KEGG   DRUG: Dexamethasone
Entry
D00292                      Drug                                   

Name
Dexamethasone (JP17/USP/INN);
Decadron (TN);
Maxidex (TN)
Product
  Generic
DEXAMETHASONE (A-S Medication Solutions), DEXAMETHASONE (A-S Medication Solutions), DEXAMETHASONE (A-S Medication Solutions), DEXAMETHASONE (A-S Medication Solutions), DEXAMETHASONE (Bryant Ranch Prepack), DEXAMETHASONE (Bryant Ranch Prepack), DEXAMETHASONE (Bryant Ranch Prepack), DEXAMETHASONE (Bryant Ranch Prepack), DEXAMETHASONE (Cardinal Health), DEXAMETHASONE (Fera Pharmaceuticals), HIDEX 6-DAY (Gentex Pharma), DEXAMETHASONE (Golden State Medical Supply), DEXAMETHASONE (Lake Erie Medical DBA Quality Care Products LLC), DEXABLISS (Levins Pharmaceuticals), DEXAMETHASONE (Morton Grove Pharmaceuticals), DEXAMETHASONE (NuCare Pharmaceuticals), DEXAMETHASONE (PD-Rx Pharmaceuticals), DEXAMETHASONE (PD-Rx Pharmaceuticals), DEXAMETHASONE (PD-Rx Pharmaceuticals), DXEVO (Phlight Pharma), DECADRON (Pragma Pharmaceuticals), DEXAMETHASONE (Preferred Pharmaceuticals), DEXAMETHASONE (Preferred Pharmaceuticals), DEXAMETHASONE (Proficient Rx LP), DEXAMETHASONE (Proficient Rx LP), TAPERDEX 6-DAY (Proficient Rx LP), TAPERDEX 12-DAY (Proficient Rx LP), TAPERDEX 6-DAY (Quality Care Products), DEXAMETHASONE (REMEDYREPACK), DEXAMETHASONE (RedPharm Drug), DEXAMETHASONE (RedPharm Drug), DEXAMETHASONE (Rising Pharmaceuticals), DEXAMETHASONE (STI Pharma LLC), DEXAMETHASONE (Xspire Pharma), TAPERDEX 6-DAY (Xspire Pharma), TAPERDEX 7-DAY (Xspire Pharma), TAPERDEX 12-DAY (Xspire Pharma), DEXAMETHASONE 6-DAY (Xspire Pharma), DEXAMETHASONE (medsource pharmaceuticals), DEXAMETHASONE (Larken Laboratories), DEXAMETHASONE (Larken Laboratories), DXEVO (Skylar Laboratories), DEXAMETHASONE INTENSOL (West-Ward Pharmaceuticals Corp.)
Formula
C22H29FO5
Exact mass
392.1999
Mol weight
392.4611
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG01635  CYP3A4 inducer
Remark
Same as: C15643
Therapeutic category: 1315 2399 2454 2646
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Product (mixture): D08733<JP> D10296<US> D11177<US> D11178<US>
Efficacy
Anti-inflammatory, Antipruritic, Glucocorticoid receptor agonist
  Disease
Diabetic macular edema [DS:H01651]
Asthma [DS:H00079]
Atopic dermatitis [DS:H01358]
Contact dermatitis [DS:H01357]
Allergic rhinitis [DS:H01360]
Bullous dermatitis herpetiformis [DS:H01362]
Mycosis fungoides [DS:H01463]
Pemphigus [DS:H01648]
Erythema multiforme [DS:H01695]
Stevens-Johnson syndrome [DS:H01694]
Congenital adrenal hyperplasia [DS:H00216]
Ulcerative colitis [DS:H01466]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Congenital (erythroid) hypoplastic anemia; Diamond-Blackfan anemia [DS:H00237]
Pure red cell aplasia [DS:H01586]
Multiple sclerosis [DS:H01490]
Temporal arteritis [DS:H01698]
Nephrotic syndrome [DS:H01657]
Pulmonary tuberculosis [DS:H00342]
Acute gouty arthritis [DS:H01532]
Ankylosing spondylitis [DS:H01674]
Psoriatic arthritis [DS:H01507]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Dermatomyositis and polymyositis [DS:H01604]
Systemic lupus erythematosus [DS:H00080]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Structure map
map07043  Antineoplastics - hormones
map07046  Immunosuppressive agents
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Dexamethasone
   D00292  Dexamethasone (JP17/USP/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Dexamethasone
    D00292  Dexamethasone (JP17/USP/INN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Dexamethasone
     D00292  Dexamethasone (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1315  Ophthalmic cortisones
     D00292  Dexamethasone (JP17/USP/INN)
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2399  Others
     D00292  Dexamethasone (JP17/USP/INN)
  24  Hormones
   245  Adrenal hormone preparations
    2454  Fluorinated adrenocorticotropic hormones
     D00292  Dexamethasone (JP17/USP/INN)
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D00292  Dexamethasone (JP17/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00292  Dexamethasone (JP17/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Dexamethasone
    D00292  Dexamethasone (JP17/USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Dexamethasone
    D00292  Dexamethasone (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00292  Dexamethasone (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00292  Dexamethasone
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00292
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00292
Topical steroids potency [br08317.html]
 Classification in Japan
  D00292
Rx-to-OTC switch list in Japan [br08314.html]
 D00292
Other DBs
CAS: 50-02-2
PubChem: 7847358
ChEBI: 41879
ChEMBL: CHEMBL1698267 CHEMBL1723662 CHEMBL378081 CHEMBL384467
DrugBank: DB01234
PDB-CCD: DEX[PDBj]
LigandBox: D00292
NIKKAJI: J1.356K
LinkDB
KCF data

ATOM        28
            1   C2x C     6.5292  -16.7310
            2   C5x C     6.5292  -18.0917
            3   C2x C     7.7075  -18.7720
            4   C2y C     8.8859  -18.0917
            5   C1z C     8.8859  -16.7310
            6   C2x C     7.7075  -16.0507
            7   C1x C    10.0643  -18.7720
            8   C1x C    11.2426  -18.0917
            9   C1y C    11.2426  -16.7310
            10  C1z C    10.0643  -16.0507
            11  C1y C    12.4210  -16.0507
            12  C1z C    12.4210  -14.6900
            13  C1x C    11.2426  -14.0097
            14  C1y C    10.0643  -14.6900
            15  C1x C    14.7777  -16.0507
            16  C1y C    14.7777  -14.6900
            17  C1z C    13.5994  -14.0097
            18  C1a C     8.8859  -15.3703
            19  O1a O     8.8879  -14.0109
            20  C1a C    12.4210  -13.3294
            21  C1a C    15.9436  -14.0168
            22  C5a C    13.5994  -12.3089
            23  X   F    10.0643  -17.4113
            24  O1a O    14.7777  -13.1194
            25  O5x O     5.3509  -18.7720
            26  O5a O    14.7817  -11.6263
            27  C1b C    12.4249  -11.6308
            28  O1a O    11.2650  -12.3007
BOND        31
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   14  19 1 #Up
            23   12  20 1 #Up
            24   16  21 1 #Down
            25   17  22 1 #Up
            26   10  23 1 #Down
            27   17  24 1 #Down
            28    2  25 2
            29   22  26 2
            30   22  27 1
            31   27  28 1

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