KEGG   PATHWAY: asun00260
Entry
asun00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Arthrobacter sunyaminii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
asun00260  Glycine, serine and threonine metabolism
asun00260

Module
asun_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:asun00260]
asun_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:asun00260]
asun_M00555  Betaine biosynthesis, choline => betaine [PATH:asun00260]
asun_M00621  Glycine cleavage system [PATH:asun00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Arthrobacter sunyaminii [GN:asun]
Gene
KG104_01115  aspartate kinase [KO:K00928] [EC:2.7.2.4]
KG104_14610  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KG104_12875  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
KG104_12865  homoserine kinase [KO:K00872] [EC:2.7.1.39]
KG104_12870  threonine synthase [KO:K01733] [EC:4.2.3.1]
KG104_07590  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
KG104_04535  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KG104_17100  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KG104_01850  aminotransferase class V-fold PLP-dependent enzyme [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
KG104_07405  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KG104_00350  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KG104_02135  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
KG104_12415  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KG104_02590  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
KG104_09640  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
KG104_17115  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
KG104_17110  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
KG104_07125  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KG104_10075  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KG104_17105  gcvH; glycine cleavage system protein GcvH [KO:K02437]
KG104_15950  GMC family oxidoreductase N-terminal domain-containing protein [KO:K17755] [EC:1.1.3.17]
KG104_14965  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
KG104_15945  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
KG104_01940  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
KG104_14755  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
KG104_17095  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
KG104_04755  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
KG104_07980  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
KG104_07975  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
KG104_01550  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
asun00010  Glycolysis / Gluconeogenesis
asun00020  Citrate cycle (TCA cycle)
asun00230  Purine metabolism
asun00250  Alanine, aspartate and glutamate metabolism
asun00270  Cysteine and methionine metabolism
asun00290  Valine, leucine and isoleucine biosynthesis
asun00300  Lysine biosynthesis
asun00330  Arginine and proline metabolism
asun00460  Cyanoamino acid metabolism
asun00470  D-Amino acid metabolism
asun00564  Glycerophospholipid metabolism
asun00620  Pyruvate metabolism
asun00630  Glyoxylate and dicarboxylate metabolism
asun00640  Propanoate metabolism
asun00680  Methane metabolism
asun00860  Porphyrin metabolism
asun00920  Sulfur metabolism
KO pathway
ko00260   
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