KEGG   NETWORK: N01072
Entry
N01072                      Network                                

Name
ITGA/B-RhoGEF-RhoA signaling pathway
Definition
FN1 -> (ITGA+ITGB) -> PTK2 -> ARHGEF28 -> RHOA
  Expanded
2335 -> ((3672,3673,3674,3675,3676,3678,3679,8516,3680,8515,22801,3685)+(3688,3690,3691,3693,3694,3695,3696)) -> 5747 -> 64283 -> 387
Class
nt06135 Cytoskeletal regulation (viruses and bacteria)
Type
Reference
Gene
2335  FN1; fibronectin 1
3672  ITGA1; integrin subunit alpha 1
3673  ITGA2; integrin subunit alpha 2
3674  ITGA2B; integrin subunit alpha 2b
3675  ITGA3; integrin subunit alpha 3
3676  ITGA4; integrin subunit alpha 4
3678  ITGA5; integrin subunit alpha 5
3679  ITGA7; integrin subunit alpha 7
8516  ITGA8; integrin subunit alpha 8
3680  ITGA9; integrin subunit alpha 9
8515  ITGA10; integrin subunit alpha 10
22801  ITGA11; integrin subunit alpha 11
3685  ITGAV; integrin subunit alpha V
3688  ITGB1; integrin subunit beta 1
3690  ITGB3; integrin subunit beta 3
3691  ITGB4; integrin subunit beta 4
3693  ITGB5; integrin subunit beta 5
3694  ITGB6; integrin subunit beta 6
3695  ITGB7; integrin subunit beta 7
3696  ITGB8; integrin subunit beta 8
5747  PTK2; protein tyrosine kinase 2
64283  ARHGEF28; Rho guanine nucleotide exchange factor 28
387  RHOA; ras homolog family member A
Reference
  Authors
Lim Y, Lim ST, Tomar A, Gardel M, Bernard-Trifilo JA, Chen XL, Uryu SA, Canete-Soler R, Zhai J, Lin H, Schlaepfer WW, Nalbant P, Bokoch G, Ilic D, Waterman-Storer C, Schlaepfer DD
  Title
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility.
  Journal
J Cell Biol 180:187-203 (2008)
DOI:10.1083/jcb.200708194
Reference
  Authors
Tomar A, Schlaepfer DD
  Title
Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility.
  Journal
Curr Opin Cell Biol 21:676-83 (2009)
DOI:10.1016/j.ceb.2009.05.006
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