KEGG   PATHWAY: aqs00260
Entry
aqs00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Aquitalea sp. USM4
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
aqs00260  Glycine, serine and threonine metabolism
aqs00260

Module
aqs_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:aqs00260]
aqs_M00555  Betaine biosynthesis, choline => betaine [PATH:aqs00260]
aqs_M00621  Glycine cleavage system [PATH:aqs00260]
aqs_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:aqs00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Aquitalea sp. USM4 [GN:aqs]
Gene
DKK66_03715  aspartate kinase [KO:K00928] [EC:2.7.2.4]
DKK66_14330  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
DKK66_14335  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
DKK66_03890  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
DKK66_09265  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
DKK66_03880  threonine synthase [KO:K01733] [EC:4.2.3.1]
DKK66_06350  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
DKK66_02700  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
DKK66_04240  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
DKK66_03685  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
DKK66_02570  glycerate kinase [KO:K00865] [EC:2.7.1.165]
DKK66_15170  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
DKK66_03635  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
DKK66_17255  3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
DKK66_12060  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
DKK66_11985  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
DKK66_11990  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
DKK66_12695  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
DKK66_12680  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
DKK66_03075  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DKK66_08560  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DKK66_12685  gcvH; glycine cleavage system protein GcvH [KO:K02437]
DKK66_11070  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
DKK66_08765  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
DKK66_10710  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
DKK66_12195  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
DKK66_10715  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
DKK66_04780  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
DKK66_10825  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
DKK66_10830  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
DKK66_10805  N-methylproline demethylase [KO:K21833] [EC:1.5.7.3]
DKK66_10810  (Fe-S)-binding protein [KO:K21834]
DKK66_10815  electron transfer flavoprotein subunit alpha [KO:K25960]
DKK66_10820  electron transfer flavoprotein subunit beta [KO:K25961]
DKK66_10770  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
DKK66_10760  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
DKK66_10775  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
DKK66_10765  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
DKK66_15540  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
DKK66_17660  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
DKK66_10940  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
DKK66_07155  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
DKK66_14365  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
DKK66_14360  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
aqs00010  Glycolysis / Gluconeogenesis
aqs00020  Citrate cycle (TCA cycle)
aqs00230  Purine metabolism
aqs00250  Alanine, aspartate and glutamate metabolism
aqs00270  Cysteine and methionine metabolism
aqs00290  Valine, leucine and isoleucine biosynthesis
aqs00300  Lysine biosynthesis
aqs00330  Arginine and proline metabolism
aqs00460  Cyanoamino acid metabolism
aqs00470  D-Amino acid metabolism
aqs00564  Glycerophospholipid metabolism
aqs00620  Pyruvate metabolism
aqs00630  Glyoxylate and dicarboxylate metabolism
aqs00640  Propanoate metabolism
aqs00680  Methane metabolism
aqs00860  Porphyrin metabolism
aqs00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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