KEGG   ORTHOLOGY: K24152
Entry
K24152                      KO                                     

Name
S
Definition
SARS coronavirus spike glycoprotein
Pathway
ko03230  Viral genome structure
ko05171  Coronavirus disease - COVID-19
Network
nt06136  Complement activation (viruses)
nt06171  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  Element
N01307  SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
N01312  SARS-CoV-2 S to lectin pathway of complement activation
N01314  SARS-CoV-2 S to classical pathway of complement activation
N01316  SARS-CoV-2 S/N to lectin pathway of coagulation activation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K24152  S; SARS coronavirus spike glycoprotein
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K24152  S; SARS coronavirus spike glycoprotein
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K24152  S; SARS coronavirus spike glycoprotein
   03210 Viral fusion proteins
    K24152  S; SARS coronavirus spike glycoprotein
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Coronavirus
   K24152  S; SARS coronavirus spike glycoprotein
Viral fusion proteins [BR:ko03210]
 Class I fusion proteins
  Coronaviridae
   K24152  S; SARS coronavirus spike glycoprotein
Genes
VG: 1489668(S) 43740568(S) 9714824(S)
Reference
  Authors
Rota PA, Oberste MS, Monroe SS, Nix WA, Campagnoli R, Icenogle JP, Penaranda S, Bankamp B, Maher K, Chen MH, Tong S, Tamin A, Lowe L, Frace M, DeRisi JL, Chen Q, Wang D, Erdman DD, Peret TC, Burns C, Ksiazek TG, Rollin PE, Sanchez A, Liffick S, Holloway B, Limor J, McCaustland K, Olsen-Rasmussen M, Fouchier R, Gunther S, Osterhaus AD, Drosten C, Pallansch MA, Anderson LJ, Bellini WJ
  Title
Characterization of a novel coronavirus associated with severe acute respiratory syndrome.
  Journal
Science 300:1394-9 (2003)
DOI:10.1126/science.1085952
  Sequence
[vg:1489668]
Reference
  Authors
Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, Choe H, Farzan M
  Title
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.
  Journal
Nature 426:450-4 (2003)
DOI:10.1038/nature02145
Reference
  Authors
Wu F, Zhao S, Yu B, Chen YM, Wang W, Song ZG, Hu Y, Tao ZW, Tian JH, Pei YY, Yuan ML, Zhang YL, Dai FH, Liu Y, Wang QM, Zheng JJ, Xu L, Holmes EC, Zhang YZ
  Title
A new coronavirus associated with human respiratory disease in China.
  Journal
Nature 10.1038/s41586-020-2008-3 (2020)
DOI:10.1038/s41586-020-2008-3
  Sequence
Reference
  Authors
Hoffmann M, Kleine-Weber H, Schroeder S, Kruger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, Muller MA, Drosten C, Pohlmann S
  Title
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.
  Journal
Cell 181:271-280.e8 (2020)
DOI:10.1016/j.cell.2020.02.052
LinkDB

KEGG   ORTHOLOGY: K24106
Entry
K24106                      KO                                     

Name
N
Definition
SARS coronavirus nucleocapsid protein
Pathway
ko03230  Viral genome structure
ko05171  Coronavirus disease - COVID-19
Network
nt06136  Complement activation (viruses)
nt06171  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  Element
N01316  SARS-CoV-2 S/N to lectin pathway of coagulation activation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K24106  N; SARS coronavirus nucleocapsid protein
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K24106  N; SARS coronavirus nucleocapsid protein
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K24106  N; SARS coronavirus nucleocapsid protein
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Coronavirus
   K24106  N; SARS coronavirus nucleocapsid protein
Genes
VG: 1489678(N) 43740575(N) 9714831(N)
Reference
  Authors
Wu F, Zhao S, Yu B, Chen YM, Wang W, Song ZG, Hu Y, Tao ZW, Tian JH, Pei YY, Yuan ML, Zhang YL, Dai FH, Liu Y, Wang QM, Zheng JJ, Xu L, Holmes EC, Zhang YZ
  Title
A new coronavirus associated with human respiratory disease in China.
  Journal
Nature 10.1038/s41586-020-2008-3 (2020)
DOI:10.1038/s41586-020-2008-3
  Sequence
LinkDB

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