Entry
Name
Spliceosome - Aquila chrysaetos chrysaetos (golden eagle)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
BRITE hierarchy
Pathway map
Other DBs
Organism
Aquila chrysaetos chrysaetos (golden eagle) [GN:
achc ]
Gene
115333770 SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893 ]
115333919 RBMX; RNA-binding motif protein, X chromosome isoform X1 [KO:K12885 ]
115334123 TCERG1; transcription elongation regulator 1 isoform X1 [KO:K12824 ]
115334842 SNRPC; U1 small nuclear ribonucleoprotein C isoform X1 [KO:K11095 ]
115337470 HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886 ]
115337709 SNRPA; LOW QUALITY PROTEIN: U1 small nuclear ribonucleoprotein A [KO:K11091 ]
115337888 DHX16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1 [KO:K12813 ] [EC:5.6.2.6 ]
115338849 LSM5; U6 snRNA-associated Sm-like protein LSm5 isoform X1 [KO:K12624 ]
115339030 TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897 ]
115339535 SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' [KO:K11086 ]
115339660 CCDC12; coiled-coil domain-containing protein 12 isoform X1 [KO:K12871 ]
115340760 PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838 ]
115342432 PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821 ]
115342460 HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741 ]
115344079 U2AF1; splicing factor U2AF 35 kDa subunit isoform X2 [KO:K12836 ]
115344837 SNRPB2; U2 small nuclear ribonucleoprotein B'' isoform X1 [KO:K11094 ]
115344894 EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852 ]
115346172 PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843 ]
115346940 PRPF8; LOW QUALITY PROTEIN: pre-mRNA-processing-splicing factor 8 [KO:K12856 ]
115347002 SART1; LOW QUALITY PROTEIN: U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984 ]
115348621 SMNDC1; survival of motor neuron-related-splicing factor 30 [KO:K12839 ]
115348765 LSM7; U6 snRNA-associated Sm-like protein LSm7 isoform X1 [KO:K12626 ]
115349273 HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887 ]
115349313 SF3A2; LOW QUALITY PROTEIN: splicing factor 3A subunit 2 [KO:K12826 ]
115349753 HNRNPU; heterogeneous nuclear ribonucleoprotein U isoform X1 [KO:K12888 ]
115349898 USP39; U4/U6.U5 tri-snRNP-associated protein 2 isoform X1 [KO:K12847 ]
115349923 SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846 ]
115351208 HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741 ]
115351545 SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900 ]
115351731 SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein isoform X1 [KO:K12857 ]
115351900 SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893 ]
115352638 PHF5A; PHD finger-like domain-containing protein 5A isoform X1 [KO:K12834 ]
Reference
Authors
Wahl MC, Will CL, Luhrmann R
Title
The spliceosome: design principles of a dynamic RNP machine.
Journal
Reference
Authors
Morris DP, Greenleaf AL
Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
Journal
Reference
Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
Journal
Reference
Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
Title
Spliceosome structure: piece by piece.
Journal
KO pathway