KEGG   MODULE: M00376
Entry
M00376            Pathway   Module                                 
Name
3-Hydroxypropionate bi-cycle
Definition
(K02160+K01961+K01962+K01963) K14468 K14469 K15052 K05606 (K01847,K01848+K01849) (K14471+K14472) (K00239+K00240+K00241) K01679
K08691 K14449 K14470 K09709
Diagram
M00376

Orthology
K01961,K01962,K01963  
acetyl-CoA carboxylase carboxyl transferase [EC:6.4.1.2] [RN:R00742]
K02160  
acetyl-CoA carboxylase biotin carboxyl carrier protein [RN:R00742]
K14468  
malonyl-CoA reductase / 3-hydroxypropionate dehydrogenase (NADP+) [EC:1.2.1.75 1.1.1.298] [RN:R00740 R09289]
K14469  
acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase [EC:1.3.1.84 4.2.1.116 6.2.1.36] [RN:R09286 R03045 R00919]
K15052  
propionyl-CoA carboxylase [EC:6.4.1.3] [RN:R01859]
K05606  
methylmalonyl-CoA epimerase [EC:5.1.99.1] [RN:R02765]
K01847,K01848,K01849  
methylmalonyl-CoA mutase [EC:5.4.99.2] [RN:R00833]
K14471,K14472  
succinyl-CoA:(S)-malate CoA transferase [EC:2.8.3.-] [RN:R00406]
K00239,K00240,K00241  
succinate dehydrogenase [EC:1.3.5.1] [RN:R02164]
K01679  
fumarate hydratase [EC:4.2.1.2] [RN:R01082]
K08691  
malyl-CoA/(S)-citramalyl-CoA lyase [EC:4.1.3.24 4.1.3.25] [RN:R00473 R00934 R00237]
K14449  
2-methylfumaryl-CoA hydratase [EC:4.2.1.148] [RN:R05076]
K14470  
2-methylfumaryl-CoA isomerase [EC:5.4.1.3] [RN:R09283]
K09709  
3-methylfumaryl-CoA hydratase [EC:4.2.1.153] [RN:R09282]
Class
Pathway modules; Energy metabolism; Carbon fixation
Pathway
map00720  Other carbon fixation pathways
map01200  Carbon metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
R00742  
R00740  
R09289  
R09286  
R03045  
R00919  
R01859  
R02765  
R00833  
R00406  
R02164  
R01082  
R00406  
R00473  
R00934  
R05076  
R09283  
R09282  
R00237  
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00222  3-Oxopropanoate
C01013  3-Hydroxypropanoate
C05668  3-Hydroxypropionyl-CoA
C00894  Propenoyl-CoA
C00100  Propanoyl-CoA
C00683  (S)-Methylmalonyl-CoA
C01213  (R)-Methylmalonyl-CoA
C00091  Succinyl-CoA
C00042  Succinate
C00122  Fumarate
C00149  (S)-Malate
C04348  (3S)-3-Carboxy-3-hydroxypropanoyl-CoA
C00048  Glyoxylate
C06027  L-erythro-3-Methylmalyl-CoA
C06028  Mesaconyl-CoA
C18323  Mesaconyl-C4-CoA
C01011  (3S)-Citramalyl-CoA
C00022  Pyruvate
RModule
RM019  Acyl-CoA conversion via dicarboxylate semialdehyde
Comment
Organism group: photosynthetic green nonsulfur bacteria
Reference
PMID:19955419
  Authors
Zarzycki J, Brecht V, Muller M, Fuchs G
  Title
Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus.
  Journal
Proc Natl Acad Sci U S A 106:21317-22 (2009)
DOI:10.1073/pnas.0908356106
Reference
PMID:19103151
  Authors
Xin Y, Lu YK, Fromme R, Fromme P, Blankenship RE
  Title
Purification, characterization and crystallization of menaquinol:fumarate oxidoreductase from the green filamentous photosynthetic bacterium Chloroflexus aurantiacus.
  Journal
Biochim Biophys Acta 1787:86-96 (2009)
DOI:10.1016/j.bbabio.2008.11.010
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