KEGG   PATHWAY: amd00520
Entry
amd00520                    Pathway                                
Name
Amino sugar and nucleotide sugar metabolism - Amycolatopsis mediterranei U32
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
amd00520  Amino sugar and nucleotide sugar metabolism
amd00520

Module
amd_M00554  UDP-Gal biosynthesis, Gal => UDP-Gal [PATH:amd00520]
amd_M00909  UDP-GlcNAc biosynthesis, prokaryotes, Fru-6P => UDP-GlcNAc [PATH:amd00520]
amd_M00995  UDP-MurNAc biosynthesis, Fru-6P => UDP-MurNAc [PATH:amd00520]
amd_M01000  GDP-Man biosynthesis, Fru-6P => GDP-Man [PATH:amd00520]
amd_M01004  UDP-Galf biosynthesis, UDP-Glc => UDP-Galf [PATH:amd00520]
Other DBs
GO: 0006040 0009225
Organism
Amycolatopsis mediterranei U32 [GN:amd]
Gene
AMED_0105  ugd; UDP glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22]
AMED_0201  galE; UDP-glucose 4-epimerase [KO:K01784] [EC:5.1.3.2]
AMED_0224  glf; UDP-galactopyranose mutase [KO:K01854] [EC:5.4.99.9]
AMED_0277  [KO:K01183] [EC:3.2.1.14]
AMED_0450  murB; UDP-N-acetylmuramate dehydrogenase [KO:K00075] [EC:1.3.1.98]
AMED_0468  galE; UDP-glucose 4-epimerase [KO:K01784] [EC:5.1.3.2]
AMED_0547  algD; GDP-mannose 6-dehydrogenase [KO:K00066] [EC:1.1.1.132]
AMED_0568  rfbF; glucose-1-phosphate cytidylyltransferase [KO:K00978] [EC:2.7.7.33]
AMED_0576  rfbA; glucose-1-phosphate thymidylyltransferase [KO:K00973] [EC:2.7.7.24]
AMED_0728  glmM; phosphoglucosamine mutase [KO:K03431] [EC:5.4.2.10]
AMED_0736  glmS; glucosamine--fructose-6-phosphate aminotransferase [KO:K00820] [EC:2.6.1.16]
AMED_0750  wecB; UDP-N-acetylglucosamine 2-epimerase [KO:K01791] [EC:5.1.3.14]
AMED_0906  [KO:K01840] [EC:5.4.2.8]
AMED_1016  [KO:K00966] [EC:2.7.7.13]
AMED_1370  manX; mannose/sorbose-specific IIA subunit of PTS system [KO:K02793] [EC:2.7.1.191]
AMED_1594  manA; mannose-6-phosphate isomerase [KO:K01809] [EC:5.3.1.8]
AMED_1706  abfA; alpha-N-arabinofuranosidase [KO:K20844] [EC:3.2.1.55]
AMED_1906  anmK; anhydro-N-acetylmuramic acid kinase [KO:K09001] [EC:2.7.1.170]
AMED_2414  galE; UDP-glucose 4-epimerase [KO:K01784] [EC:5.1.3.2]
AMED_2415  galK; galactokinase [KO:K00849] [EC:2.7.1.6]
AMED_2451  glk; glucokinase [KO:K25026]
AMED_2467  [KO:K01183] [EC:3.2.1.14]
AMED_2602  ppgK; polyphosphate glucokinase [KO:K00886] [EC:2.7.1.63]
AMED_2725  nagE; PTS system, glucose/maltose/N-acetylglucosamine-specific IIC component [KO:K02804] [EC:2.7.1.193]
AMED_2728  nagE; PTS system, glucose/maltose/N-acetylglucosamine-specific IIA component [KO:K02777] [EC:2.7.1.-]
AMED_2807  pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
AMED_3066  abfA; alpha-N-arabinofuranosidase [KO:K20844] [EC:3.2.1.55]
AMED_3286  [KO:K15921] [EC:3.2.1.55]
AMED_3292  abfA; alpha-L-arabinofuranosidase [KO:K20844] [EC:3.2.1.55]
AMED_3314  nagZ; beta-N-acetylhexosaminidase [KO:K12373] [EC:3.2.1.52]
AMED_3420  [KO:K15855] [EC:3.2.1.165]
AMED_3530  abfA; alpha-N-arabinofuranosidase [KO:K20844] [EC:3.2.1.55]
AMED_3531  abfA; alpha-N-arabinofuranosidase [KO:K20844] [EC:3.2.1.55]
AMED_3994  abfA; alpha-N-arabinofuranosidase [KO:K20844] [EC:3.2.1.55]
AMED_4269  ugd; UDP glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22]
AMED_4365  nagZ; beta-N-acetylhexosaminidase [KO:K01207] [EC:3.2.1.52]
AMED_4463  glgC; glucose-1-phosphate adenylyltransferase [KO:K00975] [EC:2.7.7.27]
AMED_4980  qdb; UDP-sulfoquinovose synthase [KO:K06118] [EC:3.13.1.1]
AMED_4982  galE; UDP-glucose 4-epimerase [KO:K01784] [EC:5.1.3.2]
AMED_5049  [KO:K01183] [EC:3.2.1.14]
AMED_5066  [KO:K12373] [EC:3.2.1.52]
AMED_5067  [KO:K15855] [EC:3.2.1.165]
AMED_5393  rfbA; glucose-1-phosphate thymidylyltransferase [KO:K00973] [EC:2.7.7.24]
AMED_5449  galE; UDP-glucose 4-epimerase [KO:K01784] [EC:5.1.3.2]
AMED_6070  [KO:K12373] [EC:3.2.1.52]
AMED_6094  [KO:K15855] [EC:3.2.1.165]
AMED_6414  [KO:K01198] [EC:3.2.1.37]
AMED_6675  [KO:K12373] [EC:3.2.1.52]
AMED_6991  [KO:K01233] [EC:3.2.1.132]
AMED_7041  glk; glucokinase [KO:K25026]
AMED_7070  [KO:K01183] [EC:3.2.1.14]
AMED_7405  wecB; UDP-N-acetylglucosamine 2-epimerase [KO:K01791] [EC:5.1.3.14]
AMED_7433  glmS; glucosamine--fructose-6-phosphate aminotransferase [KO:K00820] [EC:2.6.1.16]
AMED_7484  abfA; alpha-N-arabinofuranosidase [KO:K01209] [EC:3.2.1.55]
AMED_7519  [KO:K01183] [EC:3.2.1.14]
AMED_7770  murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [KO:K00790] [EC:2.5.1.7]
AMED_8012  manA; mannose-6-phosphate isomerase [KO:K01809] [EC:5.3.1.8]
AMED_8015  manB; phosphomannomutase [KO:K01840] [EC:5.4.2.8]
AMED_8125  [KO:K01207] [EC:3.2.1.52]
AMED_8234  glmU; N-acetylglucosamine-1-phosphate uridyltransferase [KO:K04042] [EC:2.7.7.23 2.3.1.157]
AMED_8265  [KO:K12373] [EC:3.2.1.52]
AMED_8311  galU; UTP--glucose-1-phosphate uridylyltransferase [KO:K00963] [EC:2.7.7.9]
AMED_8330  galT; galactose-1-phosphate uridylyltransferase [KO:K00965] [EC:2.7.7.12]
AMED_8427  scrK; fructokinase [KO:K00847] [EC:2.7.1.4]
AMED_8584  glmD; glucosamine-6-phosphate deaminase [KO:K00820] [EC:2.6.1.16]
AMED_8808  [KO:K01207] [EC:3.2.1.52]
AMED_8812  murQ; N-acetylmuramic acid 6-phosphate etherase [KO:K07106] [EC:4.2.1.126]
AMED_8909  wecB; UDP-N-acetylglucosamine 2-epimerase [KO:K01791] [EC:5.1.3.14]
AMED_9120  nagA; N-acetylglucosamine-6-phosphate deacetylase [KO:K01443] [EC:3.5.1.25]
Compound
C00029  UDP-glucose
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00052  UDP-alpha-D-galactose
C00085  D-Fructose 6-phosphate
C00095  D-Fructose
C00096  GDP-mannose
C00103  D-Glucose 1-phosphate
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00167  UDP-glucuronate
C00181  D-Xylose
C00190  UDP-D-xylose
C00191  D-Glucuronate
C00203  UDP-N-acetyl-D-galactosamine
C00216  D-Arabinose
C00259  L-Arabinose
C00267  alpha-D-Glucose
C00275  D-Mannose 6-phosphate
C00325  GDP-L-fucose
C00329  D-Glucosamine
C00333  D-Galacturonate
C00352  D-Glucosamine 6-phosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00394  GDP-glucose
C00446  alpha-D-Galactose 1-phosphate
C00461  Chitin
C00498  ADP-glucose
C00501  CDP-glucose
C00617  UDP-D-galacturonate
C00636  D-Mannose 1-phosphate
C00645  N-Acetyl-D-mannosamine
C00668  alpha-D-Glucose 6-phosphate
C00714  Pectin
C00734  Chitosan
C00842  dTDP-glucose
C00935  UDP-L-arabinose
C00976  GDP-D-mannuronate
C00984  alpha-D-Galactose
C01019  L-Fucose
C01050  UDP-N-acetylmuramate
C01132  N-Acetyl-D-galactosamine
C01170  UDP-N-acetyl-D-mannosamine
C01623  UDP-apiose
C01674  Chitobiose
C02262  D-Galactosamine
C02280  GDP-L-galactose
C02352  1,4-beta-D-Xylan
C02474  Arabinan
C02713  N-Acetylmuramate
C02985  L-Fucose 1-phosphate
C03733  UDP-alpha-D-galactofuranose
C03737  alpha-D-Xylose 1-phosphate
C03906  beta-L-Arabinose 1-phosphate
C04037  1-Phospho-alpha-D-galacturonate
C04257  N-Acetyl-D-mannosamine 6-phosphate
C04501  N-Acetyl-alpha-D-glucosamine 1-phosphate
C04631  UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
C05385  D-Glucuronate 1-phosphate
C06023  D-Glucosaminide
C06156  alpha-D-Glucosamine 1-phosphate
C06376  N-Acetyl-D-galactosamine 6-phosphate
C06377  D-Galactosamine 6-phosphate
C11521  UDP-6-sulfoquinovose
C15925  GDP-L-gulose
C16183  alpha-D-Arabinopyranose 1-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C17269  GDP-D-arabinopyranose
C18060  N-Acetyl-alpha-D-galactosamine 1-phosphate
C18094  UDP-L-arabinofuranose
C19769  1,6-Anhydro-N-acetyl-beta-muramate
C21027  N-Acetylmuramic acid alpha-1-phosphate
C22029  alpha-D-Galactosamine 1-phosphate
Reference
PMID:2793832
  Authors
Wyk P, Reeves P
  Title
Identification and sequence of the gene for abequose synthase, which confers antigenic specificity on group B salmonellae: homology with galactose epimerase.
  Journal
J Bacteriol 171:5687-93 (1989)
DOI:10.1128/JB.171.10.5687-5693.1989
Reference
PMID:8071227
  Authors
Thorson JS, Lo SF, Ploux O, He X, Liu HW
  Title
Studies of the biosynthesis of 3,6-dideoxyhexoses: molecular cloning and characterization of the asc (ascarylose) region from Yersinia pseudotuberculosis serogroup VA.
  Journal
J Bacteriol 176:5483-93 (1994)
DOI:10.1128/JB.176.17.5483-5493.1994
Reference
PMID:8444803
  Authors
Kessler AC, Haase A, Reeves PR
  Title
Molecular analysis of the 3,6-dideoxyhexose pathway genes of Yersinia pseudotuberculosis serogroup IIA.
  Journal
J Bacteriol 175:1412-22 (1993)
DOI:10.1128/JB.175.5.1412-1422.1993
Reference
PMID:9811644
  Authors
Danese PN, Oliver GR, Barr K, Bowman GD, Rick PD, Silhavy TJ
  Title
Accumulation of the enterobacterial common antigen lipid II biosynthetic intermediate stimulates degP transcription in Escherichia coli.
  Journal
J Bacteriol 180:5875-84 (1998)
DOI:10.1128/JB.180.22.5875-5884.1998
Reference
  Authors
Skurnik M, Peippo A, Ervela E
  Title
Characterization of the O-antigen gene clusters of Yersinia pseudotuberculosis and the cryptic O-antigen gene cluster of Yersinia pestis shows that the plague bacillus is most closely related to and has evolved from Y. pseudotuberculosis serotype O:1b.
  Journal
Mol Microbiol 37:316-30 (2000)
DOI:10.1046/j.1365-2958.2000.01993.x
Reference
  Authors
Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV
  Title
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
  Journal
Nature 406:959-64 (2000)
DOI:10.1038/35023079
Reference
  Authors
Ringenberg M, Lichtensteiger C, Vimr E
  Title
Redirection of sialic acid metabolism in genetically engineered Escherichia coli.
  Journal
Glycobiology 11:533-9 (2001)
DOI:10.1093/glycob/11.7.533
Reference
  Authors
McCoy AJ, Sandlin RC, Maurelli AT
  Title
In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance.
  Journal
J Bacteriol 185:1218-28 (2003)
DOI:10.1128/JB.185.4.1218-1228.2003
Reference
  Authors
JACOBSON B, DAVIDSON EA
  Title
Biosynthesis of uronic acids by skin enzymes. I. Uridine diphosphate-D-glucuronic acid-5-epimerase.
  Journal
J Biol Chem 237:638-42 (1962)
Reference
  Authors
Seifert GJ
  Title
Nucleotide sugar interconversions and cell wall biosynthesis: how to bring the inside to the outside.
  Journal
Curr Opin Plant Biol 7:277-84 (2004)
DOI:10.1016/j.pbi.2004.03.004
Reference
  Authors
Uehara T, Park JT
  Title
The N-acetyl-D-glucosamine kinase of Escherichia coli and its role in murein recycling.
  Journal
J Bacteriol 186:7273-9 (2004)
DOI:10.1128/JB.186.21.7273-7279.2004
Reference
  Authors
Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR.
  Title
A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose.
  Journal
J Biol Chem 280:14154-67 (2005)
DOI:10.1074/jbc.M414265200
Reference
  Authors
Williams GJ, Breazeale SD, Raetz CR, Naismith JH.
  Title
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis.
  Journal
J Biol Chem 280:23000-8 (2005)
DOI:10.1074/jbc.M501534200
Reference
  Authors
Maliekal P, Vertommen D, Delpierre G, Van Schaftingen E
  Title
Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase.
  Journal
Glycobiology 16:165-72 (2006)
DOI:10.1093/glycob/cwj050
Reference
  Authors
Campbell CT, Yarema KJ
  Title
Large-scale approaches for glycobiology.
  Journal
Genome Biol 6:236 (2005)
DOI:10.1186/gb-2005-6-11-236
Reference
  Authors
Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT
  Title
MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall.
  Journal
J Bacteriol 188:1660-2 (2006)
DOI:10.1128/JB.188.4.1660-1662.2006
Reference
  Authors
Lanot A, Hodge D, Jackson RG, George GL, Elias L, Lim EK, Vaistij FE, Bowles DJ
  Title
The glucosyltransferase UGT72E2 is responsible for monolignol 4-O-glucoside production in Arabidopsis thaliana.
  Journal
Plant J 48:286-95 (2006)
DOI:10.1111/j.1365-313X.2006.02872.x
Reference
  Authors
Muller R, Morant M, Jarmer H, Nilsson L, Nielsen TH
  Title
Genome-wide analysis of the Arabidopsis leaf transcriptome reveals interaction of phosphate and sugar metabolism.
  Journal
Plant Physiol 143:156-71 (2007)
DOI:10.1104/pp.106.090167
Reference
  Authors
Oka T, Nemoto T, Jigami Y
  Title
Functional analysis of Arabidopsis thaliana RHM2/MUM4, a multidomain protein involved in UDP-D-glucose to UDP-L-rhamnose conversion.
  Journal
J Biol Chem 282:5389-403 (2007)
DOI:10.1074/jbc.M610196200
Reference
  Authors
Greenberg DE, Porcella SF, Zelazny AM, Virtaneva K, Sturdevant DE, Kupko JJ 3rd, Barbian KD, Babar A, Dorward DW, Holland SM.
  Title
Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis.
  Journal
J Bacteriol 189:8727-36 (2007)
DOI:10.1128/JB.00793-07
Reference
  Authors
Kotake T, Hojo S, Tajima N, Matsuoka K, Koyama T, Tsumuraya Y
  Title
A bifunctional enzyme with L-fucokinase and GDP-L-fucose pyrophosphorylase activities salvages free L-fucose in Arabidopsis.
  Journal
J Biol Chem 283:8125-35 (2008)
DOI:10.1074/jbc.M710078200
Reference
  Authors
Vorholter FJ, Schneiker S, Goesmann A, Krause L, Bekel T, Kaiser O, Linke B, Patschkowski T, Ruckert C, Schmid J, Sidhu VK, Sieber V, Tauch A, Watt SA, Weisshaar B, Becker A, Niehaus K, Puhler A.
  Title
The genome of Xanthomonas campestris pv. campestris B100 and its use for the reconstruction of metabolic pathways involved in xanthan biosynthesis.
  Journal
J Biotechnol 134:33-45 (2008)
DOI:10.1016/j.jbiotec.2007.12.013
Reference
  Authors
Albermann C, Piepersberg W
  Title
Expression and identification of the RfbE protein from Vibrio cholerae O1 and its use for the enzymatic synthesis of GDP-D-perosamine.
  Journal
Glycobiology 11:655-61 (2001)
DOI:10.1093/glycob/11.8.655
Related
pathway
amd00010  Glycolysis / Gluconeogenesis
amd00040  Pentose and glucuronate interconversions
amd00051  Fructose and mannose metabolism
amd00052  Galactose metabolism
amd00053  Ascorbate and aldarate metabolism
amd00500  Starch and sucrose metabolism
amd00521  Streptomycin biosynthesis
amd00523  Polyketide sugar unit biosynthesis
amd00525  Acarbose and validamycin biosynthesis
amd00541  Biosynthesis of various nucleotide sugars
amd00550  Peptidoglycan biosynthesis
KO pathway
ko00520   

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