KEGG   PATHWAY: bhai00260
Entry
bhai00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Bacillus haikouensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bhai00260  Glycine, serine and threonine metabolism
bhai00260

Module
bhai_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bhai00260]
bhai_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bhai00260]
bhai_M00621  Glycine cleavage system [PATH:bhai00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bacillus haikouensis [GN:bhai]
Gene
KJK41_09500  dapG; aspartate kinase [KO:K00928] [EC:2.7.2.4]
KJK41_16485  aspartate kinase [KO:K00928] [EC:2.7.2.4]
KJK41_18505  aspartate kinase [KO:K00928] [EC:2.7.2.4]
KJK41_09495  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KJK41_02400  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
KJK41_02410  homoserine kinase [KO:K00872] [EC:2.7.1.39]
KJK41_02405  threonine synthase [KO:K01733] [EC:4.2.3.1]
KJK41_13020  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
KJK41_20845  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KJK41_19990  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KJK41_12405  gpmA; 2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
KJK41_12560  phosphoglycerate mutase family protein [KO:K01834] [EC:5.4.2.11]
KJK41_14795  phosphoglycerate mutase family protein [KO:K01834] [EC:5.4.2.11]
KJK41_06690  phosphoglycerate mutase family protein [KO:K01834] [EC:5.4.2.11]
KJK41_18830  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
KJK41_19105  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KJK41_19110  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
KJK41_11405  HAD family hydrolase [KO:K25528] [EC:3.1.3.3]
KJK41_21280  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
KJK41_18160  flavin monoamine oxidase family protein [KO:K00274] [EC:1.4.3.4]
KJK41_15125  gcvPA; aminomethyl-transferring glycine dehydrogenase subunit GcvPA [KO:K00282] [EC:1.4.4.2]
KJK41_15120  gcvPB; aminomethyl-transferring glycine dehydrogenase subunit GcvPB [KO:K00283] [EC:1.4.4.2]
KJK41_15130  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
KJK41_14910  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KJK41_02320  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KJK41_08415  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KJK41_18265  gcvH; glycine cleavage system protein GcvH [KO:K02437]
KJK41_10285  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
KJK41_15755  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
KJK41_15815  bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase [KO:K17217] [EC:4.4.1.1 4.4.1.2]
KJK41_09030  sdaAB; L-serine ammonia-lyase, iron-sulfur-dependent subunit beta [KO:K01752] [EC:4.3.1.17]
KJK41_09035  sdaAA; L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha [KO:K01752] [EC:4.3.1.17]
KJK41_02395  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
KJK41_11680  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
KJK41_13430  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
KJK41_13435  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
KJK41_18535  aspartate aminotransferase family protein [KO:K00836] [EC:2.6.1.76]
KJK41_18530  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bhai00010  Glycolysis / Gluconeogenesis
bhai00020  Citrate cycle (TCA cycle)
bhai00230  Purine metabolism
bhai00250  Alanine, aspartate and glutamate metabolism
bhai00270  Cysteine and methionine metabolism
bhai00290  Valine, leucine and isoleucine biosynthesis
bhai00300  Lysine biosynthesis
bhai00330  Arginine and proline metabolism
bhai00460  Cyanoamino acid metabolism
bhai00470  D-Amino acid metabolism
bhai00564  Glycerophospholipid metabolism
bhai00600  Sphingolipid metabolism
bhai00620  Pyruvate metabolism
bhai00630  Glyoxylate and dicarboxylate metabolism
bhai00640  Propanoate metabolism
bhai00680  Methane metabolism
bhai00860  Porphyrin metabolism
bhai00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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