KEGG   PATHWAY: acoz00983
Entry
acoz00983                   Pathway                                
Name
Drug metabolism - other enzymes - Anopheles coluzzii
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
acoz00983  Drug metabolism - other enzymes
acoz00983

Organism
Anopheles coluzzii [GN:acoz]
Gene
120957045  inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
120955121  GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
120951441  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120951442  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120952638  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120953808  xanthine dehydrogenase 1-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120953811  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120953812  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120953813  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120953814  aldehyde oxidase 3-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120956350  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120956351  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120960068  inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
120953500  venom carboxylesterase-6-like [KO:K01044] [EC:3.1.1.1]
120953501  venom carboxylesterase-6-like [KO:K01044] [EC:3.1.1.1]
120953502  venom carboxylesterase-6-like [KO:K01044] [EC:3.1.1.1]
120953503  venom carboxylesterase-6-like [KO:K01044] [EC:3.1.1.1]
120951287  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
120958710  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
120959006  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
120959007  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
120960113  uncharacterized protein LOC120960113 [KO:K00699] [EC:2.4.1.17]
120953259  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
120953260  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
120954599  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
120954755  UDP-glucuronosyltransferase 2B9-like [KO:K00699] [EC:2.4.1.17]
120948138  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
120955198  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
120948893  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
120949183  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
120949990  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
120951035  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
120957987  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
120956713  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
120955288  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
120948807  dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
120947547  dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
120959792  beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
120951657  uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
120947795  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
120949484  uridine-cytidine kinase isoform X1 [KO:K00876] [EC:2.7.1.48]
120947231  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
120948714  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
120958486  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
120960721  LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
120950558  ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
120951225  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
120951583  LOW QUALITY PROTEIN: nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
120950856  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
120955586  deoxyuridine 5'-triphosphate nucleotidohydrolase [KO:K01520] [EC:3.6.1.23]
120952433  glutathione S-transferase D7 [KO:K00799] [EC:2.5.1.18]
120959218  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
120960599  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
120961135  uncharacterized protein LOC120961135 [KO:K00799] [EC:2.5.1.18]
120953564  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120953565  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
120947660  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
120954846  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120954904  microsomal glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
120948928  glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
120949165  glutathione S-transferase D5-like [KO:K00799] [EC:2.5.1.18]
120949488  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120949489  glutathione S-transferase D5-like [KO:K00799] [EC:2.5.1.18]
120949491  glutathione S-transferase D1-like [KO:K00799] [EC:2.5.1.18]
120956731  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
120956871  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120956872  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120956873  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120956874  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120956875  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
120956876  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120956877  glutathione S-transferase E14-like [KO:K00799] [EC:2.5.1.18]
120956878  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
120949965  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
120957398  prostaglandin E synthase-like [KO:K00799] [EC:2.5.1.18]
120950829  glutathione S-transferase D5-like [KO:K00799] [EC:2.5.1.18]
120951126  glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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