KEGG   MODULE: M00885
Entry
M00885            Pathway   Module                                 
Name
Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA)
Definition
K02078
K11263+K18472 K00645 K11608
K11609+K11610+(K27071+K27072,K27689)+K11611
Diagram
M00885  Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA)
M00885

Class
Pathway modules; Lipid metabolism; Fatty acid metabolism
Pathway
map00074  Mycolic acid biosynthesis
map01100  Metabolic pathways
Orthology
K02078  
acpM; acyl carrier protein
K11263  
accA3; acetyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.3.4.14] [RN:R00742]
K18472  
accD6; acetyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 2.1.3.15] [RN:R00742]
K00645  
fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39] [RN:R01626]
K11608  
mtfabH; mycobacterial beta-ketoacyl-[acyl-carrier protein] synthase III [EC:2.3.1.301] [RN:R13257]
K11609  
kasA; meromycolic acid 3-oxoacyl-[acyl-carrier protein] synthase I [EC:2.3.1.293] [RN:R13258 R13262 R13266]
K11610  
mabA; meromycolic acid 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.-] [RN:R13259 R13263 R13267]
K27071  
hadA; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadA [EC:4.2.1.-] [RN:R13260 R13264 R13268]
K27072  
hadB; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadB [EC:4.2.1.-] [RN:R13260 R13264 R13268]
K27689  
hadAB; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadAB [EC:4.2.1.-] [RN:R13260 R13264 R13268]
K11611  
inhA; meromycolic acid enoyl-[acyl-carrier protein] reductase [EC:1.3.1.118] [RN:R13261 R13265 R13269]
Complete
mtu  Mycobacterium tuberculosis H37Rv
mtv  Mycobacterium tuberculosis H37Rv
mtc  Mycobacterium tuberculosis CDC1551
mra  Mycobacterium tuberculosis H37Ra
mtf  Mycobacterium tuberculosis F11
mtb  Mycobacterium tuberculosis KZN 1435
mtk  Mycobacterium tuberculosis KZN 4207
mtz  Mycobacterium tuberculosis KZN 605
mti  Mycobacterium tuberculosis RGTB423
mtur  Mycobacterium tuberculosis CCDC5079
mto  Mycobacterium tuberculosis CTRI-2
mtd  Mycobacterium tuberculosis UT205
mtj  Mycobacterium tuberculosis Beijing/NITR203
mtub  Mycobacterium tuberculosis 7199-99
mtx  Mycobacterium tuberculosis EAI5
mtul  Mycobacterium tuberculosis Haarlem
mtut  Mycobacterium tuberculosis BT1
mtuu  Mycobacterium tuberculosis BT2
mtq  Mycobacterium tuberculosis HKBS1
mbo  Mycobacterium tuberculosis variant bovis AF2122/97
mbb  Mycobacterium tuberculosis variant bovis BCG Pasteur 1173P2
mbt  Mycobacterium tuberculosis variant bovis BCG Tokyo 172
mbm  Mycobacterium tuberculosis variant bovis BCG Mexico
mbk  Mycobacterium tuberculosis variant bovis BCG Korea 1168P
mbx  Mycobacterium tuberculosis variant bovis BCG ATCC 35743
maf  Mycobacterium tuberculosis variant africanum
mmic  Mycobacterium tuberculosis variant microti
mce  Mycobacterium canettii CIPT 140010059
mcq  Mycobacterium canettii CIPT 140060008
mcv  Mycobacterium canettii CIPT 140070008
mcx  Mycobacterium canettii CIPT 140070010
mcz  Mycobacterium canettii CIPT 140070017
mory  Mycobacterium orygis
mpa  Mycobacterium avium subsp. paratuberculosis K-10
mao  Mycobacterium avium subsp. paratuberculosis MAP4
mavi  Mycobacterium avium subsp. paratuberculosis E1
mavu  Mycobacterium avium subsp. paratuberculosis E93
mav  Mycobacterium avium 104
mavm  Mycobacterium avium subsp. avium
mit  Mycobacterium intracellulare MOTT-02
mia  Mycobacterium intracellulare ATCC 13950
mid  Mycobacterium intracellulare subsp. intracellulare
myo  Mycobacterium intracellulare subsp. yongonense
mchi  Mycobacterium intracellulare subsp. chimaera
mir  Mycobacterium paraintracellulare
mmal  Mycobacterium marseillense
mlp  Mycobacterium lepraemurium
mman  Mycobacterium mantenii
mser  Mycobacterium senriense
mul  Mycobacterium ulcerans
mmi  Mycobacterium marinum M
mmae  Mycobacterium marinum E11
mli  Mycobacterium liflandii
mpse  Mycobacterium pseudoshottsii
msho  Mycobacterium shottsii
mmm  Mycobacterium sp. MOTT36Y
mkn  Mycobacterium kansasii ATCC 12478
mshg  Mycobacterium shigaense
mfj  Mycobacterium florentinum
msto  Mycobacterium stomatepiae
msim  Mycobacterium simiae
mku  Mycobacterium kubicae
mlw  Mycobacterium lentiflavum
mpag  Mycobacterium paragordonae
mgor  Mycobacterium vicinigordonae
mbai  Mycobacterium basiliense
mseo  Mycobacterium seoulense
mlj  Mycobacterium lacus
mbrd  Mycobacterium branderi
mshj  Mycobacterium shinjukuense
mspg  Mycobacterium spongiae
mot  Mycobacterium ostraviense
mhaf  Mycobacterium hainanense
mfx  Mycolicibacterium fallax
mij  Mycolicibacterium insubricum
maub  Mycolicibacterium aubagnense
mphu  Mycolicibacterium phocaicum
mmuc  Mycolicibacterium mucogenicum
mkr  Mycolicibacillus koreensis
mpak  Mycolicibacillus parakoreensis
mab  Mycobacteroides abscessus ATCC 19977
mmv  Mycobacteroides abscessus subsp. massiliense GO 06
mabb  Mycobacteroides abscessus subsp. bolletii 50594
mabl  Mycobacteroides abscessus subsp. massiliense CCUG 48898 = JCM 15300
miz  Mycobacteroides immunogenum
mste  Mycobacteroides stephanolepidis
msao  Mycobacteroides saopaulense
msal  Mycobacteroides salmoniphilum
mmin  Mycolicibacter minnesotensis
mhib  Mycolicibacter hiberniae
mher  Mycolicibacter heraklionensis
mvm  Mycolicibacter virginiensis
mkk  Mycobacterium kokjensenii
asd  Hoyosella subflava
nfa  Nocardia farcinica IFM 10152
nfr  Nocardia farcinica NCTC11134
ncy  Nocardia cyriacigeorgica
nbr  Nocardia brasiliensis
nno  Nocardia nova
nsl  Nocardia mangyaensis
nsr  Nocardia seriolae
ntp  Nocardia terpenica
noz  Nocardia sp. CS682
nod  Nocardia otitidiscaviarum
nah  Nocardia arthritidis
nad  Nocardia asteroides
nwl  Nocardia wallacei
nie  Nocardia iowensis
nhu  Nocardia huaxiensis
nya  Nocardia yamanashiensis
ngp  Nocardia gipuzkoensis
nspu  Nocardia sputorum
nyu  Nocardia yunnanensis
nvu  Nocardia vulneris
rha  Rhodococcus jostii
rer  Rhodococcus erythropolis PR4
rey  Rhodococcus erythropolis CCM2595
reb  Rhodococcus erythropolis BG43
rqi  Rhodococcus qingshengii
rop  Rhodococcus opacus B4
roa  Rhodococcus opacus PD630
rpy  Rhodococcus pyridinivorans SB3094
rby  Rhodococcus pyridinivorans TG9
rhb  Rhodococcus sp. B7740
rav  Rhodococcus aetherivorans IcdP1
rhu  Rhodococcus sp. PBTS 1
rhq  Rhodococcus sp. p52
rhod  Rhodococcus sp. 008
rrt  Rhodococcus rhodochrous
rcr  Rhodococcus coprophilus
rtm  Rhodococcus triatomae
rko  Rhodococcus koreensis
rgo  Rhodococcus globerulus
roz  Rhodococcus oxybenzonivorans
rpsk  Rhodococcus pseudokoreensis
rgor  Rhodococcus gordoniae
rhop  Rhodococcus sp. P1Y
rhoo  Rhodococcus sp. DN22
rhou  Rhodococcus sp. 11-3
rhow  Rhodococcus sp. WB1
rhoj  Rhodococcus sp. JVH1
rhos  Rhodococcus sp. M8-50
rhoq  Rhodococcus sp. M8-33
rhoy  Rhodococcus sp. AH-ZY2
rhoh  Rhodococcus sp. H-CA8f
rhox  Rhodococcus sp. D-6
rhjs  Rhodococcus sp. JS3073
rsf  Rhodococcus sacchari
rhzq  Rhodococcus sp. 21391
rhzg  Rhodococcus sp. 2G
rhbh  Rhodococcus sp. BH4
rhpd  Rhodococcus sp. PD04
rhon  Rhodococcus sp. NJ-530
rhwb  Rhodococcus sp. WB9
rhsq  Rhodococcus sp. SGAir0479
rhwy  Rhodococcus sp. WAY2
rhdm  Rhodococcus sp. DMU1
rhwq  Rhodococcus sp. W8901
rhmm  Rhodococcus sp. M8
rhzp  Rhodococcus sp. ZPP
rhrc  Rhodococcus sp. RCBS9
rhny  Rhodococcus sp. NyZ502
rhrd  Rhodococcus sp. RDE2
rfa  Rhodococcoides fascians D188
rhs  Rhodococcoides fascians PBTS 2
req  Prescottella equi
psow  Prescottella soli
whr  Williamsia herbipolensis
gbr  Gordonia bronchialis
gpo  Gordonia polyisoprenivorans
gor  Gordonia sp. KTR9
goq  Gordonia phthalatica
gta  Gordonia terrae
gru  Gordonia rubripertincta
gom  Gordonia insulae
gav  Gordonia alkanivorans
god  Gordonia sp. 135
gos  Gordonia sp. SMJS1
goj  Gordonia sp. JH63
gam  Gordonia amarae
gpd  Gordonia pseudamarae
gji  Gordonia jinghuaiqii
goi  Gordonia otitidis
ghn  Gordonia hongkongensis
gami  Gordonia amicalis
gmg  Gordonia mangrovi
gsi  Gordonia sihwensis
goo  Gordonia sp. X0973
gop  Gordonia sp. PS3
spin  Skermania pinensis
 » show all
Reaction
R00742  
R01626  
R13257  
R13258  
R13259  
R13260  
R13261  
R13262  
R13263  
R13264  
R13265  
R13266  
R13267  
R13268  
R13269  
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00229  Acyl-carrier protein
C01209  Malonyl-[acyl-carrier protein]
C02843  Long-chain acyl-CoA
C22858  Long-chain 3-oxoacyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C22859  Long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein]
C22860  Long-chain trans-2-enoyl-[acyl-carrier protein]
C22861  Very-long-chain acyl-[acyl-carrier protein]
C22862  Very-long-chain 3-oxoacyl-[acyl-carrier protein]
C22863  Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein]
C22864  Very-long-chain trans-2-enoyl-[acyl-carrier protein]
C22865  Ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein]
C22866  Ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein]
C22867  Ultra-long-chain mono-unsaturated (3R)-3-hydroxyacyl-[acyl-carrier protein]
C22868  Ultra-long-chain mono-unsaturated trans-2-enoyl-[acyl-carrier protein]
RModule
RM021  Fatty acid synthesis using malonyl-CoA
Reference
PMID:15653820
  Authors
Takayama K, Wang C, Besra GS.
  Title
Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 18:81-101 (2005)
DOI:10.1128/CMR.18.1.81-101.2005
Reference
PMID:21204864
  Authors
Gago G, Diacovich L, Arabolaza A, Tsai SC, Gramajo H.
  Title
Fatty acid biosynthesis in actinomycetes.
  Journal
FEMS Microbiol Rev 35:475-97 (2011)
DOI:10.1111/j.1574-6976.2010.00259.x
Reference
PMID:24374164
  Authors
Marrakchi H, Laneelle MA, Daffe M.
  Title
Mycolic acids: structures, biosynthesis, and beyond.
  Journal
Chem Biol 21:67-85 (2014)
DOI:10.1016/j.chembiol.2013.11.011
Reference
PMID:22216317
  Authors
Cantaloube S, Veyron-Churlet R, Haddache N, Daffe M, Zerbib D.
  Title
The Mycobacterium tuberculosis FAS-II dehydratases and methyltransferases define  the specificity of the mycolic acid elongation complexes.
  Journal
PLoS One 6:e29564 (2011)
DOI:10.1371/journal.pone.0029564
Reference
PMID:17804795
  Authors
Sacco E, Covarrubias AS, O'Hare HM, Carroll P, Eynard N, Jones TA, Parish T, Daffe M, Backbro K, Quemard A
  Title
The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis.
  Journal
Proc Natl Acad Sci U S A 104:14628-33 (2007)
DOI:10.1073/pnas.0704132104
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