KEGG   ORTHOLOGY: K05085
Entry
K05085                      KO                                     
Symbol
ERBB4, HER4
Name
receptor tyrosine-protein kinase erbB-4 [EC:2.7.10.1]
Pathway
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04020  Calcium signaling pathway
map04151  PI3K-Akt signaling pathway
map05014  Amyotrophic lateral sclerosis
map05205  Proteoglycans in cancer
Disease
H00058  Amyotrophic lateral sclerosis (ALS)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4
   04012 ErbB signaling pathway
    K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4
   04020 Calcium signaling pathway
    K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4
   04151 PI3K-Akt signaling pathway
    K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4
Genes
HSA: 2066(ERBB4)
PTR: 459919(ERBB4)
PPS: 100996186(ERBB4)
GGO: 101131773(ERBB4)
PON: 100938677(ERBB4)
NLE: 100598496(ERBB4)
MCC: 693341(ERBB4)
MCF: 102141308(ERBB4)
MTHB: 126932508
CSAB: 103217777(ERBB4)
CATY: 105580144(ERBB4)
PANU: 100998445(ERBB4)
TGE: 112636548(ERBB4)
RRO: 104658903(ERBB4)
RBB: 108517585(ERBB4)
TFN: 117094169
PTEH: 111548039(ERBB4)
CANG: 105504791(ERBB4)
CJC: 100402965(ERBB4)
SBQ: 101049355(ERBB4)
CSYR: 103260440(ERBB4)
MMUR: 105862314(ERBB4)
LCAT: 123643488(ERBB4)
PCOQ: 105823921(ERBB4)
OGA: 100950688(ERBB4)
MMU: 13869(Erbb4)
MCAL: 110312376(Erbb4)
MPAH: 110321248(Erbb4)
RNO: 59323(Erbb4)
MCOC: 116088530(Erbb4)
CGE: 100760475
MAUA: 101831481(Erbb4)
PLEU: 114693631(Erbb4)
MORG: 121433401(Erbb4)
MFOT: 126508767
AAMP: 119821978(Erbb4)
NGI: 103744489(Erbb4)
HGL: 101725806(Erbb4)
CPOC: 100724678(Erbb4)
DORD: 105982090(Erbb4)
DSP: 122107486(Erbb4)
NCAR: 124979980
OCU: 100009328
OPI: 101534591(ERBB4)
TUP: 102482008(ERBB4)
CFA: 488508(ERBB4)
CLUD: 112656400(ERBB4)
VVP: 112922459(ERBB4)
VLG: 121480598(ERBB4)
AML: 100470612(ERBB4)
UMR: 103659965(ERBB4)
UAH: 113250501(ERBB4)
UAR: 123798269(ERBB4)
ELK: 111138855
LLV: 125095556
MPUF: 101672764(ERBB4)
ORO: 101371484
EJU: 114215947(ERBB4)
ZCA: 113920155(ERBB4)
MLX: 118012082(ERBB4)
NSU: 110592019(ERBB4)
LWW: 102747863(ERBB4)
FCA: 101100073(ERBB4)
PYU: 121031014(ERBB4)
PBG: 122481727(ERBB4)
LRUF: 124514153
PTG: 102950188(ERBB4)
PPAD: 109265121(ERBB4)
AJU: 106974147(ERBB4)
HHV: 120245818(ERBB4)
BTA: 522419(ERBB4)
BOM: 102265783(ERBB4)
BBUB: 102400549(ERBB4)
BBIS: 105003731(ERBB4)
CHX: 102180167(ERBB4)
OAS: 101103044(ERBB4)
ODA: 120854102
CCAD: 122426466(ERBB4)
SSC: 100525789(ERBB4)
CFR: 102522654(ERBB4)
CBAI: 105072941(ERBB4)
CDK: 105099620(ERBB4)
VPC: 102544772(ERBB4)
BACU: 103004826(ERBB4)
LVE: 103078350(ERBB4)
OOR: 101278439(ERBB4)
DLE: 111171792(ERBB4)
PCAD: 102975726(ERBB4)
PSIU: 116756965(ERBB4)
ECB: 100050182(ERBB4)
EPZ: 103558743
EAI: 106837675(ERBB4)
MYB: 102241613(ERBB4)
MYD: 102765674(ERBB4)
MMYO: 118661478(ERBB4)
MLF: 102442922(ERBB4)
MNA: 107524731(ERBB4)
PKL: 118709193(ERBB4)
HAI: 109390432(ERBB4)
DRO: 112307700(ERBB4)
SHON: 118984230(ERBB4)
AJM: 119044331(ERBB4)
PDIC: 114494770(ERBB4)
PHAS: 123828079(ERBB4)
MMF: 118625188(ERBB4)
RFQ: 117026370(ERBB4)
PALE: 102895574(ERBB4)
PGIG: 120587606
PVP: 105291094(ERBB4)
RAY: 107517636(ERBB4)
MJV: 108400921
TOD: 119255187(ERBB4)
SARA: 101557114(ERBB4)
LAV: 100656755(ERBB4)
TMU: 101360755
ETF: 101652176(ERBB4)
DNM: 101441399
MDO: 100014865(ERBB4)
GAS: 123242724(ERBB4)
SHR: 100931663(ERBB4)
PCW: 110223279(ERBB4)
OAA: 100077353(ERBB4)
GGA: 395671(ERBB4)
PCOC: 116235913(ERBB4)
MGP: 100539508(ERBB4)
CJO: 107316482(ERBB4)
NMEL: 110399647(ERBB4)
APLA: 101801144(ERBB4)
ACYG: 106034472(ERBB4)
AFUL: 116490568(ERBB4)
TGU: 100231016(ERBB4)
LSR: 110478436(ERBB4)
SCAN: 103814752(ERBB4)
PMOA: 120511492(ERBB4)
OTC: 121339684(ERBB4)
PRUF: 121364430(ERBB4)
GFR: 102045033(ERBB4)
FAB: 101808540(ERBB4)
PHI: 102113512(ERBB4)
PMAJ: 107207560(ERBB4)
CCAE: 111931698 111931870(ERBB4)
CCW: 104694541(ERBB4)
CBRC: 103624346(ERBB4)
ETL: 114062626(ERBB4)
ZAB: 102064627(ERBB4)
FPG: 101910610(ERBB4)
FCH: 102046664(ERBB4)
CLV: 102091363(ERBB4)
EGZ: 104124291(ERBB4)
NNI: 104010094(ERBB4)
ACUN: 113482047(ERBB4)
TALA: 104359725(ERBB4)
PADL: 103921667(ERBB4)
AFOR: 103900412(ERBB4)
ACHC: 115342928(ERBB4)
HLE: 104841538(ERBB4)
AGEN: 126042224
GCL: 127018190
CCRI: 104159093(ERBB4)
OHA: 104339193
DPUB: 104302703(ERBB4)
PGUU: 104461678(ERBB4)
CPEA: 104388112(ERBB4)
CVF: 104288743(ERBB4)
CUCA: 104067404(ERBB4)
TEO: 104383971(ERBB4)
AAM: 106492330(ERBB4)
AROW: 112976707(ERBB4)
NPD: 112955177(ERBB4)
TGT: 104580883
DNE: 112979245(ERBB4)
SCAM: 104153020(ERBB4)
ASN: 102387680(ERBB4)
AMJ: 102559834(ERBB4)
CPOO: 109322736(ERBB4)
GGN: 109301656(ERBB4)
CMY: 102939092(ERBB4)
CPIC: 101941047(ERBB4)
TST: 117885003(ERBB4)
CABI: 116837850(ERBB4)
MRV: 120374435(ERBB4)
ACS: 100558986(erbb4)
PVT: 110072384(ERBB4)
SUND: 121919152(ERBB4)
PBI: 103055996(ERBB4)
PMUR: 107301863(ERBB4)
CTIG: 120318875(ERBB4)
PGUT: 117675245(ERBB4)
VKO: 123024389(ERBB4)
PMUA: 114583404(ERBB4)
ZVI: 118096713(ERBB4)
GJA: 107120657(ERBB4)
STOW: 125425852(ERBB4)
XLA: 108703039 724070(erbb4.L)
XTR: 100493234(erbb4)
NPR: 108792763(ERBB4)
RTEM: 120944427(ERBB4)
BBUF: 121007601(ERBB4)
BGAR: 122944375(ERBB4)
DRE: 100007677(erbb4a) 101885162(si:ch73-383l1.1) 569836(erbb4b)
CCAR: 109052551
PPRM: 120460532(si:ch73-383l1.1) 120460557(erbb4a) 120461608(erbb4b)
MAMB: 125270579(erbb4b) 125272833(si:ch73-383l1.1) 125272835(erbb4a)
TFD: 113648904 113649035(erbb4a)
AMEX: 103033543(erbb4) 103038099
EEE: 113579187(erbb4) 113579192
TRU: 101074687 101079286(erbb4)
LCO: 104928902 104929362(erbb4)
NCC: 104953634(erbb4)
ELY: 117249751 117250770(erbb4b)
PLEP: 121949565(erbb4b) 121963010
ESP: 116673917(erbb4) 116698166
PFLV: 114550836 114563973(erbb4)
GAT: 120825010(si:ch73-383l1.1) 120833897
MSAM: 119903962(erbb4b) 119904608
MZE: 101467929(erbb4) 101478875
OAU: 116312076 116332215(si:ch73-383l1.1)
OLA: 101165111(erbb4) 101165379
OML: 112155138 112156664(si:ch73-383l1.1)
XMA: 102230380(erbb4) 102231767
XCO: 114140872(erbb4) 114148479
XHE: 116716082(erbb4) 116723227
PRET: 103461563 103476823(erbb4)
PLAI: 106948936(erbb4) 106956630
PMEI: 106918512(erbb4) 106923420
CVG: 107084231 107088040(erbb4)
NWH: 119418845(erbb4b) 119429101
CSEM: 103389576(erbb4) 103392212
POV: 109631409(erbb4)
SLAL: 111662725 111665293(erbb4)
HCQ: 109528703(erbb4) 109531201
BPEC: 110156208 110170911(erbb4)
MALB: 109968758(erbb4)
OTW: 112224855 112238881 112240957(si:ch73-383l1.1)
ONE: 115111274
SALP: 112068952
SFM: 108922269 108928922(erbb4)
LOC: 102686973(erbb4)
PSEX: 120530767
LCM: 102360220(ERBB4)
RTP: 109923881
CIN: 778964
SKO: 100313534
 » show all
Reference
PMID:8383326
  Authors
Plowman GD, Culouscou JM, Whitney GS, Green JM, Carlton GW, Foy L, Neubauer MG, Shoyab M
  Title
Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.
  Journal
Proc Natl Acad Sci U S A 90:1746-50 (1993)
DOI:10.1073/pnas.90.5.1746
  Sequence
[hsa:2066]
Reference
  Authors
Holbro T, Hynes NE.
  Title
ErbB receptors: directing key signaling networks throughout life.
  Journal
Annu Rev Pharmacol Toxicol 44:195-217 (2004)
DOI:10.1146/annurev.pharmtox.44.101802.121440
Reference
  Authors
Citri A, Yarden Y.
  Title
EGF-ERBB signalling: towards the systems level.
  Journal
Nat Rev Mol Cell Biol 7:505-16 (2006)
DOI:10.1038/nrm1962
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