KEGG   ORTHOLOGY: K05783
Entry
K05783                      KO                                     
Symbol
benD-xylL
Name
dihydroxycyclohexadiene carboxylate dehydrogenase [EC:1.3.1.25 1.3.1.-]
Pathway
map00362  Benzoate degradation
map00364  Fluorobenzoate degradation
map00622  Xylene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00551  Benzoate degradation, benzoate => catechol / methylbenzoate => methylcatechol
Reaction
R00813  (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)
R05292  cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)
R05293  cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NADP+ oxidoreductase (decarboxylating)
R05309  1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate:NAD+ oxidoreductase (decarboxylating)
R05314  1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating)
R08111  3-fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate:NAD+oxidoreductase (decarboxylating)
R08112  5-fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate:NAD+oxidoreductase (decarboxylating)
R08113  4-fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate:NAD+oxidoreductase (decarboxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K05783  benD-xylL; dihydroxycyclohexadiene carboxylate dehydrogenase
   00364 Fluorobenzoate degradation
    K05783  benD-xylL; dihydroxycyclohexadiene carboxylate dehydrogenase
   00622 Xylene degradation
    K05783  benD-xylL; dihydroxycyclohexadiene carboxylate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.25  1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
     K05783  benD-xylL; dihydroxycyclohexadiene carboxylate dehydrogenase
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K05783
Other DBs
COG: COG1028
GO: 0047116
Genes
EFE: EFER_1485(benD)
KPN: KPN_01869
KPU: KP1_2934
KPM: KPHS_28390
KPP: A79E_2376
KPH: KPNIH24_14210(benD)
KPZ: KPNIH27_13570(benD)
KPV: KPNIH29_14240(benD)
KPW: KPNIH30_14505(benD)
KPY: KPNIH31_13520(benD)
KPG: KPNIH32_14400(benD)
KPC: KPNIH10_14040(benD)
KPQ: KPR0928_14020(benD)
KPT: VK055_0615
KPO: KPN2242_12265(benD)
KPR: KPR_2933(benD)
KPJ: N559_2421
KPI: D364_09585(benD)
KPA: KPNJ1_02608
KPS: KPNJ2_02563
KPX: PMK1_04210(lvr)
KPB: FH42_05420(benD)
KPNE: KU54_012115(benD)
KPNU: LI86_12050(benD)
KPNK: BN49_2969(benD)
KVA: Kvar_2435
KPE: KPK_2488(cbeD)
KPK: A593_24210(benD)
KVD: KR75_22145(benD)
KVQ: SP68_02890(benD)
KOC: AB185_22235(benD)
KQU: AVR78_18380(benD)
EAE: EAE_19880(benD)
EAR: CCG29904
KQV: B8P98_13160(benD)
KAR: LGL98_11655
KGR: JJJ10_14635
KLM: BWI76_13720(benD)
ROR: RORB6_06755(benD)
RON: TE10_13830(benD)
RPLN: B1209_13860(benD)
RAO: DSD31_13375
RTG: NCTC13098_03815(lvr_2)
CSED: JY391_11115
CAF: AL524_15085
CFAR: CI104_13175(benD)
CIR: C2U53_22220(benD)
CTEL: GBC03_17315
EBT: EBL_c18160
PGE: LG71_16210(benD)
BUF: D8682_03275
IZH: FEM41_18110
PSGC: G163CM_11650(lvr)
EBF: D782_2133
EBU: CUC76_01775(benD)
SMW: SMWW4_v1c30600
SMAF: D781_2850
SRZ: AXX16_2219
SERM: CLM71_14595(benD)
SFJ: SAMEA4384070_3090(xecD)
SSUR: ATE40_011850(benD)
SRHZ: FO014_19065
SENP: KHA73_15020
SNEM: NLX84_15360(benD)
SGRI: SGBXF1_03052(xecD)
RBAD: H2866_19745
XSA: SB85_10140(benD)
XRY: QN244_18680
PSD: DSC_14910(benD)
PWI: MWN52_14980
VNA: PN96_18365(benD)
VEJ: VEJY3_17926(benD)
VJP: NP165_16980(benD)
VIB: VspSTUT11_38640(benD)
PAE: PA2515(xylL)
PAEV: N297_2586
PAEI: N296_2586
PAU: PA14_32130(xylL)
PAP: PSPA7_2722(xylL)
PAG: PLES_27801(xylL)
PAF: PAM18_2524(benD)
PNC: NCGM2_3520(benD)
PAEB: NCGM1900_4012(benD)
PDK: PADK2_12670(benD)
PSG: G655_12450(benD)
PRP: M062_13075(benD)
PAEP: PA1S_13070(benD)
PAER: PA1R_gp0309
PAEM: U769_12650(benD)
PAEL: T223_14270(benD)
PAES: SCV20265_2794
PAEU: BN889_02739(benD)
PAEG: AI22_20850(benD)
PAEC: M802_2583
PAEO: M801_2451
SECH: B18_24650
PMK: MDS_4167
PRE: PCA10_30910(benD)
PPSE: BN5_3608(benD)
PFUW: KF707C_15520(bzaB) KF707C_28440
PCQ: PcP3B5_23360(lvr)
PNT: G5B91_12950 G5B91_33240
PPAA: B7D75_12600
PPU: PP_3164(benD)
PPF: Pput_2551
PPG: PputGB1_2685
PPW: PputW619_2707
PPT: PPS_2762
PPB: PPUBIRD1_2569(benD)
PPI: YSA_10652
PPX: T1E_1059(benD)
PPUH: B479_13460(benD)
PPUT: L483_17645(benD)
PPUN: PP4_25400(benD) PP4_48180(benD)
PPUD: DW66_3021
PFV: Psefu_2026
PMON: X969_13160(benD)
PMOT: X970_12805(benD)
PPJ: RK21_01914
PPSL: BJP27_02335(benD)
PALD: LU682_014705
PIX: RIN61_25045
PFL: PFL_3855(xylL)
PPRC: PFLCHA0_c39130(xylL)
PPRO: PPC_3951(benD)
PFE: PSF113_2894(benD)
PFN: HZ99_02920(benD)
PFO: Pfl01_2324 Pfl01_2965(benD)
PMAN: OU5_6167(xylL)
PAZO: AYR47_21845(benD)
PMUD: NCTC8068_02088(xylL)
PFX: A7318_13915(benD)
PEN: PSEEN3140(benD)
PLUL: FOB45_00445
PBA: PSEBR_a2882
PPUU: PputUW4_03254(xylL)
PDR: H681_11365(benD)
PSV: PVLB_12230(benD)
PKC: PKB_2103(xylL)
PCH: EY04_20395(benD)
PCZ: PCL1606_21670
PCP: JM49_10825(benD)
PCHP: C4K32_4170
PFZ: AV641_09800(benD)
PLQ: AA042_19050(benD)
PALK: PSAKL28_52390
PSES: PSCI_4806(benD)
PSEM: TO66_21090(benD)
PPSY: AOC04_06645(benD)
PSOS: POS17_3976(benD)
PFK: PFAS1_22860(benD)
PSET: THL1_2895
PSIL: PMA3_10990(benD)
PYM: AK972_2990
PALL: UYA_06695(benD) UYA_20405(benD)
PUM: HGP31_18590
PPSH: G5J76_17155
PGY: AWU82_15480(benD)
PLAL: FXN65_12620
PEZ: HWQ56_13965
PDW: BV82_2263
PZE: HU754_016970
PSEP: C4K39_5809
PPII: QL104_20245
PTZ: HU718_017520
PSHH: HU773_013520
PANH: HU763_012295
PAZE: KSS91_10650
PORY: EJA05_13820
PWZ: J7655_17885
PTK: EXN22_01370
PTW: TUM18999_29750(xylL)
PTAE: NCTC10697_02700(benD)
PGF: J0G10_14060
PCAV: D3880_08570
PJU: L1P09_13265
PPHN: HU825_11445
PIZ: LAB08_R37340
PSIH: LOY51_13760
PFIT: KJY40_13375
PASI: LG197_19385
PKM: PZ739_13785
PNB: NK667_09060
PSOA: PSm6_53110(xylL)
PTAI: ICN73_19815
PKK: QQ992_13220
PKJ: Q1W70_24410
PHYG: JTY93_12530
PHOM: KJF94_14040
PCHE: QYM18_03975
PCUC: PSH97_17065
PTRL: OU419_12615 OU419_14760
PSJY: AA098_13780(benD)
PSHS: JJN09_12610
PLAU: I0D68_18555
PSNC: C0058_16835(benD)
PFOU: OZ911_14925
PSKP: KU43P_26680(xylL)
PSA: PST_1670(benD)
PSR: PSTAA_1698(benD)
PSC: A458_09170(benD)
PSJ: PSJM300_08880(benD)
PSH: Psest_2696
PSTU: UIB01_13630(benD)
PSED: DM292_11225
PCHL: LLJ08_12930
PBM: CL52_07430(benD)
PKG: LW136_09530
SDEG: GOM96_16690
AVN: Avin_08620(benD)
AVL: AvCA_08620(benD)
AVD: AvCA6_08620(benD)
ACX: Achr_32810(benD)
HPEG: EAO82_00580
PDEN: F1C79_04600
HASM: QAO71_14875(benD)
PBAU: OS670_01855
MHC: MARHY0281(benD)
MAD: HP15_1108
MPQ: ABA45_01255(benD)
MARI: ACP86_12000(benD)
MANP: EHN06_02095
PCR: Pcryo_1264
PSO: PSYCG_06665(benD)
PALI: A3K91_1588
PSPG: AK823_04985
PSYG: AK825_05000
PSYP: E5677_05445
ACB: A1S_1212
ABY: ABAYE2558(benD)
ABC: ACICU_01189
ABN: AB57_1347
ABB: ABBFA_02336(lvr)
ABX: ABK1_1644
ABZ: ABZJ_01348
ABR: ABTJ_02517
ABD: ABTW07_1376
ABH: M3Q_1568
ABAD: ABD1_12210(benD)
ABJ: BJAB07104_01359
ABAB: BJAB0715_01371
ABAJ: BJAB0868_01307
ABAZ: P795_11430
ABK: LX00_05835
ABAU: IX87_04590
ABAA: IX88_08130
ABW: BL01_13775
ABAL: ABLAC_20300
ACC: BDGL_000463(benD)
ANO: RR32_12270
ALC: OTEC02_13000
ACAL: BUM88_05780
ASEI: I8T81_13015
ACD: AOLE_13350(benD)
ACI: ACIAD1439(benD)
ATT: AMQ28_00600
AEI: AOY20_11285
AJO: RZ95_08915
ACW: A0J50_11650
ACV: AMD27_07845
AJN: BVL33_09975
ASOL: BEN76_06765
ASJ: AsACE_CH01477(benD)
AID: CTZ23_07100
ADV: DJ533_10820
ARJ: DOM24_07535
AWU: BEN71_06045
ACUM: C9E88_012210
AGU: AS4_23700(benD)
ALW: FOB21_01940
ADS: FPL17_10305
ABER: BSR55_11570
ATN: FM020_08965
ALJ: G8D99_08475
ATG: J4G44_08925
AVB: RYU24_15340(benD)
ABOU: ACBO_16050(benD)
AGYL: FPL18_02705
AVZ: HWI77_08295
ATZ: M5E07_08995(benD)
APRL: PY247_10070(benD)
AVIV: LF296_04285(benD)
ACIE: KIP84_12180
MOI: MOVS_09455
MNJ: LU290_09610
MHAC: LU276_00910
AMG: AMEC673_15500(benD)
ALR: DS731_05535
CYQ: Q91_2245
CZA: CYCME_2563(benD)
CYY: CPC19_01575
CCAG: SR908_06600(benD)
HAK: KO116_00235
HHU: AR456_17680(benD)
HSI: BOX17_05810(benD)
HHH: CLM76_07040(benD)
HBE: BEI_1519
HPRO: LMS44_22930
HQD: K1Y77_14475
HASO: B2G49_18140(benD)
HCAM: I4484_18800
HAAH: HALA3H3_1060003(benD)
HABD: OM794_22010(benD)
HPIZ: GYM47_16275
HNP: SR894_21530(benD)
APAC: S7S_13320
MME: Marme_1558
MARS: A8C75_10510(benD)
MGEO: CFI10_04840(benD)
MSEC: LN244_11355
MRZ: KDW95_03785
ASIM: FE240_08800
OCE: GU3_01775
OPE: PU634_15430(benD)
ZDF: AN401_00165(benD)
GBI: PG2T_09665
NLN: ORY85_09480
VMS: LVJ82_06055
USU: LVJ78_07365
UTE: LVJ83_07960
PSE: NH8B_1753(benD)
RSC: RCFBP_11859(benD)
RSL: RPSI07_1884(benD)
RSN: RSPO_c01859
RSY: RSUY_19290
RSG: JK151_11745
RPI: Rpic_1367
RPF: Rpic12D_1431
RPJ: N234_27840 N234_37270(benD)
RMN: TK49_11665(benD)
RIN: ACS15_1754
RWE: KOL96_15110
REH: H16_A1960(benD)
CNC: CNE_1c19300(benD)
CUH: BJN34_08575(benD)
REU: Reut_B4406
RME: Rmet_4885(benD)
CBW: RR42_s0554
CCUP: BKK81_23220(benD)
CUP: BKK80_33070(benD)
CUU: BKK79_23955(benD)
CPAU: EHF44_23095
COX: E0W60_20505 E0W60_32235
CUK: KB879_22055
BMA: BMAA0184
BMV: BMASAVP1_1357(benD)
BML: BMA10229_1552(benD)
BMN: BMA10247_A0212(benD)
BMAL: DM55_3534
BMAE: DM78_4623
BMAQ: DM76_4231
BMAI: DM57_14455(benD)
BMAF: DM51_3935
BMAZ: BM44_3496
BMAB: BM45_4332
BPS: BPSS1906(benD)
BPM: BURPS1710b_A1002(benD)
BPL: BURPS1106A_A2584(benD)
BPD: BURPS668_A2728(benD)
BPSE: BDL_5312
BPSM: BBQ_4224
BPSU: BBN_5371
BPSD: BBX_4477
BPZ: BP1026B_II2045(benD)
BPQ: BPC006_II2547
BPK: BBK_4645
BPSH: DR55_5828
BPSA: BBU_4103
BPSO: X996_5626
BUT: X994_5189
BTE: BTH_II0470
BTQ: BTQ_3763
BTJ: BTJ_4794
BTZ: BTL_5580
BTD: BTI_5084
BTV: BTHA_4621
BTHE: BTN_5251
BTHM: BTRA_5521
BTHA: DR62_5380(benD)
BTHL: BG87_5596
BOK: DM82_6196
BOC: BG90_4468
BUU: WS70_27015(benD)
BSAV: WS86_28725(benD)
BHG: I6G56_27550
BUD: AQ610_29995(benD)
BVI: Bcep1808_5828
BVE: AK36_5311
BUR: Bcep18194_C7049
BCM: Bcenmc03_6134
BCH: Bcen2424_6527
BCEN: DM39_5094
BCEW: DM40_5132
BCEO: I35_7537
BAM: Bamb_6581
BAC: BamMC406_6296
BMJ: BMULJ_05284(benD)
BMU: Bmul_3241
BMK: DM80_4620
BMUL: NP80_3313
BCED: DM42_7057
BCEP: APZ15_36345(benD)
BDL: AK34_5715
BPYR: ABD05_32070(benD)
BCON: NL30_37450(benD)
BUB: BW23_4425
BDF: WI26_27680(benD)
BLAT: WK25_16340(benD)
BTEI: WS51_27265(benD)
BSEM: WJ12_16745(benD)
BPSL: WS57_00510(benD)
BMEC: WJ16_18210(benD)
BSTG: WT74_22610(benD)
BSTL: BBJ41_36465(benD)
BARI: NLX30_38100(benD)
BAEN: L3V59_35265
BSER: R0290_32735(benD)
BUG: BC1001_1344
BGO: BM43_5498
BYI: BYI23_D002180
BUK: MYA_5341
BUE: BRPE67_DCDS03930
BUL: BW21_4619
BUQ: AC233_11160
BUM: AXG89_16415(benD)
BUI: AX768_26125(benD)
BURK: DM992_37910
BXE: Bxe_B0912(benD)
BXB: DR64_6233
BPH: Bphy_5349
BGE: BC1002_6177
BPX: BUPH_01851
BPY: Bphyt_1594
BUZ: AYM40_26005(benD)
BCAI: K788_0005752
PSPW: BJG93_32100
PARB: CJU94_35245(benD) CJU94_37920(benD)
PHS: C2L64_29825(benD) C2L64_48515(benD)
PTER: C2L65_18575(benD)
PCJ: CUJ87_08370(benD)
PTS: CUJ90_10080(benD)
PCAF: DSC91_002403
PTRO: G5S35_36180
PGIS: I6I06_20450 I6I06_20465
PACP: FAZ97_31360
PACS: FAZ98_17695
PDIO: PDMSB3_2246.1(benD)
PSAA: QEN71_10475
PKF: RW095_28370(benD)
PPAI: E1956_38610
PLAD: PPGU16_38070(benD)
PWU: A8O14_09090(benD)
PANN: PanNE5_25540(benD)
PANX: OYT13_18585(benD)
CABA: SBC2_79750
BUO: BRPE64_DCDS08510
CABK: NK8_62330(benD)
TVL: FAZ95_35085
TCAR: U0034_22855
BPT: Bpet1396(benD)
BHO: D560_1121
BHM: D558_1108
BTRM: SAMEA390648701944(benD)
AXY: AXYL_01800
AIS: BUW96_17365
ACHR: C2U31_10450(benD)
ACHB: DVB37_15210
ACHO: H4P35_21825
AMUI: PE062_18435
APES: FOC84_03560
AAEG: RA224_23820
AFA: UZ73_17880(benD)
AFQ: AFA_08575(benD)
AAQU: D3M96_09795
AAMM: FE795_07790
ALCN: MID00_18825
OUR: CEQ07_11095
OUE: I6G29_07010
RMK: RAN89_10545(benD)
PNA: Pnap_2109
ACRA: BSY15_1216
ACIQ: ACDW_43960
CSER: CCO03_07070(benD)
CODO: LAD35_11955
ADN: Alide_2649
HPSE: HPF_01835(lvr)
DIH: G7047_12820
SIMP: C6571_19145
JAJ: EKL02_16455
JAS: FJQ89_23180
HSE: Hsero_1311(cbeD)
HSZ: ACP92_06560(benD)
HRB: Hrubri_1137(cbeD)
HHF: E2K99_06475
HFR: G5S34_06740
HEW: HBDW_11900
MASW: AM586_16570(benD)
MVAR: MasN3_08590(benD)
MLIR: LPB04_18845
MALI: EYF70_17200
MUM: FCL38_01220
PLUE: EWM63_24860
TMJ: P0M04_19620(benD)
GLC: JQN73_16180
AON: DEH84_15075
RBU: PG1C_04535
DAR: Daro_2781
DDEN: KI615_11390
TMZ: Tmz1t_3099
THK: CCZ27_03210(benD) CCZ27_16240(benD)
THAG: CKCBHOJB_01554(lvr)
AMIH: CO731_00666(ydaD)
ANJ: AMD1_0688(benD)
PHT: BLM14_21520(benD)
SFH: SFHH103_03581
SFD: USDA257_c54420(benD)
SINO: SS05631_c27060
ESJ: SJ05684_b58660
EAK: EKH55_4347
EGI: PZN02_004568(benD)
STEG: QA637_26185(benD)
EAD: OV14_a1474(fabG2)
EAH: FA04_27030(benD)
ENP: JVX98_05245
AVF: RvVAR031_pl03340(benD)
RHK: Kim5_CH01085(benD)
RSUL: N2599_31260(benD)
ARA: Arad_12206
BBET: F8237_17750
BOS: BSY19_2041
XAU: Xaut_4355
XDI: EZH22_09305
LNE: FZC33_07195
MET: M446_1327
MNO: Mnod_2371
MEE: DA075_16970
MTEA: DK419_08715
MIND: mvi_57260(benD)
RHZ: RHPLAN_59320
RUT: FIU92_22560(novJ)
CMAR: IMCC12053_2583
CEH: CEW89_02920(benD)
CON: TQ29_16490(benD)
SULD: B5M07_19090(benD)
SULB: IV89_003561
RMM: ROSMUCSMR3_03736(lvr)
ROK: RAK1035_2575
ROT: FIV09_19530(ycdF3)
RMAI: MACH21_04310(benD)
PDE: Pden_1180
PCON: B0A89_14340(benD)
PZH: CX676_12390(benD)
PPAN: ESD82_01805
PSAN: HGN31_00295
PALP: JHW40_08100
PFEO: E3U26_15400
TEC: AKL02_003795
LVR: T8T21_16925(benD)
NAR: Saro_0540 Saro_3837
NPP: PP1Y_AT15839 PP1Y_AT31260
NPN: JI59_24685
NRE: BES08_19580(benD)
NOG: GKE62_05255
NDR: HT578_08795
NHUM: PQ457_18340(benD)
SWI: Swit_2636 Swit_5024
SPHD: HY78_12335(benD)
SPHM: G432_15085(benD)
SNAP: PQ455_02565(benD)
SSAG: KV697_00100
SPHR: BSY17_105
SPHT: K426_21224(benD)
SYA: A6768_16780(benD)
SBAR: H5V43_22415
SPAG: sphantq_03331
SPHY: CHN51_07050
BLAS: BSY18_3981
BFW: B5J99_00990(benD)
ALB: AEB_P2434
CNA: AB433_18075
ERY: CP97_14260
RGI: RGI145_20865(benD)
RMUC: FOB66_02980
AZL: AZL_a07370(benD)
AZM: DM194_25860
AZS: E6C72_15470
SMUC: JL100_027665
SROE: JL101_026020
PARH: I5S86_15030
MMAT: MMAGJ_52720(benD)
CGL: Cgl2407(Cgl2407)
CGB: cg2640(benD)
CGU: WA5_2323(BenD)
CGT: cgR_2288
CGS: C624_11685(benD)
CGG: C629_11695(benD)
CGM: cgp_2640(benD)
CGJ: AR0_11525(benD)
CGQ: CGLAR1_11375(benD)
CGX: SB89_11180(benD)
CEF: CE2308
CHN: A605_11140(benD)
CCN: H924_10135(benD)
CMD: B841_10265(benD)
CII: CIMIT_11045(benD)
CMQ: B840_09755(xylL)
CDX: CDES_10945(benD)
CSTA: CSTAT_12750(benD)
CCJZ: ccrud_10715(benD)
CAMG: CAMM_12485(benD)
CSUR: N24_2477(benD)
CCYS: SAMEA4530656_0415(benD)
CYZ: C3B44_09185
CCOE: CETAM_10400(lvr)
COK: COCCU_10780(lvr2)
CPOY: GP475_09410
CHIN: J5O04_00825
CFAC: CFAEC_10595(ycdF)
CATR: CATRI_09855(ycdF)
CGF: CGUA_10475(fabG9)
CSUE: QP029_00475
CBRE: QP027_08665
BFV: C628_11665(benD)
RHA: RHA1_ro02387(benD)
RQI: C1M55_27410(benD)
ROP: ROP_21010(benD)
ROA: Pd630_LPD06583
RPY: Y013_13600(benD)
RBY: CEJ39_00980(benD)
RAV: AAT18_24450(benD)
RRZ: CS378_14030(benD)
RHQ: IM25_04945(benD)
RHOD: AOT96_07380(benD)
RRT: 4535765_04644(benD)
RCR: NCTC10994_02858(benD)
RKO: JWS14_12420
ROZ: CBI38_27130(benD)
RPSK: JWS13_33420
RGOR: NMQ04_19740(benD)
RHOU: KZJ41_25905
RHOW: A4U64_00115(benD)
RHOJ: JVH1_25345
DTM: BJL86_1202
DPC: A6048_05505(benD)
DLU: A6035_05570(benD)
DKN: NHB83_05170
SQZ: FQU76_02750
STSU: B7R87_02845(benD)
SLUO: PS467_07665(benD)
ARU: ASPU41_14625(benD)
ARN: CGK93_10510(benD)
ACRY: AC20117_04985(benD)
ARTP: E5206_02265
AOD: Q8Z05_21375
ARTU: E7Y32_05890
ARTZ: FCN77_12600
PAGO: IRJ34_09825
APN: Asphe3_35130
PSUL: AU252_22710(benD)
PSNI: NIBR502771_06640
PSEY: GU243_07215
PDEL: JCQ34_18045
POK: SMD14_09435
PSLS: KTR40_17835
PSFE: NG819_14460
GLU: F0M17_16120
KPL: KPaMU14_10935(benD)
KFV: AS188_00025(benD)
KRS: EQG70_04345
SATK: SA2016_0099
CCYC: SCMU_25440(benD)
CIG: E7744_08330
PAEY: KUF55_15625
SVI: Svir_19240
ACTY: OG774_03995
SHT: KO02_15975(benD)
FSE: DI487_06970
FAG: K5I29_09300
FAV: LNP19_12820
CSAL: NBC122_01822(ycdF)
CHRC: QGN23_05710
 » show all
Reference
PMID:1740120
  Authors
Neidle E, Hartnett C, Ornston LN, Bairoch A, Rekik M, Harayama S
  Title
cis-diol dehydrogenases encoded by the TOL pWW0 plasmid xylL gene and the Acinetobacter calcoaceticus chromosomal benD gene are members of the short-chain alcohol dehydrogenase superfamily.
  Journal
Eur J Biochem 204:113-20 (1992)
DOI:10.1111/j.1432-1033.1992.tb16612.x
  Sequence
[aci:ACIAD1439]
LinkDB

KEGG   ENZYME: 1.3.1.67
Entry
EC 1.3.1.67                 Enzyme                                 
Name
cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD(P)+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NAD(P)+ = 4-methylcatechol + NAD(P)H + CO2 [RN:R05292 R05293]
Reaction(KEGG)
R05292 R05293
Substrate
cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate [CPD:C06729];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
4-methylcatechol [CPD:C06730];
NADH [CPD:C00004];
NADPH [CPD:C00005];
CO2 [CPD:C00011]
Comment
Involved in the p-xylene degradation pathway in bacteria.
History
EC 1.3.1.67 created 2000
Pathway
ec00622  Xylene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Reference
1  [PMID:3711022]
  Authors
Whited GM, McCombie WR, Kwart LD, Gibson DT.
  Title
Identification of cis-diols as intermediates in the oxidation of aromatic acids by a strain of Pseudomonas putida that contains a TOL plasmid.
  Journal
J Bacteriol 166:1028-39 (1986)
DOI:10.1128/JB.166.3.1028-1039.1986
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.67
IUBMB Enzyme Nomenclature: 1.3.1.67
ExPASy - ENZYME nomenclature database: 1.3.1.67
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.67
BRENDA, the Enzyme Database: 1.3.1.67
LinkDB

KEGG   REACTION: R05292
Entry
R05292                      Reaction                               
Name
cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)
Definition
cis-1,2-Dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NAD+ <=> 4-Methylcatechol + CO2 + NADH + H+
Equation
C06729 + C00003 <=> C06730 + C00011 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00271  C06729_C06730
Enzyme
1.3.1.67
Pathway
rn00622  Xylene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00551  Benzoate degradation, benzoate => catechol / methylbenzoate => methylcatechol
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.67
     R05292  cis-1,2-Dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NAD+ <=> 4-Methylcatechol + CO2 + NADH + H+
Orthology
K05783  dihydroxycyclohexadiene carboxylate dehydrogenase [EC:1.3.1.25 1.3.1.-]
Other DBs
RHEA: 24231
LinkDB

KEGG   REACTION: R05293
Entry
R05293                      Reaction                               
Name
cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NADP+ oxidoreductase (decarboxylating)
Definition
cis-1,2-Dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ <=> 4-Methylcatechol + CO2 + NADPH + H+
Equation
C06729 + C00006 <=> C06730 + C00011 + C00005 + C00080
Reaction class
RC00001  C00005_C00006
RC00271  C06729_C06730
Enzyme
1.3.1.67
Pathway
rn00622  Xylene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.67
     R05293  cis-1,2-Dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ <=> 4-Methylcatechol + CO2 + NADPH + H+
Orthology
K05783  dihydroxycyclohexadiene carboxylate dehydrogenase [EC:1.3.1.25 1.3.1.-]
Other DBs
RHEA: 24227
LinkDB

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