KEGG ORTHOLOGY: K10381

ORTHOLOGY: K10381

Entry

K10381                      KO

Symbol

DSP

Name

desmoplakin

Pathway

map04382

Cornified envelope formation

map04519

Cadherin signaling

map04820

Cytoskeleton in muscle cells

map05412

Arrhythmogenic right ventricular cardiomyopathy

Disease

H00293

Arrhythmogenic right ventricular cardiomyopathy

H00717

Striate palmoplantar keratoderma

H00893

Dilated cardiomyopathy with woolly hair, keratoderma, and tooth agenesis

H01737

Epidermolysis bullosa

H02094

Carvajal syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04519 Cadherin signaling
    K10381  DSP; desmoplakin
09140 Cellular Processes
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    K10381  DSP; desmoplakin
09150 Organismal Systems
  09158 Development and regeneration
   04382 Cornified envelope formation
    K10381  DSP; desmoplakin
09160 Human Diseases
  09166 Cardiovascular disease
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K10381  DSP; desmoplakin
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K10381  DSP; desmoplakin
   04147 Exosome
    K10381  DSP; desmoplakin
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Intermediate filaments
   Intermediate filament-binding proteins
    K10381  DSP; desmoplakin
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K10381  DSP; desmoplakin

Genes

HSA:

1832(DSP)

PTR:	462420(DSP)

PPS:	100975288(DSP)

GGO:	101124337(DSP)

PON:	100442770(DSP)

PPYG:

129038508(DSP)

NLE:	100588753(DSP)

HMH:	116459683(DSP)

SSYN:

129472999(DSP)

MCC:	694860(DSP)

MCF:	102145051(DSP)

MTHB:

126952654

MNI:	105487390(DSP)

CSAB:

103222210(DSP)

CATY:

105572499(DSP)

PANU:

101009732(DSP)

TGE:	112622294(DSP)

MLEU:

105546480(DSP)

RRO:	104676835(DSP)

RBB:	108534318(DSP)

TFN:	117086694(DSP)

PTEH:

111548611(DSP)

CANG:

105526802(DSP)

CJC:	100397847(DSP)

SBQ:	101036202(DSP)

CIMI:

108302985

ANAN:

105708714(DSP)

CSYR:

103270068(DSP)

MMUR:

105865208(DSP)

LCAT:

123638245

ERUF:

138399048(DSP)

PCOQ:

105806478(DSP)

OGA:	100953441(DSP)

MMU:	109620(Dsp)

MCAL:

110307787(Dsp)

MPAH:

110333603(Dsp)

RNO:	306871(Dsp)

MCOC:

116081423(Dsp)

ANU:	117713617(Dsp)

ASYL:

127664927(Dsp)

MUN:	110546334(Dsp)

CGE:	100767947(Dsp)

MAUA:

101826587

PROB:

127229329(Dsp)

PLEU:

114710563

PMAV:

102918938(Dsp)

MORG:

121434153

MFOT:

126501525

AAMP:

119816825

CNL:	130885968(Dsp)

NGI:	103732907(Dsp)

HGL:	101708187(Dsp)

CPOC:

100721053(Dsp)

CCAN:

109692206(Dsp)

DORD:

105985971(Dsp)

DSP:

122114033

DMER:

138828458(Dsp)

PLOP:

NCAR:

MMMA:

ITI:

OCU:

OPI:

OCZ:

TUP:	102472324(DSP)

GVR:	103596455(DSP)

CFA:	488207(DSP)

CLUD:

112658666

VVP:	112920561(DSP)

VLG:

121500007

NPO:	129508185(DSP)

AML:	100481906(DSP)

UMR:

103665148

UAH:	113264429(DSP)

UAR:

123801502

ELK:

111156714

LLV:

125102303

MPUF:

101676103(DSP)

MNP:	132017588(DSP)

MLK:	131834503(DSP)

NVS:

122912595

ORO:	101367962(DSP)

EJU:	114223875(DSP)

ZCA:

113926679

MLX:	118027438(DSP)

MANO:

123837476(DSP)

NSU:

110586592

LWW:	102726320(DSP)

FCA:	101098382(DSP)

PYU:

121020570

PCOO:

112853407(DSP)

PBG:

122489259

PVIV:

125166298(DSP)

LRUF:

124528872

LGF:

123608066

AJU:

106971813

PTG:	102950216(DSP)

PPAD:

109249424(DSP)

PUC:

125939433

PLEZ:

122219589

HHV:

120246789

CCRU:

144236337(DSP)

BTA:	514360(DSP)

BOM:	102286855(DSP)

BIU:	109577228(DSP)

BJV:	133236730(DSP)

BBUB:

102411643

BKE:	129645403(DSP)

BBIS:

104985605(DSP)

CHX:	102175346(DSP) 102181879

OAS:	101119169(DSP)

OCAN:

138425868(DSP)

BTAX:

128056268(DSP)

CSUM:

138097862(DSP)

ODA:

120869991

CCAD:

122429711

MREE:

136151590(DSP)

OVR:	110122213(DSP)

MBEZ:

129543189(DSP)

SSC:	100156744(DSP)

CFR:	102521485(DSP)

CBAI:

105061635(DSP)

CDK:	105100281(DSP)

VPC:	102532225(DSP)

BACU:

103006262(DSP)

BMUS:

118904192

LVE:	103080449(DSP)

OOR:	101285221(DSP)

LALB:

132527733(DSP)

GMF:	115866170(DSP)

DDP:	132432845(DSP)

DLE:	111181341(DSP)

PCAD:

102986031(DSP)

PSIU:

116762563(DSP)

PPHC:

136128755(DSP)

NASI:

112395564(DSP)

ECB:	100061514(DSP)

EPZ:	103549294(DSP)

EAI:

106832090

MYB:	102253798(DSP)

MYD:	102758255(DSP)

MMYO:

118676335

MLF:	102420838(DSP)

MDT:	132230698(DSP)

MYUM:

139003645(DSP)

PKL:

118724485

EFUS:

103298123(DSP)

MNA:	107529112(DSP)

DRO:	112297537(DSP)

SHON:

118986430

AJM:	119063941(DSP)

PDIC:

114496282

PHAS:

123820813

MMF:

118626472

PPAM:

129085525(DSP)

HAI:	109395509(DSP)

RFQ:	117026664(DSP)

PALE:

102879486(DSP)

PGIG:

120607671

PVP:	105296755(DSP)

RAY:

107507209

MJV:	108395625(DSP)

TOD:	119251586(DSP)

SARA:

101545353(DSP)

SFUM:

130017740(DSP)

SETR:

125996160(DSP)

LAV:	100656995(DSP)

TMU:

101354982

ETF:

101642389

DNM:	101422607(DSP)

MDO:	100027776(DSP)

GAS:

123240358

SHR:	105749752(DSP)

AFZ:

127544194

PCW:	110224081(DSP)

TVP:

118834812

PBRV:

138173509(DSP)

MLAO:

141503073(DSP)

OAA:

100083608

TACU:

119949523

GGA:	420869(DSP)

PCOC:

116226437(DSP)

MGP:	100540737(DSP)

CJO:	107309644(DSP)

TPAI:

128087908(DSP)

LMUT:

125691466

NMEL:

110393856(DSP)

APLA:

101804915

AACU:

137850574(DSP)

OJA:	118162367(DSP)

ACYG:

106034878(DSP)

CATA:

118254759(DSP)

AFUL:

116486474(DSP)

TGU:	100223866(DSP)

LSR:	110472670(DSP)

VMC:	128812260(DSP)

VCHA:

128793442(DSP)

AIB:	137478815(DSP)

SCAN:

103815845(DSP)

PMOA:

120503555

OTC:

121340460

PRUF:

121357819

ATRC:

139602461(DSP)

MATE:

118694779(DSP)

MAEN:

136553640(DSP)

GFR:	102038842(DSP)

FAB:	101813215(DSP)

OMA:	130249708(DSP)

PHI:	102108521(DSP)

PMAJ:

107200808(DSP)

CCAE:

111923816(DSP)

CCW:

104691380

CBRC:

103624228(DSP)

ACOE:

138106848(DSP)

ETL:	114064373(DSP)

ZAB:	102070932(DSP)

ZLE:	135444115(DSP)

ACHL:

103808674(DSP)

SVG:	106858928(DSP)

MMEA:

130575311(DSP)

HRT:	120749578(DSP)

SATI:

136364793(DSP)

CFAI:

136292291(DSP)

CCIC:

134047746(DSP)

NNT:	104399296(DSP)

SHAB:

115616367(DSP)

POCC:

134163211(DSP)

FPG:	101911523(DSP)

FCH:	102047218(DSP)

FRS:

119145220

CCRI:

104164269(DSP)

ACUN:

113476518(DSP)

ANOC:

141957717(DSP)

SURA:

141944949(DSP)

TALA:

104363522

ACHC:

115353040

HALD:

104323340(DSP)

HLE:	104835317(DSP)

AGEN:

126048693

HHAR:

128136501(DSP)

BBUT:

142042270(DSP)

GCL:

127012742

CSTI:

104549836(DSP)

LDI:	104348184(DSP)

MNB:	103768092(DSP)

DPUB:

104297244(DSP)

PPUS:

135184925(DSP)

IIN:	128967446(DSP)

AVIT:

104275099(DSP)

BRHI:

104496131(DSP)

EGZ:

104127689

NNI:	104021830(DSP)

PCRI:

104038591(DSP)

PCAO:

104049457(DSP)

PARX:

142053028(DSP)

PADL:

103919023(DSP)

AFOR:

103898810(DSP)

FGA:	104069403(DSP)

CBOR:

142079093(DSP)

GSTE:

104257126(DSP)

CBOY:

140647981(DSP)

MAME:

142405824(DSP)

CLV:	102097900(DSP)

CNIC:

135984891(DSP)

MUI:	104533813(DSP)

PGUU:

104461285(DSP)

PLET:

104617691(DSP)

EHS:	104514974(DSP)

CMAC:

104480028(DSP)

CUCA:

104062104(DSP)

PCUR:

138718926(DSP)

TEO:	104383561(DSP)

BREG:

104642123(DSP)

GAME:

129203130(DSP)

OHA:	104326652(DSP)

ACAR:

104529891(DSP)

CPEA:

104391600(DSP)

CVF:	104286791(DSP)

RTD:	128906134(DSP)

CRID:

134511648(DSP)

LMIC:

141739195(DSP)

NARQ:

141464114(DSP)

AAM:	106483753(DSP)

AROW:

112969495(DSP)

NPD:	112952012(DSP)

TGT:	104566651(DSP)

DNE:	112992008(DSP)

SCAM:

104146149(DSP)

ASN:	102374902(DSP)

AMJ:	102572957(DSP)

CPOO:

109315366(DSP)

GGN:	109301272(DSP)

PSS:	102448947(DSP)

CIZ:	142009517(DSP)

CMY:

102945966

CCAY:

125632119

LKP:	140907017(DSP)

NDS:	141982637(DSP)

DCC:

119851219

CPIC:

101934548(DSP)

TST:	117873187(DSP)

EOB:	135874205(DSP)

CABI:

116818023(DSP)

MRV:

120398103

EMQ:	137166561(DSP)

ACS:	100556454(dsp)

ASAO:

132774575(DSP)

PVT:	110080857(DSP)

SUND:

121929270

PBI:	103066816(DSP)

PMUR:

107282997(DSP)

CTIG:

120311135

TSR:	106541329(DSP)

PGUT:

117672466(DSP)

PCAE:

139314812(DSP)

APRI:

131196338(DSP)

PTEX:

113445729(DSP)

NSS:	113418022(DSP)

VKO:

123036303

PMUA:

114600923(DSP)

PRAF:

128417794(DSP)

ZVI:	118089784(DSP)

HCG:	128324213(DSP)

GJA:	107121267(DSP)

STOW:

125439414

EMC:	129333379(DSP)

XLA:	398354(dsp.L)

NPR:	108790136(DSP)

RTEM:

120940692

ACAT:

141144911(DSP)

PADS:

140331042(DSP)

BBUF:

121001158

BGAR:

122938204

DTC:	141083025(DSP)

PWL:	138267962(DSP)

MUO:	115473778(DSP)

GSH:	117355748(DSP)

DRE:	324023(dspA) 327364(dspB)

DAES:

130239481(dspa) 130248198

SRX:	107705101 107708583 107728115 107739175

SANH:

107660412 107661358 107671686 107672942

SGH:	107557021 107567016 107567868 107593747

CCAR:

109099500(wu:fi04e12) 109107560(dspa) 109109423

CAUA:

113039870 113046128 113068547 113120559

CGIB:

127938481 127951013 127984031 128024612

PTET:

122325362(wu:fi04e12) 122326741(dspa)

LROH:

127177511(dspa) 127182870(wu:fi04e12)

GRF:	141344035 141344955 141348682

OMC:	131523054(dspa) 131527125(dspb)

PPRM:

120481075(dspa) 120492027(wu:fi04e12)

RKG:	130100787(dspa) 130100830(wu:fi04e12)

MAMB:

125250289(dspa) 125278578(wu:fi04e12)

CIDE:

127502070(wu:fi04e12) 127522625

CERY:

137002550(dspa) 137019252(dspb)

MASI:

127409598 127416292(wu:fi04e12) 127441063 127441934

TROS:

130553843(dspa) 130565545(wu:fi04e12)

TDW:	130417200(dspa) 130434119(wu:fi04e12)

MANU:

129429233(dspb) 129441782(dspa)

PDAB:

135738427(dspb) 135767346(dspa)

IPU:	108267071(dspa) 108279784(wu:fi04e12)

IFU:	128610618(dspa) 128620776(wu:fi04e12)

PHYP:

113525283 113529172

SMEO:

124388149(dspa) 124400923(wu:fi04e12)

TFD:	113640174(dspa) 113662379(wu:fi04e12)

TVC:	132849169(dspa) 132854833

CGAR:

128523231(dspa) 128542609(wu:fi04e12)

NGRA:

132881517(dspb) 132883589(dspa)

TRN:	134312564(dspa) 134320536(dspb)

AMEX:

103047355(dspa)

CMAO:

118815874(wu:fi04e12) 118826305(dspa)

EEE:	113571556 113587162

CHAR:

105899310(dspa)

SPIL:

134073723(dspa) 134102056

ASAD:

121677597 121706030(dspa)

TRU:	101063843(dsp) 115247960

TFS:	130538673(dspa)

TNG:	GSTEN00028289G001 GSTEN00028290G001

NCC:

104949487

TBEN:

117489015

CGOB:

115022208(dsp)

PGEO:

117462507(dspa)

GACU:

117558421

EMAC:

134865925

ELY:	117271750(dspa)

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

114564887(dsp)

GAT:	120815807(dspa)

PPUG:

119209149

AFB:

129111946

CLUM:

117746170

PSWI:

130197950(dspa)

CANA:

137803628(dspa)

CVE:	137892476 137892477

MSAM:

119902053(dspa)

SCHU:

122887424

EARM:

139287392 139295945(dspa)

CUD:	121520720(dspa)

SPUL:

138612216(dspa)

LMIX:

132979189(dspa)

HTC:	141804094(dspa)

ALAT:

119010861(dspa)

ASTR:

137611892(dspa)

PKLU:

139202740 139213745(dspa)

LCO:	104929327(dsp)

MZE:	101474907(dspa)

ONL:	100706971(dsp)

OAU:

116318690

OLA:	101165763(dsp)

OML:

112147629

CSAI:

133452756

XMA:	102225160(dsp)

XCO:	114147098(dsp)

XHE:	116722253(dsp)

PRET:

103479559(dsp)

PFOR:

103143003(dsp)

PLAI:

106958826(dsp)

PMEI:

106918915(dsp)

GAF:

122841228

PPRL:

129361585

CVG:	107092417(dsp)

CTUL:

119795675

GMU:

124869828

NFU:	107383919(dsp)

KMR:	108239610 108239630

ALIM:

106534014(dsp)

NWH:	119414209 119414210

LTU:	140269520(dspa)

MCEP:

125010335(dspA)

AOCE:

111568715(dspa)

EJA:	138202991(dspa)

BFRE:

138617248(dspa)

LCF:

108883422

CSEM:

103396289(dsp)

POV:	109642257(dsp)

SSEN:

122769552(dspa)

SSOE:

131462931(dspa)

HHIP:

HSP:

PPLT:

SMAU:

SDU:	111231030(dsp)

SLAL:

111670504(dsp)

XGL:	120798662(dspa)

HCQ:	109521215(dsp)

SSCV:

125985320(dspa)

SBIA:

133503555 133511373

PEE:

133411158

PTAO:

133488874

BPEC:

110158163(dsp)

ENY:	140356555(dspa)

MALB:

109957738

BSPL:

114844280

SJO:	128369205(dspa)

SSCO:

133990284(dspa)

TTY:	137194250(dspa)

GMH:	115549256(dsp)

SASA:

106560365 106569165 106584072 106599719

STRU:

115157126(dspa) 115158647 115169644 115192284

OTW:	112226843 112250196 112251318 112260574(dspa)

OMY:	110508634 110521766(wu:fi04e12) 110524668 110530427

OGO:	123996711 124009400 124038699 124041776

ONE:	115102995 115108612 115114516 115145387

OKI:	109871663 109874603 109897206 109902792

OKE:	118393426 118394763 118402011

OMM:	135513093 135556221 135558790

OCLA:

139376141 139387089 139406766 139409424

SALP:

111956506 111971218 111975539 111979761

SNH:	120020301 120052636 120054298 120055949(dspa)

SFON:

129813989(dspa) 129823627 129855485 129869533

CCLU:

121533877 121535308 121540482 121581002

ELS:	105011942 105013915(dsp)

OEP:	134013045(dspb) 134036847(dspa)

SFM:	108932770 108937755 108939342(dsp)

PKI:	111835203 111845909 111850072

AANG:

118225962 118233777(dspa)

AROT:

135253970(dspb) 135260764(dspa)

CCOG:

133126462 133136524(dspa) 133136655 133137557 133137559

LOC:	102691942(dsp)

PSPA:

121309051 121314516

ARUT:

117394390 117400270

PSEX:

120529513(dspa)

LCM:	102352179(DSP)

CMK:	103185081(dspa)

CPLA:

122549187

CPUN:

140477245(dspa)

HOC:

SCAU:

LERI:

HAKA:

Reference

PMID:23137101

Authors

Rasmussen TB, Hansen J, Nissen PH, Palmfeldt J, Dalager S, Jensen UB, Kim WY, Heickendorff L, Molgaard H, Jensen HK, Sorensen KE, Baandrup UT, Bross P, Mogensen J

Title

Protein expression studies of desmoplakin mutations in cardiomyopathy patients reveal different molecular disease mechanisms.

Journal

Clin Genet 84:20-30 (2013)
DOI:10.1111/cge.12056

Sequence

[hsa:1832]

LinkDB

DBGET integrated database retrieval system