KEGG   PATHWAY: ath00053
Entry
ath00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Arabidopsis thaliana (thale cress)
Class
Metabolism; Carbohydrate metabolism
Pathway map
ath00053  Ascorbate and aldarate metabolism
ath00053

Module
ath_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:ath00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Arabidopsis thaliana (thale cress) [GN:ath]
Gene
AT5G39320  UDG4; UDP-glucose 6-dehydrogenase family protein [KO:K00012] [EC:1.1.1.22]
AT1G26570  UGD1; UDP-glucose dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
AT5G15490  UGD3; UDP-glucose 6-dehydrogenase family protein [KO:K00012] [EC:1.1.1.22]
AT3G29360  UGD2; UDP-glucose 6-dehydrogenase family protein [KO:K00012] [EC:1.1.1.22]
AT3G01010  UDP-glucose/GDP-mannose dehydrogenase family protein [KO:K00012] [EC:1.1.1.22]
AT5G52560  USP; UDP-sugar pyrophosphorylase [KO:K12447] [EC:2.7.7.64]
AT5G14470  GHMP kinase family protein [KO:K16190] [EC:2.7.1.43]
AT3G01640  GLCAK; glucuronokinase G [KO:K16190] [EC:2.7.1.43]
AT2G19800  MIOX2; myo-inositol oxygenase 2 [KO:K00469] [EC:1.13.99.1]
AT1G14520  MIOX1; myo-inositol oxygenase 1 [KO:K00469] [EC:1.13.99.1]
AT4G26260  MIOX4; myo-inositol oxygenase 4 [KO:K00469] [EC:1.13.99.1]
AT5G56640  MIOX5; myo-inositol oxygenase 5 [KO:K00469] [EC:1.13.99.1]
AT2G37790  AKR4C10; NAD(P)-linked oxidoreductase superfamily protein [KO:K00002] [EC:1.1.1.2]
AT5G01670  NAD(P)-linked oxidoreductase superfamily protein [KO:K00002] [EC:1.1.1.2]
AT5G11540  GulLO3; D-arabinono-1,4-lactone oxidase family protein [KO:K00103] [EC:1.1.3.8]
AT2G46750  GulLO2; D-arabinono-1,4-lactone oxidase family protein [KO:K00103] [EC:1.1.3.8]
AT2G46740  GulLO5; D-arabinono-1,4-lactone oxidase family protein [KO:K00103] [EC:1.1.3.8]
AT1G32300  GulLO1; D-arabinono-1,4-lactone oxidase family protein [KO:K00103] [EC:1.1.3.8]
AT2G46760  GulLO6; D-arabinono-1,4-lactone oxidase family protein [KO:K00103] [EC:1.1.3.8]
AT5G56490  GulLO4; D-arabinono-1,4-lactone oxidase family protein [KO:K00103] [EC:1.1.3.8]
AT5G56470  GulLO7; FAD-dependent oxidoreductase family protein [KO:K00103] [EC:1.1.3.8]
AT5G28840  GME; GDP-D-mannose 3',5'-epimerase [KO:K10046] [EC:5.1.3.18 5.1.3.-]
AT5G55120  VTC5; GDP-L-galactose phosphorylase VITAMIN C DEFECTIVE 5 (VTC5) [KO:K14190] [EC:2.7.7.69]
AT4G26850  VTC2; GDP-L-galactose phosphorylase 1 [KO:K14190] [EC:2.7.7.69]
AT3G02870  VTC4; Inositol monophosphatase family protein [KO:K10047] [EC:3.1.3.25 3.1.3.93]
AT4G39120  IMPL2; inositol monophosphatase family protein [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
AT4G33670  NAD(P)-linked oxidoreductase superfamily protein [KO:K17744] [EC:1.1.1.316]
AT3G47930  GLDH; L-galactono-1,4-lactone dehydrogenase [KO:K00225] [EC:1.3.2.3]
AT4G00110  GAE3; UDP-D-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
AT4G30440  GAE1; UDP-D-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
AT4G12250  GAE5; UDP-D-glucuronate 4-epimerase 5 [KO:K08679] [EC:5.1.3.6]
AT2G45310  GAE4; UDP-D-glucuronate 4-epimerase 4 [KO:K08679] [EC:5.1.3.6]
AT1G02000  GAE2; UDP-D-glucuronate 4-epimerase 2 [KO:K08679] [EC:5.1.3.6]
AT3G23820  GAE6; UDP-D-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
AT5G03630  ATMDAR2; Pyridine nucleotide-disulfide oxidoreductase family protein [KO:K08232] [EC:1.6.5.4]
AT3G52880  MDAR1; monodehydroascorbate reductase 1 [KO:K08232] [EC:1.6.5.4]
AT3G27820  MDAR4; monodehydroascorbate reductase 4 [KO:K08232] [EC:1.6.5.4]
AT3G09940  MDHAR; monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
AT1G63940  MDAR6; monodehydroascorbate reductase 6 [KO:K08232] [EC:1.6.5.4]
AT1G07890  APX1; ascorbate peroxidase 1 [KO:K00434] [EC:1.11.1.11]
AT3G09640  APX2; ascorbate peroxidase 2 [KO:K00434] [EC:1.11.1.11]
AT4G35000  APX3; ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
AT4G35970  APX5; ascorbate peroxidase 5 [KO:K00434] [EC:1.11.1.11]
AT1G77490  TAPX; thylakoidal ascorbate peroxidase [KO:K00434] [EC:1.11.1.11]
AT4G08390  SAPX; stromal ascorbate peroxidase [KO:K00434] [EC:1.11.1.11]
AT4G32320  APX6; ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
AT1G19550  Glutathione S-transferase family protein [KO:K21888] [EC:1.8.5.1 2.5.1.18]
AT1G19570  DHAR1; dehydroascorbate reductase [KO:K21888] [EC:1.8.5.1 2.5.1.18]
AT1G75270  DHAR2; dehydroascorbate reductase 2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
AT5G16710  DHAR3; dehydroascorbate reductase 1 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
AT5G21100  Plant L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
AT1G55570  sks12; SKU5 similar 12 [KO:K00423] [EC:1.10.3.3]
AT5G21105  Plant L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
AT3G13390  sks11; SKU5 similar 11 [KO:K00423] [EC:1.10.3.3]
AT1G55560  sks14; SKU5 similar 14 [KO:K00423] [EC:1.10.3.3]
AT3G13400  sks13; SKU5 similar 13 [KO:K00423] [EC:1.10.3.3]
AT1G23800  ALDH2B7; aldehyde dehydrogenase 2B7 [KO:K00128] [EC:1.2.1.3]
AT3G48000  ALDH2B4; aldehyde dehydrogenase 2B4 [KO:K00128] [EC:1.2.1.3]
AT4G34240  ALDH3I1; aldehyde dehydrogenase 3I1 [KO:K00128] [EC:1.2.1.3]
AT1G44170  ALDH3H1; aldehyde dehydrogenase 3H1 [KO:K00128] [EC:1.2.1.3]
AT4G36250  ALDH3F1; aldehyde dehydrogenase 3F1 [KO:K00128] [EC:1.2.1.3]
AT1G54100  ALDH7B4; aldehyde dehydrogenase 7B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
ath00020  Citrate cycle (TCA cycle)
ath00040  Pentose and glucuronate interconversions
ath00051  Fructose and mannose metabolism
ath00520  Amino sugar and nucleotide sugar metabolism
ath00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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