KEGG   PATHWAY: bage00260
Entry
bage00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Buttiauxella agrestis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bage00260  Glycine, serine and threonine metabolism
bage00260

Module
bage_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bage00260]
bage_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bage00260]
bage_M00621  Glycine cleavage system [PATH:bage00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Buttiauxella agrestis [GN:bage]
Gene
BADSM9389_38310  lysC; lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
BADSM9389_06180  bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
BADSM9389_40630  bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
BADSM9389_30080  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BADSM9389_02680  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BADSM9389_06190  homoserine kinase [KO:K00872] [EC:2.7.1.39]
BADSM9389_06200  threonine synthase [KO:K01733] [EC:4.2.3.1]
BADSM9389_27700  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
BADSM9389_10600  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BADSM9389_26460  glyoxylate/hydroxypyruvate reductase GhrA [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BADSM9389_01910  ghrB; glyoxylate/hydroxypyruvate reductase GhrB [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BADSM9389_31220  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BADSM9389_36230  glycerate 2-kinase [KO:K00865] [EC:2.7.1.165]
BADSM9389_08990  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BADSM9389_30440  glycerate kinase [KO:K11529] [EC:2.7.1.165]
BADSM9389_13110  2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
BADSM9389_06100  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
BADSM9389_40950  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
BADSM9389_07350  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BADSM9389_27380  3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
BADSM9389_06030  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
BADSM9389_19760  bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BADSM9389_41000  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
BADSM9389_40990  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BADSM9389_21340  tynA; primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
BADSM9389_07450  aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
BADSM9389_07430  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
BADSM9389_34300  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BADSM9389_07440  glycine cleavage system protein H [KO:K02437]
BADSM9389_10250  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
BADSM9389_18680  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BADSM9389_08880  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BADSM9389_18010  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BADSM9389_40210  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
BADSM9389_07260  tdcB; bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB [KO:K01754] [EC:4.3.1.19]
BADSM9389_15860  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
BADSM9389_30300  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
BADSM9389_00210  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
BADSM9389_08390  aspartate/glutamate racemase [KO:K25316] [EC:5.1.1.10]
BADSM9389_20040  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
BADSM9389_20050  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
BADSM9389_21700  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
BADSM9389_21690  2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bage00010  Glycolysis / Gluconeogenesis
bage00020  Citrate cycle (TCA cycle)
bage00230  Purine metabolism
bage00250  Alanine, aspartate and glutamate metabolism
bage00270  Cysteine and methionine metabolism
bage00290  Valine, leucine and isoleucine biosynthesis
bage00300  Lysine biosynthesis
bage00330  Arginine and proline metabolism
bage00460  Cyanoamino acid metabolism
bage00470  D-Amino acid metabolism
bage00564  Glycerophospholipid metabolism
bage00600  Sphingolipid metabolism
bage00620  Pyruvate metabolism
bage00630  Glyoxylate and dicarboxylate metabolism
bage00640  Propanoate metabolism
bage00680  Methane metabolism
bage00860  Porphyrin metabolism
bage00920  Sulfur metabolism
KO pathway
ko00260   
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