Entry Name NAD biosynthesis, tryptophan => quinolinate => NAD
Definition (K00453,K00463) (K01432,K14263,K07130) K00486 K01556 K00452 K00767 (K00969,K06210) (K01916,K01950)
Diagram M00912 NAD biosynthesis, tryptophan => quinolinate => NAD
Class Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolismBRITE hierarchy
Pathway map00760 Nicotinate and nicotinamide metabolism
Orthology
nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:
2.4.2.19 ] [RN:
R03348 ]
Ortholog table Taxonomy Complete ptr Pan troglodytes (chimpanzee)
pps Pan paniscus (bonobo)
ggo Gorilla gorilla gorilla (western lowland gorilla)
pon Pongo abelii (Sumatran orangutan)
ppyg Pongo pygmaeus (Bornean orangutan)
nle Nomascus leucogenys (northern white-cheeked gibbon)
hmh Hylobates moloch (silvery gibbon)
ssyn Symphalangus syndactylus (siamang)
mcc Macaca mulatta (rhesus monkey)
mcf Macaca fascicularis (crab-eating macaque)
mthb Macaca thibetana thibetana (Pere David's macaque)
mni Macaca nemestrina (pig-tailed macaque)
csab Chlorocebus sabaeus (green monkey)
caty Cercocebus atys (sooty mangabey)
panu Papio anubis (olive baboon)
tge Theropithecus gelada (gelada)
mleu Mandrillus leucophaeus (drill)
rro Rhinopithecus roxellana (golden snub-nosed monkey)
rbb Rhinopithecus bieti (black snub-nosed monkey)
tfn Trachypithecus francoisi (Francois's langur)
pteh Piliocolobus tephrosceles (Ugandan red Colobus)
cang Colobus angolensis palliatus (Angola colobus)
cjc Callithrix jacchus (white-tufted-ear marmoset)
sbq Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
cimi Cebus imitator (Panamanian white-faced capuchin)
anan Aotus nancymaae (Ma's night monkey)
csyr Carlito syrichta (Philippine tarsier)
mmur Microcebus murinus (gray mouse lemur)
lcat Lemur catta (Ring-tailed lemur)
pcoq Propithecus coquereli (Coquerel's sifaka)
oga Otolemur garnettii (small-eared galago)
mmu Mus musculus (house mouse)
mcal Mus caroli (Ryukyu mouse)
mpah Mus pahari (shrew mouse)
rno Rattus norvegicus (rat)
mcoc Mastomys coucha (southern multimammate mouse)
anu Arvicanthis niloticus (African grass rat)
asyl Apodemus sylvaticus (European woodmouse)
mun Meriones unguiculatus (Mongolian gerbil)
cge Cricetulus griseus (Chinese hamster)
maua Mesocricetus auratus (golden hamster)
prob Phodopus roborovskii (desert hamster)
pleu Peromyscus leucopus (white-footed mouse)
morg Microtus oregoni (creeping vole)
mfot Alexandromys fortis (reed vole)
aamp Arvicola amphibius (Eurasian water vole)
ngi Nannospalax galili (Upper Galilee mountains blind mole rat)
hgl Heterocephalus glaber (naked mole-rat)
cpoc Cavia porcellus (domestic guinea pig)
ccan Castor canadensis (American beaver)
dord Dipodomys ordii (Ord's kangaroo rat)
dsp Dipodomys spectabilis (banner-tailed kangaroo rat)
dmer Dipodomys merriami (Merriam's kangaroo rat)
plop Perognathus longimembris pacificus (Pacific pocket mouse)
ncar Sciurus carolinensis (gray squirrel)
mmma Marmota marmota marmota (Alpine marmot)
iti Ictidomys tridecemlineatus (thirteen-lined ground squirrel)
opi Ochotona princeps (American pika)
ocz Ochotona curzoniae (black-lipped pika)
tup Tupaia chinensis (Chinese tree shrew)
gvr Galeopterus variegatus (Sunda flying lemur)
cfa Canis lupus familiaris (dog)
clud Canis lupus dingo (dingo)
vvp Vulpes vulpes (red fox)
vlg Vulpes lagopus (Arctic fox)
npo Nyctereutes procyonoides (raccoon dog)
aml Ailuropoda melanoleuca (giant panda)
umr Ursus maritimus (polar bear)
uah Ursus arctos (brown bear)
uar Ursus americanus (American black bear)
elk Enhydra lutris kenyoni (northern sea otter)
llv Lutra lutra (Eurasian river otter)
mpuf Mustela putorius furo (domestic ferret)
mnp Mustela nigripes (black-footed ferret)
mlk Mustela lutreola (European mink)
nvs Neogale vison (American mink)
oro Odobenus rosmarus divergens (Pacific walrus)
eju Eumetopias jubatus (Steller sea lion)
zca Zalophus californianus (California sea lion)
mlx Mirounga leonina (Southern elephant seal)
nsu Neomonachus schauinslandi (Hawaiian monk seal)
lww Leptonychotes weddellii (Weddell seal)
fca Felis catus (domestic cat)
pyu Herpailurus yagouaroundi (jaguarundi)
pbg Prionailurus bengalensis (leopard cat)
pviv Prionailurus viverrinus (fishing cat)
lgf Leopardus geoffroyi (Geoffroy's cat)
aju Acinonyx jubatus (cheetah)
ppad Panthera pardus (leopard)
puc Panthera uncia (snow leopard)
hhv Hyaena hyaena (striped hyena)
biu Bos indicus (zebu cattle)
bbub Bubalus bubalis (water buffalo)
bbis Bison bison bison (American bison)
btax Budorcas taxicolor (takin)
csum Capricornis sumatraensis (Sumatran serow)
oda Oryx dammah (scimitar-horned oryx)
ccad Cervus canadensis (wapiti)
mree Muntiacus reevesi (Reeves' muntjac)
ovr Odocoileus virginianus (white-tailed deer)
mbez Moschus berezovskii (Chinese forest musk deer)
cfr Camelus ferus (Wild Bactrian camel)
cbai Camelus bactrianus (Bactrian camel)
cdk Camelus dromedarius (Arabian camel)
vpc Vicugna pacos (alpaca)
bacu Balaenoptera acutorostrata scammoni (minke whale)
bmus Balaenoptera musculus (blue whale)
lve Lipotes vexillifer (Yangtze River dolphin)
oor Orcinus orca (killer whale)
lalb Lagenorhynchus albirostris (white-beaked dolphin)
gmf Globicephala melas (long-finned pilot whale)
ddp Delphinus delphis (saddleback dolphin)
dle Delphinapterus leucas (beluga whale)
pcad Physeter macrocephalus (sperm whale)
psiu Phocoena sinus (vaquita)
pphc Phocoena phocoena (harbor porpoise)
nasi Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
ecb Equus caballus (horse)
epz Equus przewalskii (Przewalski's horse)
mmyo Myotis myotis (greater mouse-eared bat)
mdt Myotis daubentonii (Daubenton's bat)
myum Myotis yumanensis (Yuma myotis)
pkl Pipistrellus kuhlii (Kuhl's pipistrelle)
efus Eptesicus fuscus (big brown bat)
mna Miniopterus natalensis (Natal long-fingered bat)
dro Desmodus rotundus (common vampire bat)
shon Sturnira hondurensis
pdic Phyllostomus discolor (pale spear-nosed bat)
phas Phyllostomus hastatus (greater spear-nosed bat)
mmf Molossus molossus (Pallas's mastiff bat)
ppam Pteronotus mesoamericanus (Parnell's mustached bat)
hai Hipposideros armiger (great roundleaf bat)
rfq Rhinolophus ferrumequinum (greater horseshoe bat)
pale Pteropus alecto (black flying fox)
pgig Pteropus vampyrus (Indian flying fox)
pvp Pteropus vampyrus (large flying fox)
ray Rousettus aegyptiacus (Egyptian rousette)
mjv Manis javanica (Malayan pangolin)
tod Talpa occidentalis (Iberian mole)
sara Sorex araneus (European shrew)
sfum Sorex fumeus (smoky shrew)
setr Suncus etruscus (white-toothed pygmy shrew)
lav Loxodonta africana (African savanna elephant)
tmu Trichechus manatus latirostris (Florida manatee)
etf Echinops telfairi (small Madagascar hedgehog)
dnm Dasypus novemcinctus (nine-banded armadillo)
mdo Monodelphis domestica (gray short-tailed opossum)
gas Gracilinanus agilis (agile gracile opossum)
shr Sarcophilus harrisii (Tasmanian devil)
afz Antechinus flavipes (yellow-footed antechinus)
pcw Phascolarctos cinereus (koala)
tvp Trichosurus vulpecula (common brushtail)
pbrv Petaurus breviceps papuanus (sugar glider)
mlao Macrotis lagotis (bilby)
oaa Ornithorhynchus anatinus (platypus)
tacu Tachyglossus aculeatus (Australian echidna)
gga Gallus gallus (chicken)
mgp Meleagris gallopavo (turkey)
cjo Coturnix japonica (Japanese quail)
cata Cygnus atratus (black swan)
tgu Taeniopygia guttata (zebra finch)
lsr Lonchura striata (white-rumped munia)
otc Onychostruthus taczanowskii (white-rumped snowfinch)
atrc Agelaius tricolor (tricolored blackbird)
oma Oenanthe melanoleuca (Eastern black-eared wheatear)
phi Pseudopodoces humilis (Tibetan ground-tit)
acoe Aphelocoma coerulescens (scrub jay)
etl Empidonax traillii (willow flycatcher)
hrt Hirundo rustica (Barn swallow)
sati Sylvia atricapilla (blackcap)
ccic Cinclus cinclus (white-throated dipper)
agen Astur gentilis (Northern goshawk)
hhar Harpia harpyja (harpy eagle)
cbor Calonectris borealis (Cory's shearwater)
cboy Ciconia boyciana (Oriental stork)
mame Mycteria americana (wood stork)
cnic Caloenas nicobarica (Nicobar pigeon)
crid Chroicocephalus ridibundus (black-headed gull)
arow Apteryx rowi (Okarito brown kiwi)
asn Alligator sinensis (Chinese alligator)
amj Alligator mississippiensis (American alligator)
ciz Carettochelys insculpta (pitted-shelled turtle)
cmy Chelonia mydas (green sea turtle)
ccay Caretta caretta (Loggerhead turtle)
dcc Dermochelys coriacea (leatherback sea turtle)
cpic Chrysemys picta (western painted turtle)
cabi Chelonoidis abingdonii (Abingdon island giant tortoise)
mrv Mauremys reevesii (Reeves's turtle)
acs Anolis carolinensis (green anole)
asao Anolis sagrei ordinatus (Brown anole)
pvt Pogona vitticeps (central bearded dragon)
sund Sceloporus undulatus (fence lizard)
pbi Python bivittatus (Burmese python)
pmur Protobothrops mucrosquamatus (Taiwan habu)
ctig Crotalus tigris (Tiger rattlesnake)
pgut Pantherophis guttatus (corn snake)
pcae Pituophis catenifer annectens (San Diego gophersnake)
apri Ahaetulla prasina (Asian vine snake)
ptex Pseudonaja textilis (eastern brown snake)
nss Notechis scutatus (mainland tiger snake)
vko Varanus komodoensis (Komodo dragon)
pmua Podarcis muralis (common wall lizard)
praf Podarcis raffonei (Aeolian wall lizard)
zvi Zootoca vivipara (common lizard)
hcg Hemicordylus capensis (graceful crag lizard)
gja Gekko japonicus (Schlegel's Japanese gecko)
stow Sphaerodactylus townsendi (Townsend's least gecko)
emc Eublepharis macularius (Leopard gecko)
xla Xenopus laevis (African clawed frog)
xtr Xenopus tropicalis (tropical clawed frog)
rtem Rana temporaria (common frog)
acat Aquarana catesbeiana (American bullfrog)
bbuf Bufo bufo (common toad)
dtc Dendrobates tinctorius (dyeing poison frog)
muo Microcaecilia unicolor
gsh Geotrypetes seraphini (Gaboon caecilian)
char Clupea harengus (Atlantic herring)
spil Sardina pilchardus (sardine)
tru Takifugu rubripes (torafugu)
tfs Takifugu flavidus (sansaifugu)
tng Tetraodon nigroviridis (spotted green pufferfish)
lco Larimichthys crocea (large yellow croaker)
tben Trematomus bernacchii (emerald rockcod)
pgeo Pseudochaenichthys georgianus (South Georgia icefish)
gacu Gymnodraco acuticeps
emac Eleginops maclovinus (Patagonian blennie)
ely Epinephelus lanceolatus (giant grouper)
efo Epinephelus fuscoguttatus (brown-marbled grouper)
sluc Sander lucioperca (pikeperch)
ecra Etheostoma cragini (Arkansas darter)
esp Etheostoma spectabile (orangethroat darter)
pflv Perca flavescens (yellow perch)
gat Gasterosteus aculeatus (three-spined stickleback)
ppug Pungitius pungitius (ninespine stickleback)
afb Anoplopoma fimbria (sablefish)
pswi Pseudoliparis swirei (Mariana hadal snailfish)
cana Clinocottus analis (woolly sculpin)
cve Cebidichthys violaceus (monkeyface prickleback)
msam Micropterus salmoides (largemouth bass)
schu Siniperca chuatsi (mandarin fish)
cud Cheilinus undulatus (humphead wrasse)
spul Semicossyphus pulcher (California sheephead)
lmix Labrus mixtus (cuckoo wrasse)
htc Halichoeres trimaculatus (threespot wrasse)
alat Acanthopagrus latus (yellowfin seabream)
astr Antennarius striatus (striated frogfish)
mze Maylandia zebra (zebra mbuna)
onl Oreochromis niloticus (Nile tilapia)
oau Oreochromis aureus (blue tilapia)
ola Oryzias latipes (Japanese medaka)
oml Oryzias melastigma (Indian medaka)
csai Cololabis saira (Pacific saury)
xma Xiphophorus maculatus (southern platyfish)
xco Xiphophorus couchianus (Monterrey platyfish)
xhe Xiphophorus hellerii (green swordtail)
pret Poecilia reticulata (guppy)
pfor Poecilia formosa (Amazon molly)
plai Poecilia latipinna (sailfin molly)
pmei Poecilia mexicana (shortfin molly)
gaf Gambusia affinis (western mosquitofish)
pprl Poeciliopsis prolifica (blackstripe livebearer)
cvg Cyprinodon variegatus (sheepshead minnow)
ctul Cyprinodon tularosa (White Sands pupfish)
gmu Girardinichthys multiradiatus (darkedged splitfin)
nfu Nothobranchius furzeri (turquoise killifish)
kmr Kryptolebias marmoratus (mangrove rivulus)
alim Austrofundulus limnaeus (annual killifish)
nwh Nematolebias whitei (Rio pearlfish)
aoce Amphiprion ocellaris (clown anemonefish)
eja Embiotoca jacksoni (black perch)
bfre Brachyistius frenatus (kelp perch)
mcep Mugil cephalus (flathead mullet)
csem Cynoglossus semilaevis (tongue sole)
pov Paralichthys olivaceus (Japanese flounder)
ssen Solea senegalensis (Senegalese sole)
ssoe Solea solea (common sole)
hhip Hippoglossus hippoglossus (Atlantic halibut)
hsp Hippoglossus stenolepis (Pacific halibut)
pplt Pleuronectes platessa (European plaice)
smau Scophthalmus maximus (turbot)
lcf Lates calcarifer (barramundi perch)
sdu Seriola dumerili (greater amberjack)
slal Seriola lalandi dorsalis (Yellowtail amberjack)
xgl Xiphias gladius (swordfish)
hcq Hippocampus comes (tiger tail seahorse)
sscv Syngnathus scovelli (Gulf pipefish)
sbia Syngnathoides biaculeatus (alligator pipefish)
pee Phycodurus eques (leafy seadragon)
ptao Phyllopteryx taeniolatus (common seadragon)
bpec Boleophthalmus pectinirostris (great blue-spotted mudskipper)
eny Eucyclogobius newberryi (tidewater goby)
malb Monopterus albus (swamp eel)
bspl Betta splendens (Siamese fighting fish)
sjo Scomber japonicus (chub mackerel)
ssco Scomber scombrus (Atlantic mackerel)
tty Thunnus thynnus (Atlantic bluefin tuna)
sasa Salmo salar (Atlantic salmon)
stru Salmo trutta (river trout)
otw Oncorhynchus tshawytscha (Chinook salmon)
omy Oncorhynchus mykiss (rainbow trout)
ogo Oncorhynchus gorbuscha (pink salmon)
oki Oncorhynchus kisutch (coho salmon)
oke Oncorhynchus keta (chum salmon)
omm Oncorhynchus masou masou (cherry salmon)
ocla Oncorhynchus clarkii lewisi (westslope cutthroat trout)
salp Salvelinus sp. IW2-2015 (Arctic char)
snh Salvelinus namaycush (lake trout)
sfon Salvelinus fontinalis (brook trout)
cclu Coregonus clupeaformis (lake whitefish)
els Esox lucius (northern pike)
oep Osmerus eperlanus (European smelt)
sfm Scleropages formosus (Asian bonytongue)
pki Paramormyrops kingsleyae
aang Anguilla anguilla (European eel)
arot Anguilla rostrata (American eel)
ccog Conger conger (European conger)
loc Lepisosteus oculatus (spotted gar)
pspa Polyodon spathula (Mississippi paddlefish)
arut Acipenser ruthenus (sterlet)
psex Polypterus senegalus (gray bichir)
lcm Latimeria chalumnae (coelacanth)
leri Leucoraja erinaceus (little skate)
haka Hemitrygon akajei (red stingray)
pmrn Petromyzon marinus (sea lamprey)
lrj Lethenteron reissneri (Far Eastern brook lamprey)
bfo Branchiostoma floridae (Florida lancelet)
bbel Branchiostoma belcheri (Belcher's lancelet)
sclv Styela clava (leathery sea squirt)
spu Strongylocentrotus purpuratus (purple sea urchin)
lpic Lytechinus pictus (painted urchin)
lvg Lytechinus variegatus (green sea urchin)
aplc Acanthaster planci (crown-of-thorns starfish)
arun Luidia clathrata (European starfish)
aamu Asterias amurensis (Northern Pacific seastar)
sko Saccoglossus kowalevskii (acorn worm)
rsan Rhipicephalus sanguineus (brown dog tick)
rmp Rhipicephalus microplus (southern cattle tick)
vde Varroa destructor (honeybee mite)
goe Galendromus occidentalis (western predatory mite)
cscu Centruroides sculpturatus (bark scorpion)
cvs Centruroides vittatus (striped bark scorpion)
lpol Limulus polyphemus (Atlantic horseshoe crab)
lgi Lottia gigantea (owl limpet)
pvul Patella vulgata (common limpet)
pcan Pomacea canaliculata (golden apple snail)
bgt Biomphalaria glabrata (bloodfluke planorb)
gae Gigantopelta aegis (peltospirid snail)
hrf Haliotis rufescens (red abalone)
hrj Haliotis rubra (blacklip abalone)
hasi Haliotis asinina (tropical abalone)
hcra Haliotis cracherodii (black abalone)
cvn Crassostrea virginica (eastern oyster)
oed Ostrea edulis (European flat oyster)
myi Mizuhopecten yessoensis (Yesso scallop)
airr Argopecten irradians (bay scallop)
mmer Mercenaria mercenaria (northern quahog)
rphi Ruditapes philippinarum (Manila clam)
dpol Dreissena polymorpha (zebra mussel)
maea Mya arenaria (softshell)
ljp Liolophura japonica (common chiton)
llon Lineus longissimus (bootlace worm)
nve Nematostella vectensis (starlet sea anemone)
epa Exaiptasia diaphana (Aiptasia)
aten Actinia tenebrosa (Australian red waratah sea anemone)
adf Acropora digitifera (stony coral)
mcaz Montipora capricornis (leaf plate montipora)
pdam Pocillopora damicornis (lace coral)
spis Stylophora pistillata (Smooth Cauliflower Coral)
xen Xenia sp. Carnegie-2017 (soft corals)
hsy Hydractinia symbiolongicarpus
aqu Amphimedon queenslandica (sponge)
sce Saccharomyces cerevisiae (budding yeast)
seub Saccharomyces eubayanus
spao Saccharomyces paradoxus
ago Eremothecium gossypii
erc Eremothecium cymbalariae
lth Lachancea thermotolerans
vpo Vanderwaltozyma polyspora
zro Zygosaccharomyces rouxii
tpf Tetrapisispora phaffii
tdl Torulaspora delbrueckii
zmk Zygotorulaspora mrakii
dha Debaryomyces hansenii
pic Scheffersomyces stipitis
pgu Meyerozyma guilliermondii
spaa Spathaspora passalidarum
lbg Lodderomyces beijingensis
cot Candida orthopsilosis
clu Clavispora lusitaniae ATCC 42720
clus Clavispora lusitaniae CBS 6936
asau Australozyma saopauloensis
bbrx Brettanomyces bruxellensis
opa Ogataea parapolymorpha
ppei Pyricularia pennisetigena
tmn Phaeoacremonium minimum
fpu Fusarium pseudograminearum
fvr Fusarium verticillioides
tre Trichoderma reesei QM6a
trr Trichoderma reesei RUT C-30
amus Akanthomyces muscarius
plj Purpureocillium lilacinum
chig Colletotrichum higginsianum
cdet Colletotrichum destructivum
ssl Sclerotinia sclerotiorum
bfu Botrytis cinerea (gray mold)
psco Mollisia scopiformis
bsc Bipolaris sorokiniana
aalt Alternaria alternata
pfj Pseudocercospora fijiensis
bcom Baudoinia panamericana
ptrc Puccinia triticina (wheat leaf rust)
pstr Puccinia striiformis f. sp. tritici (wheat yellow rust fungus)
mlr Melampsora larici-populina
rie Rhizophagus irregularis
tact Thalassomonas actiniarum
tvd Thalassomonas viridans
bstl Burkholderia stabilis
msd Myxococcus stipitatus
mlan Myxococcus landrumensis
bdq Bdellovibrio sp. qaytius
ctm Chloracidobacterium thermophilum
cvl Chloracidobacterium validum
chlo Chloracidobacterium sp. MS 40/45
hsw Hymenobacter swuensis
hym Hymenobacter sp. APR13
hyp Hymenobacter psoromatis
hyz Hymenobacter sp. PAMC 26628
htb Hymenobacter tibetensis
hyk Hymenobacter yonginensis
hcw Hymenobacter canadensis
laci Lacinutrix sp. Bg11-31
nsd Nonlabens tegetincola
nob Nonlabens sp. MB-3u-79
pom Polaribacter sp. MED152
prn Polaribacter reichenbachii
pola Polaribacter sp. BM10
poa Polaribacter sp. ALD11
phal Polaribacter haliotis
plit Polaribacter litorisediminis
ppec Polaribacter pectinis
pbat Polaribacter batillariae
pcea Polaribacter cellanae
pun Polaribacter sejongensis
phg Polaribacter huanghezhanensis
mod Myroides odoratimimus
tdi Tenacibaculum dicentrarchi
ten Tenacibaculum todarodis
tje Tenacibaculum jejuense
foh Formosa sp. Hel3_A1_48
seon Seonamhaeicola sp. S2-3
psyn Psychroserpens sp. NJDZ02
mesq Mesoflavibacter sp. HG96
kut Kutzneria sp. CA-103260
nhy Natronosporangium hydrolyticum
» show all Reaction Compound C04409 2-Amino-3-carboxymuconate semialdehyde
C01185 Nicotinate D-ribonucleotide
Reference Authors Panozzo C, Nawara M, Suski C, Kucharczyka R, Skoneczny M, Becam AM, Rytka J, Herbert CJ
Title Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae.
Journal Reference Authors Wogulis M, Chew ER, Donohoue PD, Wilson DK
Title Identification of formyl kynurenine formamidase and kynurenine aminotransferase from Saccharomyces cerevisiae using crystallographic, bioinformatic and biochemical evidence.
Journal Reference Authors Kurnasov O, Goral V, Colabroy K, Gerdes S, Anantha S, Osterman A, Begley TP
Title NAD biosynthesis: identification of the tryptophan to quinolinate pathway in bacteria.
Journal LinkDB All DBs
