KEGG   MODULE: M00912
Entry
M00912            Pathway   Module                                 
Name
NAD biosynthesis, tryptophan => quinolinate => NAD
Definition
(K00453,K00463) (K01432,K14263,K07130) K00486 K01556 K00452 K00767 (K00969,K06210) (K01916,K01950)
Diagram
M00912

Orthology
K00453  
tryptophan 2,3-dioxygenase [EC:1.13.11.11] [RN:R00678]
K00463  
indoleamine 2,3-dioxygenase [EC:1.13.11.52] [RN:R00678]
K01432,K14263,K07130  
kynurenine formamidase [EC:3.5.1.9] [RN:R01959]
K00486  
kynurenine 3-monooxygenase [EC:1.14.13.9] [RN:R01960]
K01556  
kynureninase [EC:3.7.1.3] [RN:R02668]
K00452  
3-hydroxyanthranilate 3,4-dioxygenase [EC:1.13.11.6] [RN:R02665]
K00767  
nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19] [RN:R03348]
K00969,K06210  
nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18] [RN:R03005]
K01916  
NAD+ synthase [EC:6.3.1.5] [RN:R00189]
K01950  
NAD+ synthase (glutamine-hydrolysing) [EC:6.3.5.1] [RN:R00257]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00380  Tryptophan metabolism
map00760  Nicotinate and nicotinamide metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
R00678  
R01959  
R01960  
R02668  
R02665  
R04293  
R03348  
R03005  
R00189,R00257  
Compound
C00078  L-Tryptophan
C02700  L-Formylkynurenine
C00328  L-Kynurenine
C03227  3-Hydroxy-L-kynurenine
C00632  3-Hydroxyanthranilate
C04409  2-Amino-3-carboxymuconate semialdehyde
C03722  Quinolinate
C01185  Nicotinate D-ribonucleotide
C00857  Deamino-NAD+
C00003  NAD+
Reference
PMID:12062417
  Authors
Panozzo C, Nawara M, Suski C, Kucharczyka R, Skoneczny M, Becam AM, Rytka J, Herbert CJ
  Title
Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae.
  Journal
FEBS Lett 517:97-102 (2002)
DOI:10.1016/s0014-5793(02)02585-1
Reference
PMID:18205391
  Authors
Wogulis M, Chew ER, Donohoue PD, Wilson DK
  Title
Identification of formyl kynurenine formamidase and kynurenine aminotransferase from Saccharomyces cerevisiae using crystallographic, bioinformatic and biochemical evidence.
  Journal
Biochemistry 47:1608-21 (2008)
DOI:10.1021/bi701172v
Reference
PMID:14700627
  Authors
Kurnasov O, Goral V, Colabroy K, Gerdes S, Anantha S, Osterman A, Begley TP
  Title
NAD biosynthesis: identification of the tryptophan to quinolinate pathway in bacteria.
  Journal
Chem Biol 10:1195-204 (2003)
DOI:10.1016/j.chembiol.2003.11.011
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