KEGG   PATHWAY: acc00260
Entry
acc00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Acinetobacter pittii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
acc00260  Glycine, serine and threonine metabolism
acc00260

Module
acc_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:acc00260]
acc_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:acc00260]
acc_M00555  Betaine biosynthesis, choline => betaine [PATH:acc00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Acinetobacter pittii [GN:acc]
Gene
BDGL_000425  lysC; aspartate kinase [KO:K00928] [EC:2.7.2.4]
BDGL_003339  asd; aspartate-semialdehyde dehydrogenase, NAD(P)-binding protein [KO:K00133] [EC:1.2.1.11]
BDGL_001073  hom; putative homoserine dehydrogenase (HDH) [KO:K00003] [EC:1.1.1.3]
BDGL_003150  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BDGL_002709  thrB; putative homoserine kinase (ThrB) [KO:K02204] [EC:2.7.1.39]
BDGL_002226  thrH; bifunctional phosphoserine phosphatase/homoserine phosphotransferase [KO:K02203] [EC:3.1.3.3 2.7.1.39]
BDGL_003149  thrC; threonine synthase, pyridoxal-5'-phosphate-dependent enzyme [KO:K01733] [EC:4.2.3.1]
BDGL_001800  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BDGL_001741  tkrA; 2-keto-D-gluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BDGL_002077  glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
BDGL_003143  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
BDGL_001276  pgdH; putative D-3-phosphoglycerate dehydrogenase (PgdH) [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BDGL_002617  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BDGL_002053  serC; 3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
BDGL_002857  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
BDGL_001983  NADP-dependent dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BDGL_001334  tynA; copper amine oxidase [KO:K00276] [EC:1.4.3.21]
BDGL_001064  acoD; dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenase complexes) [KO:K00382] [EC:1.8.1.4]
BDGL_002394  pdhD; putative pyridine nucleotide-disulfide oxidoreductase, class I [KO:K00382] [EC:1.8.1.4]
BDGL_002147  lpdG; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BDGL_000921  gcvH; glycine cleavage complex protein H, carrier of aminomethyl moiety via covalently bound lipoyl cofactor [KO:K02437]
BDGL_002480  pssA; phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
BDGL_000204  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BDGL_000205  betB; NAD+-dependent betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BDGL_000366  hypothetical protein [KO:K00130] [EC:1.2.1.8]
BDGL_000680  sdaA; iron-sulfur-dependent L-serine dehydratase single chain form [KO:K01752] [EC:4.3.1.17]
BDGL_001397  ilvA; threonine dehydratase biosynthetic (threonine deaminase) [KO:K01754] [EC:4.3.1.19]
BDGL_002245  tdcB; threonine dehydratase catabolic [KO:K01754] [EC:4.3.1.19]
BDGL_000253  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
BDGL_001700  racD; aspartate racemase [KO:K25316] [EC:5.1.1.10]
BDGL_000716  alr2; alanine racemase [KO:K25317] [EC:5.1.1.10]
BDGL_002330  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
BDGL_002335  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
BDGL_001053  trpB2; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
BDGL_001923  dat; diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
BDGL_001922  ddc; L-2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
acc00010  Glycolysis / Gluconeogenesis
acc00020  Citrate cycle (TCA cycle)
acc00230  Purine metabolism
acc00250  Alanine, aspartate and glutamate metabolism
acc00270  Cysteine and methionine metabolism
acc00290  Valine, leucine and isoleucine biosynthesis
acc00300  Lysine biosynthesis
acc00330  Arginine and proline metabolism
acc00460  Cyanoamino acid metabolism
acc00470  D-Amino acid metabolism
acc00564  Glycerophospholipid metabolism
acc00620  Pyruvate metabolism
acc00630  Glyoxylate and dicarboxylate metabolism
acc00640  Propanoate metabolism
acc00680  Methane metabolism
acc00860  Porphyrin metabolism
acc00920  Sulfur metabolism
KO pathway
ko00260   
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