KEGG   ORTHOLOGY: K21052
Entry
K21052                      KO                                     
Symbol
TMEM5
Name
alpha-dystroglycan beta1,4-xylosyltransferase [EC:2.4.2.61]
Pathway
map00515  Mannose type O-glycan biosynthesis
map01100  Metabolic pathways
Module
M00872  O-glycan biosynthesis, mannose type (core M3)
Disease
H00120  Muscular dystrophy-dystroglycanopathy type A
H02307  Muscular dystrophy-dystroglycanopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00515 Mannose type O-glycan biosynthesis
    K21052  TMEM5; alpha-dystroglycan beta1,4-xylosyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K21052  TMEM5; alpha-dystroglycan beta1,4-xylosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.2  Pentosyltransferases
    2.4.2.61  alpha-dystroglycan beta1,4-xylosyltransferase
     K21052  TMEM5; alpha-dystroglycan beta1,4-xylosyltransferase
Glycosyltransferases [BR:ko01003]
 Glycan extension
  O-Glycan
   K21052  TMEM5; alpha-dystroglycan beta1,4-xylosyltransferase
Other DBs
RN: R12244
Genes
HSA: 10329(RXYLT1)
PTR: 452041(RXYLT1)
PPS: 100992813(RXYLT1)
GGO: 101133488(RXYLT1)
PON: 100460186(RXYLT1)
NLE: 100584744(RXYLT1)
MCC: 717102(RXYLT1)
MCF: 102139236(RXYLT1)
MTHB: 126930862
CSAB: 103238633(TMEM5)
CATY: 105600545(TMEM5)
PANU: 101025195(RXYLT1)
TGE: 112634609(RXYLT1)
RRO: 104680841(RXYLT1)
RBB: 108530040(TMEM5)
TFN: 117089823(RXYLT1)
PTEH: 111551238(RXYLT1)
CJC: 100396930(TMEM5)
SBQ: 101051694(TMEM5)
CSYR: 103266851(TMEM5)
MMUR: 105880958(TMEM5)
LCAT: 123639566(RXYLT1)
OGA: 100966708(RXYLT1)
MMU: 216395(Rxylt1)
MCAL: 110303339(Tmem5)
MPAH: 110326592(Tmem5)
RNO: 299841(Rxylt1)
MCOC: 116076336(Rxylt1)
MUN: 110544358
CGE: 100757873(Rxylt1)
MAUA: 101841827(Rxylt1)
PLEU: 114693289(Rxylt1)
MORG: 121455631(Rxylt1)
MFOT: 126494502
AAMP: 119803677(Rxylt1)
NGI: 103732350
HGL: 101716790(Tmem5) 106007506
CPOC: 100732505(Rxylt1)
CCAN: 109688718(Tmem5)
DORD: 105990711(Tmem5)
DSP: 122124346(Rxylt1)
NCAR: 124983033
OCU: 100345411(TMEM5)
OPI: 101534296(RXYLT1)
TUP: 102496430(TMEM5)
CFA: 608152(RXYLT1)
CLUD: 112677924(RXYLT1)
VVP: 112922312(RXYLT1)
VLG: 121492180(RXYLT1)
AML: 100464740(RXYLT1)
UMR: 103656829(TMEM5)
UAH: 113256338(RXYLT1)
UAR: 123787181(RXYLT1)
ELK: 111159758
LLV: 125107638
MPUF: 101692107(TMEM5)
ORO: 101385557(TMEM5)
EJU: 114214982(RXYLT1)
ZCA: 113923143(RXYLT1)
MLX: 118008632(RXYLT1)
NSU: 110570589(RXYLT1)
FCA: 101101235(TMEM5)
PYU: 121040832(RXYLT1)
PBG: 122473937(RXYLT1)
LRUF: 124502540
PTG: 102958532(TMEM5)
PPAD: 109270421(TMEM5)
AJU: 106981335(RXYLT1)
HHV: 120233157(RXYLT1)
BTA: 515147(RXYLT1)
BOM: 102280602(TMEM5)
BIU: 109559282(TMEM5)
BBUB: 102406645(RXYLT1)
CHX: 102188924(TMEM5)
OAS: 101112124(RXYLT1)
ODA: 120858488(RXYLT1)
CCAD: 122427575(RXYLT1)
SSC: 100155789(TMEM5)
CFR: 102515986(RXYLT1)
CBAI: 105081364(TMEM5)
CDK: 105089266(RXYLT1)
VPC: 102529141(RXYLT1)
BACU: 103019229(TMEM5)
LVE: 103083549(TMEM5)
OOR: 101289176(TMEM5)
DLE: 111173799(RXYLT1)
PCAD: 102973659(RXYLT1)
PSIU: 116761140 116761329(RXYLT1)
ECB: 100056566(RXYLT1)
EPZ: 103553856(TMEM5)
EAI: 106843751(RXYLT1)
MYB: 102249341(TMEM5)
MYD: 102767891(TMEM5)
MMYO: 118651451(RXYLT1)
MLF: 102427668(RXYLT1) 102441512
MNA: 107527142(TMEM5)
PKL: 118729942(RXYLT1)
HAI: 109381648(TMEM5)
DRO: 112319159(RXYLT1)
SHON: 118998717(RXYLT1)
AJM: 119045542(RXYLT1)
PDIC: 114514076(RXYLT1)
PHAS: 123812739(RXYLT1)
MMF: 118624068(RXYLT1)
RFQ: 117029102(RXYLT1)
PALE: 102877783(RXYLT1)
PGIG: 120605002(RXYLT1)
PVP: 105301072(RXYLT1)
RAY: 107508215(TMEM5)
MJV: 108403882 108405319(TMEM5)
TOD: 119248114(RXYLT1)
SARA: 101537526(TMEM5)
LAV: 100665764(RXYLT1)
TMU: 101347097
DNM: 101424956(RXYLT1)
GAS: 123248666(RXYLT1)
SHR: 100933243(RXYLT1)
OAA: 100086919(RXYLT1)
GGA: 417820(RXYLT1)
PCOC: 116226623(RXYLT1)
MGP: 100544427(RXYLT1)
CJO: 107310084(RXYLT1)
NMEL: 110392741(TMEM5)
APLA: 101796104(RXYLT1)
ACYG: 106047283(RXYLT1)
AFUL: 116501929(RXYLT1)
TGU: 100218010(RXYLT1)
LSR: 110479854(RXYLT1)
SCAN: 103820429(RXYLT1)
PMOA: 120499876(RXYLT1)
OTC: 121339510(RXYLT1)
PRUF: 121352594(RXYLT1)
GFR: 102039233(TMEM5)
FAB: 101807811(TMEM5)
PHI: 102110954(TMEM5)
PMAJ: 107205102(RXYLT1)
CCAE: 111932408(RXYLT1)
CCW: 104698351(RXYLT1)
CBRC: 103614876(TMEM5)
ETL: 114059396(RXYLT1)
ZAB: 102074450(RXYLT1)
ACHL: 103799890(TMEM5)
FPG: 101921640(TMEM5)
FCH: 102053891(RXYLT1)
CLV: 102086203(TMEM5)
EGZ: 104135953(TMEM5)
NNI: 104011529(TMEM5)
PLET: 104615153(TMEM5)
PCRI: 104030082(TMEM5)
ACUN: 113491375(RXYLT1)
TALA: 104361336(RXYLT1)
PADL: 103919977(TMEM5)
AFOR: 103900416(TMEM5)
ACHC: 115336229(RXYLT1)
CCRI: 104159796(TMEM5)
CSTI: 104553898(TMEM5)
EHS: 104504207(TMEM5)
CMAC: 104485510(TMEM5)
MUI: 104538499(TMEM5)
FGA: 104083800(TMEM5)
GSTE: 104257914(TMEM5)
LDI: 104355077(TMEM5)
MNB: 103768433(TMEM5)
OHA: 104326782(TMEM5)
NNT: 104411615(TMEM5)
DPUB: 104305215(TMEM5)
PGUU: 104467845(TMEM5)
ACAR: 104529490(RXYLT1)
AVIT: 104268716(TMEM5)
CVF: 104288962(TMEM5)
AAM: 106488143(TMEM5)
AROW: 112977820(RXYLT1)
NPD: 112947669(RXYLT1)
DNE: 112978733(RXYLT1)
ASN: 102382915(RXYLT1)
AMJ: 102576823(TMEM5)
CPOO: 109315551(TMEM5)
GGN: 109295685(TMEM5)
PSS: 102459090(RXYLT1)
CMY: 102939667(RXYLT1)
CPIC: 101945589(RXYLT1)
TST: 117877384(RXYLT1)
CABI: 116818548(RXYLT1)
MRV: 120384091(RXYLT1)
ACS: 100560359 103278900(tmem5)
PVT: 110075094(TMEM5)
SUND: 121931898(RXYLT1)
PBI: 103064453(RXYLT1)
PMUR: 107293325(RXYLT1)
CTIG: 120307420(RXYLT1)
TSR: 106543805(TMEM5)
PGUT: 117655858(RXYLT1)
VKO: 123019915(RXYLT1)
PMUA: 114605526(RXYLT1)
ZVI: 118091498(RXYLT1)
GJA: 107123401(TMEM5)
STOW: 125435129(RXYLT1)
XLA: 446820(rxylt1.S)
XTR: 100145540(rxylt1)
NPR: 108792582(TMEM5)
RTEM: 120932022(RXYLT1)
BBUF: 120980170(RXYLT1)
BGAR: 122925898(RXYLT1)
DRE: 557187(rxylt1)
SANH: 107670366(tmem5) 107684684
CCAR: 109110172(tmem5)
PPRM: 120462030(rxylt1)
MAMB: 125254800(rxylt1)
IPU: 108264772(rxylt1) 124627936
PHYP: 113534283(rxylt1)
SMEO: 124396125(rxylt1)
TFD: 113652270(rxylt1)
AMEX: 103039815(tmem5)
EEE: 113577197(rxylt1)
TRU: 101064249(rxylt1)
LCO: 104923719(rxylt1)
NCC: 104949270(tmem5)
CGOB: 115009478(rxylt1)
ELY: 117253306(rxylt1)
EFO: 125886990(rxylt1)
PLEP: 121950421(rxylt1)
SLUC: 116038615(rxylt1)
ECRA: 117948638(rxylt1)
ESP: 116694819(rxylt1)
PFLV: 114559947(rxylt1)
PPUG: 119195733(rxylt1)
MSAM: 119894254(rxylt1)
CUD: 121514766(rxylt1)
ALAT: 119024414(rxylt1)
MZE: 101485151(rxylt1)
ONL: 100696362(rxylt1)
OAU: 116312560(rxylt1)
OLA: 101158942(rxylt1)
OML: 112152355(rxylt1)
XMA: 102232454(rxylt1)
XCO: 114155264(rxylt1)
XHE: 116734586(rxylt1)
PRET: 103466210(tmem5)
PFOR: 103144377(tmem5)
PLAI: 106956353(tmem5)
PMEI: 106918862(tmem5)
GAF: 122836255(rxylt1)
CVG: 107082444(tmem5)
CTUL: 119796790(rxylt1)
GMU: 124855859(rxylt1)
NFU: 107389076(tmem5)
KMR: 108237463(rxylt1)
ALIM: 106523189 106534997(tmem5)
NWH: 119415608(rxylt1)
AOCE: 111575928(tmem5)
MCEP: 125014796(rxylt1)
CSEM: 103380416(tmem5)
POV: 109641917(tmem5)
SSEN: 122775364(rxylt1)
HHIP: 117763567(rxylt1)
HSP: 118110149(rxylt1)
LCF: 108875264(rxylt1)
SDU: 111228597(tmem5)
SLAL: 111661770(rxylt1)
XGL: 120793739(rxylt1)
HCQ: 109530509(tmem5)
BPEC: 110161333(tmem5)
MALB: 109961858(tmem5)
BSPL: 114858005(rxylt1)
SASA: 100380601(tmem5)
STRU: 115152203(rxylt1) 115197402
OTW: 112252554(rxylt1)
OMY: 110523037(rxylt1)
OGO: 124002735(rxylt1)
ONE: 115108969(rxylt1)
SALP: 111952823(rxylt1)
SNH: 120054086(rxylt1)
CCLU: 121576979(rxylt1)
ELS: 105018139(rxylt1)
SFM: 108935981(rxylt1)
PKI: 111860961(rxylt1)
AANG: 118231063(rxylt1)
LOC: 102687159(tmem5)
PSPA: 121319998(rxylt1)
ARUT: 117419593(rxylt1)
LCM: 102347491(TMEM5)
CMK: 103179815(rxylt1)
RTP: 109927331(tmem5)
BFO: 118415550
BBEL: 109466277
CIN: 100176272
SCLV: 120338962
SPU: 583032
APLC: 110974336
SKO: 100371491
BTAB: 109039481
CLEC: 106669996
HHAL: 106678765
NLU: 111058530
FOC: 113211456
ZNE: 110831162
CSEC: 111867064
DMK: 116925727
PVM: 113803028
PJA: 122259296
PCHN: 125044686
HAME: 121854756
PCLA: 123762342
PTRU: 123514028
HAZT: 108674530
DSV: 119466506
RSAN: 119372286
RMP: 119163079
VDE: 111249696
VJA: 111269078
DPTE: 113794600
DFR: 124490005
CSCU: 111635261
PTEP: 107455480
SDM: 118187245
PCAN: 112571562
BGT: 106079271
GAE: 121369246
HRF: 124133040
HRJ: 124277484
CRG: 105323570
MYI: 110443872
PMAX: 117331769
MMER: 123529023
OBI: 106874473
OSN: 115216551
ATEN: 116306927
ADF: 107327964
AMIL: 114956532
PDAM: 113679018
SPIS: 111323979
DGT: 114526485
HMG: 101235002
 » show all
Reference
  Authors
Manya H, Yamaguchi Y, Kanagawa M, Kobayashi K, Tajiri M, Akasaka-Manya K, Kawakami H, Mizuno M, Wada Y, Toda T, Endo T
  Title
The Muscular Dystrophy Gene TMEM5 Encodes a Ribitol beta1,4-Xylosyltransferase Required for the Functional Glycosylation of Dystroglycan.
  Journal
J Biol Chem 291:24618-24627 (2016)
DOI:10.1074/jbc.M116.751917
  Sequence
[hsa:10329]
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