KEGG   ORTHOLOGY: K20483
Entry
K20483                      KO                                     
Symbol
lanB, nisB, spaB, epiB
Name
class I lanthipeptide synthase [EC:3.13.2.4]
Pathway
map02020  Two-component system
map02024  Quorum sensing
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    K20483  lanB, nisB, spaB, epiB; class I lanthipeptide synthase
 09140 Cellular Processes
  09145 Cellular community - prokaryotes
   02024 Quorum sensing
    K20483  lanB, nisB, spaB, epiB; class I lanthipeptide synthase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.13  Acting on carbon-sulfur bonds
   3.13.2  Thioether and trialkylsulfonium hydrolases
    3.13.2.4  lanthipeptide synthase
     K20483  lanB, nisB, spaB, epiB; class I lanthipeptide synthase
Genes
VNI: VIBNI_B1812
THAT: H3N35_22020
TACT: SG35_022980
TVD: SG34_024275
PPHE: PP2015_3327
PRR: AT705_11950
PLZ: S4054249_20625
PPIS: B1L02_18300
PEA: PESP_a3853
PSEN: PNC201_17645
PVB: J5X90_05210
PSAZ: PA25_32100
PFLI: CTT31_17920
PMAZ: R5H13_18935
PSRR: ELR70_24415
ALTA: D1814_06875
COX: E0W60_29620
PBH: AAW51_2959
KIA: G8A07_03785
EHB: E7V67_017105
ENU: PYH37_000034
RUA: D1823_08320
RUT: FIU92_04935
TOM: BWR18_06450
MFB: MFUL124B02_22920
MYM: A176_005603
PFLY: VZL07_21025
CCX: COCOR_03285(spaB) COCOR_03658(spaB1) COCOR_05225(spaB2)
CEXI: ACN6A2_36035
PPAK: JY651_26715
AGE: AA314_06592
AVM: JQX13_15470 JQX13_38760
MBD: MEBOL_000584 MEBOL_005034
CFUS: CYFUS_002182 CYFUS_005054 CYFUS_005356
PBRU: LZC95_09240
PRUE: LVJ94_02345 LVJ94_13945 LVJ94_17420 LVJ94_34510
PALJ: LZC94_02205 LZC94_22875
MRM: A7982_04560 A7982_13709
LLU: AKJ09_10455
HOH: Hoch_0066
NANN: O0S08_10550
SBF: JCM31447_05530
PIJ: QEJ31_06410
PUV: PUV_03460
RPOR: RHAB15C_0000324
MRI: Mal4_44730
GEP: Q9293_09080 Q9293_10980
MSIL: METEAL_19570
MSEA: METESE_23990
DYS: G7050_16785
ACOU: A5CBH24_15680
CPI: Cpin_1436 Cpin_3392
CBAE: COR50_19595
CHIH: GWR21_22690
COY: HF329_03460 HF329_14570
CFIL: MYF79_07215 MYF79_12505
CHF: KTO58_20200 KTO58_25915
CSAC: SIO70_08480 SIO70_32930
CHIM: CK934_02865 CK934_08595
CHII: UNH65_01905 UNH65_13925
NDF: KRR40_27300
ARB: A9P82_12035 A9P82_13015
ARAC: E0W69_002660 E0W69_006185
FLN: FLA_0877
PHE: Phep_0556
PEP: AQ505_08925 AQ505_14565
PCM: AY601_0764 AY601_1454 AY601_1970 AY601_2739 AY601_3221
PSTY: BFS30_13025 BFS30_23090 BFS30_24520
PGS: CPT03_02265 CPT03_13430
PEK: FFJ24_010530 FFJ24_012040 FFJ24_018235 FFJ24_020860
PROE: H9L23_02305 H9L23_18970 H9L23_20800 H9L23_20865
PEX: IZT61_15765
PMUO: LOK61_15200
PRK: H9N25_12960 H9N25_17145 H9N25_17180
PGJ: QG516_01395 QG516_22040
PEV: KYH19_16930 KYH19_21170 KYH19_21240
PEDO: AB3G38_01365 AB3G38_01910 AB3G38_06625 AB3G38_08670 AB3G38_15725 AB3G38_21615 AB3G38_23455
SHG: Sph21_0696 Sph21_1090 Sph21_4476
SHT: KO02_01480
SPHN: BV902_14640
SMIZ: 4412673_00290
SPDR: G6053_11295 G6053_11615 G6053_29545
STHA: NCTC11429_03847
SMUI: I6J00_03245
SSIY: JVX97_18860
SPRZ: VXM68_00770
MUP: A0256_00385
MGOT: MgSA37_03131 MgSA37_03804
MUH: HYN43_003215 HYN43_015235 HYN43_015250
MGIN: FRZ54_07985
MGK: FSB76_01450
MRUB: DEO27_003615 DEO27_015185 DEO27_015200 DEO27_021225 DEO27_021660 DEO27_028130
MGOS: DIU38_015525 DIU38_015540 DIU38_023015
MMAB: HQ865_00650
MGIK: GO620_000560 GO620_012020
MROB: HH214_10495
MJJ: PQO05_10850 PQO05_25450
MSAB: SNE25_04565 SNE25_09500
MUY: SNE26_07260 SNE26_14515 SNE26_14535 SNE26_20525
MUG: INP83_06815
OLI: FKG96_02410 FKG96_20305
SBX: CA265_17700
EMAI: KZP23_17075
SLI: Slin_0903 Slin_2131 Slin_4704 Slin_4714
SRD: SD10_14005 SD10_28260
SMON: AWR27_12965 AWR27_15200
SPIR: CWM47_21445 CWM47_31820 CWM47_36570
SPIK: EXU85_28790
SPIB: G8759_28660
SOQ: LQ777_29915 LQ777_30150
SFOL: H3H32_11395 H3H32_25020
SENF: GJR95_14770
EOL: Emtol_0103
ALS: DJ013_15640
DCN: MUK70_25515
DPF: ON006_04775 ON006_08460 ON006_13250 ON006_13345
DEND: ACN9ML_00845
RSI: Runsl_2466
RUP: DTQ70_28975
FAE: FAES_1247(epiB) FAES_1339 FAES_2037 FAES_pFAES01088(spaB)
HSW: Hsw_0204
HCW: O3303_21625
HCU: MUN79_08930
HCF: MUN80_08270 MUN80_21785
PKO: PKOR_15840
PACT: CA264_09795 CA264_09830
PONT: C1N53_08295
MARP: QYS47_30455 QYS47_30480
FLL: EI427_16415
CLIT: OQ292_21270
CHRW: KA713_09870
ATK: AUTU_20610
FKI: FK004_03275
FCR: HYN56_16490 HYN56_19800 HYN56_19825
FEN: J0383_09795
FSD: LXD69_03140 LXD69_10485 LXD69_12805
FPB: NLJ00_10080
FCS: TRV642_2118(nisB) TRV642_3916 TRV642_4590
FHU: M0M44_06600
FCU: NOX80_02985 NOX80_08680
FDV: JJC05_08805
FCG: LNP23_06005
FLZ: GIY83_08720
FLR: ABFU83_14610
FLF: FLGSB24_16830
FSF: AABD74_20965
LNU: N7U66_12830
NOB: CW736_02045
PBAT: JL193_11330
TMP: F9Y86_04335
TOV: PG911_00500
TPLT: T19A05C_0760
KOS: KORDIASMS9_00808(nisB)
KAN: IMCC3317_31900(nisB_2)
AQB: D1818_13270
AQE: NBT05_04465
AQR: HN014_06040
GAA: HX109_04970
FBU: UJ101_01069
EAO: BD94_1460
EEN: BBD30_10490
ELB: VO54_01463 VO54_02679
ELZ: FCS00_05725
ELT: FGE20_01375
ELIZ: JCR23_13360
CHZ: CHSO_0796 CHSO_3638
CGN: OK18_07960 OK18_18460
CIH: ATE47_14120
CHH: A0O34_05895 A0O34_21735
CIO: CEQ15_20025 CEQ15_22010
CHRY: CEY12_13380 CEY12_18215
CPIP: CJF12_15885
CHRS: EAG08_11960
CARH: EGY05_00760
CSHA: EG350_19790
CNK: EG343_06480 EG343_17370
CJT: EG359_18060
CCAU: EG346_03010 EG346_05695 EG346_21640
CBEN: EG339_08750
CTAI: NCTC12078_02356
CLAC: EG342_06990 EG342_21320
CSAL: NBC122_02755(nisB_2)
CBP: EB354_03200
CNP: M0D58_11440
CCAO: H5J24_19185
CRHI: KB553_01010 KB553_14540 KB553_19140 KB553_22380
CDAE: MUU74_12130
CTUR: LNP04_01035
CHRJ: CHRYMOREF3P_3187
CORA: N0B40_19885
CHRC: QGN23_01345
CFLU: ODZ84_17185 ODZ84_18115
CCUC: JNG87_03535
CHRR: ACL0VS_07435
KFA: Q73A0000_07055
EVA: EIB75_08100
CIV: IMZ16_09565
BSUS: Q433_01235(subB)
BSN: BSn5_12560
BSS: BSUW23_16560(spaB)
BST: GYO_3696
BIT: BIS30_06530
BSON: S101395_04836
BMOJ: HC660_32640(sblB)
BTF: YBT020_05955
BTHT: H175_233p093
BTHU: YBT1518_19980 YBT1518_25730
BMYO: BG05_2735
BBY: CY96_27575
BNT: GSN03_15675
BACY: QF06_07330 QF06_15250
BAWR: D9C22_08860 D9C22_18145
BMQ: BMQ_pBM70150
BCL: ABC3559
BLE: BleG1_0224
SHUA: PQ477_09590
BGI: BGM20_16025
LGY: T479_22485
BTHV: CQJ30_18235
GKA: GK0300
GTE: GTCCBUS3UF5_3840
GTM: GT3921_17950
BCAL: CWI35_08705
GTN: GTNG_0266(spaB)
AFL: Aflv_2440(spaB)
SAM: MW1764(bsaB)
SAS: SAS1745
SAC: SACOL1877(epiB)
SAX: USA300HOU_1814(epiB)
SAA: SAUSA300_1766(epiB)
SAO: SAOUHSC_01952
SAE: NWMN_1715(bsaB)
SUV: SAVC_08345
SUE: SAOV_1806
SUT: SAT0131_01943
SUZ: MS7_1822
SUF: SARLGA251_17050
SAUZ: SAZ172_1835(lanB)
SAUF: X998_1840
SAB: SAB1682c
SAUM: BN843_18280
SAUR: SABB_03490(epiB)
SAUI: AZ30_09230
SCAP: AYP1020_0360
SLZ: B5P37_08600
SARL: SAP2_01390
SSH: NCTC13712_01802
SSAC: I6I31_07400
MEPI: KFV12_00370
BFM: BP422_03715
BRUM: NDK47_17225
PPY: PPE_01455(pnlB)
PPM: PPSC2_07495(bsaB)
PPO: PPM_1424(bsaB)
PPOL: X809_08165
PPQ: PPSQR21_015860 PPSQR21_045960 PPSQR21_048920
PPOY: RE92_04400 RE92_14520
PLV: ERIC2_c31290
PPEO: ABE82_08710
PBV: AR543_02145
PAIH: ASL14_13570
PKA: PQ456_01215
PHK: SK066_01210
PNK: AASFL403_08595
PLZH: C0638_24555
PACL: DCC85_19075
PELG: ACJ7K1_06285
PASZ: KAI36_01562(nisB)
ANX: ACH33_16075
ATHE: K3F53_02805
TUM: CBW65_03320 CBW65_23330
TAB: CIG75_06680
LLT: CVCAS_0588(nisB)
LLS: lilo_0557(nisB)
LLX: NCDO2118_1271(nisB)
LLJ: LG36_0631(nisB)
LACN: QJV49_10890
SPH: MGAS10270_Spy0922
SPI: MGAS10750_Spy0958
SPJ: MGAS2096_Spy0881
SPK: MGAS9429_Spy0926
SPB: M28_Spy0784
SPYO: STAB901_04690
SPW: SPCG_0145
SNV: SPNINV200_01410
STC: str0098
STL: stu0098(labB)
STN: STND_0102
STW: Y1U_C0091
SSUS: NJAUSS_0612
SUI: SSUJS14_0625
SDG: SDE12394_01385 SDE12394_01390
SDQ: SDSE167_0324 SDSE167_0325
STB: SGPB_1104(nsuB)
STRS: SSAL8618_00820
SIB: SIR_0587(epiB)
SIU: SII_0989
SEQI: A6J79_10715
SMEN: SAMEA4412692_0449
SPOC: NCTC10925_00694(nsuB)
LAW: LACWKB8_1292
LHS: DLD54_06225
LROS: LROSL1_2322
WPA: CO680_03740
CCB: Clocel_4257
CRW: CROST_000290(nisB)
CAUN: CLAUR_029660(nisB)
CRAS: KVH43_13035
ROB: CK5_35910
BYL: A4V09_08150
SCAG: ACI3DM_05760
VGU: HYG85_07155
VPY: HZI73_04960
TIZ: RBU61_03610
MLW: MJO58_12120
MPHU: MPHO_39000
MFLU: HZU40_22905
NBR: O3I_005645 O3I_014620
NOZ: DMB37_01800
NIE: KV110_21880
NSPU: IFM12276_53020
NVU: V7968_13030 V7968_22390
GMG: NWF22_05130
SCO: SCO0269(SCF1.11) SCO6930(SC1G8.02c)
SGR: SGR_3847 SGR_5947
SFI: SFUL_5862
SGRF: SGFS_020120 SGFS_064360
SCYE: R2B67_03805 R2B67_23905
SCB: SCAB_32031
SVL: Strvi_1314 Strvi_3084 Strvi_5421
SHY: SHJG_0235 SHJG_7925
SHO: SHJGH_7687
SRC: M271_10110
SMAL: SMALA_2712
SAUO: BV401_15615
SSOI: I1A49_15470
SANT: QR300_08455
SBH: SBI_06949
SDV: BN159_7742
SALS: SLNWT_1142 SLNWT_1181
SLV: SLIV_36570
STRE: GZL_00810 GZL_05721 GZL_07086
SLD: T261_1299 T261_1703 T261_8500
SXI: SXIM_01800 SXIM_36750
STRM: M444_18490 M444_22370 M444_36750
STRC: AA958_15640
SAMB: SAM23877_7260
SCZ: ABE83_15105
STRF: ASR50_00545 ASR50_02320 ASR50_34890
STRT: A8713_00050
SCLF: BB341_06935 BB341_16125
SGS: AVL59_25170
SGM: GCM10017557_34380
SCAD: DN051_07245
SNR: SNOUR_03855 SNOUR_26775 SNOUR_32455
SALU: DC74_2051 DC74_6284 DC74_7903
SALL: SAZ_33105 SAZ_40790
STRD: NI25_06430
SSIA: A7J05_06850
SVU: B1H20_18185
SPUN: BFF78_08035
SGV: B1H19_05675 B1H19_06510
SFK: KY5_0111c KY5_1225c KY5_7245c
SGE: DWG14_06036
SRJ: SRO_3847
SVQ: N6Q81_33430
SLK: SLUN_04615
SDX: C4B68_00395 C4B68_07050
SQZ: FQU76_24365
SNQ: CP978_26355
STIR: DDW44_30835
SKA: CP970_20025 CP970_42345
SGZ: C0216_09880 C0216_32285 C0216_32645
SNK: CP967_19705
SHAW: CEB94_33765
SSPO: DDQ41_08205 DDQ41_25215
SPAD: DVK44_00590 DVK44_04650 DVK44_21620
SAQU: EJC51_17960
SGF: HEP81_01488
SRIM: CP984_09035
SSUB: CP968_31990
SPHV: F9278_14760 F9278_23705
SFUG: CNQ36_16660
SPAC: B1H29_07995 B1H29_19680
STSU: B7R87_18360 B7R87_20565 B7R87_24100 B7R87_26920
SGX: H4W23_12985
SCOE: CP976_26345
SBAT: G4Z16_00535 G4Z16_06545
SSPB: CP982_02300
SPLA: CP981_33925
SCYG: S1361_32735
SDW: K7C20_32410
SVD: CP969_17285
SMOB: J7W19_20930 J7W19_29375
SPRA: CP972_03630
SPEU: CGZ69_14840
SROI: IAG44_39815
SDD: D9753_20300
SMAO: CAG99_14140 CAG99_18990
SYAN: NRK68_00285
SAKB: K1J60_22735
STAA: LDH80_14675
SNIG: HEK616_10020
SCAE: IHE65_15000
STUB: MMF93_21485
SSPN: LXH13_21435
STUD: STRTU_000637
STEE: F3L20_18415
SGK: PET44_10885 PET44_14030 PET44_17250 PET44_34200
SYUN: MOV08_26985 MOV08_32535
SOV: QZH56_36465
SHAU: K9S39_23695 K9S39_31050
SKG: KJK29_06450
SFP: QUY26_27285
STTN: BSL84_27520
SCAY: PYS65_05995
SARM: DVA86_32180
SPRF: K4G22_17895
STPB: QR97_02035
SRPA: HEP86_10655 HEP86_35460 HEP86_36800
SMIB: SMIR_04430
STRW: QHG49_16800
SCHE: QRN89_16920
SGLY: P8A20_24950 P8A20_30170
STRV: EZV63_30475
STAC: ABII15_14905 ABII15_35875
STYI: C9F11_01935 C9F11_21040 C9F11_36425
STRJ: H7827_09555
SEXP: SLV14_000941 SLV14_001741
SFLU: ACKTSN_21470
SSTO: ACE1OC_06325 ACE1OC_40155
SLUA: AB8735_03335 AB8735_38545
STGO: KBP30_00920
STCM: SCMC78_62340
STID: G7Z12_04170
STRQ: CGL27_01195 CGL27_16470 CGL27_38735
SHUG: ABVG11_26650
SCT: SCAT_0532 SCAT_2821
SCY: SCATT_05420 SCATT_28070
KSK: KSE_04760 KSE_58820
KAB: B7C62_17030
KIT: CFP65_1558
KIS: HUT16_27260
KCM: ABWK59_33220
KNB: ACF9IK_09485 ACF9IK_13955 ACF9IK_30070
KIC: KCMC57_up61590
KPUR: ACFCLZ_18925
STRI: C7M71_008480 C7M71_017725 C7M71_022645
PPOD: AB0761_10765
YIA: LO772_08170 LO772_16255 LO772_27135
STRH: GXP74_38555
ABRY: NYE86_08205
AREV: RVR_2394 RVR_5510
CCAP: AES38_14935
AIG: QDX25_06065 QDX25_08180
CCEU: CBR64_15405
PROU: AB1046_03110
PROZ: ACO229_06830
CFEN: KG102_11435
OEK: FFI11_016975
BRT: J4N02_00045
PSOI: PCC79_16960
NOY: EXE57_10140
KQI: F1D05_10855
THAO: NI17_009790
TALX: FOF52_10225 FOF52_15445
NDA: Ndas_4694
NAL: B005_2169 B005_4395
NGV: CDO52_03830 CDO52_26060
NEX: NE857_03340 NE857_22005 NE857_26280
NAKE: KGD83_01680
NCG: KGD84_19000
NOCB: UIS43_17085
STRR: EKD16_21865
TCU: Tcur_4647
ACTW: F7P10_18935
AGRA: AGRA3207_002565 AGRA3207_003487 AGRA3207_004966
AMAZ: LUW76_20860 LUW76_25210
SPIQ: OHA34_14150
ACTQ: OG417_25085 OG417_33030 OG417_45315
NOW: GBF35_16225 GBF35_37465 GBF35_40655
NGN: LCN96_15940 LCN96_25340
FRA: Francci3_1127 Francci3_1821 Francci3_2033 Francci3_3315
FAL: FRAAL2701 FRAAL6344
FRE: Franean1_0056 Franean1_1332 Franean1_2799 Franean1_6755
FRI: FraEuI1c_0880 FraEuI1c_6946
SACG: FDZ84_24720
AAB: A4R43_24695
AACD: LWP59_37695
ATHM: L1857_05350
AMOG: QRX60_17695
AMYZ: HUW46_04507
ANW: QP939_03990
ABAR: AMYBAR_005259
PHH: AFB00_04975
SSYI: EKG83_09690 EKG83_25600 EKG83_26670
SACX: IOD16_27110
KAL: KALB_7176
KPHY: AOZ06_04945 AOZ06_15790 AOZ06_16525 AOZ06_40720
LXR: ACRSBM_34685
ACTA: C1701_26075
ACAU: ACOJVX_10490 ACOJVX_12520 ACOJVX_19315
ALO: CRK57671 CRK59225 CRK59311
ACTU: Actkin_04238
CROS: N8J89_17975 N8J89_24315
UME: RM788_18745 RM788_33255 RM788_37900 RM788_43995
SAQ: Sare_0602
MAU: Micau_4116 Micau_6129
MICB: MicB006_5567 MicB006_6145
MTUA: CSH63_04335
MICH: FJK98_32135
MCAB: HXZ27_15435
MSAG: GCM10017556_24520
MCRA: ID554_13015
VER: HUT12_05010
MENO: Jiend_16190
MCHL: PVK74_10565 PVK74_24325 PVK74_30045
MFEU: H1D33_24730
MPRN: Q3V37_17420
MICF: QQG74_21530
MICN: WHN02_22630
AIH: Aiant_48030
ACTL: L3i22_023820
ASIC: Q0Z83_089730
AFS: AFR_18395
PSUU: Psuf_023060
PRY: Prubr_65870 Prubr_74650
DVC: Dvina_51895
NHY: JQS43_14320 JQS43_21950
CAI: Caci_3936
SNA: Snas_3602 Snas_5417
NAV: JQS30_06000
BLN: Blon_0520
BLON: BLIJ_0523
AEY: CDG81_17725
KBS: EPA93_05220 EPA93_12365 EPA93_15465 EPA93_28600 EPA93_44275 EPA93_45600 EPA93_45930
 » show all
Reference
PMID:7689965
  Authors
Kuipers OP, Beerthuyzen MM, Siezen RJ, De Vos WM
  Title
Characterization of the nisin gene cluster nisABTCIPR of Lactococcus lactis. Requirement of expression of the nisA and nisI genes for development of immunity.
  Journal
Eur J Biochem 216:281-91 (1993)
DOI:10.1111/j.1432-1033.1993.tb18143.x
  Sequence
[llt:CVCAS_0588]
Reference
PMID:23071302
  Authors
Zhang Q, Yu Y, Velasquez JE, van der Donk WA.
  Title
Evolution of lanthipeptide synthetases.
  Journal
Proc Natl Acad Sci U S A 109:18361-6 (2012)
DOI:10.1073/pnas.1210393109
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