Entry
Name
homogentisate 1,2-dioxygenase;
homogentisicase;
homogentisate oxygenase;
homogentisate dioxygenase;
homogentisate oxidase;
homogentisic acid oxidase;
homogentisic acid oxygenase;
homogentisic oxygenase;
homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
homogentisate:oxygen 1,2-oxidoreductase (ring-opening)
Reaction(IUBMB)
homogentisate + O2 = 4-maleylacetoacetate [RN:
R02519 ]
Reaction(KEGG)
Substrate
Product
4-maleylacetoacetate [CPD:
C01036 ]
Comment
Requires Fe2+.
History
EC 1.13.11.5 created 1961 as EC 1.99.2.5, transferred 1965 to EC 1.13.1.5, transferred 1972 to EC 1.13.11.5
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K00451 homogentisate 1,2-dioxygenase
Genes
OAA : 100086427 114817468(HGD)
STOW : 125437077(HGD) 125437081
SANH : 107663684 107666642
CCAR : 109088610 109095912
CAUA : 113042450 113066221
CGIB : 127946596 128013516
MASI : 127432043 127434355
MSAM : 119908883(hgd) 119911736
OMY : 110489574 110536580(hgd)
OMM : 135517141 135523181(hgd)
OCLA : 139366912 139420669
SALP : 111973385 112069460(hgd)
CCLU : 121549899 121569338
ARUT : 117405197 117972906
LERI : 129695143 129702531(hgd)
LPIC : 129258871 129258873
PFLL : 139142844 139142851
DSI : Dsimw501_GD23768(Dsim_GD23768)
AALB : 109405872 109407208
PPYR : 116179161 116179263
PPOI : 119114693 119114696
CSCU : 111631667 111631676
LPOL : 106469027 106473344
CBR : CBG_12429(Cbr-hgo-1)
MAEA : 128237368 128238556
LLON : 135488045 135488756
CSAT : 104725929 104729209 104761434
MINC : 123195723 123202176 123206139
GMX : 100779961(HGO2) 100801346(HGO1)
CILL : 122280501 122288875
SSPL : 121768464 121769793
PSOM : 113287515 113308157
TAES : 123088644 123151102 123164099
MFLO : 136527218 136534987
PVIR : 120671449 120702315
ACAK : 137951183 137960563 137960611 137960630
SMO : SELMODRAFT_151052 SELMODRAFT_267178
SLB : AWJ20_2760 AWJ20_4026
NTE : NEUTE1DRAFT131902(NEUTE1DRAFT_131902)
SMP : 10807342(SMAC4_00712)
PAN : PODANSg100 PODANSg2853
PBEL : QC761_121290 QC761_403440
PPSD : QC762_121290 QC762_403440
PPSP : QC763_121290 QC763_403440
PPSA : QC764_121290 QC764_403440
RTHE : 98126620(VTJ83DRAFT_5382)
PPEI : PpBr36_08738 PpBr36_10021
TMN : UCRPA7_1112 UCRPA7_2142
SSCK : SPSK_00790 SPSK_02446
FGR : FGSG_02347 FGSG_06450 FGSG_08358
FPU : FPSE_03776 FPSE_08970
FPOA : FPOAC1_002454 FPOAC1_004447
FVN : FVRRES_02743 FVRRES_04955 FVRRES_11110
FVR : FVEG_02332 FVEG_03311 FVEG_04413 FVEG_09414
FOX : FOXG_03463 FOXG_04831 FOXG_10758 FOXG_19494
NHE : NECHADRAFT_32303 NECHADRAFT_40957 NECHADRAFT_46144 NECHADRAFT_67097 NECHADRAFT_94705 NECHADRAFT_97663
FFC : NCS54_00223200 NCS54_00374300 NCS54_00749800 NCS54_00866100 NCS54_01415900
FKR : NCS57_00218500 NCS57_00791300 NCS57_00908100 NCS57_01397600
FMU : J7337_005008 J7337_006228 J7337_006452 J7337_008673
TATV : 25781682(TrAtP1_008515) 25786300(TrAtP1_005500)
TASP : 36617862(TrAFT101_002891)
MAW : 19245855(J3458_000867) 19246444(J3458_012988) 19249157(J3458_019787)
MAJ : MAA_00833 MAA_02383 MAA_06959
MBRN : 26239979(hmgA_0) 26243032(hmgA_1) 26246394(hgd)
PCHM : VFPPC_01270 VFPPC_08542
AMUS : LMH87_002195 LMH87_011314
PLJ : 28882318(PLICBS_001645) 28884765(PLICBS_005977)
PTKZ : JDV02_008598 JDV02_009807
VAL : VDBG_07081 VDBG_08479 VDBG_09166 VDBG_09257
VDA : VDAG_06721 VDAG_07316 VDAG_07414 VDAG_08144
CFJ : CFIO01_03520 CFIO01_05396 CFIO01_07806 CFIO01_08037
CLUP : CLUP02_04833 CLUP02_15116 CLUP02_16612 CLUP02_18155
CHIG : CH63R_00313 CH63R_04716 CH63R_06442 CH63R_13631
CDET : 87939009(CDEST_02506) 87941785(CDEST_05282) 87947210(CDEST_10710) 87947820(CDEST_11320)
SAPO : SAPIO_CDS10917 SAPIO_CDS1219 SAPIO_CDS5012 SAPIO_CDS6382 SAPIO_CDS6861 SAPIO_CDS6868
ELA : UCREL1_2812 UCREL1_7100 UCREL1_8075
PFY : PFICI_01705 PFICI_04567 PFICI_04610 PFICI_05682 PFICI_07598 PFICI_15239
PSCO : LY89DRAFT_573869 LY89DRAFT_611135 LY89DRAFT_656190 LY89DRAFT_688794 LY89DRAFT_689015 LY89DRAFT_701440 LY89DRAFT_719797
GLZ : GLAREA_00182 GLAREA_01457 GLAREA_02218
ANI : ANIA_01897 ANIA_04012 ANIA_06390
AFM : AFUA_2G04220 AFUA_6G10810
ACT : ACLA_084540 ACLA_090310
NFI : NFIA_056580 NFIA_081010
AOR : AO090003000210 AO090012000156
ANG : An01g02960 An11g00430 An11g02180
AFV : AFLA_001483 AFLA_001867
ALUC : AKAW2_20464A AKAW2_80046A AKAW2_80190S
ACHE : ACHE_80519S ACHE_80819A
APUU : APUU_21177A APUU_40341A APUU_51366S
PCS : N7525_001661 N7525_006312
PDP : PDIP_36330 PDIP_39100
TMF : EYB26_001651 EYB26_002021 EYB26_006366 EYB26_008212
TRG : TRUGW13939_00537 TRUGW13939_00897 TRUGW13939_05264 TRUGW13939_05729 TRUGW13939_10127
CPW : 9691344(D8B26_001866)
PNO : SNOG_04149 SNOG_06876 SNOG_15060
PTE : PTT_06607 PTT_17327 PTT_19145
PTRR : 6340251(PtrM4_012410) 6345953(PtrM4_139940) 6349700(PtrM4_000790)
BZE : COCCADRAFT_101645 COCCADRAFT_38639 COCCADRAFT_97519
BSC : COCSADRAFT_119584 COCSADRAFT_202103 COCSADRAFT_41925
BOR : COCMIDRAFT_34972 COCMIDRAFT_35017 COCMIDRAFT_8872 COCMIDRAFT_98703
AALT : CC77DRAFT_1043610 CC77DRAFT_1067544 CC77DRAFT_932428
ADAC : 96087360(ACET3X_007038) 96089840(ACET3X_009518) 96090039(ACET3X_009717)
ARAB : EKO05_0001614 EKO05_0006629
PFJ : MYCFIDRAFT_148993 MYCFIDRAFT_30146 MYCFIDRAFT_37377
FFU : CLAFUR5_01625 CLAFUR5_06809 CLAFUR5_07308
CBET : CB0940_00723 CB0940_09148
BCOM : BAUCODRAFT_172492 BAUCODRAFT_188715 BAUCODRAFT_72326
NPA : UCRNP2_10214 UCRNP2_1358 UCRNP2_61
TASA : A1Q1_01421 A1Q1_06335
CCAC : CcaHIS019_0111860(CcaverHIS019_0111860) CcaHIS019_0212070(CcaverHIS019_0212070)
TVS : TRAVEDRAFT_124955 TRAVEDRAFT_20432
PCO : PHACADRAFT_201465 PHACADRAFT_206661 PHACADRAFT_251625 PHACADRAFT_251627 PHACADRAFT_251631 PHACADRAFT_258050 PHACADRAFT_95803
HIR : HETIRDRAFT_157104(hmga1)
ADL : AURDEDRAFT_158980 AURDEDRAFT_158981
ABP : AGABI1DRAFT60983(AGABI1DRAFT_60983) AGABI1DRAFT76664(AGABI1DRAFT_76664)
ABV : AGABI2DRAFT200921(AGABI2DRAFT_200921) AGABI2DRAFT227930(AGABI2DRAFT_227930)
SGRA : EX895_001521 EX895_001903
PTM : GSPATT00008167001 GSPATT00011843001
SPAR : SPRG_01675 SPRG_05357
XPH : XppCFBP6546_09490(hmgA)
XHD : LMG31886_05020(hmgA)
LEZ : GLE_4302(hmgA) GLE_5298(hmgA)
LYA : RDV84_07075(hmgA) RDV84_11545(hmgA)
LLZ : LYB30171_02347(hmgA)
DJI : CH75_00600 CH75_23680
VPG : LZI70_13815 LZI70_19300
PAEB : NCGM1900_4478(hmgA)
PVD : CFBP1590__3431(hmgA)
PPRC : PFLCHA0_c09830(hmgA)
PMUD : NCTC8068_00968(hmgA)
PFW : PF1751_v1c09830(hmgA)
PPUU : PputUW4_00825(hmgA)
PKC : PKB_4442(homogentisate_1)
PBZ : GN234_02870 GN234_23520
PTRT : HU722_0006350(hmgA)
PTW : TUM18999_36980(hmgA)
PTAE : NCTC10697_03596(hmgA)
PKH : JLK41_08870 JLK41_09310
SCAA : TUM17387_23050(hmgA)
GAG : Glaag_2943 Glaag_3477
PMES : FX988_01240 FX988_01799
SALH : HMF8227_00846(hmgA)
LLG : 44548918_00993(hmgA)
LJR : NCTC11533_01176(hmgA)
LCJ : NCTC11976_01954(hmgA)
LWA : SAMEA4504053_1479(hmgA)
LSS : NCTC12082_00264(hmgA)
LADL : NCTC12735_00688(hmgA)
LANT : TUM19329_15970(hmgA)
RHEI : ATY27_04565 ATY27_12375
GAI : IMCC3135_20580(hmgA)
HAAH : HALA3H3_470012(hmgA)
AEL : NCTC12917_02474(hmgA)
RNC : GO999_17540 GO999_24250
CNC : CNE_2c16640(hmgA) CNE_BB2p00950
BMV : BMASAVP1_A0856(hmgA)
BML : BMA10229_A2688(hmgA)
BPM : BURPS1710b_3228(hmgA)
BPL : BURPS1106A_3213(hmgA)
BCEN : DM39_631(hmgA) DM39_6327
BUQ : AC233_02690 AC233_21040
BURT : BTHE68_05150(hmgA_1) BTHE68_57970 BTHE68_62650(hmgA_2)
BXE : Bxe_A2725 Bxe_A3900 Bxe_C0994 Bxe_C1025
BXB : DR64_1576(hmgA) DR64_408(hmgA) DR64_7427(hmgA) DR64_7457(hmgA)
BGE : BC1002_0545 BC1002_4182
BUZ : AYM40_02690 AYM40_11890 AYM40_12010
PSPW : BJG93_10175(hmgA) BJG93_23965(hmgA)
PHS : C2L64_14550 C2L64_23690 C2L64_23775 C2L64_49110
PTER : C2L65_12580 C2L65_26795 C2L65_26880
PACP : FAZ97_02705 FAZ97_21760
PPAI : E1956_00080 E1956_33600
PLG : NCTC10937_01910(hmgA)
BUE : BRPE67_ACDS05070(hmgA)
TVL : FAZ95_18170 FAZ95_29525
BTRM : SAMEA390648701819(hmgA)
ADY : HLG70_00725(hmgA) HLG70_25990(hmgA)
PUS : CKA81_00540 CKA81_10420
CDN : BN940_02501 BN940_02506
PIG : EGT29_12160 EGT29_27510 EGT29_28040
RHF : EUB48_13380 EUB48_20855
VPE : Varpa_0299 Varpa_3814
VAZ : H7F35_13575 H7F35_29010
COF : FOZ74_13235 FOZ74_14980
MLIR : LPB04_14255 LPB04_17395
URU : DSM104443_03474(hmgA)
UPL : DSM104440_02992(hmgA)
MESU : LHFGNBLO_004523(hmgA)
SMEL : SM2011_c03208(hmgA)
SFD : USDA257_c54130(hmgA)
SAME : SAMCFNEI73_Ch3371(hmgA)
REC : RHECIAT_CH0001827(hmgA)
REL : REMIM1_CH01787(hmgA)
REP : IE4803_CH01766(hmgA)
REI : IE4771_CH01818(hmgA)
RHL : LPU83_pLPU83d0038(hmgA)
RGA : RGR602_PC00750(hmgA)
RPHA : AMC79_CH01800(hmgA)
RHID : FFM81_012345 FFM81_027515
RLW : RlegWSM1455_07870(hmgA)
NPM : QEO92_18810(hmgA) QEO92_33075(hmgA)
BSEP : HAP48_0013645(hmgA)
BCAN : BcanWSM471_02520(hmgA)
VGO : GJW-30_1_01001(hmgA)
MAQU : Maq22A_c05975(hmgA)
MIND : mvi_01060(hmgA_1) mvi_47110(hmgA_2)
CHEL : AL346_18215 AL346_23590
CDQ : BOQ54_10175 BOQ54_19110
PHR : C6569_03260 C6569_06030
RLI : RLO149_c008120(hmgA)
PHP : PhaeoP97_00274(hmgA)
PPIC : PhaeoP14_03009(hmgA)
SINL : DSM14862_02990(hmgA)
SULP : AADW22_16680(hmgA) AADW22_18205(hmgA)
SPSE : SULPSESMR1_02733(hmgA)
AHT : ANTHELSMS3_02401(hmgA)
LALG : LentiSH36_00908(hmgA)
ACLD : ACIRQ6_02440(hmgA) ACIRQ6_14570(hmgA)
LVS : LOKVESSMR4R_00432(hmgA)
YRH : AABB31_00450(hmgA) AABB31_11105(hmgA)
GYJ : AADW23_09305(hmgA) AADW23_16865(hmgA)
AALK : LGT41_0002105(hmgA)
SPHD : HY78_04905 HY78_22015
SBIN : SBA_ch1_11320(hmgA)
SCH : Sphch_0441 Sphch_3305 Sphch_3716
SPAG : sphantq_02153(hmgA)
AZL : AZL_024670(hmgA) AZL_d04870(hmgA)
ALI : AZOLI_2566 AZOLI_p40081(hmgA)
ATI : AL072_06600 AL072_23070
AHU : A6A40_10195 A6A40_25900
AZM : DM194_09595 DM194_23730
AZZ : DEW08_07765 DEW08_20280
AOZ : HUE56_06105 HUE56_12290
AZS : E6C72_02325 E6C72_25585
AZP : E6C67_00455 E6C67_25575
TII : DY252_04675 DY252_18970
THAI : IT893_02420 IT893_16150
TLU : R1T41_04665 R1T41_11020(hmgA)
TTB : MACH01_04900(hmgA) MACH01_31750
THGO : M9H61_10405(hmgA) M9H61_17225
SCL : sce4892(hgo) sce5980
SCU : SCE1572_19485 SCE1572_35540
MRM : A7982_01352 A7982_12505
GEP : Q9293_02400 Q9293_02410
FOK : KK2020170_05720(hmgA)
PHG : KCTC32516_00506(hmgA)
AALG : AREALGSMS7_02133(hmgA)
AANR : KCTC52924_00764(hmgA)
FAY : Q4Q34_05915 Q4Q34_10755
KOS : KORDIASMS9_00876(hmgA)
KAN : IMCC3317_31320(hmgA)
SPON : HME9304_02092(hmgA)
FBU : UJ101_00093(HGD|hmgA)
PTAN : CRYO30217_00118(hmgA)
PCAY : FRD00_16220 FRD00_23665
BDA : FSZ17_10760 FSZ17_12110
PASA : BAOM_0797 BAOM_0884 BAOM_4377
MAVM : MAA44156_00671(hmgA)
MSER : MTY59_02230(hmgA) MTY59_18930(hmgA)
MDX : BTO20_12715 BTO20_24865
MFJ : MFLOJ_19930(hmgA_1) MFLOJ_57000(hmgA_2)
MSTO : MSTO_22270(hmgA_1) MSTO_59900(hmgA_2)
MSAK : MSAS_17300(hmgA_1) MSAS_50790(hmgA_2)
MHEK : JMUB5695_03493(hmgA)
MKY : IWGMT90018_15310(hmgA_1) IWGMT90018_44930(hmgA_2)
MPHL : MPHLCCUG_01762(hmgA)
MTHN : 4412656_01360 4412656_03935
MAUB : MAUB_05750(hmgA_1) MAUB_14600(hmgA_2)
MPHU : MPHO_06970(hmgA_1) MPHO_56650(hmgA_2)
MMUC : C1S78_014855 C1S78_019000
MMAT : MMAGJ_16070(hmgA_1) MMAGJ_50100(hmgA_2)
MBOK : MBOE_42670(hmgA_1) MBOE_54370(hmgA_2)
ROA : Pd630_LPD06498 Pd630_LPD12068
RRT : 4535765_00669 4535765_04485(hmgA)
RCR : NCTC10994_02055 NCTC10994_02930
RKO : JWS14_12040 JWS14_45925
ROZ : CBI38_22715 CBI38_26755 CBI38_32010
RHOJ : JVH1_25730 JVH1_38320
RHJS : OYT95_27115 OYT95_42910
GTA : BCM27_06725 BCM27_24545
GJI : H1R19_01040 H1R19_22570
SPIN : KV203_02790 KV203_11955
SSX : SACTE_1151 SACTE_6245
STRP : F750_1523 F750_7027
STRE : GZL_00573 GZL_06819
SAMB : SAM23877_1773(hmgA)
SLE : sle_54030(sle_54030)
SCLF : BB341_23335 BB341_30145
SKY : D0C37_00565 D0C37_27550
SGM : GCM10017557_65570(hmgA)
SDX : C4B68_01885 C4B68_02070 C4B68_32000
SAQU : EJC51_11435 EJC51_42805
STUI : GCM10017668_13010(hmgA)
SPEU : CGZ69_05780 CGZ69_07135
SANU : K7396_28320(hmgA) K7396_33900
SGOB : test1122_01690(hmgA)
SDEC : L3078_09830(hmgA) L3078_44205
SRUG : F0345_01115 F0345_04640
SAKB : K1J60_00640 K1J60_35670(hmgA)
SVIO : HWN34_00415 HWN34_25820
SCAE : IHE65_01770 IHE65_35755(hmgA)
SXT : KPP03845_101945(hmgA)
STUD : STRTU_003718 STRTU_005688(hmgA)
SYUN : MOV08_02235 MOV08_31810(hmgA)
SARG : HKX69_27555(hmgA) HKX69_35030
SLUO : PS467_10275(hmgA) PS467_35230
SCHE : QRN89_00300 QRN89_06715(hmgA)
SGLY : P8A20_29370(hmgA) P8A20_37665
STRV : EZV63_03765 EZV63_06795(hmgA)
ARTP : E5206_13675 E5206_14425
NAQU : ENKNEFLB_04097(hmgA)
NFC : KG111_00775 KG111_03965
NOCL : KM427_04530 KM427_20370
SAIU : J4H86_20460 J4H86_24415
AGRA : AGRA3207_001951 AGRA3207_003754 AGRA3207_004983 AGRA3207_005030 AGRA3207_005283
AMAZ : LUW76_23225 LUW76_25680
SPIQ : OHA34_21860 OHA34_27450
SVI : Svir_07000 Svir_18910
AACD : LWP59_06205 LWP59_14370(hmgA)
ATHM : L1857_12660 L1857_17400(hmgA)
ARHD : VSH64_10335 VSH64_37895
ACYN : ORV05_13615 ORV05_20910(hmgA) ORV05_26910
PSEE : FRP1_17230 FRP1_28410
PSEH : XF36_15965 XF36_28950
PSEQ : AD006_07585 AD006_24685
PECQ : AD017_04275 AD017_15400
PBRO : HOP40_08550 HOP40_21325 HOP40_21825
KUT : JJ691_65480(hmgA_1) JJ691_76360(hmgA_2)
MSAG : GCM10017556_20820(hmgA)
ACTR : Asp14428_51650(hmgA)
EKE : EK0264_09525 EK0264_12230
BALA : DSM104299_01744(hmgA) DSM104299_04055
LEPV : J4558_10645 J4558_24195
» show all
Taxonomy
Reference
Authors
Adachi K, Iwayama Y, Tanioka H, Takeda Y.
Title
Purification and properties of homogentisate oxygenase from Pseudomonas fluorescens.
Journal
Reference
Authors
CRANDALL DI, HALIKIS DN.
Title
Homogentisic acid oxidase. I. Distribution in animal tissue and relation to tyrosine metabolism in rat kidney.
Journal
J Biol Chem 208:629-38 (1954)
Reference
3
Authors
Hayaishi O.
Title
Direct oxygenation by O2, oxygenases.
Journal
In: Boyer PD, Lardy H, Myrback K (eds). The Enzymes. 2nd ed. Vol. 8. New York: Academic Press; 1963. p. 353-371.
Reference
Authors
KITA H, KAMIMOTO M, SENOH S, ADACHI T, TAKEDA Y.
Title
CRYSTALLIZATION AND SOME PROPERTIES OF 3,4-DIHYDROXYPHENYLACETATE-2,3-OXYGENASE.
Journal
Reference
Authors
KNOX WE, EDWARDS SW.
Title
Homogentisate oxidase of liver.
Journal
J Biol Chem 216:479-87 (1955)
Reference
Authors
RAVDIN RG, CRANDALL DI.
Title
The enzymatic conversion of homogentisic acid to 4-fumarylacetoacetic acid.
Journal
J Biol Chem 189:137-49 (1951)
Other DBs
ExPASy - ENZYME nomenclature database: 1.13.11.5
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.5
LinkDB
All DBs