KEGG   PATHWAY: bgd00260
Entry
bgd00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia gladioli BSR3
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bgd00260  Glycine, serine and threonine metabolism
bgd00260

Module
bgd_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bgd00260]
bgd_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bgd00260]
bgd_M00555  Betaine biosynthesis, choline => betaine [PATH:bgd00260]
bgd_M00621  Glycine cleavage system [PATH:bgd00260]
bgd_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bgd00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Burkholderia gladioli BSR3 [GN:bgd]
Gene
bgla_1g26470  aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]
bgla_2g18170  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
bgla_1g23230  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
bgla_2g04250  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
bgla_2g21430  Homoserine kinase [KO:K02204] [EC:2.7.1.39]
bgla_1g23220  Threonine synthase [KO:K01733] [EC:4.2.3.1]
bgla_2g12120  aromatic amino acid beta-eliminating lyase/threonine aldolase [KO:K01620] [EC:4.1.2.48]
bgla_2g18230  Phenylserine aldolase [KO:K01620] [EC:4.1.2.48]
bgla_2g28410  Threonine aldolase [KO:K01620] [EC:4.1.2.48]
bgla_1g16470  L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
bgla_1g36910  Beta-eliminating lyase superfamily [KO:K01620] [EC:4.1.2.48]
bgla_2g04800  Serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
bgla_1g07320  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
bgla_1g02940  putative 2-hydroxyacid dehydrogenase family protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
bgla_1g36480  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
bgla_2g20790  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
bgla_2g08130  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
bgla_1g22210  Gluconate 2-dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
bgla_1g10220  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
bgla_1g23950  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
bgla_1g35480  Phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
bgla_1g06130  hypothetical protein [KO:K15634] [EC:5.4.2.11]
bgla_2g19120  D-3-phosphoglycerate dehydrogenase, putative [KO:K00058] [EC:1.1.1.95 1.1.1.399]
bgla_2g26690  D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
bgla_1g38400  Glyoxylate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
bgla_1g09590  Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
bgla_1p0770  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
bgla_1g22580  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
bgla_1g07300  Short-chain dehydrogenase/reductase SDR [KO:K16066] [EC:1.1.1.381 1.1.1.-]
bgla_2g00080  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
bgla_2g00090  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
bgla_1g01180  Glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
bgla_1g01200  Glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
bgla_2g03070  hypothetical protein [KO:K00382] [EC:1.8.1.4]
bgla_1g28040  Dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
bgla_1g18080  Dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
bgla_1g01190  Glycine cleavage system H protein [KO:K02437]
bgla_1g14680  Scyllo-inosamine-4-phosphate amidinotransferase [KO:K00613] [EC:2.1.4.1]
bgla_1g29400  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
bgla_2g07150  Choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
bgla_2g18520  Betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
bgla_2g07160  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
bgla_2g18610  putative aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
bgla_2g07660  Iron-sulfur cluster-binding protein, rieske family protein [KO:K00479] [EC:1.14.13.251]
bgla_2g07670  Ferredoxin [KO:K21832] [EC:1.14.13.251]
bgla_2g07620  NADH:flavin oxidoreductase/NADH oxidase [KO:K21833] [EC:1.5.7.3]
bgla_2g07630  Fe-S oxidoreductase [KO:K21834]
bgla_2g07640  Electron transfer flavoprotein, alpha subunit [KO:K25960]
bgla_2g07650  hypothetical protein [KO:K25961]
bgla_2g06670  Sarcosine oxidase, alpha subunit family protein [KO:K00302] [EC:1.5.3.24 1.5.3.1]
bgla_2g06650  Sarcosine oxidase beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
bgla_2g06680  Sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
bgla_2g06660  SoxD [KO:K00304] [EC:1.5.3.24 1.5.3.1]
bgla_1g01160  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
bgla_2g06640  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
bgla_2g09870  Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
bgla_1g34460  Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
bgla_1g24170  Threonine dehydratase catabolic [KO:K01754] [EC:4.3.1.19]
bgla_2g24970  Pyridoxal-5'-phosphate-dependent protein beta subunit [KO:K01754] [EC:4.3.1.19]
bgla_1g34510  hypothetical protein [KO:K01753] [EC:4.3.1.18]
bgla_1g28130  putative racemase [KO:K25316] [EC:5.1.1.10]
bgla_2g18110  Tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
bgla_2g18130  Tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
bgla_1g14730  diaminobutyrate/2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
bgla_2g20660  aminotransferase class-III [KO:K15785] [EC:2.6.1.76]
bgla_2g20670  succinate semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bgd00010  Glycolysis / Gluconeogenesis
bgd00020  Citrate cycle (TCA cycle)
bgd00230  Purine metabolism
bgd00250  Alanine, aspartate and glutamate metabolism
bgd00270  Cysteine and methionine metabolism
bgd00290  Valine, leucine and isoleucine biosynthesis
bgd00300  Lysine biosynthesis
bgd00330  Arginine and proline metabolism
bgd00460  Cyanoamino acid metabolism
bgd00470  D-Amino acid metabolism
bgd00564  Glycerophospholipid metabolism
bgd00600  Sphingolipid metabolism
bgd00620  Pyruvate metabolism
bgd00630  Glyoxylate and dicarboxylate metabolism
bgd00640  Propanoate metabolism
bgd00680  Methane metabolism
bgd00860  Porphyrin metabolism
bgd00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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