KEGG   PATHWAY: achc03040
Entry
achc03040                   Pathway                                
Name
Spliceosome - Aquila chrysaetos chrysaetos (golden eagle)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
achc03040  Spliceosome
achc03040

Other DBs
GO: 0005681
Organism
Aquila chrysaetos chrysaetos (golden eagle) [GN:achc]
Gene
115333450  [KO:K14276]
115333586  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
115333770  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
115333855  [KO:K12883]
115333868  RBM25; RNA-binding protein 25 isoform X1 [KO:K12822]
115333919  RBMX; RNA-binding motif protein, X chromosome isoform X1 [KO:K12885]
115333969  ZMAT2; zinc finger matrin-type protein 2 [KO:K12848]
115334025  RBM22; pre-mRNA-splicing factor RBM22 isoform X1 [KO:K12872]
115334033  THOC3; THO complex subunit 3 [KO:K12880]
115334065  DDX46; probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
115334103  SLU7; pre-mRNA-splicing factor SLU7 isoform X1 [KO:K12819]
115334123  TCERG1; transcription elongation regulator 1 isoform X1 [KO:K12824]
115334604  SNW1; SNW domain-containing protein 1 [KO:K06063]
115334746  [KO:K14277]
115334747  [KO:K14280]
115334842  SNRPC; U1 small nuclear ribonucleoprotein C isoform X1 [KO:K11095]
115334891  [KO:K11097]
115334931  BCAS2; pre-mRNA-splicing factor SPF27 isoform X1 [KO:K12861]
115335146  PPIL1; LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
115335174  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
115335345  PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
115335486  CDC40; pre-mRNA-processing factor 17 [KO:K12816]
115335782  BUD31; protein BUD31 homolog [KO:K12873]
115336164  WBP11; WW domain-binding protein 11 [KO:K12866]
115336382  SNRPF; small nuclear ribonucleoprotein F [KO:K11098]
115336917  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
115337470  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
115337709  SNRPA; LOW QUALITY PROTEIN: U1 small nuclear ribonucleoprotein A [KO:K11091]
115337888  DHX16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1 [KO:K12813] [EC:5.6.2.6]
115338330  [KO:K14277]
115338331  [KO:K14277]
115338332  [KO:K14277]
115338333  [KO:K14277]
115338463  [KO:K14277]
115338464  [KO:K14277]
115338465  [KO:K14277]
115338467  [KO:K14277]
115338555  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
115338612  SRSF7; serine/arginine-rich splicing factor 7 [KO:K12896]
115338701  [KO:K12896]
115338849  LSM5; U6 snRNA-associated Sm-like protein LSm5 isoform X1 [KO:K12624]
115339021  DHX15; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
115339030  TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897]
115339150  CTNNBL1; beta-catenin-like protein 1 isoform X1 [KO:K12864]
115339216  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
115339442  PRPF6; pre-mRNA-processing factor 6 [KO:K12855]
115339535  SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' [KO:K11086]
115339561  RP9; retinitis pigmentosa 9 protein [KO:K19604]
115339660  CCDC12; coiled-coil domain-containing protein 12 isoform X1 [KO:K12871]
115339948  SNRPD1; small nuclear ribonucleoprotein Sm D1 [KO:K11087]
115340090  THOC1; THO complex subunit 1 isoform X2 [KO:K12878]
115340760  PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838]
115341054  PRPF18; pre-mRNA-splicing factor 18 isoform X2 [KO:K12817]
115341234  SNRPA1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
115341365  DDX5; probable ATP-dependent RNA helicase DDX5 isoform X1 [KO:K12823] [EC:5.6.2.7]
115341728  LSM8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
115341825  RBM17; splicing factor 45 isoform X1 [KO:K12840]
115341986  ALYREF; THO complex subunit 4 [KO:K12881]
115342200  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
115342345  [KO:K14276]
115342360  [KO:K14279]
115342361  [KO:K14280]
115342432  PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
115342460  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
115342813  SF3B1; splicing factor 3B subunit 1 isoform X1 [KO:K12828]
115342833  PLRG1; pleiotropic regulator 1 [KO:K12862]
115343132  PPIH; peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
115343432  [KO:K14277]
115343713  LSM6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
115344079  U2AF1; splicing factor U2AF 35 kDa subunit isoform X2 [KO:K12836]
115344184  [KO:K14276]
115344188  [KO:K14276]
115344189  [KO:K14276]
115344190  [KO:K14279]
115344320  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
115344341  DDX42; ATP-dependent RNA helicase DDX42 isoform X1 [KO:K12835] [EC:5.6.2.7]
115344474  CRNKL1; crooked neck-like protein 1 [KO:K12869]
115344829  SF3B5; splicing factor 3B subunit 5 [KO:K12832]
115344837  SNRPB2; U2 small nuclear ribonucleoprotein B'' isoform X1 [KO:K11094]
115344894  EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
115345128  DHX8; ATP-dependent RNA helicase DHX8 isoform X1 [KO:K12818] [EC:5.6.2.6]
115345261  [KO:K14277]
115345272  [KO:K14280]
115345467  SF3B4; splicing factor 3B subunit 4 isoform X1 [KO:K12831]
115345633  SNRPD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
115345812  DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
115346172  PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
115346226  SF3A1; splicing factor 3A subunit 1 [KO:K12825]
115346344  RBM8A; RNA-binding protein 8A [KO:K12876]
115346486  SF3B3; splicing factor 3B subunit 3 [KO:K12830]
115346677  [KO:K14276]
115346680  [KO:K14278]
115346681  [KO:K14278]
115346847  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
115346859  [KO:K12842]
115346940  PRPF8; LOW QUALITY PROTEIN: pre-mRNA-processing-splicing factor 8 [KO:K12856]
115347002  SART1; LOW QUALITY PROTEIN: U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
115347063  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
115347111  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
115347777  [KO:K14279]
115347790  [KO:K14280]
115348621  SMNDC1; survival of motor neuron-related-splicing factor 30 [KO:K12839]
115348765  LSM7; U6 snRNA-associated Sm-like protein LSm7 isoform X1 [KO:K12626]
115348803  PRPF38B; pre-mRNA-splicing factor 38B [KO:K12850]
115348949  MAGOH; protein mago nashi homolog [KO:K12877]
115349048  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
115349096  [KO:K12841]
115349273  HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887]
115349313  SF3A2; LOW QUALITY PROTEIN: splicing factor 3A subunit 2 [KO:K12826]
115349618  LSM4; U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
115349667  PRPF38A; pre-mRNA-splicing factor 38A [KO:K12849]
115349704  [KO:K14279]
115349705  [KO:K14280]
115349706  [KO:K14280]
115349715  [KO:K14279]
115349726  [KO:K14279]
115349727  [KO:K14279]
115349728  [KO:K14279]
115349753  HNRNPU; heterogeneous nuclear ribonucleoprotein U isoform X1 [KO:K12888]
115349898  USP39; U4/U6.U5 tri-snRNP-associated protein 2 isoform X1 [KO:K12847]
115349923  SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
115349958  SNRPG; small nuclear ribonucleoprotein G [KO:K11099]
115349980  SNRNP200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
115351010  DDX23; LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
115351136  [KO:K12893]
115351208  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
115351235  CDC5L; cell division cycle 5-like protein isoform X2 [KO:K12860]
115351271  SF3B6; splicing factor 3B subunit 6 [KO:K12833]
115351422  [KO:K14276]
115351423  [KO:K14276]
115351424  [KO:K14276]
115351425  [KO:K14276]
115351430  [KO:K14276]
115351431  [KO:K14276]
115351432  [KO:K14276]
115351433  [KO:K14276]
115351510  PPIE; peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
115351536  AQR; RNA helicase aquarius [KO:K12874]
115351543  SYF2; pre-mRNA-splicing factor SYF2 [KO:K12868]
115351545  SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900]
115351731  SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein isoform X1 [KO:K12857]
115351900  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
115351948  SF3A3; splicing factor 3A subunit 3 [KO:K12827]
115352054  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
115352237  [KO:K14277]
115352632  SNU13; NHP2-like protein 1 [KO:K12845]
115352638  PHF5A; PHD finger-like domain-containing protein 5A isoform X1 [KO:K12834]
115352903  TXNL4A; thioredoxin-like protein 4A isoform X1 [KO:K12859]
115353414  CWC15; spliceosome-associated protein CWC15 homolog [KO:K12863]
115353630  [KO:K14276]
115353641  [KO:K14276]
115353689  LSM3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
115353829  ISY1; pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
121232948  [KO:K12882]
Reference
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   

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