KEGG   NETWORK: N01662
Entry
N01662                      Network                                
Name
IFN-RIPK1/3 signaling pathway
Definition
IFN -> IFNR -> JAKs -> STAT+IRF9 => (RIPK1+RIPK3)
  Expanded
(3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452,3458) -> (3454,3455,3459,3460) -> (3716,3717,3718,7297) -> ((6772,6773,6774,6775,6776,6778)+10379) => (8737+11035)
Class
nt06527 Necroptosis
Type
Reference
Pathway
hsa04217  Necroptosis
Gene
3439  IFNA1; interferon alpha 1
3440  IFNA2; interferon alpha 2
3441  IFNA4; interferon alpha 4
3442  IFNA5; interferon alpha 5
3443  IFNA6; interferon alpha 6
3444  IFNA7; interferon alpha 7
3445  IFNA8; interferon alpha 8
3446  IFNA10; interferon alpha 10
3447  IFNA13; interferon alpha 13
3448  IFNA14; interferon alpha 14
3449  IFNA16; interferon alpha 16
3451  IFNA17; interferon alpha 17
3452  IFNA21; interferon alpha 21
3458  IFNG; interferon gamma
3454  IFNAR1; interferon alpha and beta receptor subunit 1
3455  IFNAR2; interferon alpha and beta receptor subunit 2
3459  IFNGR1; interferon gamma receptor 1
3460  IFNGR2; interferon gamma receptor 2
3716  JAK1; Janus kinase 1
3717  JAK2; Janus kinase 2
3718  JAK3; Janus kinase 3
7297  TYK2; tyrosine kinase 2
6772  STAT1; signal transducer and activator of transcription 1
6773  STAT2; signal transducer and activator of transcription 2
6774  STAT3; signal transducer and activator of transcription 3
6775  STAT4; signal transducer and activator of transcription 4
6776  STAT5A; signal transducer and activator of transcription 5A
6778  STAT6; signal transducer and activator of transcription 6
10379  IRF9; interferon regulatory factor 9
8737  RIPK1; receptor interacting serine/threonine kinase 1
11035  RIPK3; receptor interacting serine/threonine kinase 3
Reference
PMID:25592536
  Authors
Pasparakis M, Vandenabeele P
  Title
Necroptosis and its role in inflammation.
  Journal
Nature 517:311-20 (2015)
DOI:10.1038/nature14191
Reference
PMID:25049377
  Authors
McComb S, Cessford E, Alturki NA, Joseph J, Shutinoski B, Startek JB, Gamero AM, Mossman KL, Sad S
  Title
Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages.
  Journal
Proc Natl Acad Sci U S A 111:E3206-13 (2014)
DOI:10.1073/pnas.1407068111
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