KEGG   PATHWAY: ani00260
Entry
ani00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Aspergillus nidulans
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ani00260  Glycine, serine and threonine metabolism
ani00260

Module
ani_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ani00260]
ani_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ani00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Aspergillus nidulans [GN:ani]
Gene
ANIA_08859  aspartate kinase [KO:K00928] [EC:2.7.2.4]
ANIA_04793  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
ANIA_02882  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
ANIA_08843  homoserine kinase [KO:K00872] [EC:2.7.1.39]
ANIA_03031  threonine synthase THR4 [KO:K01733] [EC:4.2.3.1]
ANIA_07564  hypothetical protein [KO:K01620] [EC:4.1.2.48]
ANIA_05426  hypothetical protein [KO:K01620] [EC:4.1.2.48]
ANIA_10745  hypothetical protein [KO:K00600] [EC:2.1.2.1]
ANIA_03058  glycine hydroxymethyltransferase SHM2 [KO:K00600] [EC:2.1.2.1]
ANIA_01342  alanine--glyoxylate transaminase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
ANIA_06943  hypothetical protein [KO:K00865] [EC:2.7.1.165]
ANIA_03059  protein pgmA [KO:K15633] [EC:5.4.2.12]
ANIA_07108  hypothetical protein [KO:K15918] [EC:2.7.1.31]
ANIA_08866  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ANIA_10298  hypothetical protein [KO:K00831] [EC:2.6.1.52]
ANIA_00179  hypothetical protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
ANIA_00618  hypothetical protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
ANIA_02284  5-aminolevulinate synthase hemA [KO:K00643] [EC:2.3.1.37]
ANIA_02566  hypothetical protein [KO:K00274] [EC:1.4.3.4]
ANIA_03291  hypothetical protein [KO:K00274] [EC:1.4.3.4]
ANIA_07641  hypothetical protein [KO:K00276] [EC:1.4.3.21]
ANIA_08454  hypothetical protein [KO:K00276] [EC:1.4.3.21]
ANIA_02532  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
ANIA_01586  hypothetical protein [KO:K00276] [EC:1.4.3.21]
ANIA_05690  hypothetical protein [KO:K00276] [EC:1.4.3.21]
ANIA_06092  protein ANAO [KO:K00276] [EC:1.4.3.21]
ANIA_10901  hypothetical protein [KO:K00281] [EC:1.4.4.2]
ANIA_01198  glycine decarboxylase subunit T [KO:K00605] [EC:2.1.2.10]
ANIA_01074  glycine decarboxylase subunit H [KO:K02437]
ANIA_00174  hypothetical protein [KO:K00273] [EC:1.4.3.3]
ANIA_10701  hypothetical protein [KO:K17103] [EC:2.7.8.8]
ANIA_01430  hypothetical protein [KO:K00130] [EC:1.2.1.8]
ANIA_08654  hypothetical protein [KO:K00309] [EC:1.5.3.10]
ANIA_08123  protein faoA [KO:K00306] [EC:1.5.3.1 1.5.3.7]
ANIA_08657  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
ANIA_08982  protein alcU [KO:K00306] [EC:1.5.3.1 1.5.3.7]
ANIA_02786  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
ANIA_04975  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
ANIA_05820  cystathionine beta-synthase CYS4 [KO:K01697] [EC:4.2.1.22]
ANIA_01446  cystathionine gamma-lyase CYS3 [KO:K01758] [EC:4.4.1.1]
ANIA_03830  threonine ammonia-lyase ileA [KO:K01754] [EC:4.3.1.19]
ANIA_02525  threo-3-hydroxy-L-aspartate ammonia-lyase SRY1 [KO:K01754] [EC:4.3.1.19]
ANIA_03866  hypothetical protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
ANIA_04217  hypothetical protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
ANIA_07140  D-serine ammonia-lyase DSD1 [KO:K20498] [EC:4.3.1.18]
ANIA_05444  hypothetical protein [KO:K01694] [EC:4.2.1.20]
ANIA_06231  tryptophan synthase TRP5 [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ani00010  Glycolysis / Gluconeogenesis
ani00020  Citrate cycle (TCA cycle)
ani00230  Purine metabolism
ani00250  Alanine, aspartate and glutamate metabolism
ani00270  Cysteine and methionine metabolism
ani00290  Valine, leucine and isoleucine biosynthesis
ani00300  Lysine biosynthesis
ani00330  Arginine and proline metabolism
ani00460  Cyanoamino acid metabolism
ani00470  D-Amino acid metabolism
ani00564  Glycerophospholipid metabolism
ani00600  Sphingolipid metabolism
ani00620  Pyruvate metabolism
ani00630  Glyoxylate and dicarboxylate metabolism
ani00640  Propanoate metabolism
ani00680  Methane metabolism
ani00860  Porphyrin metabolism
ani00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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