KO:K11903]
VAPA_2c03160  hypothetical protein [KO:K11903]
VAPA_1c06280  putative type VI secretion lipoprotein, VC_A0113 family [KO:K11906]
VAPA_1c02450  type VI secretion lipoprotein, VC_A0113 family [KO:K11906]
VAPA_1c05940  icmF2; putative type VI secretion protein IcmF [KO:K11891]
VAPA_1c02480  icmF1; type VI secretion protein IcmF [KO:K11891]
VAPA_1c05930  putative type IV / VI secretion system protein, DotU family [KO:K11892]
VAPA_1c02470  type IV/VI secretion system protein, DotU family [KO:K11892]
VAPA_1c06070  clpV1; type VI secretion ATPase, ClpV1 family [KO:K11907]
VAPA_1c02350  type VI secretion ATPase, ClpV1 family [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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