KEGG   ORTHOLOGY: K04515
Entry
K04515                      KO                                     

Name
CAMK2
Definition
calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
Pathway
ko04012  ErbB signaling pathway
ko04020  Calcium signaling pathway
ko04024  cAMP signaling pathway
ko04066  HIF-1 signaling pathway
ko04114  Oocyte meiosis
ko04217  Necroptosis
ko04261  Adrenergic signaling in cardiomyocytes
ko04310  Wnt signaling pathway
ko04360  Axon guidance
ko04713  Circadian entrainment
ko04720  Long-term potentiation
ko04722  Neurotrophin signaling pathway
ko04725  Cholinergic synapse
ko04728  Dopaminergic synapse
ko04740  Olfactory transduction
ko04745  Phototransduction - fly
ko04750  Inflammatory mediator regulation of TRP channels
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04916  Melanogenesis
ko04921  Oxytocin signaling pathway
ko04922  Glucagon signaling pathway
ko04925  Aldosterone synthesis and secretion
ko04934  Cushing syndrome
ko04971  Gastric acid secretion
ko05012  Parkinson disease
ko05031  Amphetamine addiction
ko05152  Tuberculosis
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05214  Glioma
Disease
H00768  Autosomal recessive mental retardation
H00773  Autosomal dominant mental retardation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04310 Wnt signaling pathway
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04066 HIF-1 signaling pathway
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04020 Calcium signaling pathway
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04024 cAMP signaling pathway
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04217 Necroptosis
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04922 Glucagon signaling pathway
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04912 GnRH signaling pathway
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04921 Oxytocin signaling pathway
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04916 Melanogenesis
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04925 Aldosterone synthesis and secretion
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
  09154 Digestive system
   04971 Gastric acid secretion
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
  09156 Nervous system
   04725 Cholinergic synapse
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04728 Dopaminergic synapse
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04720 Long-term potentiation
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04722 Neurotrophin signaling pathway
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
  09157 Sensory system
   04745 Phototransduction - fly
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04740 Olfactory transduction
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04750 Inflammatory mediator regulation of TRP channels
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
  09158 Development and regeneration
   04360 Axon guidance
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   05205 Proteoglycans in cancer
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
  09162 Cancer: specific types
   05214 Glioma
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
  09165 Substance dependence
   05031 Amphetamine addiction
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CAMK group
  CAMK2 family
   K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
Other DBs
GO: 0004683
Genes
HSA: 815(CAMK2A) 816(CAMK2B) 817(CAMK2D) 818(CAMK2G)
PTR: 461445(CAMK2D) 462189(CAMK2A) 738167(CAMK2B) 738330(CAMK2G)
PPS: 100973727(CAMK2A) 100982179(CAMK2G) 100983859(CAMK2D) 100986246(CAMK2B)
GGO: 101134676(CAMK2D) 101136547(CAMK2G) 101148194(CAMK2B) 101153594(CAMK2A)
PON: 100172212(CAMK2A) 100433531(CAMK2B) 100436747(CAMK2D) 100462386(CAMK2G)
NLE: 100580290(CAMK2D) 100591995(CAMK2B) 100597007(CAMK2G) 100600165(CAMK2A)
MCC: 702504(CAMK2D) 705980(CAMK2G) 706977(CAMK2B) 710540(CAMK2A)
MCF: 101865637(CAMK2G) 101866326(CAMK2D) 101926613(CAMK2B) 102126681(CAMK2A)
CSAB: 103215984(CAMK2G) 103226136(CAMK2B) 103236144(CAMK2D) 103244792(CAMK2A)
RRO: 104669984(CAMK2G) 104670410(CAMK2A) 104671146(CAMK2B) 104676623(CAMK2D)
RBB: 108512486(CAMK2D) 108516884(CAMK2G) 108529387 108532044(CAMK2A) 108544005
CJC: 100390938(CAMK2A) 100391424 100397956(CAMK2D) 100405903(CAMK2G) 100410352(CAMK2B)
SBQ: 101031635(CAMK2G) 101038342(CAMK2D) 101041452(CAMK2A) 101041781 101052251(CAMK2B)
MMU: 108058(Camk2d) 12322(Camk2a) 12323(Camk2b) 12325(Camk2g)
MCAL: 110284502(Camk2a) 110290827(Camk2d) 110305925(Camk2b) 110309790(Camk2g)
MPAH: 110320932(Camk2d) 110325574(Camk2g) 110331006(Camk2b) 110332832(Camk2a)
RNO: 103693838(NEWGENE_621802) 171140(Camk2g) 24245(Camk2b) 24246(Camk2d) 25400(Camk2a)
MUN: 110546095(Camk2b) 110546686(Camk2a) 110551996(Camk2g) 110565513 110565514
CGE: 100752268 100763272(Camk2g) 100765253(Camk2a) 100769205(Camk2b)
NGI: 103734983(Camk2b) 103736933(Camk2g) 103743264(Camk2d) 103747079(Camk2a)
HGL: 101711305(Camk2d) 101713923(Camk2g) 101718749(Camk2b) 101722229(Camk2a)
OCU: 100101556(CAMK2G) 100101557(CAMK2D) 100341507(CAMK2A) 100342451(CAMK2B)
TUP: 102472689(CAMK2B) 102482912(CAMK2D) 102494625(CAMK2A) 102503259(CAMK2G)
CFA: 482687 489050(CAMK2G) 610764(CAMK2D) 612941(CAMK2A)
VVP: 112911701(CAMK2B) 112924513(CAMK2G) 112927337(CAMK2A) 112931026(CAMK2D)
AML: 100466256(CAMK2D) 100474459(CAMK2G) 100475467(CAMK2A) 100478243(CAMK2B)
UMR: 103661761(CAMK2D) 103664598(CAMK2A) 103668027(CAMK2G) 103674683(CAMK2B)
UAH: 113255589(CAMK2D) 113257849(CAMK2B) 113259192(CAMK2G) 113263946(CAMK2A)
ORO: 101367567(CAMK2G) 101375584(CAMK2D) 101375944(CAMK2A) 101384300(CAMK2B)
FCA: 101084342(CAMK2A) 101098090(CAMK2G) 101098221(CAMK2D) 101098615(CAMK2B)
PTG: 102950197(CAMK2D) 102957556(CAMK2G) 102964851(CAMK2B) 102966494(CAMK2A)
PPAD: 109248360(CAMK2D) 109264424(CAMK2G) 109267916(CAMK2B) 109275954
AJU: 106968235(CAMK2B) 106970983(CAMK2G) 106977318(CAMK2D) 106985400(CAMK2A)
BTA: 282162(CAMK2G) 525416(CAMK2B) 530719(CAMK2A) 532713(CAMK2D)
BOM: 102271451(CAMK2A) 102279381(CAMK2G) 102280002 102281822(CAMK2B)
BIU: 109553698(CAMK2G) 109557541(CAMK2B) 109560236(CAMK2D) 109562200(CAMK2A)
BBUB: 102389415(CAMK2G) 102396037(CAMK2B) 102397549(CAMK2A) 102416446(CAMK2D)
CHX: 102175934(CAMK2D) 102176762(CAMK2B) 102185084(CAMK2A) 102185715(CAMK2G)
OAS: 101108884(CAMK2G) 101113850(CAMK2D) 101118870(CAMK2B) 443453(CAMK2A)
SSC: 100516166(CAMK2B) 100626014(CAMK2A) 397394(CAMK2G) 397674(CAMK2D)
CFR: 102506589(CAMK2B) 102512557(CAMK2A) 102521522(CAMK2D) 102522167(CAMK2G)
CDK: 105089916(CAMK2D) 105092345(CAMK2B) 105092453(CAMK2G) 105098484(CAMK2A)
BACU: 102999844(CAMK2G) 103003341(CAMK2B) 103012734(CAMK2D) 103018247(CAMK2A)
LVE: 103072903(CAMK2G) 103075213(CAMK2B) 103081366(CAMK2A) 103088458(CAMK2D)
OOR: 101269181(CAMK2D) 101271879(CAMK2A) 101281498(CAMK2G) 101287513(CAMK2B)
DLE: 111183091(CAMK2A) 111183530(CAMK2G) 111184516(CAMK2B) 111186068(CAMK2D)
PCAD: 102980540(CAMK2B) 102988954(CAMK2D) 102994812(CAMK2G) 102995187(CAMK2A)
ECB: 100064138(CAMK2G) 100071654(CAMK2A) 100072618(CAMK2D) 100146368(CAMK2B)
EPZ: 103549121(CAMK2A) 103549465(CAMK2G) 103549616(CAMK2D) 103554952(CAMK2B)
EAI: 106822866(CAMK2B) 106838495(CAMK2A) 106843233(CAMK2D) 106843543(CAMK2G)
MYB: 102252254(CAMK2D) 102257317(CAMK2A) 102260966(CAMK2B) 102262365(CAMK2G)
MYD: 102764742(CAMK2A) 102765684(CAMK2D) 102773049(CAMK2G)
MNA: 107527851(CAMK2D) 107535228(CAMK2A) 107542053(CAMK2B) 107545830(CAMK2G)
HAI: 109372542(CAMK2G) 109373019(CAMK2B) 109375001(CAMK2A) 109390284(CAMK2D)
DRO: 112305463(CAMK2G) 112306861(CAMK2B) 112312435(CAMK2D) 112319561(CAMK2A)
PALE: 102880869(CAMK2D) 102888385(CAMK2A) 102888982(CAMK2B) 102896030(CAMK2G)
RAY: 107497167(CAMK2A) 107498266(CAMK2G) 107510894(CAMK2D) 107512385(CAMK2B)
MJV: 108385398(CAMK2A) 108394027(CAMK2B) 108398760(CAMK2G) 108400883
LAV: 100653927(CAMK2G) 100658516(CAMK2B) 100663321(CAMK2D) 104846071(CAMK2A)
MDO: 100010898(CAMK2G) 100011784(CAMK2D) 100024521(CAMK2B) 100028973(CAMK2A)
SHR: 100913975(CAMK2D) 100916233(CAMK2G) 100918427(CAMK2B) 100934917(CAMK2A)
PCW: 110192850(CAMK2A) 110206572(CAMK2B) 110218623(CAMK2D) 110221437(CAMK2G)
OAA: 100074083(CAMK2D) 100079279(CAMK2A) 100089453(CAMK2G) 100089905(CAMK2B)
GGA: 374174(CAMK2B) 374175(CAMK2A) 422688(CAMK2D) 423737(CAMK2G)
MGP: 100541354(CAMK2D) 100541823(CAMK2G) 100546125(CAMK2B) 100550458(CAMK2A)
CJO: 107313595(CAMK2D) 107315812(CAMK2G) 107320147(CAMK2A) 107323605(CAMK2B)
NMEL: 110387161(CAMK2B) 110397346(CAMK2D) 110399309(CAMK2G) 110405364(CAMK2A)
APLA: 101801648(CAMK2D) 101802786 101804017(CAMK2G)
ACYG: 106032824(CAMK2A) 106033089(CAMK2G) 106038617(CAMK2D)
TGU: 100219415(CAMK2D) 100220435(CAMK2A) 100226008(CAMK2G) 100228031(CAMK2B)
LSR: 110471178(CAMK2D) 110478273(CAMK2B) 110480733(CAMK2G) 110482768(CAMK2A)
SCAN: 103813998(CAMK2G) 103815714(CAMK2D) 103817304(CAMK2A) 103822722(CAMK2B)
GFR: 102031855(CAMK2D) 102036854(CAMK2G) 102040653(CAMK2A) 102041076(CAMK2B)
FAB: 101806876(CAMK2D) 101810626(CAMK2A) 101812759(CAMK2G) 101817363(CAMK2B)
PHI: 102104310(CAMK2B) 102104633(CAMK2G) 102108054(CAMK2D) 102112061(CAMK2A)
PMAJ: 107203083(CAMK2D) 107206815(CAMK2G) 107210746(CAMK2A) 107213806
CCAE: 111928996(CAMK2D) 111931070(CAMK2G) 111935541(CAMK2A) 111945916
CCW: 104683185(CAMK2B) 104689694(CAMK2A) 104696844(CAMK2D) 104697948(CAMK2G)
ETL: 114058136(CAMK2G) 114063195(CAMK2A) 114069625(CAMK2D) 114071691(CAMK2B)
FPG: 101914593(CAMK2D) 101915367(CAMK2G) 101918953(CAMK2A) 101923748(CAMK2B)
FCH: 102051471(CAMK2D) 102052104(CAMK2A) 102057655(CAMK2G)
CLV: 102083707(CAMK2B) 102086515(CAMK2G) 102090258(CAMK2D) 102095946(CAMK2A)
EGZ: 104123272(CAMK2A) 104129105(CAMK2G) 104135961
NNI: 104014199(CAMK2A) 104016939(CAMK2G) 104019154(CAMK2D) 104022609(CAMK2B)
ACUN: 113479615(CAMK2D) 113481572(CAMK2G) 113485161(CAMK2A)
PADL: 103915611(CAMK2G) 103915821(CAMK2A) 103926125(CAMK2D)
AAM: 106491995(CAMK2D) 106493448(CAMK2A) 106494574(CAMK2B) 106498878(CAMK2G)
ASN: 102369083(CAMK2B) 102372048(CAMK2A) 102376749(CAMK2G) 102382581(CAMK2D)
AMJ: 102562159(CAMK2G) 102564631(CAMK2B) 102570318(CAMK2D) 106736808(CAMK2A)
PSS: 102445881(CAMK2D) 102452528(CAMK2G) 102461772(CAMK2A)
CMY: 102932986(CAMK2B) 102935217(CAMK2D) 102935773(CAMK2G) 102938664(CAMK2A)
CPIC: 101933671(CAMK2B) 101939367(CAMK2A) 101952653(CAMK2D) 101952899(CAMK2G)
ACS: 100552004(camk2d) 100554504(camk2b) 100562492(camk2g) 100563784(camk2a)
PVT: 110077789(CAMK2G) 110083899 110084335(CAMK2B) 110086082(CAMK2A)
PBI: 103054335(CAMK2A) 103062746(CAMK2B) 103063596 103065234(CAMK2G)
PMUR: 107286231(CAMK2B) 107286689(CAMK2D) 107290559 107293182
TSR: 106544195(CAMK2G) 106547696(CAMK2B) 106547763(CAMK2A) 106557171
PMUA: 114585935 114591346(CAMK2A) 114597036(CAMK2G) 114604777(CAMK2D)
GJA: 107110299 107117391(CAMK2B) 107122036 107123332(CAMK2A)
XLA: 108696257 108712641 380508(camk2g.S) 397789(camk2b.L) 398376 399160(camk2d.S) 399284(camk2a.S)
XTR: 100101771(camk2a) 100135023(camk2d) 100135711(camk2g) 780379(camk2b)
NPR: 108785601(CAMK2B) 108785806(CAMK2A) 108798063 108804479(CAMK2G)
DRE: 436815(camk2d2) 445208(camk2d1) 550436(camk2a) 562064(camk2b1) 791855(camk2g1) 793359(camk2g2) 798222(camk2b)
IPU: 108255499 108260541 108263497(camk2g) 108267517(camk2d1) 108273829 108277079(camk2b) 108278566(CAMK2A)
LCM: 102346458(CAMK2G) 102360076 102360263(CAMK2B) 102361646(CAMK2A)
CMK: 103180901(camk2d) 103181591(camk2g) 103188234(camk2a) 103190417
RTP: 109912036 109922295(camk2d)
CIN: 100181678
APLC: 110977564
SKO: 100371971(CAMK2D)
DME: Dmel_CG18069(CaMKII)
DER: 6555827
DSE: 6620107
DSI: Dsimw501_GD28701(Dsim_GD28701)
DAN: 6505477
DSR: 110185473
DPE: 6602545
DMN: 108164456
DWI: 6651093
DAZ: 108617865
DNV: 108655409
DHE: 111598041
DVI: 6636205
MDE: 101888482
LCQ: 111680369
AAG: 5578710
AALB: 109428414
AME: 551691(Camkii)
BIM: 100745387
BTER: 100648089
CCAL: 108623622
OBB: 114880753
SOC: 105205626
AEC: 105148855
ACEP: 105625869
PBAR: 105433286
VEM: 105560165
HST: 105185279
DQU: 106742123
CFO: 105254953
LHU: 105669204
PGC: 109859326
OBO: 105281406
PCF: 106784523
NVI: 100122555
CSOL: 105364037
MDL: 103575949
TCA: 655266
DPA: 109534487
ATD: 109596600
NVL: 108561165
BMOR: 100462731(CaMKII)
BMAN: 114249291
PMAC: 106715049
PRAP: 110999070
HAW: 110375303
TNL: 113502491
PXY: 105391166
API: 100161639
DNX: 107171609
AGS: 114127462
RMD: 113556511
BTAB: 109043856
CLEC: 106663853
ZNE: 110832661
FCD: 110842877
TUT: 107359488
DPTE: 113790681
CEL: CELE_K11E8.1(unc-43)
CBR: CBG04391(Cbr-unc-43)
BMY: Bm1_37225
TSP: Tsp_02594
PCAN: 112574878
CRG: 105341112
MYI: 110448224
OBI: 106874089
LAK: 106174951
SHX: MS3_01904
EGL: EGR_06207
SPAR: SPRG_14823
 » show all
Reference
  Authors
Illario M, Cavallo AL, Bayer KU, Di Matola T, Fenzi G, Rossi G, Vitale M
  Title
Calcium/calmodulin-dependent protein kinase II binds to Raf-1 and modulates integrin-stimulated ERK activation.
  Journal
J Biol Chem 278:45101-8 (2003)
DOI:10.1074/jbc.M305355200
  Sequence
[hsa:815]
Reference
PMID:2543961
  Authors
Hanley RM, Payne ME, Cruzalegui F, Christenson MA, Means AR
  Title
Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain.
  Journal
Nucleic Acids Res 17:3992 (1989)
DOI:10.1093/nar/17.10.3992
  Sequence
[mmu:12322]
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