KEGG   DRUG: OlanzapineHelp
Entry
D00454                      Drug                                   

Name
Olanzapine (JAN/USAN/INN);
Zyprexa (TN)
Product
  Generic
OLANZAPINE (A-S Medication Solutions), OLANZAPINE (A-S Medication Solutions), OLANZAPINE (ACETRIS HEALTH), OLANZAPINE (Ajanta Pharma Limited), OLANZAPINE (Ajanta Pharma Limited), OLANZAPINE (American Health Packaging), OLANZAPINE (American Health Packaging), OLANZAPINE (American Regent), OLANZAPINE (Aphena Pharma Solutions - Tennessee), OLANZAPINE (Apotex Corp.), OLANZAPINE (Apotex Corp.), OLANZAPINE (Ascend Laboratories), OLANZAPINE (Aurobindo Pharma Limited), OLANZAPINE (Aurobindo Pharma Limited), OLANZAPINE (AvPAK), OLANZAPINE (AvPAK), OLANZAPINE (Avera McKennan Hospital), OLANZAPINE (Bryant Ranch Prepack), OLANZAPINE (Bryant Ranch Prepack), OLANZAPINE (Bryant Ranch Prepack), OLANZAPINE (Bryant Ranch Prepack), OLANZAPINE (Cardinal Health), OLANZAPINE (Cardinal Health), OLANZAPINE (Clinical Solutions Wholesale), OLANZAPINE (Clinical Solutions Wholesale), OLANZAPINE (Clinical Solutions Wholesale), OLANZAPINE (Contract Pharmacy Services-PA), OLANZAPINE (Contract Pharmacy Services-PA), OLANZAPINE (Dispensing Solutions), OLANZAPINE (Dispensing Solutions), OLANZAPINE (Dr. Reddy's Laboratories), OLANZAPINE (Dr. Reddy's Laboratories), OLANZAPINE (Dr. Reddy's Laboratories), OLANZAPINE (Dr.Reddy's Laboratories Limited), OLANZAPINE (Jiangsu Hansoh Pharmaceutical Group), OLANZAPINE (Jubilant Cadista Pharmaceuticals), OLANZAPINE (Lake Erie Medical DBA Quality Care Products LLC), OLANZAPINE (Lake Erie Medical DBA Quality Care Products LLC), OLANZAPINE (Macleods Pharmaceuticals Limited), OLANZAPINE (Macleods Pharmaceuticals Limited), OLANZAPINE (Major Pharmaceuticals), OLANZAPINE (Major Pharmaceuticals), OLANZAPINE (Major Pharmaceuticals), OLANZAPINE (Mylan Institutional), OLANZAPINE (Mylan Pharmaceuticals), OLANZAPINE (NCS HealthCare of KY), OLANZAPINE (NCS HealthCare of KY), OLANZAPINE (NCS HealthCare of KY), OLANZAPINE (Par Pharmaceutical), OLANZAPINE (Prasco Laboratories), OLANZAPINE (Prasco Laboratories), OLANZAPINE (Preferred Pharmaceuticals), OLANZAPINE (Proficient Rx LP), OLANZAPINE (Proficient Rx LP), OLANZAPINE (Proficient Rx LP), OLANZAPINE (Proficient Rx LP), OLANZAPINE (Proficient Rx LP), OLANZAPINE (Proficient Rx LP), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (REMEDYREPACK), OLANZAPINE (RPK Pharmaceuticals), OLANZAPINE (Rebel Distributors Corp), OLANZAPINE (Rebel Distributors Corp), OLANZAPINE (Rebel Distributors Corp), OLANZAPINE (Sandoz), OLANZAPINE (Sandoz), OLANZAPINE (Sunshine Lake Pharma), OLANZAPINE (TYA Pharmaceuticals), OLANZAPINE (TYA Pharmaceuticals), OLANZAPINE (TYA Pharmaceuticals), OLANZAPINE (TYA Pharmaceuticals), OLANZAPINE (TYA Pharmaceuticals), OLANZAPINE (TYA Pharmaceuticals), OLANZAPINE (Teva Pharmaceuticals USA), OLANZAPINE (Teva Pharmaceuticals USA), OLANZAPINE (Teva Pharmaceuticals USA), OLANZAPINE (Torrent Pharmaceuticals Limited), OLANZAPINE (Virtus Pharmaceuticals)
Formula
C17H20N4S
Exact mass
312.1409
Mol weight
312.4325
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
  DG01475  Dopamine D3-receptor antagonist
  DG01476  Dopamine D4-receptor antagonist
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Enzyme substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
Remark
Same as: C07322
Therapeutic category: 1179 2391
ATC code: N05AH03
Chemical structure group: DG00898
Product (DG00898): D00454<JP/US> D06623<US>
Product (mixture): D10206<US>
Efficacy
Antipsychotic
  Disease
Schizophrenia [DS:H01649]
Bipolar I disorder, manic or mixed episodes [DS:H01653]
Comment
Multi-acting-receptor-targeting-antipsychotics (MARTA)
Target
HTR2 [HSA:3356 3357 3358] [KO:K04157]
HTR6 [HSA:3362] [KO:K04162]
HRH1 [HSA:3269] [KO:K04149]
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
DRD2 [HSA:1813] [KO:K04145]
DRD3 [HSA:1814] [KO:K04146]
DRD4 [HSA:1815] [KO:K04147]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544]; CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
map07117  Benzodiazepine family
map07211  Serotonin receptor agonists/antagonists
map07213  Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AH Diazepines, oxazepines and thiazepines
     N05AH03 Olanzapine
      D00454  Olanzapine (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antipsychotics
  2nd Generation/Atypical
   Olanzapine
    D00454  Olanzapine (JAN/USAN/INN)
 Bipolar Agents
  Bipolar Agents, Other
   Olanzapine
    D00454  Olanzapine (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00454  Olanzapine (JAN/USAN/INN)
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2391  Antiemetics
     D00454  Olanzapine (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D00454  Olanzapine (JAN/USAN/INN) <JP/US>
   Dopamine
    DRD2
     D00454  Olanzapine (JAN/USAN/INN) <JP/US>
    DRD3
     D00454  Olanzapine (JAN/USAN/INN) <JP/US>
    DRD4
     D00454  Olanzapine (JAN/USAN/INN) <JP/US>
   Histamine
    HRH1
     D00454  Olanzapine (JAN/USAN/INN) <JP/US>
   Serotonin
    HTR2
     D00454  Olanzapine (JAN/USAN/INN) <JP/US>
    HTR6
     D00454  Olanzapine (JAN/USAN/INN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D00454
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00454
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00454
BRITE hierarchy
Other DBs
CAS: 132539-06-1
PubChem: 7847520
ChEBI: 7735
ChEMBL: CHEMBL715
DrugBank: DB00334
LigandBox: D00454
NIKKAJI: J489.991A
LinkDB All DBs
KCF data Show

ATOM        22
            1   C8y C    18.4919  -10.5513
            2   C8y C    17.6483   -9.4316
            3   C8y C    17.9905   -8.0673
            4   N4x N    19.2617   -7.4901
            5   N5x N    19.9065  -10.5817
            6   C8y C    20.5211   -8.1208
            7   C8y C    20.8046   -9.4994
            8   S2x S    16.7987   -7.3203
            9   C8y C    15.7200   -8.2230
            10  C8x C    16.2450   -9.4575
            11  C1a C    14.3803   -7.9003
            12  N1y N    17.7660  -11.7484
            13  C8x C    22.1331   -9.9409
            14  C8x C    23.1798   -9.0111
            15  C8x C    22.8963   -7.6326
            16  C8x C    21.5678   -7.1910
            17  C1x C    16.3806  -11.7887
            18  C1x C    15.7162  -13.0210
            19  N1y N    16.4511  -14.2126
            20  C1x C    17.8365  -14.2422
            21  C1x C    18.5010  -12.9400
            22  C1a C    15.7566  -15.4262
BOND        25
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 2
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 1
            9     8   9 1
            10    9  10 2
            11    2  10 1
            12    9  11 1
            13    1  12 1
            14    7  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18    6  16 2
            19   12  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   12  21 1
            25   19  22 1

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