KEGG   DRUG: Lenvatinib mesylate
Entry
D09920                      Drug                                   
Name
Lenvatinib mesylate (USAN);
Lenvatinib mesilate (JAN);
Lenvima (TN)
Product
LENVIMA (Eisai)
Formula
C21H19ClN4O4. CH4SO3
Exact mass
522.0976
Mol weight
522.9586
Structure
Simcomp
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Transporter substrate
 DG01665  ABCB1 substrate
Remark
Therapeutic category: 4291
ATC code: L01EX08
Chemical structure group: DG01362
Product (DG01362): D09920<JP/US>
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
  Disease
Thyroid cancer [DS:H00032]
Renal cell carcinoma [DS:H00021]
Hepatocellular carcinoma [DS:H00048]
Endometrial cancer [DS:H00026]
Target
VEGFR1 (FLT1) [HSA:2321] [KO:K05096]
VEGFR2 (KDR) [HSA:3791] [KO:K05098]
VEGFR3 (FLT4) [HSA:2324] [KO:K05097]
FGFR [HSA:2260 2263 2261 2264] [KO:K04362 K05093 K05094 K05095]
RET [HSA:5979] [KO:K05126]
  Pathway
hsa04010  MAPK signaling pathway
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer
hsa05216  Thyroid cancer
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Transporter: ABCB1 [HSA:5243]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01E PROTEIN KINASE INHIBITORS
    L01EX Other protein kinase inhibitors
     L01EX08 Lenvatinib
      D09920  Lenvatinib mesylate (USAN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Lenvatinib
    D09920  Lenvatinib mesylate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D09920  Lenvatinib mesylate (USAN); Lenvatinib mesilate (JAN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG01362  Lenvatinib
     D09920  Lenvatinib mesylate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG01362  Lenvatinib
    D09920  Lenvatinib mesylate
 Transporter substrate
  DG01665  ABCB1 substrate
   DG01362  Lenvatinib
    D09920  Lenvatinib mesylate
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   FGFR family
    FGFR
     D09920  Lenvatinib mesylate (USAN) <JP/US>
   VEGFR family
    VEGFR1 (FLT1)
     D09920  Lenvatinib mesylate (USAN) <JP/US>
    VEGFR2 (KDR)
     D09920  Lenvatinib mesylate (USAN) <JP/US>
    VEGFR3 (FLT4)
     D09920  Lenvatinib mesylate (USAN) <JP/US>
   RET family
    RET
     D09920  Lenvatinib mesylate (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09920
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09920
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09920
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09920
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09920
 Drug transporters
  D09920
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG01362  Lenvatinib
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG01362  Lenvatinib
 Transporter substrate
  DG01665  ABCB1 substrate
   DG01362  Lenvatinib
Other DBs
CAS: 857890-39-2
PubChem: 135626657
ChEBI: 85995
LigandBox: D09920
LinkDB
KCF data

ATOM        35
            1   C8y C    12.8800  -22.4700
            2   C8y C    12.8800  -23.8700
            3   C8x C    14.1400  -24.5700
            4   C8y C    15.3300  -23.8700
            5   C8y C    15.3300  -22.4700
            6   C8x C    14.1400  -21.7700
            7   C8y C    16.5200  -24.5700
            8   C8x C    17.7800  -23.8700
            9   C8x C    17.7800  -22.4700
            10  N5x N    16.5200  -21.7700
            11  O2a O    16.5200  -25.9700
            12  C8y C    17.7800  -26.6700
            13  C8x C    17.7800  -28.0700
            14  C8y C    18.9700  -28.7700
            15  C8y C    20.1600  -28.0700
            16  C8x C    20.1600  -26.6700
            17  C8x C    18.9700  -25.9700
            18  O2a O    11.6900  -21.7700
            19  C5a C    11.6900  -24.5700
            20  N1a N    10.5000  -23.8700
            21  O5a O    11.6900  -25.9700
            22  X   Cl   18.9700  -30.1700
            23  N1b N    21.4200  -28.7700
            24  C5a C    22.6100  -28.0700
            25  N1b N    23.8000  -28.7700
            26  O5a O    22.6100  -26.6700
            27  C1a C    10.5000  -22.4000
            28  C1y C    24.9900  -28.0700
            29  C1x C    26.3900  -28.0700
            30  C1x C    25.6900  -26.8100
            31  C1a C    21.2100  -23.1700
            32  S4a S    22.6100  -23.1700
            33  O1d O    24.0100  -23.1700
            34  O1d O    22.6100  -21.7700
            35  O1d O    22.6100  -24.5700
BOND        37
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    7  11 1
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   12  17 1
            20    1  18 1
            21    2  19 1
            22   19  20 1
            23   19  21 2
            24   14  22 1
            25   15  23 1
            26   23  24 1
            27   24  25 1
            28   24  26 2
            29   18  27 1
            30   25  28 1
            31   28  29 1
            32   28  30 1
            33   30  29 1
            34   31  32 1
            35   32  33 1
            36   32  34 2
            37   32  35 2

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