KEGG   DRUG: Imipramine pamoate
Entry
D08071                      Drug                                   

Name
Imipramine pamoate (USP);
Imipramine embonate;
Tofranil-pm (TN)
Product
  Generic
Formula
(C19H24N2)2. C23H16O6
Exact mass
948.4826
Mol weight
949.1841
Structure
Class
Neuropsychiatric agent
 DG01730  Non-selective monoamine reuptake inhibitor
 DG01728  Tricyclic antidepressant
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01639  CYP2C19 substrate
 DG01644  CYP2D6 substrate
 DG02913  CYP3A4 substrate
Remark
ATC code: N06AA02
Chemical structure group: DG00928
Product (DG00928): D00815<JP/US> D08071<US>
Efficacy
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI)
  Disease
Depression [DS:H01646]
Comment
Active form of prodrug: Desipramine [DR:D07791]
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]; CYP1A2 [HSA:1544], CYP3A4 [HSA:1576], CYP2C19 [HSA:1557]
Interaction
Structure map
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA02 Imipramine
      D08071  Imipramine pamoate (USP) <US>
USP drug classification [BR:br08302]
 Antidepressants
  Tricyclics
   Imipramine
    D08071  Imipramine pamoate (USP)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D08071  Imipramine pamoate (USP) <US>
    SLC6A4 (HTT)
     D08071  Imipramine pamoate (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08071
Prodrugs [br08324.html]
 DG00928
Other DBs
CAS: 10075-24-8
PubChem: 96024762
ChEMBL: CHEMBL3989845
LigandBox: D08071
NIKKAJI: J245.438F
LinkDB
KCF data

ATOM        71
            1   C1x C    19.6700  -22.5400
            2   C8y C    18.8300  -21.4200
            3   C8y C    19.1800  -20.0200
            4   N1y N    20.4400  -19.4600
            5   C1x C    21.0700  -22.5400
            6   C8y C    21.7000  -20.0900
            7   C8y C    21.9800  -21.4900
            8   C8x C    18.1300  -19.0400
            9   C8x C    16.8000  -19.4600
            10  C8x C    16.4500  -20.7900
            11  C8x C    17.5000  -21.8400
            12  C8x C    23.3100  -21.9100
            13  C8x C    24.3600  -21.0000
            14  C8x C    24.0800  -19.5300
            15  C8x C    22.7500  -19.1100
            16  C1b C    20.4400  -18.0600
            17  C1b C    21.6300  -17.3600
            18  C1b C    22.8200  -18.0600
            19  N1c N    24.0800  -17.4300
            20  C1a C    25.2700  -18.1300
            21  C1a C    24.0800  -16.0300
            22  C8x C    29.6800  -20.6500
            23  C8x C    29.6800  -21.9800
            24  C8x C    30.8700  -22.6800
            25  C8x C    32.0600  -21.9800
            26  C8y C    32.0600  -20.6500
            27  C8y C    30.8700  -19.9500
            28  C8y C    33.2500  -19.9500
            29  C8y C    33.2500  -18.5500
            30  C8y C    32.0600  -17.9200
            31  C8x C    30.8700  -18.5500
            32  C1b C    35.0700  -20.7900
            33  C8y C    36.6800  -19.9500
            34  C8y C    37.8700  -20.6500
            35  C8y C    39.0600  -19.9500
            36  C8x C    39.0600  -18.5500
            37  C8y C    37.8700  -17.9200
            38  C8y C    36.6800  -18.6200
            39  C8x C    37.8700  -21.9800
            40  C8x C    39.0600  -22.6800
            41  C8x C    40.2500  -21.9800
            42  C8x C    40.2500  -20.6500
            43  C6a C    32.0600  -16.5200
            44  O6a O    33.2500  -15.8200
            45  O6a O    30.8700  -15.8200
            46  C6a C    37.8700  -16.5200
            47  O6a O    36.6800  -15.8200
            48  O6a O    39.0600  -15.8200
            49  O1a O    34.4400  -17.9200
            50  O1a O    35.4900  -17.9200
            51  C1x C    19.6700  -22.5400
            52  C1x C    21.0700  -22.5400
            53  C8y C    21.9800  -21.4900
            54  C8y C    21.7000  -20.0900
            55  N1y N    20.4400  -19.4600
            56  C8y C    19.1800  -20.0200
            57  C8y C    18.8300  -21.4200
            58  C8x C    17.5000  -21.8400
            59  C8x C    16.4500  -20.7900
            60  C8x C    16.8000  -19.4600
            61  C8x C    18.1300  -19.0400
            62  C1b C    20.4400  -18.0600
            63  C1b C    21.6300  -17.3600
            64  C1b C    22.8200  -18.0600
            65  N1c N    24.0800  -17.4300
            66  C1a C    25.2700  -18.1300
            67  C1a C    24.0800  -16.0300
            68  C8x C    22.7500  -19.1100
            69  C8x C    24.0800  -19.5300
            70  C8x C    24.3600  -21.0000
            71  C8x C    23.3100  -21.9100
BOND        78
            1    22  23 2
            2    23  24 1
            3    24  25 2
            4    25  26 1
            5    26  27 2
            6    22  27 1
            7    26  28 1
            8    28  29 2
            9    29  30 1
            10   30  31 2
            11   27  31 1
            12   28  32 1
            13   32  33 1
            14   33  34 1
            15   34  35 2
            16   35  36 1
            17   36  37 2
            18   37  38 1
            19   33  38 2
            20   34  39 1
            21   39  40 2
            22   40  41 1
            23   41  42 2
            24   35  42 1
            25   30  43 1
            26   43  44 2
            27   43  45 1
            28   37  46 1
            29   46  47 2
            30   46  48 1
            31   29  49 1
            32   38  50 1
            33    3   4 1
            34    1   5 1
            35    4   6 1
            36    2   3 1
            37    5   7 1
            38    1   2 1
            39    6   7 1
            40    3   8 2
            41    8   9 1
            42    9  10 2
            43   10  11 1
            44    2  11 2
            45    7  12 2
            46   12  13 1
            47   13  14 2
            48   14  15 1
            49    6  15 2
            50    4  16 1
            51   16  17 1
            52   17  18 1
            53   18  19 1
            54   19  20 1
            55   19  21 1
            56   56  55 1
            57   51  52 1
            58   55  54 1
            59   57  56 1
            60   52  53 1
            61   51  57 1
            62   54  53 1
            63   56  61 2
            64   61  60 1
            65   60  59 2
            66   59  58 1
            67   57  58 2
            68   53  71 2
            69   71  70 1
            70   70  69 2
            71   69  68 1
            72   54  68 2
            73   55  62 1
            74   62  63 1
            75   63  64 1
            76   64  65 1
            77   65  66 1
            78   65  67 1
BRACKET     1    15.0500  -23.1000   15.0500  -15.2600
            1    26.9500  -15.2600   26.9500  -23.1000
            1  2
 ORIGINAL  1    1   5   7   6   4   3   2  11  10   9   8  16  17  18  19  20
            1   21  15  14  13  12
 REPEAT    1   51  52  53  54  55  56  57  58  59  60  61  62  63  64  65  66
            1   67  68  69  70  71

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