| Entry |
|
|---|
| Name |
Zn to anterograde axonal transport
|
|---|
| Definition |
Zn2+ -> GSK3B -> MAPT -| (TUBA+TUBB) |
|---|
| Expanded |
C00038 -> 2932 -> 4137 -| ((7846,10376,84790,7278,113457,112714,7277,51807)+(203068,81027,7280,347733,10381,10382,10383,84617,347688)) |
|---|
| Class |
|
|---|
| Type |
Env factor
|
|---|
| Pathway |
|
|---|
| Disease |
|
|---|
| Gene |
| 2932 | GSK3B; glycogen synthase kinase 3 beta |
| 4137 | MAPT; microtubule associated protein tau |
| 7846 | TUBA1A; tubulin alpha 1a |
| 10376 | TUBA1B; tubulin alpha 1b |
| 84790 | TUBA1C; tubulin alpha 1c |
| 7278 | TUBA3C; tubulin alpha 3c |
| 113457 | TUBA3D; tubulin alpha 3d |
| 112714 | TUBA3E; tubulin alpha 3e |
| 7277 | TUBA4A; tubulin alpha 4a |
| 51807 | TUBA8; tubulin alpha 8 |
| 203068 | TUBB; tubulin beta class I |
| 81027 | TUBB1; tubulin beta 1 class VI |
| 7280 | TUBB2A; tubulin beta 2A class IIa |
| 347733 | TUBB2B; tubulin beta 2B class IIb |
| 10381 | TUBB3; tubulin beta 3 class III |
| 10382 | TUBB4A; tubulin beta 4A class IVa |
| 10383 | TUBB4B; tubulin beta 4B class IVb |
| 84617 | TUBB6; tubulin beta 6 class V |
| 347688 | TUBB8; tubulin beta 8 class VIII |
|
|---|
| Perturbant |
|
|---|
| Reference |
|
|---|
| Authors |
Li Y, Jiao Q, Xu H, Du X, Shi L, Jia F, Jiang H |
|---|
| Title |
Biometal Dyshomeostasis and Toxic Metal Accumulations in the Development of Alzheimer's Disease. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Wang L, Yin YL, Liu XZ, Shen P, Zheng YG, Lan XR, Lu CB, Wang JZ |
|---|
| Title |
Current understanding of metal ions in the pathogenesis of Alzheimer's disease. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Wang ZX, Tan L, Yu JT |
|---|
| Title |
Axonal transport defects in Alzheimer's disease. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Wang JZ, Wang ZH, Tian Q |
|---|
| Title |
Tau hyperphosphorylation induces apoptotic escape and triggers neurodegeneration in Alzheimer's disease. |
|---|
| Journal |
|
|---|
| LinkDB |
|
|---|
